Author: tianli

Application of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2: This example illustrates the preparation of 3,3-dimethyl-1 -pyrrolo[1 ,2-b]pyridazin- 3-yl-4H-isoquinolinea) Preparation of 1 ,3,3-trimethyl-4H-isoquinolineAcetonitrile (1.5 g, 37 mmol) was slowly added to 98% sulfuric acid (50 g, 0.5 mol) at 0 00. Then 2-methyl-i -phenyl-propan-2-ol (5.0 g, 33 mmol) was added to this solution at 0 00 The reaction mixture was allowed to reach room temperature, stirred for 1 h at this temperature and poured on aqueous sodium hydroxide solution of pH 9. The mixture was extracted withethyl acetate, the organic layer washed with water and brine, dried over sodium sulfate and evaporated under reduced pressure to obtain 1 ,3,3-trimethyl-4H-isoquinoline (4.3 g, 25 mmol, 74 %), which was pure enough to be directly used in the next step. 1H-NMR (400 MHz, 0D013): oe (ppm) = 1.20 (s, 6H), 2.37 (s, 3H), 2.69 (s, 2H), 7.14 (d, 1H), 7.27-7.36 (m, 2H), 7.48 (d, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-86-7, 2-Methyl-1-phenyl-2-propanol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA (CHINA) INVESTMENT CO., LTD.; BOU HAMDAN, Farhan; QUARANTA, Laura; TRAH, Stephan; LAMBERTH, Clemens; LU, Long; LU, Qiang; WO2015/117563; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol, molecular formula is C9H20O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H20O5

O-Tosyltetraethyleneglycol Methyl Ether (109) Tetraethyleneglycol monomethyl ether (2.0 g, 9.6 mmol) was combined with pyridine (0.93 mL, 11.5 mmol) in methylene chloride (20 mL) at 0 C. p-Toluenesulfonyl chloride (2.2 g, 11.5 mimol) dissolved in methylene chloride (10 mL) was added dropwise and the reaction was allowed to warm to room temperature as the ice bath thawed. After stirring nine days, the product mixture was transferred to a separatory funnel with water (70 mL). The layers were separated and the aqueous layer was extracted with methylene chloride (3*20 mL). The extracts were combined and evaporated. The residue (3.3 g) was chromatographed (silica gel, 4:1 to 3:1 gradient elution, methylene chloride/ethyl acetate) to afford 2.5 g (70%) of compound 109 as an oil. 1H NMR (300 MHz, DMSO-d6) delta 1.56 (br s, 411), 2.42 (br s, 2H), 3.34 (br s, 4H), 6.05 (s, 3H), 7.09 (s, 0.5H), 7.26 (s, 0.5H), 7.42 (br s, 2H), 7.70 (br s, 2H), 8.87 (br d, 2H), 9.07 (s, 2H), 9.22 (br s, 1H), 10.51 (s, 1H). CI MS m/z=363 [C16H26O7S+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 23783-42-8.

Reference:
Patent; CYFI, INC.; US2003/199456; (2003); A1;,
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Synthetic Route of 217479-60-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 217479-60-2, name is 2,4,6-Trichlorobenzyl alcohol, molecular formula is C7H5Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example P9 Preparation of 1,3,5-trichloro-2-chloromethyl-benzene To a stirred solution of 2,4,6-trichlorobenzylalcohol (10.0 g; 47.3 mmol) in chloroform (100 ml) kept under nitrogen atmosphere, thionyl chloride (6.07 ml; 85.1 mmol) was added slowly at 0 C. over a period of 15 minutes followed by catalytic amount of DMF. The reaction mix was allowed to stir at ambient temp for 3 hours. The reaction mixture was quenched with 50 ml of water; the aqueous layer was extracted with DCM (3*100 ml). The combined organic layer was washed with 5% sodium bicarbonate solution (2*50 ml) followed by brine (50 ml) and dried over anhydrous sodium sulphate. The solvent was evaporated under reduced pressure. 10.9 g (100% of theory) of 1,3,5-trichloro-2-chloromethyl-benzene was obtained in form of a white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.37 (s, 2H); 4.82 (s, 2H) MS [M+H]+231/233.

