Month: June 2021

Related Products of 28539-02-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3. 3-(4-tert-butylsulfanvIthieno[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)cyclopent-2-en-1-one Lithium bis(trimethylsilyl)amide (1.0 M in THF, 0.66 mL, 0.66 mmol) is added to a solution of 3-(4-tert-butylsulfanylthieno[3,2-d]pyrimidin-7-yl)cyclopent-2-en-1-one (0.10 g, 0.33 mmol) in THF (2.0 mL) at -78 C. and the resulting mixture is stirred at this temperature over 1 hr. To this mixture, a solution of 1-hydroxymethylbenzotriazole (0.10 g, 0.66 mmol) in a mixture of THF (1.0 mL) and hexamethylphosphoramide (HMPA, 0.10 mL) is added. The resulting mixture is stirred at -78 C. for 2 hr then quenched with saturated aqueous NH4Cl (1.0 mL). THF is removed in vacuo and the resulting residue is taken up in dichloromethane, dried with Na2SO4, filtered and concentrated in vacuo. The crude is purified by chromatograph to give desired title compound as a solid (0.08 g, 69%). LCMS (m/z) M+H=335.4; tR=2.89 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Patent; Wang, Zhong; Smith, Emilie D.; Veal, James M.; Huang, Kenneth H.; Atkinson, Robert N.; Jiang, Rong; US2012/77814; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2516-33-8, Cyclopropylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To a solution of (3,3-difluorocyclobutyl)methanol (4.0 g, 32.8 mmol) in dichloromethane (109 ml) at room temperature was added Dess-Martin Periodinane (16.7 g, 39.3 mmol). After 2 h, the reaction was diluted with two volumes of ether and treated with sodiumthiosulfate (32 g) in water (160 mL). After stirring at room temperature for 10 min, the layers were separated. The ethereal was washed with saturated sodium bicarbonate (2X), dried over magnesium sulfate, and filtered. The resulting solution was concentrated via distillation of the solvent through a short path distillation apparatus. The distillation was discontinued when 6.56 g remained in the boiling flask. Integration of the 1H NMR showed product as a 28.4 wt% solution in diethyl ether (1.86 g, 47% yield). The material was directly used without further concentration

The synthetic route of 2516-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Degnan, Andrew P.; Maxwell, Darrell; Balakrishnan, Anand; Brown, Jeffrey M.; Easton, Amy; Gulianello, Michael; Hanumegowda, Umesh; Hill-Drzewi, Melissa; Miller, Regina; Santone, Kenneth S.; Senapati, Arun; Shields, Eric E.; Sivarao, Digavalli V.; Westphal, Ryan; Whiterock, Valerie J.; Zhuo, Xiaoliang; Bronson, Joanne J.; Macor, John E.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 24; (2016); p. 5871 – 5876;,
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Application of 1589-47-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1589-47-5, name is 2-Methoxypropan-1-ol. A new synthetic method of this compound is introduced below.

The distillate of example 2 was dewatered by means of azeotropic distillation using a distillation column having an inner diameter of 25 mm and a filling with stainless steel coils. The column had a separation efficiency of 25 theoretical stages and was equipped with external electric heating to compensate heat loss. The distillate of example 2 was fed continuously at a rate of 150 g/h to the 3rd theoretical stage (counted from the top) of said column. Additionally benzene was fed to the top of the column. The reboiler was heated to obtain 1235 g/h distillate. The distillate was condensed and transferred to a phase separation vessel, in that it separated to a benzene phase and an aqueous phase. The benzene phase was again fed to the top of the column and the aqueous phase was removed at a rate of 115 g/h. Simultaneously, a bottom product was removed at a rate of 35 g/h. The content of organic compounds of the bottom product was analyzed via gc-analysis. The water content was determined by Karl-Fischer-Titration.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1589-47-5, 2-Methoxypropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; DEGUSSA AG; UHDE GMBH; WO2004/773; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H9BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H9BrO

(1) 6-Bromoindan-1-ol (3.01 g) and dihydropyrane (1.78 g) are dissolved in dichloromethane (50 ml), and thereto is added pyridinium p-toluenesulfonate (178 mg), and the mixture is stirred at room temperature for 1.5 hour. The reaction solution is washed with a saturated aqueous sodium hydrogen carbonate solution, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate) to give 6-bromo-1-tetrahydropyranyloxyindane (4.10 g). MS (m/z): 296, 298 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tanabe Seiyaku Co., Ltd.; US5830873; (1998); A;,
Alcohol – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H13NO

