Category: alcohols-buliding-blocks

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Phenoxyphenyl)methanol

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80 C. for 3.5 hours.. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water.. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride. Properties of the compound: 1H-NMR(CDCl3, delta): 4..58(2H, s), 6.96-7.03(4H, m), 7.11-7.14(1H, m), 7.32-7.37(4H, m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6352985; (2002); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100058-61-5, name is 3-(Benzyloxy)cyclobutanol, the common compound, a new synthetic route is introduced below. SDS of cas: 100058-61-5

Step 1: 2-[5-(3-benzyloxycyclobutoxy)-2,2-difluoro-pentoxy]tetrahydropyran To a solution of 3-benzyloxycyclobutanol (2.59 g, 14.53 mmol, 1.10 eq) in N,N-dimethylformamide (100 mL) was added sodium hydride (581 mg, 14.53 mmol, 60% in mineral oil, 1.10 eq) at 0 C. under nitrogen. The mixture was stirred at 0 C. for 0.5 hours and added a solution of (4,4-difluoro-5-tetrahydropyran-2-yloxy-pentyl) 4-methylbenzenesulfonate (5.0 g, 13.21 mmol, 1.00 eq) [prepared as described for Compound 171] in N,N-dimethylformamide (20 mL) dropwise at 0 C. The reaction mixture was stirred at 60 C. for 6 hours. The mixture was cooled to 25 C. and poured into ice-water (w/w=1/1) (30 mL) and stirred for 15 minutes. The aqueous phase was extracted with ethyl acetate (100 mL*3). The combined organic phase was washed with brine (100 mL*3), dried with anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography (Petroleum ether/Ethyl acetate=1/0, 20/1) to afford 2-[5-(3-benzyloxycyclobutoxy)-2,2-difluoro-pentoxy]tetrahydropyran (1.75 g, 4.21 mmol, 32% yield, 92% purity) as a colorless oil.

The synthetic route of 100058-61-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Flanagan, John J.; Dong, Hanqing; Ishchenko, Alexey; (559 pag.)US2018/125821; (2018); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 7-Hydroxy-4-(trifluoromethyl)coumarin

Under an argon atmosphere, 4-Trifluoromethylumbelliferone (0.2 g, 0.869 mmol) and pyridineIt was cooled and dissolved in emissions (4.3 mL) ice.Anhydrous trifluoromethanesulfonic acid (0.16 mL, 0.956 mmol) was added dropwise.Then the mixture was stirred at room temperature for 2 hours.After completion of the reaction, and extracted with ethyl acetate, 1 TadashiIt was washed at a constant hydrochloric acid and a saturated saline solution.The organic layer was dried over anhydrous sodium sulfate and the solvent was distilled off.Purification silica gel column (SiOTwo. At 40 g), resulting white solid compound (285 mg, 90percent)

With the rapid development of chemical substances, we look forward to future research findings about 575-03-1.

Reference:
Patent; HIROSAKI UNIVERSITY; PEPTIDE INSTITUTE INCORPORATED; YAMADA, KATSUYA; SASAKI, AYAKO; TESHIMA, TADASHI; YAMAMOTO, TOSHIHIRO; OTSUKA, YUJI; (81 pag.)JP2015/205870; (2015); A;,
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Reference of 202865-66-5, Adding some certain compound to certain chemical reactions, such as: 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-66-5.

Example 1; (3’R,4’S,5S,5’S,6’R)-3-[(4-ethylphenyl)methyl]-6′-(hydroxymethyl)-3′,4′,5′,6′-tetrahydrospiro[thieno[2,3,f]isobenzofuran-5(7H),2′-[2H]pyran]-3′,4′,5′-triol; 1) Synthesis of 5-bromo-2-fluoro-4-hydroxymethylbenzaldehyde; [Show Image] Tetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydrofuran (4.5 mL). To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0°C, and the solution was then stirred for 15 minutes. The solution was cooled to -78°C, and a solution of (2-bromo-5-fluorophenyl)-methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise. The temperature of the solution was raised over 2 hours to -40°C. The solution was again cooled to -78°C, and N,N-dimethylformamide (0.47 mL, 6.07 mmol)was added thereto. The temperature of the solution was raised to room temperature, and the solution was then stirred for 30 minutes. Saturated aqueous ammonium chloride was added, and the resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative). 1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J = 10.6 Hz), 8.01 (1H, d, J = 6.2 Hz), 10.29 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 202865-66-5, (2-Bromo-5-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP2048152; (2009); A1;,
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Application of 3597-91-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. A new synthetic method of this compound is introduced below.