According to the analysis of related databases, 217479-60-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA CROP PROTECTION LLC; Stierli, Daniel; Walter, Harald; US2013/72535; (2013); A1;,
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Application of 15258-73-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15258-73-8, name is (2,6-Dichlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of M-5 (0.126 g, 0.43 mmol), 2,6-dichlorobenzylalcohol (0.075 g, 0.43 mmol) and PPh3 (0.113 g, 0.43 mmol) in dry THF (4 mL) at 0 C under Ar is added DEAD (0.068 mL). The reaction mixture is permitted to warm to room temperature, and is stirred for 18 h. It is concentrated, and the residue is purified by silica chromatography: TLC (7:3 hexanes/EtOAc) Rf = 0.34; 1H NMR (CDCl3, 300 MHz) delta 8.31 (m, 1H), 7.37 (m, 2H), 7.25 (m, 2H), 7.08 (m, 1H), 5.81 (m, 1H), 5.29 (s, 2H), 4.65 (m, 1H), 3.70 (s, 3H), 3.24 (m, 2H), 1.63 (m, 1 H), 1.43 (s, 9H); 13C NMR (CDCl3, 75 MHz) delta 172.47, 155.50, 153.82, 149.71, 137.33, 137.00, 131.51, 130.72, 128.56, 123.99, 122.78, 79.74, 65.64, 53.25, 52.27, 38.43, 28.33 (3C); MS (+ESI) m/z 454.9 [M + H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15258-73-8, (2,6-Dichlorophenyl)methanol.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; EP1144365; (2004); B1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 637031-88-0, 3,3-Difluorocyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 637031-88-0, blongs to alcohols-buliding-blocks compound. Product Details of 637031-88-0

To a mixture of A-102 (180 mg, 0.61 mmol), 3,3-difluorocyclobutanol (98.5 mg, 0.91 mmol) and PPh3 (286.81 mg, 1.09 mmol) in THF (3 mL) was added DEAD (190.43 mg, 1.09 mmol) at 0 C. The mixture was allowed to warm and then was stirred at 70 C for 16 hours. After cooling to room temperature, the mixture was concentrated to give the crude product, which was purified by prep-TLC (silica gel, PE: EtOAc = 3:1) and prep-HPLC (Phenomenex Gemini (250 mm x 50 mm, 10 _); A = H20 (0.05% NH4OH) and B = CH3CN; 48-78% B over 8 minutes) to afford Compound 81 (5.08 mg, 0.01 mmol) as a solid. 1H NMR (400MHz, CDC13) _ = 9.57 (d, 1H), 8.34 (s, 1H), 7.93 (d, 2H), 6.97 (d, 2H), 4.83 -4.65 (m, 1H), 3.23 – 3.06 (m, 2H), 2.91 -2.75 (m, 2H). LCMS R, = 1.19 min using Method A, MS ESI calcd. for Ci6H12F5N40 [M+H]+ 371.1, found 371.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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Application of 2009-83-8, Adding some certain compound to certain chemical reactions, such as: 2009-83-8, name is 6-Chlorohexan-1-ol,molecular formula is C6H13ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2009-83-8.

To a 50 mL glass three-neck flask was added 2.72 g (0.01 mol) of 8-hydroxy-1,1,7,7-tetramethyljulonidine-9- Formaldehyde, 2.05 g (0.015 mol) 6-chloro-1-hexanol and 30 mL re-distilled N,N-dimethylformamide, add dry anhydrous potassium carbonate 1.7 g (0.012 mol) under N2 protection, at 120C The reaction was continued overnight . After the reaction was complete, the temperature was lowered. Potassium carbonate was removed by filtration. The filtrate was poured into water to obtain a dark blue solution, which was extracted three times with ethyl acetate. The organic phases were combined and the combined organic phases were dried over anhydrous magnesium sulfate and left overnight. , Filtration, rotary evaporation to remove ethyl acetate, the residue was separated by column chromatography (200-300 mesh silica gel as the stationary phase, with a mixture of n-hexane and ethyl acetate as the mobile phase, where: n-hexane and ethyl acetate The volume ratio was 7:1). After drying, a yellow solid was obtained as compound 1 in a yield of 61%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2009-83-8, 6-Chlorohexan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Zhen Zhen; Zhang Airui; Bo Shuhui; Liu Xinhou; Qiu Ling; Zhang Maolin; Xu Huajun; (21 pag.)CN104558005; (2018); B;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,3-Diaminopropan-2-ol

