Category: alcohols-buliding-blocks

Related Products of 3279-95-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3279-95-6, name is 2-(Aminooxy)ethanol, molecular formula is C2H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-benzo[f][1,2,3]triazolo[1,5-d][1,4]diazepine-9-carboxylic acid (55.6 mg, 0.157mmol) in THF (4 mL) was added HATU (89.4 mg, 0.235 mmol) at 0 C and the reaction mixture was stirred for 30 min. Triethylamine (47.4 mg, 0.470 mmol) and 2-(aminooxy)ethanol (18.1 mg, 0.235mmol) were then added. The resulting mixture was stirred at RT overnight and partitioned between water and DCM. The organics was extracted with DCM (3 x 20 mL) and the combined organic layer were washed with brine (2 x 30 mL), dried and concentrated under reduced pressure. The crude product was purified by preparative TLC (DCM: MeOH= 10: 1) to give 7-(4-chlorophenyl)-N-(2-hydroxyethoxy)-1-methyl-6,7-dihydro- 5H-benzo[f][1,2,3]triazolo[1,5-d][1,4]diazepine-9-carboxamide (18 mg, 28%) as a yellow solid. LCMS (Method B):: RT 2.48 min m/z 414.1 [M+H]+

According to the analysis of related databases, 3279-95-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CATALYST THERAPEUTICS PTY LTD; BURNS, Chris; GARNIER, Jean-Marc; SHARP, Phillip Patrick; FEUTRILL, John; CUZZUPE, Anthony; (140 pag.)WO2017/20086; (2017); A1;,
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Electric Literature of 626-18-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-18-6, name is 1,3-Benzenedimethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of sinomenine (658 mg, 2 mmol), p-xylylene glycol (138 mg, 1 mmol) and triphenylphosphine (768 mg, 3 mmol) in dried THF (10 mL) was added a solution of diisopropyl azodicarboxylate (0.59 mL, 3 mmol) in dry THF (2 mL) over a period of 30 min. The reaction mixture was stirred at room temperature for 12 h and then the solvent THF was removed under vacuum. Purification by silica gel column chromatography (EtOAc/CH2Cl2/MeOH, 100:0:0-0:6:1, v/v/v) afforded the title compounds (403 mg, 53%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 626-18-6, 1,3-Benzenedimethanol.

Reference:
Article; Teng, Peng; Liu, Hai-Liang; Zhang, Lei; Feng, Li-Li; Huai, Yue; Deng, Zhang-Shuang; Sun, Yang; Xu, Qiang; Li, Jian-Xin; European Journal of Medicinal Chemistry; vol. 50; (2012); p. 63 – 74;,
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Synthetic Route of 32707-89-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32707-89-4, name is (3,5-Bis(trifluoromethyl)phenyl)methanol, molecular formula is C9H6F6O, molecular weight is 244.13, as common compound, the synthetic route is as follows.

Ketones: alpha-Benzylated acetamides 19 (0.14-0.35 mmol) obtained above were dissolved in anhydrous THF (2 ml). 2 equivalents of aromatic Grignard reagents or aromatic lithium reagents (0.28-0.70 mmol) were added drop-wise. The reaction mixtures were stirred at room temperature for 10 minutes before CH2Cl2 (2 ml) and MeOH (1 ml) were added to quench the reaction. The mixtures were filtered through pads of silica gel in parallel and the silica pads were rinsed with ethyl acetate. The combined filtrates were concentrated and the residues were purified by flash chromatography on silica to give ketones 20.

Statistics shows that 32707-89-4 is playing an increasingly important role. we look forward to future research findings about (3,5-Bis(trifluoromethyl)phenyl)methanol.

Reference:
Patent; Huang, Yazhong; Hu, Shuanghua; Degnan, Andrew P.; US2006/20019; (2006); A1;,
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Reference of 4654-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4654-39-1 as follows.

1 -Bromo-4-(2-iodoethyl)benzeneA solution of 2-(4-bromophenyl)ethanol (40.0 g, 0.199 mol) in dichloromethane (10 mL) was added dropwise to a solution of imidazole (22.4 mg, 0.329 mmol), triphenylphosphine (66.5 g, 0.254 mol), and iodine (65.0 g, 0.26 mol) indichloromethane (50 mL) at 0C. When the addition was complete it was warmed to rt. After 1 hour the reaction was filtered through celite, the filtrate was washed with saturated aqueous sodium thiosufate (2×100 mL), brine (100 mL), dried over MgS04, filtered and concentrated in vacuo. Purification by flash column chromatography on silica gel (heptane/ethyl acetate 4: 1 ) afforded the title compound as a yellow-white solid (59.09 g, 60%). 1 HNMR (400 MHz, CHLOROFORM-d) delta ppm 3.14 (t, J=7.69 Hz, 2 H) 3.33 (t, J=7.69 Hz, 2 H) 7.08 (d, J=7.89 Hz, 2 H) 7.45 (d, J=8.31 Hz, 2 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1261524-75-7, name is 3-Bromo-2-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1261524-75-7