To a stirred suspension of sodium hydride (0.3Og, 80% dispersion in mineral oil) in dry N,N-dimethylformamide (2ml) under an atmosphere of nitrogen at ambient temperature was added dropwise a solution of 1-hydroxy-3-methylbut-3-ylamine (0.52g) in N1N- dimethylformamide (5ml). The mixture was stirred for 3 hours, methyl iodide (0.74g) in N,N-dimethylformamide (5ml) added over 5 minutes then stirred for another 2.25 hours and stored for 18 hours at ambient temperature. The solution was diluted with water, extracted into ethyl acetate (three times) and the extracts combined then extracted with dilute hydrochloric acid. The aqueous acidic extract was evaporated under reduced pressure and co-distilled with toluene to remove residual water to give 1-methoxy-3- methylbut-3-ylamine hydrochloride as a yellow gum.1H NMR (CDCI3) delta ppm: 1.54(6H,s); 1.96-2.00(2H,t); 3.48(3H,s); 3.62-3.66(2H,t).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2008/110355; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 597-31-9, 3-Hydroxy-2,2-dimethylpropanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Hydroxy-2,2-dimethylpropanal, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3-Hydroxy-2,2-dimethylpropanal

EXAMPLE 1Preparation of an Aqueous Polymethylol Mixture by the Hydrogenation ProcessStage a) Aldol Reaction:Approx. 750 g/h of isobutyraldehyde (approx. >99.5 GC area % of IBA) were reacted with approx. 700 g/h of formaldehyde (approx. 49% formaldehyde, 1.5% of methanol, remainder water) and 80 g/h of trimethylamine solution (50% TMA in water) in a two-stage stirred tank cascade.Stage b) Distillative Separation of the Reaction Mixture from Stage a):Subsequently, the solution was freed of low boilers by distillation in a column. The column was equipped with 1.5 m of fabric packing (specific surface area 500 m2/m3) in the rectifying section and 4 m of sheet metal packing (250 m2/m3). The aldolization discharge was fed in above the sheet metal packing. At the top of the column, a condenser with cooling water (approx. 10 C.) and a downstream phase separator was used. At the top, the distillate was fed to the condenser in gaseous form. Approx. 255 g/h of liquid condensate were obtained. In the phase separator connected downstream, an aqueous phase of 95 g/h was removed and fed completely to the column. In addition, 135 g/h were fed from the phase separator to the first stirred tank. In order to maintain the regulation temperature in the column at 85 C., 25 g/h of organic phase were additionally fed to the column. In the cold trap connected downstream of the condenser, approx. 1 g/h of liquid was obtained (approx. 80% IBA, approx. 20% TMA), which was likewise recycled.The IBA removal was conducted at a top pressure of approx. 1 bar absolute. The evaporator used was a falling film evaporator. A bottom temperature in the bottom of the column of 104 C. was established. The reflux rate (i.e. cooling water rate of the partial condenser) to the column was regulated by means of the temperature in the middle of the fabric packing; a temperature of 85 C. was established.By means of a pump, approx. 100 kg/h of liquid were drawn off from the bottom of the column. This was fed to the falling film evaporator (consisting of an oil-heated stainless steel tube, length 2.5 m, internal diameter approx. 21 mm, wall thickness approx. 2 mm). Approx. 1.5 kg/h of product with a concentration of approx. 0.3% isobutyraldehyde were drawn off from the bottom of the falling film evaporator. The vapors and excess liquid were fed to the bottom of the column. The bottom product discharged comprised approx. 70% by weight of HPA, approx. 1.5% by weight of HPN, 0.3% by weight of IBA, remainder water.Stage c) Hydrogenation of the Bottom Discharge from Stage b):The resulting bottom product was subsequently subjected to a hydrogenation by means of a fixed bed.The catalyst was activated as follows:150 ml of a Cu/Al2O3 catalyst as described in EP 44444 and PF57216 were activated in a tubular reactor at 190 C. by passing over a mixture of 5% by volume of hydrogen and 95% by volume of nitrogen (total volume 50 l (STP)/h) at ambient pressure for 24 hours.The hydrogenation was performed as follows:The starting solution used was the mixture described above as hydrogenation feed. Approx. 10% by weight based on the hydrogenation feed of a 15% aqueous solution of trimethylamine was added to the mixture. The feed thus obtained was conducted in trickle mode at H2 pressure 40 bar through the reactor heated to 120 C. The space velocity was 0.4 kg of HPA/(Icat*h). A portion of the hydrogenation discharge was added again to the feed (circulation mode). The ratio of circulation to feed was 10:1. The pH of samples of the reactor discharge at room temperature was measured at 8.9.The composition of the aqueous polymethylol mixture from stage c) was:NPG: 69% by weight Methanol: 3.5% by weight TMA: 2% by weight. organic secondary compounds (HPA, isobutanol): <2% by weight TMA formate: 1% by weight Water: 23% by weight At the same time, in my other blogs, there are other synthetic methods of this type of compound,597-31-9, 3-Hydroxy-2,2-dimethylpropanal, and friends who are interested can also refer to it. Reference:
Patent; BASF-SE; US2012/4472; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 626-18-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 626-18-6, name is 1,3-Benzenedimethanol. This compound has unique chemical properties. The synthetic route is as follows.