A solution of 1,3-diamino-2-propanol (3.15 g,0.035 mol) and Et3N (4.85 mE, 0.035 mol) in methanol (120mE) was heated to 45 C. To the solution, (l3oc)20 (17.05 g,0.078 mol) in methanol (80 mE) was dropwise added slowly.The reaction solution was stirred at 45 C. for 30 mm. Afteradditional stirring at room temperature for 1.5 h, the solventwas removed under reduced pressure. The crude productwas extracted with diethyl ether (200 mEx3) and dried oversodium sulfate to yield the compound 2 (9.94 g, 97.8%) asa white powdet EC-MS mlz (ES), 291.19 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; RC Biotechnologies, Inc.; HUANG, Chang Jiang; FANG, Jianmin; YE, Hui; ZHANG, Lezhi; (63 pag.)US2018/55948; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.Safety of Cyclopropylmethanol

10062] Into a clean, dry reactor equipped with a stirrer and under nitrogen are successively loaded 4.63 kg of DMF (5.1 eqV) and then 4.53 kg of triphenylphosphite. 2.34 kg of bromine is then introduced while maintaining the temperature at less than 12 C. The stirring speed is regulated according to the fluidity of the reaction medium. When casting ends, a very thick medium with a yellow solid suspension is obtained.10063] The set point of the jacket is then adjusted to -12 C. and then 0.96 kg of cyclopropylmethanol is introduced in such a way as not to exceed a temperature of -5 C. On completion of the addition the whole is allowed to return slowly to room temperature. The set point of the jacket is then adjusted to 64 C. for distillation, which is carried out at a pressure of 13 mbar by collecting the first 24 to 30 C. fraction at the top of the colunm, then the second 30 to 40 C. fraction (partial reflux). Two fractions, Fl (1.38 kg) and F2 (293 g), are collected. The two fractions, after washing with carbonated water and then drying by means of CaC12, lead to a final product 2a (mass 1.316 kg) having a GC relative purity of 98.7% with a yield of 73%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2516-33-8, Cyclopropylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE; GUERRET, Olivier; (6 pag.)US2016/355452; (2016); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 927-74-2, Adding some certain compound to certain chemical reactions, such as: 927-74-2, name is 3-Butyn-1-ol,molecular formula is C4H6O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-74-2.

A mixture of but-3-yn-1-ol (2.0 g, 28.6 mmol), imidazole (2.9 g, 42.9mmol), and DMAP (catalytic amount) was dissolved in anhydrousTHF (8 mL) under N2. A solution of tert-butyldimethylsilyl chloride (5.17 g, 34.3 mmol) in anhydrous THF (2 mL) was added dropwise and the mixture was stirred at r.t. for 2 h under N2. The mixture was quenched with sat. aq NH4Cl (20 mL) and extracted with hexane (3 ×20 mL). The combined organic layers were washed with brine (25mL), dried (Na2SO4), and concentrated under reduced pressure. Theresidue was purified by flash chromatography on silica gel (hexane) to afford compound 16 as a colorless oil; yield: 4.46 g (85%); Rf = 0.23 (hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 927-74-2, 3-Butyn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Puigmarti, Marc; Bosch, Ma Pilar; Guerrero, Angel; Synthesis; vol. 47; 7; (2015); p. 961 – 968;,
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Reference of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example II-a-1 CH3 SO2 OCH2 COO-nC4 H9 27.8 g (0.2 mol) of n-butyl hydroxyacetate (95% pure by GC) and 20.2 g (0.2 mol) of triethylamine are first introduced into 300 ml of dichloromethane at -5 C. 34.4 g (0.3 mol) of methanesulfonyl chloride in 50 ml of dichloromethane are slowly added dropwise at 0 to 5 C. Stirring of the batch at 0 C. is continued overnight, ice water is added, the phases are separated, and the aqueous phase is extracted twice with dichloromethane. The combined organic phases are dried, and the solvent is removed on a rotary evaporator leaving a colorless oil which is subjected to incipient distillation in vacuo. n-Butyl methylsulfonyloxyacetate is isolated as an almost colorless oil (40.5 g, 96.3% of theory, GC content 91%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bayer Aktiengesellschaft; US5698735; (1997); A;,
Alcohol – Wikipedia,
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