Category: alcohols-buliding-blocks

Application of 149965-40-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(2-Chloro-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl)methanol A suspension of (5-bromo-2-chlorophenyl)methanol (2.08 g, 9.39 mmol), potassium acetate (3.50 g, 35.7 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1 ,3,2-dioxaborolane) (2.77 g, 10.89 mmol) degassed with a stream of nitrogen for ~10 mins after which time bis(triphenylphosphine)palladium(ll) chloride (0.396 g, 0.563 mmol) was added and the mixture was heated to 120 C for 30 minutes in a microwave at high power. After this time, the suspension was cooled and filtered through celite using ethyl acetate to wash the celite. The dark colored solution was washed with water (4x gently), brine (1x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give the title compound (2.76g, 68.9%), LC-MS m/z 267.7 (M+H)+, 1 .0 minutes (ret time), 63 % purity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 149965-40-2, (5-Bromo-2-chlorophenyl)methanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; LI, Tindy; YAN, Hongxing; HEIGHTMAN, Thomas Daniel; WOOLFORD, Alison Jo-Anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; (109 pag.)WO2016/203400; (2016); A1;,
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Synthetic Route of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8Hz), 7.41 (2H, t, J=8Hz), 7.22 (2H, t, J=7Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1883-32-5, name is 2,2-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,2-Diphenylethanol

General procedure: Substrates, 1 and 2, were synthesized by the same method of 2-adamantyl chloroformate. The triphosgene treated in toluene at 0-4 C (ice bath) for 20 min. The mixture of 2-phenylethanol or 2,2-diphenylethanol with pyridine was prepared in toluene at room temperature. Then the latter mixture was added to the former solution slowly. After the stirring for 1 h, the organic mixture was washed with water and dried by magnesium sulfate. The solvent was removed by the evaporation, the colorless oil (1) or white solid (2) was obtained as a crude product. The substrate 1 was purified from vacuum distillation (120 C and 18 torr) and the substrate 2 was recrystallized by using ligroin. Solvents were purified as described previously.

With the rapid development of chemical substances, we look forward to future research findings about 1883-32-5.

Reference:
Article; Park, Kyoung-Ho; Yang, Gi-Hoon; Kyong, Jin Burm; Bulletin of the Korean Chemical Society; vol. 35; 8; (2014); p. 2263 – 2270;,
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Reference of 349-75-7 , The common heterocyclic compound, 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of the alcohol (3.839 mmol), K2CO3 (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.

The synthetic route of 349-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fukuda, Naohiro; Izumi, Minoru; Ikemoto, Tomomi; Tetrahedron Letters; vol. 56; 25; (2015); p. 3905 – 3908;,
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Synthetic Route of 29683-23-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 b Synthesis of 4-(4-Bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran To a stirring solution of 4-bromo-3,5-dimethylphenol (710 mg, 3.53 mM), tetrahydro-2H-thiopyran-4-ol (501 mg, 4.24 mM, compound of Step 1 a) and PPh3 (2316 mg, 8.83 mM) in anhydrous DCM (10 ml), DIAD (1785 mg, 8.83 mM) was added under Ar atmosphere. The reaction was warmed at RT and stirred for 16h to 18h. The reaction mixture was then concentrated under reduced pressure to afford the crude product which was purified by column chromatography to afford the title compound 4-(4-bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran (320 mg), and compound used for next step without purification. Yield: 30.1 %.