General procedure: To a solution of 1-(p-bromophenyl)ethanol I-23 (201 mg, 1.0 mmol) in DMF (2.0 mL) was added HIO3 (194 mg, 1.1 mmol) and TEMPO (7.8 mg, 0.05 mmol). The mixture was stirred for 2 h at room temperature under an Ar atmosphere. After the reaction, the reaction mixture was poured into aq Na2S2O3, and extracted with a mixture of Et2O: hexane=1:1 (3*10 mL). Then, the organic layer was poured into satd NaCl (10 mL) and extracted with Et2O (10 mL). The organic layer was dried over Na2SO4. After being filtration and removal of the solvent under reduced pressure, the residue was purified by flash short column chromatography on silica gel (EtOAc-hexane, 1:4) to give p-bromoacetophenone II-23 in 99% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Imai, Sho; Togo, Hideo; Tetrahedron; vol. 72; 44; (2016); p. 6948 – 6954;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 27489-62-9, blongs to alcohols-buliding-blocks compound. Product Details of 27489-62-9

To a mixture of trans-4-aminocyclohexanol (2.07 g, 13.6 mmol) and NaHCCbeta (3.50 g, 41.7 mmol) in H2O (20 mL) at room temperature, a solution of benzyl chloroformate (1.92 mL, 13.6 mmol) in dioxane (15 mL) was added. The mixture was stirred at room temperature for 20 h. The white precipitate was collected as benzyl (lR,4R)-4- hydroxycyclohexylcarbamate (3.37 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27489-62-9, its application will become more common.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
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Adding a certain compound to certain chemical reactions, such as: 5391-88-8, 1-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5391-88-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 5391-88-8

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5391-88-8, its application will become more common.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 47; 3; (2015); p. 323 – 329;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156-87-6, name is 3-Aminopropan-1-ol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C3H9NO

A solution of 3-aminopropan-1-ol (3 g, 39.9 mmol) and benzaldehyde (4.05 mL, 39.9 mmol) in methanol (200 mL) was stirred at room temperature overnight. The solution was cooled to 0 C., and sodium borohydride (1.813 g, 47.9 mmol) was added slowly in several portions. The resulting mixture was stirred at room temperature for three hours, and then it was partitioned between water and dichloromethane (3*). The organic extracts were combined and dried over Na2SO4, the drying agent was removed by filtration, and the solution was concentrated in vacuo to give the title compound as an oil (6.5 g, 98%)

With the rapid development of chemical substances, we look forward to future research findings about 156-87-6.

Reference:
Patent; ABBVIE INC.; Bhatia, Pramila A.; Randolph, John T.; Schrimpf, Michael R.; Zhang, Quinwei I.; US2014/171423; (2014); A1;,
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Reference of 55414-72-7, Adding some certain compound to certain chemical reactions, such as: 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol,molecular formula is C8H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55414-72-7.

The product of preparation 3 (300mg, 2.0mmol) in tetrahydrofuran (3mL) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil, 54mg, 2.3mmol) in tetrahydrofuran (2mL). The mixture was stirred for 45 minutes and the temperature was maintained at -10C. The product of preparation 5 (357mg, 1.3mmol) in tetrahydrofuran (3mL) was added dropwise and the mixture was stirred for a further hour. The temperature was then allowed to increase to 25C and the reaction was quenched with sodium hydrogen carbonate solution (5mL), and diluted with ethyl acetate (20mL) and water (10mL). The organic phase was separated, washed with brine (10mL), dried over magnesium sulfate and concentrated in vacuo to give an oily residue. Purification of the oil by column chromatography on silica gel, eluting with dichloromethane: methanol, 100: 0 to 97: 3, afforded the title compound in 59% yield, 300mg. MS APCI+ m/z 390,392 [MH]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121152; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 37585-16-3, (2-Amino-4-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (2-Amino-4-chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (2-Amino-4-chlorophenyl)methanol

A solution of (2-amino-4-chlorophenyl)methanol (5.00 g, 31.85 mmol) and pyridine (3.1 mL) in anhydrous chloroform (150 mL) was treated dropwise with a solution of 4- chlorobenzenesulfonyl chloride (7.26g ,34.58 mmol) in chloroform (30 mL) over 20 minutes at room temperature. The reaction mixture was stirred for 5 hours and evaporated to dryness. The resulting residue was taken up in ethyl acetate (200 mL) and aqueous ammonium chloride (100 mL). After stirring for 30 minutes the organic phase was separated and further washed with dilute ammonium chloride (2 x 50 mL), dried EPO over sodium sulfate, filtered and evaporated to give an oil. This was triturated in hot hexane (10OmL) and then stirred at ambient temperature for 2 hours. The solid was collected and washed with hexane to give the title compound (10.0 g). HPLC Rt = 3.04 minutes. 1H NMR (CDCI3) delta 7.75 (d, 2H), 7.53 (s, 1H), 7.45 (d, 2H), 7.09 (dd, 1 H), 7.01 (d, 1 H), 4.40 (s, 2H).

The synthetic route of 37585-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMTED; WO2007/14054; (2007); A2;,
Alcohol – Wikipedia,
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