1,3-phenylenedimethanol (2.18 g, 15.778 mmol) was dissolved in DMF (21.80 ml) and cooled to 0 C, Imidazole (2.148 g, 31.557 mmol) was added followed by the addition of tert-Butyldimethylchlorosilane (2.378 g, 15.778 mmol). The mixture was stirred at 0 C for 1 h and allowed to warm up to r.t. and stirred overnight. Upon completion of the reaction, the mixture was quenched with sat. aq. NH4C1 (10 ml), extracted with EtOAc (2 x 100 ml). The organic layer was washed with sat. aq. NaHC03solution (10 ml), dried over Na2S04and concentrated. The residue was purified by flash chromatography to give (3-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)methanol (393) as colorless oil (1.73 g, 43.4% yield)

According to the analysis of related databases, 626-18-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EISAI R&D MAN CO LTD; E Ja I Al Aendeu D Maenijimeonteu Gabu Siki Ga I Sya; ZHENG WANJUN; Jaeng , -wan-jun; ZHU XIAOJIE; Ju , -sya-o-ji-e; DU HONG; Du , -hong; POSTEMA MAARTEN; Po Seu-te-ma-, -ma-a-reu-ten; JIANG YIMIN; Jang , -w-min; LI JING; Ri , -jing; YU ROBERT; Yu , -ro-beo-teu; CHOI HYEONG WOOK; Choe , -hyeong—uk; LEE JAEMOON; I , -jae-mun; FANG FRANK; Paeng , -peu-rang-keu; CUSTAR DANIEL; Ku Seu-ta-, -da-ni-el; (178 pag.)KR2018/83863; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 4728-12-5, (2,2-Dimethyl-1,3-dioxan-5-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H14O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C7H14O3

A solution of (2,2-dimethyl-1 ,3-dioxan-5-yl)methanol (2.51 g, 17.1 mmol) and N, N- dimethylaminopyiridine (208 mg, 1.7 mmol) in dichloromethane (100 ml.) was cooled to 0 0C and p-toluenesulfonyl chloride (3.59 g, 18.8 mmol) and triethylamine (4.8 ml. 34.2 mmol) were added. The mixture was stirred overnight at rt, diluted with water, and the organic layer was separated. The solvent was removed and the crude material was purified via silica gel chromatography to give 4.16 g of the title compound. 1H NMR (DMSOd6) delta 7.78 (d, 2 H), 7.47 (d, 2 H), 4.09 (d, 2 H), 3.84 (dd, 2 H), 3.52 (dd, 2 H), 2.41 (s, 3 H), 1.79 – 1.94 (m, 1 H), 1.28 (s, 3 H), 1.18 (s, 3 H).

The synthetic route of 4728-12-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157330; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 162358-05-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 162358-05-6, name is 2-(4-Octylphenyl)ethanol. A new synthetic method of this compound is introduced below.

Example 6 Preparation of Compound of Formula VIIIn a round bottom flask, 600 ml of methylene chloride was charged and 100 gm of compound of Formula V, obtained as in Example 4, and 5.0 gm of DMAP and 110 gm of triethyl amine was added. The reaction mass was stirred for about 10 minutes and cooled at about 0-5 C. 75 gm of methane sulphonyl chloride was added at about 0-5 C. and the temperature of reaction mass was raised to about 25-30 C. The reaction mass was stirred at about 25-30 C. for about 1 hour and water (500 ml) was added to the reaction mass. The pH was adjusted to about 2-4 by using aq. HCl and the reaction mass was stirred for about 20 min. The organic layer was separated and washed with 7% bicarbonate solution followed by washing with brine. The organic layer was treated with charcoal and distilled out under vacuum and degassed to get 110 gm of compound of Formula VI.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,162358-05-6, 2-(4-Octylphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Glenmark Generics Limited; Gharpure, Milind; Narawade, Krishna; Chand, Prem; Bhirud, Shekhar; US2015/18578; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 13726-17-5, (4-Chloro-3-methoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9ClO2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9ClO2

D. Synthesis of 4-chloro-3-methoxybenzaldehyde (0202) To a solution of (4-chloro-3-methoxyphenyl)methan-1-ol (5.08 g, 29.4 mmol) in benzene (120 mL) was added MnO2 (5.65 g, 65 mmol). The reaction mixture was refluxed for 17 hr, chilled, and filtered through Celite, washing the cake with CH2Cl2 (300mL). The filtrate was concentrated in vacuo to give 4-chloro-3-methoxybenzaldehyde (4.5 g, 89%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13726-17-5, (4-Chloro-3-methoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Portola Pharmaceuticals, Inc.; Scarborough, Robert; Jantzen, Hans-Michael; Huang, Wolin; Sedlock, David; Marlowe, Charles; Kane-Maguire, Kim; (200 pag.)EP2314593; (2016); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts