Category: alcohols-buliding-blocks

Related Products of 145691-59-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 145691-59-4, name is (3,5-Dibromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

1,3-Dibromo-5-ethoxymethyl-benzene A solution of 3,5-dibromobenzyl alcohol (2.0 h, 8 mmol) in tetrahydrofuran (80 mL) was cooled to 5° C. and treated with sodium hydride (dispersion in oil 55percent; 316 mg, 8 mmol). The mixture was left to warm to room temperature and stirred for 15 min. Ethyliodide (2.35 g, 15 mmol) was added and the mixture stirred for 5 h. For the working-up, the reaction mixture was evaporated, then extracted with a mixture of ethyl acetate and saturated sodium hydrogencarbonate solution. After the aqueous layer was re-extracted twice with ethyl acetate, the organic layers were combined, dried over sodium sulfate, and evaporated under reduced pressure. There were obtained 1.15 g of the title compound (yield: 52percent) as a yellow oil in sufficient purity to be engaged in the next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 145691-59-4, (3,5-Dibromophenyl)methanol.

Reference:
Patent; Andreini, Matteo; Gabellieri, Emanuele; Guba, Wolfgang; Marconi, Guido; Narquizian, Robert; Power, Eoin; Travagli, Massimiliano; Woltering, Thomas; Wostl, Wolfgang; US2009/209529; (2009); A1;,
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Application of 30951-66-7, Adding some certain compound to certain chemical reactions, such as: 30951-66-7, name is 2-(3-Bromophenyl)propan-2-ol,molecular formula is C9H11BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 30951-66-7.

11.1 [1-(3-Bromophenyl)-1-(methyl)ethyl]oxytrimethylsilane 3.4 g of the compound prepared according to 7.1 in 80 ml of dichloromethane, at 0 C., are placed in a round-bottomed flask. 5.6 ml of triethylamine and 4.5 ml of trimethylsilane chloride are added. The mixture is stirred for one hour at 0 C. and 20 h at ambient temperature. 50 ml of water are added and the mixture is extracted with 30 ml of dichloromethane. The organic phase is washed with 20 ml of a saturated solution of sodium chloride, dried over magnesium sulphate and then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a heptane/ethyl acetate mixture. 2.5 g of compound are obtained. 1H NMR (CDCl3, delta in ppm): 0 (s, 9H); 1.45 (s, 6H); 7.15 to 7.25 (m, 3H); 7.45 (m, 1H).

According to the analysis of related databases, 30951-66-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS; US2011/65727; (2011); A1;,
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Reference of 14320-38-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, molecular weight is 84.12, as common compound, the synthetic route is as follows.

Cyclopent-3-en-l-ol (10 g, 118.9 mmol) was dissolved in DMF (100 mL) at 0 C, then lH-imidazole (17.29 mL, 261.5 mmol) was added followed by tert- butyl(chloro)dimethylsilane (21.5 g, 142.7 mmol) and warmed up to r.t.. The mixture was stirred at r.t. for 14 h, diluted with EtOAc (300 mL) and washed with 5 % LiCl (2x 100 mL), brine (50 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash column chromatography (Si02, 0-10% EtOAc in hexanes) to afford 17.2 g (73 %) of the title product as a colourless clear liquid. 1H NMR (250 MHz, CDC13) delta ppm 5.66 (s, 2H), 4.53 (tt, J 7.0, 3.6 Hz, 1H), 2.57 (dd, J 15.2, 6.8 Hz, 2H), 2.27 (dd, J 15.3, 3.6 Hz, 2H), 0.89 (s, 9H), 0.06 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis 14320-38-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki, Peter; BRACE, Gareth, Neil; BROWN, Julien, Alistair; CALMIANO, Mark, Daniel; CHOVATIA, Praful, Tulshi; DELIGNY, Michael; GALLIMORE, Ellen, Olivia; HEER, Jag, Paul; JACKSON, Victoria, Elizabeth; KROEPLIEN, Boris; MAC COSS, Malcolm; QUINCEY, Joanna, Rachel; SABNIS, Yogesh, Anil; SWINNEN, Dominique, Louis, Leon; ZHU, Zhaoning; WO2015/86526; (2015); A1;,
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Application of 17849-38-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 17849-38-6 as follows.

4-methyl-benzenesulfonamide (171mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1.0mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), 2- chlorobenzyl alcohol (171mg, 1.2 mmol) and water (1ml) were successively added 25ml Schlenk reaction flask.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.A large amount of precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 92%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17849-38-6, its application will become more common.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
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Reference of 223251-16-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 223251-16-9 as follows.

This material is prepared from the amino alcohol 1-[2-(4-Hydroxymethyl-phenoxy)-ethyl]azapine by treatment with thionyl chloride in THF at 0C. Resulting solid is used without further purification.1H-NMR (CDCl3) delta 1.7 (m, 2H), 1.9 (m, 4H), 2.2 (m, 2H), 3.1 (m, 2H), 3.4 (7, 2H), 3.6 (t.2H), 6.9 (d, 2H), 7.3 (d, 2H), 12.5 (1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,223251-16-9, its application will become more common.