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
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Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(synthesis of chromene compound) [0128] 1.18 g (2.0 mmol) of the above naphthol compound (15) and 0.81 g (3.0 mmol) of the following propargyl alcohol compound were dissolved in 50 ml of toluene, and 0.02 g of camphorsulfonic acid was added to the resulting solution and stirred under heating and reflux for 1 hour. After a reaction, the solvent was removed, and the obtained reaction product was purified by chromatography on silica gel to obtain 1.17 g of a white powder product. The yield was 70 %. [0129] The elemental analysis values of this product were 84.59 % of C and 5.93 % of H which were almost equal to the calculated values of C59H50O5 (C: 84.46 %, H: 6.01 %). [0130] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 20H peaks based on a methyl proton and a methylene proton at delta of around 1.0 to 4.0 ppm and 30H peaks based on an aromatic proton and an alkene proton at delta of around 5.5 to 9.0 ppm. [0131] Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm, and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0132] It was confirmed from the above results that the isolated product was a compound represented by the following formula (E1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tokuyama Corporation; IZUMI, Shinobu; TERANISHI, Kazuhiro; DAIKOKU, Yusuke; SANDO, Mitsuyoshi; EP2725017; (2014); A1;,
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Electric Literature of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 3,6,11-trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, methyl ester (17) To a stirred solution of 2-(2-aminoethoxyl)ethanol (1.05 g, 10 mmol, 1 equiv) in anhydrous ethanol (15 mL) at 0 C. was added di-tert-butyl dicarbonate (2.2 g, 10 mmol, 1 equiv). The reaction mixture was stirred for 2 hours at room temperature. It was concentrated under reduced pressure, re-dissolved in dichloromethane, and washed with brine. The organic extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to give the crude product as a colorless oil. The product 12 was used in the next step without further purification. 1H NMR (600 MHz, CDCl3) delta 1.44 (s, 9H), 3.33-3.34 (m, 2H), 3.54-3.59 (dt, J=10.4, 5.2 Hz, 2H), 3.73-3.75 (dt, J=4.3, 3.4 Hz, 2H).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOLEDO; Tillekeratne, L. M. Viranga; Almaliti, Jehad; Al-Hamashi, Ayad; Bhansali, Pravin; (74 pag.)US2015/329560; (2015); A1;,
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Synthetic Route of 4415-82-1 ,Some common heterocyclic compound, 4415-82-1, molecular formula is C5H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of Pyridinium chiorochromate (41.3 g, 191.6 mmol) in dichioromethane (120 mL) was added Cyclobutanemethanol (7.5 g, 87.1 mmol). The mixture was stirred fbr 1.5 hours then filtered through a pad of silica and rinsed with further dichioromethane (300 rnL). The solvent was removed under reduced pressure to give 2-cyciobutylcarbaldehyde (10,0 g, contains residual dichioromethane) that wasused without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4415-82-1, Cyclobutylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALKERMES PHARMA IRELAND LIMTED; DEAVER, Dan; BLUMBERG, Laura, Cook; EYERMAN, David; WYNN, Thomas; WO2014/190271; (2014); A2;,
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Application of 65735-71-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65735-71-9, name is (4-Chloro-3-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(4-Chloro-3-(trifluoromethyl)phenyl)methanol (5.1 g, 24.22 mmol) was added in small portions to SOCl2 (20 mL, 275 mmol). The reaction was stirred at 50 0C for 18 h and then under reflux for 23 h. The mixture was concentrated and dried under high vacuum to give the title compound as a colorless liquid (5.41 g). 1H NMR (400 MHz, CDCl3) delta ppm 4.58 (s, 2H), 7.50- 7.51(1-1, 2H), 7.71 (s, IH).

According to the analysis of related databases, 65735-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, Daniel J.; SCHRADER, Thomas O.; KASEM, Michelle; ZHU, Xiuwen; JOHNSON, Benjamin R.; LEHMANN, Juerg; HAN, Sangdon; KAWASAKI, Andrew M.; WO2011/5295; (2011); A1;,
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Related Products of 2919-23-5 , The common heterocyclic compound, 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-6-chloronicotinic acid (CAN 29241-62-1, 2.0 g, 8.46 mmol) was dissolved in DMSO (20.0 mL). Cyclobutanol (793 mg, 857 muL, 11.0 mmol) and potassium hydroxide powder (1.42 g, 25.4 mmol) were added and the mixture was stirred at room temperature overnight. Water (20 mL) was added and the mixture was acidified (under ice-water bath cooling) with 37% HCL in water (pH=2). The suspension was filtered, washed with water and the solid was dried to yield 1.88 g (82%) of the title compound as a white solid; MS (ESI): 270.2 (M-H)-.

The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hebeisen, Paul; Matile, Hugues; Roever, Stephan; Wright, Matthew; Jensen, Sannah Zoffmann; US2012/65212; (2012); A1;,
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