Author: tianli

Related Products of 50595-15-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50595-15-8, name is tert-Butyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.

A suspension of 6-bromo-N-(4-fluoro-phenyl)-nicotinamide (0.112 g, 0.38 mmol), tert-butyl glycolate (0.1 g, 0.76 mmol), and potassium tert-butoxide (0.85 g, 0.76 mmol) in THF (10 mL) was heated in a sealed tube at 70° C. After 6 h the reaction mixture was diluted with ethyl acetate and washed with water bicarbonate and dried over sodium sulfate. Removal of the solvents provided a solid. Purification by reverse phase chromatography gave 0.010 g (8percent) of the titled product as a white solid; MS (EI) m/z 345.21 (M-H)-.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,50595-15-8, tert-Butyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; Darwin Molecular Corporation; US6777432; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 3279-95-6, Adding some certain compound to certain chemical reactions, such as: 3279-95-6, name is 2-(Aminooxy)ethanol,molecular formula is C2H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3279-95-6.

General procedure: 4a-c (1 equiv) were dissolved in ethanol (10mL). O-(2-hydroxyethyl)hydroxylamine (14, 2 equiv), acetic acid (2 equiv), pyridine (2 equiv) were added to the solution. After being refluxed for 5h, ethanol was removed under reduced pressure. The products were extracted with CH2Cl2. The combined extracts were washed with 2M HCl aqueous solution and brine. The organic layer was dried with anhydrous Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (PE: EtOAc=6: 1) to yield 15a-c. 3alpha-O-(2,3,4,6-tetra-O-benzoyl-beta-d-glucopyranosyl)-17-(O-(2-hydroxyethyl)oxime)-5beta-androstane (15a). The title compound was obtained starting from 4a (600mg, 0.69mmol) (white solid, 530mg, 82.8% yield, mp 91-94C). Analytical data for 15a: ESI-MS m/z (%) 950.4 [M+Na]+; 1H NMR (400MHz, CDCl3) delta 7.87-7.67(m, 8H, Bz-H), 7.48-7.18(m, 12H, Bz-H), 5.76 (t, J=9.7Hz, 1H, H-3?), 5.49 (t, J=9.7Hz, 1H, H-2?), 5.39-5.28 (m, 1H, H-4?), 4.80 (d, J=7.9Hz, 1H, H-1?), 4.41 (m, 2H, H-6?), 3.95 (m, 3H, H-5?, =NOCH2CH2OH), 3.72 (m, 2H, =NOCH2CH2OH), 3.49 (m, 1H, H-3), 2.28 (m, 2H, H-16), 1.73-0.85 (m, 20H), 0.73 (s, 3H, 18-CH3), 0.70 (s, 3H, 19-CH3).

According to the analysis of related databases, 3279-95-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Li, Haihong; Wang, Ke; Wan, Qi; Chen, Ying; Steroids; vol. 141; (2019); p. 81 – 95;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3562-73-0, 1-(4-Biphenylyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1-(4-Biphenylyl)ethanol, blongs to alcohols-buliding-blocks compound. name: 1-(4-Biphenylyl)ethanol

h): Take a reaction tube and add sodium azide 49mg.1-[4-(1,1′-biphenyl)]ethanol 59.5 mg,400 uL of trifluoroacetic acid, 150 uL of methanesulfonic acid, 1.0 mL of n-hexane, and stirred at 50 C for 36 hours.After the reaction was completed, 10 mL of a sodium hydroxide solution was added to quench the reaction, and the mixture was extracted with ethyl acetate three times.The organic phase was washed with 5 mL of brine, and the organic phases were combined and separated by column chromatography to obtain 45.7 mg of p-phenylaniline.The yield was 90%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3562-73-0, 1-(4-Biphenylyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Peking University; Jiao Ning; Liu Jianzhong; (27 pag.)CN109134267; (2019); A;,
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Application of 52244-70-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