A solution of (3 -bromo-2- chlorophenyl)methanol (600 mg, 2.71 mmol), (2-chloro-3 -(4,4,5,5 -tetramethyl- 1,3 ,2-dioxaborolan-2- yl)phenyl)methanol (728 mg, 2.71 mmol), K2C03 (936 mg, 6.77 mmol) in 1,4-dioxane (9 mL) and water(2.3 mL) was purged with nitrogen for 5 mi Pd(dppf)C12.DCM (198 mg, 0.27 mmol) was added and the reaction mixture was heated at 100 C for 12 h. The reaction mixture was filtered through a pad of celite and the pad was washed with MeOH. The filtrate was concentrated to dryness and the residue was purified by silica gel column with 0-30% EtOAc in hexanes to give a product.

With the rapid development of chemical substances, we look forward to future research findings about 1261524-75-7.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; APPLEBY, Todd; CHO, Aesop; DU, Zhimin; GRAUPE, Michael; GUERRERO, Juan A.; JABRI, Salman Y.; LAD, Lateshkumar Thakorlal; MACHICAO TELLO, Paulo A.; MEDLEY, Jonathan William; METOBO, Samuel E.; MUKHERJEE, Prasenjit Kumar; NADUTHAMBI, Devan; NOTTE, Gregory; PARKHILL, Eric Q.; PHILLIPS, Barton W.; SIMONOVICH, Scott Preston; SQUIRES, Neil H.; VENKATARAMANI, Chandrasekar; WANG, Peiyuan; WATKINS, William J.; XU, Jie; YANG, Kin Shing; ZIEBENHAUS, Christopher Allen; (724 pag.)WO2018/195321; (2018); A1;,
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Synthetic Route of 16308-92-2, Adding some certain compound to certain chemical reactions, such as: 16308-92-2, name is (2,4-Dimethylphenyl)methanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16308-92-2.

General procedure: To a stirred mixture of Ph2PCl (6.0 mmol), NaI (6.0 mmol) and anhydrous CH3CN (5.0 mL) was added alcohol 2(1.0 mmol) at room temperature under argon atmosphere. The reaction mixture was stirred at 80 C in oil bath for 12 h. When the reaction temperature was cooled to room temperature, 30 % H2O2 aqueous (0.5 mL) was slowly added, and stirred for another 10 minutes. The organic layer was extracted with dichloromethane, washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel to obtain the corresponding phosphine oxide.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16308-92-2, (2,4-Dimethylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ma, Yutao; Chen, Feng; Bao, Jifeng; Wei, Hao; Shi, Min; Wang, Feijun; Tetrahedron Letters; vol. 57; 23; (2016); p. 2465 – 2467;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4277-34-3, name is Cyclooct-4-enol, molecular formula is C8H14O, molecular weight is 126.2, as common compound, the synthetic route is as follows.Computed Properties of C8H14O

Compound AA8. A mixture of (Z)-cyclooct-4-en-1-ol (42 mg, 330 mumol, 1.5 eq.), N,N?-disuccinimidyl carbonate (DSC) (101 mg, 396 mumol, 1.8 eq.), and TEA (40 mg, 396 mumol, 1.8 eq.) in MeCN (0.5 mL) was degassed and purged with N2 for 3 times. After stirred at 25 C for 4 h under N2, the mixture was added into a mixture of compound AA7 (91.98 mg, 220 mumol, 1 eq.) and TEA (40 mg, 396 mumol, 1.8 eq.) in DMF (0.5 mL) dropwise at 25 C under N2. After stirred at 25 C for 0.5 h under N2, the reaction mixture was filtered and the filtrate was concentrated in vacuo. The mixture was purificated by prep-HPLC (HCl) to afford compound AA8 (8.9 mg, 16 mumol, 7% yield) as a yellow oil. 1H NMR (CD3OD, 400 MHz) delta 8.47 (br s, 1H), 8.42 (s, 1H), 5.75-5.50 (m, 2H), 4.70 (br s, 1H), 4.15-4.00 (m, 1H), 3.96 (s, 3H), 3.29-3.18 (m, 4H), 3.14-2.97 (m, 2H), 2.62-2.49 (m, 2H), 2.44-2.32 (m, 1H), 2.25 (br d, J = 13.2 Hz, 2H), 2.21-2.13 (m, 2H), 2.10-2.00 (m, 1H), 1.95-1.81 (m, 4H), 1.73 (br dd, J = 4.6, 9.9 Hz, 1H), 1.68-1.34 (m, 7H), 1.10 (br s, 1H), 0.54 (br d, J = 7.3 Hz, 2H), 0.30 (br s, 1H).33

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4277-34-3, Cyclooct-4-enol, and friends who are interested can also refer to it.

