Category: alcohols-buliding-blocks

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C4H8O3

a solution of methyl (2S)-2-hydroxypropanoate (5 g, 48.03 mmol, 1.00 eq.) and 1H-imidazole (4.9 g, 71.98mmol, 1.50 eq.) in dichloromethane (100 mL) was placed into a 250-mL round-bottom flask. This was followed by the addition of a solution of tert-butyl(chloro)dimethylsilane (8.69 g, 57.66 mmol, 1.20 eq.) in dichloromethane (50 mL) dropwise with stirring at 0C. The resulting solution was stirred for 2 hours at room temperature. The reaction was then quenched by the addition of 80 mL of water/ice and extracted with dichloromethane (3×50 mL). The resultingmixture was washed with brine (2×100 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 8 g (76%) of methyl (2S)-2-[(tert- butyldimethylsilyl)oxy]propanoate as a colorless liquid.

With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.

Reference:
Patent; BASTOS Cecilia M.; MUNOZ Benito; TAIT Bradley; WO2015/196071; (2015); A1;,
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Related Products of 61367-62-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61367-62-2, name is 4-Bromo-3,5-dimethoxybenzyl alcohol. A new synthetic method of this compound is introduced below.

To a round bottom flask was added (4-bromo-3,5-dimethoxy-phenyl)methanol (Compound 10, 0.5 g, 2.02 mmol) and dichloromethane (15 mL). The reaction was cooled to 0 °C and diethylaminosulfur trifluoride (0.360 g, 2.23 mmol) was added. The reaction was allowed to warm to room temperature and stir for 1 hour. The reaction was quenched using saturated sodium bicarbonate, the layers were separated and the organic layer was dried using sodium sulfate, filtered and concentrated in vacuo. The resulting solid was purified on silica gel using ethyl acetate and hexanes as eluent. Product, 2-bromo-5-(fluoromethyl)-l,3- dimethoxybenzene, (Compound 14, 0.171 g, 33.9percent yield) was isolated as a pale yellow solid. LC-MS: tR=2.23 min; m+H=249.0, 251.0 (bromine isotopes).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; RUMINSKI, Peter, G.; MEYERS, Marvin, L.; HEIER, Richard, F.; RETTIG, Michael, P.; DIPERSIO, John; (139 pag.)WO2018/85552; (2018); A1;,
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Reference of 14320-38-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, molecular weight is 84.12, as common compound, the synthetic route is as follows.

To a solution of cyclopent-3-en-1-ol (compound 32a, 5.0 g, 59.4 mmol) in THF (100.0 ml) was added NaH (3.1 g, 77.2 mmol) in portions at 0 oC. The reaction was stirred at the same temperature for 30 minutes, then BnBr (10.2 g, 59.4 mmol) was added dropwise. The reaction was warmed to room temperature and stirred for 12 hours. The reaction was quenched with H2O (300 mL) and extracted with EtOAc twice (200 mL). The combined organic layer was dried over Na2SO4, concentrated to give compound 32b (12.5 g, crude) as a brown oil.

Statistics shows that 14320-38-8 is playing an increasingly important role. we look forward to future research findings about Cyclopent-3-enol.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HU, Taishan; KOU, Buyu; LIN, Xianfeng; LIU, Haixia; ZHANG, Zhisen; (152 pag.)WO2018/11160; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol. A new synthetic method of this compound is introduced below., SDS of cas: 171011-37-3

After dissolving Compound 3 (5.2 g, 23.9 mmol) in methylene chloride (50 milliliter), followed by adding N-bromosuccinimide (12.8 g, 71.7 mmol) at room temperature, and then the resultant solution was stirred for 6 hours. Water (200 milliliter) was poured in the resultant reaction solution, and the deposited solid was washed by ethanol, and as a result, Compound 4 was obtained. Product Amount: 6.9 g, Yield: 84 %

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 171011-37-3, (4-Bromo-1,2-phenylene)dimethanol.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1659129; (2006); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 558-42-9

Step 1: Methyl 1H-pyrazole-3-carboxylate (2.52 g, 20 mmol, 1 equiv.) was dissolved in DMF (20 mL). K2CO3 (5.53 g, 40 mmol, 2 equiv.) was added, followed by 1-chloro-2-methyl- 2-propanol (2.67 mL, 26 mmol, 1.3 equiv.). The reaction mixture was heated to 80 °C for 40 hours and cooled to room temperature. The reaction mixture was poured into water, extracted with EtOAc, and the combined organic extracts were washed with water and brine. The organic layer was concentrated, and the crude residue was purified on SiO2 (25 100percent EtOAc/Hexanes) to afford the title compound as a colorless oil that solidified upon standing (2.08 g, 53percent yield).

With the rapid development of chemical substances, we look forward to future research findings about 558-42-9.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan Reddy; MILES, Dillon Harding; POWERS, Jay Patrick; ROSEN, Brandon Reid; SHARIF, Ehesan Ul; (109 pag.)WO2018/213377; (2018); A1;,
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Related Products of 50919-06-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50919-06-7, name is 2-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 5.1.57.3. Step 3. To a solution of 2-(3-fluorophenyl)ethanol(25.26 g, 180 mmol) in pyridine (180 mL) was added TsCl(36.49 g, 186 mmol) at 0 C with silica gel blue tube. After stirringat rt for 4 h, the reaction was quenched by the addition of 2 N HCl (750 mL) at 0 C. This mixture was extracted with EtOAc (300 mL).The separable organic layer was washed with 2 N HCl (250 mL),H2O (200 mL), brine (100 mL), and dried over MgSO4, filtered, concentratedunder reduced pressure. The residue was purified by columnchromatography (SiO2, n-hexane/EtOAc = 10/1-5/1) to obtain2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate (38.54 g, 73%)as a colorless oil.

According to the analysis of related databases, 50919-06-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imaeda, Toshihiro; Ono, Koji; Nakai, Kazuo; Hori, Yasunobu; Matsukawa, Jun; Takagi, Terufumi; Fujioka, Yasushi; Tarui, Naoki; Kondo, Mitsuyo; Imanishi, Akio; Inatomi, Nobuhiro; Kajino, Masahiro; Itoh, Fumio; Nishida, Haruyuki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3719 – 3735;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (Perfluorophenyl)methanol

Example 11 In a 30 ml two-necked flask were added 0.004 g of LeOH.H2O, 0.40 g of methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.8 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropanecarboxylate was 84% based on the starting ester.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
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Related Products of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetyl chloride (1.816 g, 23.14 mmol) was added slowly to a solution of (±)-4a (1.728 g, 11.50 mmol) and dry pyridine (2.757 g,34.85 mmol) in dry CH2Cl2 (30 mL) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with water (30 mL) at 0 C. The mixture was extracted with Et2O (50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4 and filtered. After removal ofthe solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc 5/1) to afford (±)-5a (2.079 g, 94%) as a colorless oil. 1H NMR data were identical to those reported in the literature [40].

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kato, Daiki; Kawasaki, Masashi; Morita, Yuko; Okada, Takuya; Tanaka, Yasuo; Toyooka, Naoki; Tetrahedron; (2020);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 4 (Table 1, entry 2, and Scheme 6): Preparation 2-[2-(aminocarbonyl)(2- chloroethyl)-4,6-dinitroanilino] ethyl methanesulfonate (13a); A solution of 2-chloro-3,5- dinitrobenzamide (11) (250 mg, 1.15 mmol) in THF (20 mL) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added over 10 min to the stirred mixture, which was then kept at 20 0C overnight. Water (50 mL) was added, followed by EtOAc (50 mL). The mixture was separated and aqueous phase was extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine, dried and concentrated under reduced pressure, chromatography on silica gel and elution with EtOAc/petroleum ether (1:1), to give 2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitrobenzamide (12a) (350 mg, 92%) as a yellow solid: mp (EtOAc/petroleum ether) 96-100 C; 1H NMR [(CD3)2SO] delta 8.69 (d, / = 2.8 Hz, 1 H), 8.43 (s, 1 H, CONH), 8.35 (dj = 2.8 Hz, 1 H), 8.10 (s, 1 H), 5.15 (tj = 5.6 Hz, 1 H), 3.77 (m, 2 H), 3.54 (m, 4 H), 3.14 (m, 2 H); 13C NMR delta 167.6, 146.7, 143.8, 139.7, 134.1, 128.2, 123.1, 57.8, 54.3, 53.6, 41.4; Anal. Calcd. for C11H13ClN4O6: C, 39.7; H, 3.9, N, 16.8. Found: C, 38.4; H, 4.4; N, 15.7%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-52-2, 2-(Aziridin-1-yl)ethanol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6240-11-5, 1-Adamantaneethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6240-11-5, blongs to alcohols-buliding-blocks compound. Formula: C12H20O

(a) 2-[2-(1-Adamantyl)ethyloxy]ethylamine The desired intermediate was obtained, according to the procedure of Example 11, starting from 1-(2-hydroxyethyl)adamantane. Yield: 46%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6240-11-5, its application will become more common.

Reference:
Patent; Ausonia Farmaceutici s.r.l.; US4634701; (1987); A;,
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