Reference:
Patent; Wyeth; EP1159267; (2004); B1;,
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Related Products of 30379-58-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

Benzyl 2-hydroxyacetate (3.2 ml, 22.2 mmol), sodium sulfate (0.63 g, 4.4 mmol), and MeCN (34 ml) were placed in a 100 ml two-necked RBF fitted with a magnetic stirrer, a dropping funnel and a refluxing condenser. 2,2-Difluoro-2-(fluorosulfonyl)acetic acid (9.18 ml, 89 mmol) was then added with stirring at 45 0C. After addition, the mixture was further stirred for 1 h at this temperature. The reaction mixture was poured into 10% aqueous sodium carbonate and was extracted with diethyl ether, the combined extracts were washed with 10% aqueous sodium carbonate, water, brine, dried over sodium sulfate, and concentrated. The crude material was purified by column chromatography (4:1 Hexanes/EtOAc) to afford the intermediate benzyl 2-(difluoromethoxy)acetate which was dissolved in EtOAc (34 mL). N-Ethyl-N-isopropylpropan-2 -amine (0.561 ml, 3.2 mmol) was added and after degassing with nitrogen, palladium on carbon (0.680 g, 0.64 mmol) was added. The reaction was purged with hydrogen and stirred under 50 PSI of hydrogen for 24 hours. The degassed reaction was filtered through a pad of Celite and concentrate to afford the titled product as the amine salt which was used directly for subsequent reaction steps without further purification.

According to the analysis of related databases, 30379-58-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2008/147547; (2008); A1;,
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Reference of 597-31-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal. A new synthetic method of this compound is introduced below.

2) Synthesis of Hydroxypivalic Acid: Add 40 ml of water to a 500 ml three-necked flask, start stirring, add 85 g of hydroxypivalaldehyde and 0.85 g of phosphotungstic acid catalyst, and then start heating. When the temperature rises to 55 C, Adding 123g of hydrogen peroxide, and adding for 2 hours; the oxidizing liquid is dehydrated under reduced pressure, filtering after dehydration to obtain the catalyst, taking out and reusing, and cooling and crystallizing the filtrate to obtain hydroxypivalic acid solution. 3) Drying: Hydroxypivalic acid solution was filtered to obtain wet products, the use of vacuum dryer for drying, temperature control at 58 , vacuum control in 0.085MPa, the final product hydroxypivalic acid, product yield of 85%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,597-31-9, 3-Hydroxy-2,2-dimethylpropanal, and friends who are interested can also refer to it.

Reference:
Patent; Jihua Jiangcheng Chemical Industry Co., Ltd; Sun, Chengjun; Chu, Ke; (8 pag.)CN105753683; (2016); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-(2-Aminophenyl)ethanol

Under protection of nitrogen, 2-aminophenylethanol (1.30 g, 9.5 mmol) was dissolved in anhydrous tetrahydrofuran (100 mL), the resulting solution was slowly added dropwise to a suspension of sodium hydride (60%, 0.42 g, 10.4 mmol) in anhydrous tetrahydrofuran (20 mL), the mixture was stirred for 15 min at room temperature, and added with tert-butyldiphenylchlorosilane (2.86 g, 10.4 mmol), and stirred for 20 hrs at room temperature. The reaction system was added with water, and extracted with methyl tert-butyl ester. The extracts were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure, to obtain a brown oil (3.75 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD; Cheng, Jianjun; Qin, Jihong; Ye, Bin; US2014/206679; (2014); A1;,
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Related Products of 4254-29-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of indan-2-ol (15, 99.7 mg, 0.74 mmol, 1 eq.), pyridinium chlorochromate (241.9 mg, 1.12 mmol, 1.5 eq.) and CH2Cl2 (3 mL) was vigorously stirred for 4 h at rt. A small amount of silica was added. Et2O (5 mL) was added and the reaction mixture was filtered under pressure. The residue was washed with Et2O. The filtrate was concentrated in vacuo. The crude product was purified by fc (d = 2 cm, l = 11 cm, v = 10 mL, cyclohexane:EtOAc 8:2, Rf = 0.11), yellow oil, yield 67.1 mg (68 %). C9H8O (132.2 g/mol). FT-IR (neat): nu (cm-1) = 2924 (C-H), 1743 (C=O), 740 and 648 (1,2-disubst. arom.). 1H NMR (400 MHz, CDCl3): delta (ppm) = 3.57 (s, 4H, 1-CH2, 3-CH2), 7.26 – 7.34 (m, 4H, Ar-H). 13C NMR (101 MHz, CD3OD): delta (ppm) = 44.2 (2C, C-1, C-3), 125.1 (2C, Cind), 127.5 (2C, Cind), 137.9 (2C, Cqind), 215.3 (1C, C=O). Exact Mass (APCI): m/z = 133.0654 (calcd. 133.0648 for C9H9O [M+H+]). Purity (HPLC, method 2) = 98.8 % (tR = 14.29 min).

According to the analysis of related databases, 4254-29-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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Related Products of 187731-65-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.187731-65-3, name is (2-Amino-4-methoxyphenyl)methanol, molecular formula is C8H11NO2, molecular weight is 153.18, as common compound, the synthetic route is as follows.

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

The chemical industry reduces the impact on the environment during synthesis 187731-65-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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