Reference:
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; SNIR-ALKALAY, Irit; VACCA, Joseph; BEN-NERIAH, Yinon; (238 pag.)WO2019/155468; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5272-36-6, name is 3-(Trimethylsilyl)propargyl alcohol. A new synthetic method of this compound is introduced below., name: 3-(Trimethylsilyl)propargyl alcohol

According to Ladmiral V. and co-workers (16) 3-(trimethylsilyl)prop-2- yn-1-ol (2.31 ml, 15.6 mmol) and triethylamine (2.83 ml, 20.27 mmol) were dissolved in Et20 (20 ml) and cooled to -20C. A solution of methacryloyl chloride (1.81 ml, 18.56 mmol) in Et20 (10 ml) was added drop wise over 1 hour. The mixture was stirred at -20C for 30 minutes and then overnight at room temperature. Ammonium salts were removed by filtration and the volatiles were removed under reduced pressure. The yellow oil residue was purified by flash chromatography (EtP:Et2O=50:1, Rf= 0.39) (2.48 g, 12.64 mmol, Yield 81%). 1H-NMR (400 MHz, CDCI3): delta = 0.18 (s, 9H, Si(CH3)3); 1.97 (m, 3H, CH3C=CH2); 4.76 (s, 2H, OCH2); 5.62 (m, 1 H, C=CHH); 6.17 (m, 1 H, C=CHH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5272-36-6, 3-(Trimethylsilyl)propargyl alcohol.

Reference:
Patent; CHIARI, Marcella; (54 pag.)WO2016/92372; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6920-22-5, Hexane-1,2-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6920-22-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 6920-22-5

General procedure: All experiments to test the catalytic activity were performed in a Schlenk tube (50mL vol.) attached to a condenser. The catalytic activity was evaluated for HDO oxidation in basic aqueous media with H2O2 as oxidant to obtain HCA. In a typical reaction procedure, aliphatic diol (0.5mmol) and catalyst (25mg) were weighed and dispersed in deionized water (3.5mL) in a Schenk tube. 30% H2O2 (0.75mL) and 0.5M NaOH (0.75mL) were added to the above mixture, and then the Schlenk tube was mounted on a preheated oil bath at 353K. The mixture was allowed to react for various time intervals with continuous magnetic stirring (500 rpm). After the reaction, a part of the resultant solution was diluted 20 times with an aqueous H2SO4 (10mM) solution, and the catalyst was filtered off using a 0.20mum filter (Milex-LG). The obtained filtrate was analyzed by high performance liquid chromatography (HPLC, WATERS 600) using an Aminex HPX-87H column (Bio-Rad Laboratories, Inc.) attached to a refractive index detector. An aqueous 10mM H2SO4 solution (eluent) was run through the column (maintained at 323K) at a flow rate of 0.5mLmin-1. The conversion and yield(s) were determined with a calibration curve method using commercial products.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6920-22-5, Hexane-1,2-diol, and friends who are interested can also refer to it.

Reference:
Article; Tuteja, Jaya; Nishimura, Shun; Ebitani, Kohki; Catalysis Today; vol. 265; (2016); p. 231 – 239;,
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Synthetic Route of 4845-50-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4845-50-5, name is 1,4-Dioxane-2,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 88 5,7-Dihydro-7-methyl-2,4-di-1-pyrrolidinyl-6H-pyrrolo[2,3-d]pyrimidin-6-one (VII) A stirred mixture of 4-methylamino-2,6-di-1-pyrrolidinopyrimidine (V, EXAMPLE 3, 1.235 g) in 20 ml of oxygen-free ethanol (degassed with argon for 15 minutes) is treated with 600 mg of 2,3-dihydroxy-1,4-dioxane, added in one portion. The resulting mixture is stirred at 25 in a foil-wrapped flask under nitrogen for 22 hours, then cooled to 0. The solids are isolated by filtration, washed with 2*3 ml of cold ethanol, and dried (2 hours, 0.05 mm, 40), to give the title compound, mp 172-174; IR (mineral oil) 2958, 2925, 2865, 1725, 1605, 1574, 1533, 1489, 1478, 1469, 1456, 1451, 1394, 1388, 1366, 1345, 1333, 1325, 1269, 1261, 1096, 1082, 778 and 636 cm-1; NMR (CDCl3, TMS) 3.60-3.52, 3.17 and 1.94-1.89delta; CMR (CDCl3, TMS) 176.3, 164.9, 159.7, 156.2, 82.2, 46.8, 46.4, 35.3, 25.5 and 25.2delta; MS (m/z)=288; other ions at m/z 287, 272, 259, 246, 230, 216, 190, 70 and 55.

According to the analysis of related databases, 4845-50-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
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