4-Methylphenylsulfonic acid 4-(4-methoxyphenyl)butyl ester (1). Pyridine (15 mL) was added drop wise to a cooled (0° C.) solution of 4-(4-methoxyphenyl)butanol (10.0 g, 0.055 mol) and p-toluenesulfonyl chloride (13.6 g, 0.072 mol) in dry chloroform (100 mL) under stirring. The reaction mixture was stirred overnight at room temperature. After this time, the reaction was quenched with 10percent HCl (300 mL) and extracted with chloroform. The organic fraction was washed with saturated NaHCO3, water and dried over magnesium sulfate. The solvent was removed under reduced pressure and the residue purified by flash chromatography (eluent: hexane/ ethyl acetate 15:1) to provide 12.9 g (66percent) of 1 as clear oil. 1H NMR (360 MHz, CDCl3) delta1.61 (m, 4H), 2.44 (s, 3H), 2.52 (m, 2H), 3.78 (s, 3H), 4.05 (m, 2H), 6.77 (d, 2H), 7.05 (d, 2H), 7.34 (d, 2H), 7.78 (d, 2H).

Statistics shows that 52244-70-9 is playing an increasingly important role. we look forward to future research findings about 4-(4-Methoxyphenyl)-1-butanol.

Reference:
Patent; CYFI, INC.; US2003/195160; (2003); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 440-60-8, Adding some certain compound to certain chemical reactions, such as: 440-60-8, name is (Perfluorophenyl)methanol,molecular formula is C7H3F5O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 440-60-8.

General rocedure: 5.5 ml of aq. solutions of KBr (0.55 mol/dm3), 20 ml MeCN, TEMPO (0.12 g, 0.00077 mol), and 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (2a) (10 g, 0.0275 mol) were placed in the flask. 14% aq. NaOCl (48 ml) buffered by NaHCO3 (5.2 g) were added via the dropping funnel in 3 portions during two days of stirring in a room temperature (slight exothermic effect). The progress of reaction was monitored by 19F NMR spectroscopy. Then concentrated sulfuric acid followed by water was added. After extraction with diethyl ether, the organic phases were dried over magnesium sulfate. The solvent was evaporated to give a colorless liquid, which was distilled.

According to the analysis of related databases, 440-60-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ignatowska, Jolanta; Shyshkov, Oleg; Zipplies, Tilman; Hintzer, Klaus; Roeschenthaler, Gerd-Volker; Journal of Fluorine Chemistry; vol. 141; (2012); p. 35 – 40;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Typical Procedure 6: To a mixture of 2-cyclopropyl-methanol (6.15 g) and DMF (12 mL) was added NaH (60% in mineral oil, 1.5 g) at 0 C. After stirring for 4 hours at RT, the mixture was diluted with DMF (5 mL) and 5-bromo-2-fluoro-pyridine (6.00 g) was slowly added keeping the reaction temperature below 30 C. After 30 minutes at RT, the mixture was heated to 130 C. for 1 hour by microwave irradiation. After cooling to RT, the mixture was diluted with EA and washed with water (3 times). The organic phase was dried (Na2SO4) and concentrated. The residue was purified by SGC to provide 5-bromo-2-cyclopropylmethoxy-pyridine. MS ESI+: m/z=228 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; SANOFI; Schwink, Lothar; Buning, Christian; Glombik, Heiner; Poverlein, Christoph; Ritter, Kurt; Halland, Nis; Lohmann, Matthias; (52 pag.)US2018/237419; (2018); A1;,
Alcohol – Wikipedia,
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Reference of 27489-62-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below.

To a solution of trans-A- aminocyclohexanol (3 g, 26 mmol) in DMF (130 mL) at 0 C was added 60% sodium hydride in oil. The reaction mixture was stirred at 0 C for lh and then 4-fluorobenzonitrile (3.9 g, 32.6 mmol) was added. It was heated to 60 C for 2h and stirred for 12 h at room temperature. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried, filtered, and concentrated under reduced pressure to provide the titled compound (2.5 g, 44% yield). NMR (300 MHz, DMSO-c¾): 67.72 (d, J = 9 Hz, 2H), 7.09 (d, J = 9 Hz, 2H), 4.48-4.34 (m, 1H), 2.68-2.55 (m, 1H), 2.07-1.94 (m, 2H), 1.85-1.71 (m, 2H), 1.46-1.11 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27489-62-9, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce, D.; HWANG, Sung, Hee; WECKSLER, Aaron, T.; MORISSEAU, Christophe; WO2012/112570; (2012); A1;,
Alcohol – Wikipedia,
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Related Products of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

Add 1 mmol of triethylene glycol to the three-necked flask,Add 1 mmol of pyridine,Dissolve with 20 ml of dichloromethane.Stir in a 0 oC ice bath.Dissolve 1 mmol of p-methylbenzenesulfonyl chloride with dichloromethane.Slowly drip into three-necked flask.The reaction was washed with hydrochloric acid after 3 h,The organic layer was washed with water until the aqueous solution was neutral.Drying with anhydrous sodium sulfate,Column chromatography yielded the product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; Gannan Normal University; Wu Yongquan; Zeng Guanjie; Wu Renmiao; Fan Xiaolin; (15 pag.)CN105061515; (2017); B;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

[1369] A solution of 3-amino-1,1,1-trifluoropropan-2-ol (0.016 g, 0.122 mmol), HATU (0.046 mg, 0.122 mmol), and 3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)pyrazine-2-carboxylic acid (0.030 g, 0.081 mmol) (single enantiomer, synthesized according to procedure in Example 38) in DMF (0.810 mL) was stirred at rt for 5 min, treated with triethylamine (0.034 mL, 0.243 mmol), and stirred at rt for 30 min. The reaction mixture was concentrated and purified by flash column chromatography using methanol in dichloromethane (0% to 20%) to give the desired product that still contained some impurities. This material was repurified by flash column chromatography using ethyl acetate in hexanes (0% to 100%) to give the desired product as a mixture of diastereomers. The mixture of diastereomers was separated via preparative chiral HPLC (Chiral Technologies ChiralPak IA [20250 mm, 5 micron], eluting with 15% ethanol in hexanes, at flow rate of 20 mL/min, loading about 8 mg in 1.8 mL ethanol) to give the first eluting diastereomer (3.20 mg, 8.21%) as 43A and the second eluting diastereomer (3.00 mg, 7.69%) as 43B. The first diastereomer that eluted had a retention time of 12.2 min. The second diastereomer that eluted had a retention time of 16.6 min. 43A: LCMS for C18H18F6N5O4(M+H)+: m/z=482.1; Found: 482.1. 43B: LCMS for C18H18F6N5O4 (M+H)+: m/z=482.1; Found: 482.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Incyte Corporation; Douty, Brent; Ai, Yanran; Burns, David M.; Combs, Andrew P.; Falahatpisheh, Nikoo; Levy, Daniel; Polam, Padmaja; Shao, Lixin; Shepard, Stacey; Shvartsbart, Artem; Yue, Eddy W.; (132 pag.)US2020/2295; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 59767-24-7, name is 1-(4-Chlorophenyl)-1-phenylethanol. A new synthetic method of this compound is introduced below., Formula: C14H13ClO

(R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine: A mixture of (R)-2-(2-chloroethyl)-1-methyl-pyrrolidine hydrochloride (0.530 g, 2.91 mmol), 1-(4-chlorophenyl)-1-phenylethanol (1.01 g, 4.39 mmol), sodium amide (0.567 g, 14.53 mmol) and toluene (10 mL) was heated at reflux for about 8 hours, cooled to ambient temperature, and filtered. The filtrate was concentrated and the resulting residue was purified by Preparative HPLC on a Kromasil C18 (30×250 mm, 10 mum) column, by eluting with acetonitrile/0.01 M ammonium acetate (3:1) at a flow rate of 42 mL/min. The racemic title compound eluted at 1.57 min. Standard extractive workup with ethyl acetate afforded the racemic title product as an oil (0.360 g, 36%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 59767-24-7, 1-(4-Chlorophenyl)-1-phenylethanol.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2009/203763; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts