Tag: M.W=100-200

Reference of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

A 50 mL three-necked flask that had been equipped with a column fitted with a side tube and packed with 20 g of molecular sieve (4A), a condenser, a thermometer and a drying tube was loaded with 0.64 g (2 mmol) of N, N?-bis(salicylidene)ethylenediamine iron (II), 1.04 g (10 mmol) of isoprene glycol, 40 g (400 mmol) of methyl methacrylate, 0.08 g of phenothiazine and 0.2 g of tridecane. While performing stirring at atmospheric pressure, the flask was placed into an oil bath set at 120 C. so that the temperature inside the flask would be 100 to 105 C. The reaction was performed for 11 hours while totally refluxing the distilled fraction back to the reaction system through the molecular sieve. The reaction liquid was sampled at prescribed lapses of time from the start of the reaction (3 hours, 5 hours, 7 hours, 9 hours and 11 hours). The gelation of the samples of the reaction liquid was evaluated as described in Test Example 3, the results being described in Table 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2568-33-4, 3-Methylbutane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KURARAY CO., LTD.; TAKAHATA, Yusuke; KAJIYASHIKI, Tsuyoshi; (9 pag.)US2018/50975; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6282-88-8, name is 3-(4-Chlorophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(4-Chlorophenyl)propan-1-ol

3- (4-chlorophenyl) propanol (17.1g, 0.1mol) was added to DMF (150ml) added successively N- (3- chloropropyl) piperidine (17.8g, 0.11mol), potassium carbonate (6.9g, 0.05mol), potassium iodide 1g, was heated to 95 , the reaction was stirred for 12 hours.The mixture was cooled to room temperature, then diluted with 300ml water, extracted twice with 400ml of ethyl acetate, the combined organic phases, 2N sodium hydroxide and twice with brine, dried over magnesium sulfate, filtered, and HCl at room temperature gas, stirring the precipitated solid was filtered and dried to give light yellow solid solution of 29.8 g, yield 89.7%, HPLC: 99.6%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol.

Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
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Reference of 5259-98-3 , The common heterocyclic compound, 5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound 13 To a solution of 5-chloro-l-pentanol (3.0 g, 24.47 mmol) Compound 11 in DMF (20 mL) was added sodium azide (1.909 g, 29.4 mmol) Compound 12. After being stirred at 60 ¡ãC for overnight, the reaction mixture was concentrated in vacu. The residue was purified by silica gel chromatography (EtOAc/Hexane 1 :3), to give product Compound 13 as clear liquid. 1H NMR (500 MHz, CDC13) delta 3.62 (m, 2H), 3.25 (t, J= 6.9 Hz, 2H), 1.63-1.53 (m, 4H), 1.45-1.40 (m, 2H).

The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TELLERS, David; COLLETTI, Steven, L.; DUDKIN, Vadim; AARONSON, Jeffrey; MOMOSE, Aaron; TUCKER, Thomas, Joseph; YUAN, Yu; CALATI, Kathleen, B.; TIAN, Lu; PARMAR, Rubina, G.; SHAW, Anthony, W.; WANG, Weimin; STORR, Rachel, Anne; BUSUEK, Marina; KOWTONIUK, Robert, A.; WO2013/166155; (2013); A1;,
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Related Products of 3840-31-1, Adding some certain compound to certain chemical reactions, such as: 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3840-31-1.

To the solution of 3,4,5-trimethoxybenzyl alcohol (7.2 g, 36.4 mol) in dry DCM (100 mL), thionyl chloride (3.5 mL, 48.2 mmol) and pyridine (3.4 mL, 42.1 mmol) were added dropwise. The reaction mixture was stirred at RT for 1.5 h and progress was monitored by TLC (AcOEt/Hex 1:1 as mobile phase). The reaction was stopped by the addition of 100 mL H2O and extracted with 2 x 25 mL DCM. The combined organic extracts were dried over MgSO4 and evaporated in vacuo to give 87% yield. Yellow, solid.

According to the analysis of related databases, 3840-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Urbaniak, Alicja; Delgado, Magdalena; Kacprzak, Karol; Chambers, Timothy C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2766 – 2770;,
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Synthetic Route of 6214-44-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6214-44-4, name is (4-Ethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Under an argon stream, p-Ethoxybenzyl alcohol (1) (6.509, 42.7 mmol) Of anhydrous methylene chloride (90 mL), The mixed solution of anhydrous N, N-dimethylformamide (70 L) was cooled with ice, Thionyl chloride (4.0 mL, 55.7 mmol) was added, And stirred for 30 minutes. The reaction solution was concentrated and dissolved in tetrahydrofuran (30 mL) Was added dropwise to ice water (150 mL). It was extracted twice with methylene chloride (50 mL) The obtained organic layer was dried with sodium sulfate, By concentrating under reduced pressure, To give compound 2 (7.66 g) as a pale yellow liquid.

According to the analysis of related databases, 6214-44-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE; DOKKYO GAKUEN DOKKYO UNIVERSITY SCHOOL OF MEDICINE; MATSUMOTO, NOBUYUKI; ANZAI, NAOHIKO; (16 pag.)JP2018/62475; (2018); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62285-58-9, name is (2,6-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2,6-Dimethylphenyl)methanol

A solution of 2,6-Dimethylbenzyl alcohol (5.25 g, 38.6 mmol) and diisopropyl azodicarboxylate (DIAD, 8.49 g, 42 mmol) in THF (30 ml) and DMF (13 ml) was added drop wise to a solution of Ethyl 3-hydroxyphenylacetate (Step A, 6.66 g, 37 mmol) and triphenylphosphine (1 Ig, 42 mmol) in THF (100 ml). The reaction mixture was stirred at room temperature for 4 hours, diluted with ether and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash EPO chromatography on a silica gel column (hex: ethyl acetate 1:1) to give the title compound.1H NMR (270 MHz5 CDCl3): 1.2 (t, 3H); 2.4 (s, 6H); 3.5 (s, 2H); 4.1 (q, 2H); 5.1 (s, 2H); 6.9 (m, 2H); 7.15-7.35 (m, 5H).

With the rapid development of chemical substances, we look forward to future research findings about 62285-58-9.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2006/127133; (2006); A2;,
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Synthetic Route of 44565-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 44565-27-7, name is 4-Amino-2-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 7b (90 mg, 0.26 mmol) and 4-amino-2-methyl-butan-1-ol (40 mg, 0.26 mmol) were refluxed overnight in BuOH (2 mL). The resulting solution was poured into saturated NH4Cl solution, and extractedwith EtOAc. The organic layer was washed with saturated NaCl, and then dried over Na2SO4, evaporated under reduce pressure. The residue was purified by a silica gel column chromatography (CHCl3:MeOH=95:5) to give 3b as white powder (73 mg, 68 % yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 44565-27-7, 4-Amino-2-methylbutan-1-ol.

Reference:
Article; Hayashi, Ken-Ichiro; Kusaka, Naoyuki; Ando, Kazuki; Mitsui, Taichi; Aoyama, Takashi; Nozaki, Hiroshi; Bioorganic and Medicinal Chemistry Letters; vol. 22; 17; (2012); p. 5663 – 5667;,
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Related Products of 62037-46-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62037-46-1, name is 1-Amino-3-chloropropan-2-ol hydrochloride, molecular formula is C3H9Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A three-necked flask was charged with 1-amino-3-chloropropyl-2-ol hydrochloride (14.60 g, 100 mmol) and tetrahydrofuran(73 mL), water (73 mL), stirred and cooled to 0 to 5 C, added with dipotassium hydrogen phosphate (34.84 g, 200 mmol), stirred for 5 minAfter the clockwise drop of ethyl sulfonyl chloride (13.50g, 105mm0l), plus the temperature after warming to room temperature for 3-4 hours, the end of the reaction0.5mol / L dilute hydrochloric acid 73mL quenching reaction, stirring and dispensing, water and then extracted with ethyl acetate 35mL 2 times, combined organic saturatedAnd washed with salt (73 mL), dried over anhydrous sodium sulfate and concentrated to give N-(3-chloro-2-hydroxypropyl) ethane sulfonamide Followed by the next step (GC purity of about 92%).

According to the analysis of related databases, 62037-46-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Zheng Xuchun; Zhang Yiping; Wu Yihua; (16 pag.)CN106946917; (2017); A;,
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Related Products of 1562-00-1 , The common heterocyclic compound, 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Synthesis of [CmOHMIM][HOCnSO3]) and [CmOHTEA][HOCnSO3]: ILs were prepared by ion exchange method. The ion exchange of the anion chloride by the anion hydroxyalkanesulphonate was carried out using an exchange column packed with 100 g of Amberlite IR120 H-type strongly acidic cation exchange resin. The column was previously flushed thoroughly with a 1 mol L- 1 [CmOHMIM]Cl or [CmOHTEA]Cl solution until the elution was neutral, then with Milli-Q water until no chloride was detected by silver nitrate. A 100 mL of 1 mol L- 1 Na[HOCnSO3] solution was slowly run over and eluted with Milli-Q water. The eluted liquid was collected and concentrated under reduced pressure in a rotary evaporator. The residue was then vacuum dried at 323 K for 18 h to afford the IL in near-quantitative yield as a colorless viscous liquid. ILs with ions containing hydroxyl groups are usually observed to be rather viscous. 1-(2-Hydroxyethyl)-3-methyl-imidazolium hydroxymethane sulfonate ([C2OHMIM][HOC1SO3]) 1H NMR (400 MHz, D2O, 298 K): 3.89 (s, 3H), 3.91 (t, J = 5.0 Hz, 2H), 4.30 (t, J = 4.83 Hz, 2H), 4.35 (s, 2H), 7.44 (s, 1H), 7.50 (s, 1H), 8.72 (s, 1H); 13C NMR (400 MHz, D2O, 298 K): 35.29, 51.08, 59.35, 73.71, 122.01, 123.18, 135.92. ES-MS: ES+ m/z 127.00 [C2OHMIM]+, 288.87 [C2OHMIM]+?H3O2-?[C2OHMIM]+; ES- m/z 110.80 [HOC1SO3]-, 244.73 [HOC1SO3]-?H3O+?[HOC1SO3]-, 352.80 [HOC1SO3]-?[C2OHMIM]+?[HOC1SO3]-. 1-(2-Hydroxyethyl)-3-methyl-imidazolium 2-hydroxyethane sulfonate ([C2OHMIM][HOC2SO3]) 1H NMR (400 MHz, D2O, 298 K): 3.11 (t, J = 6.64 Hz, 2H), 3.89 (s, 3H), 3.89-3.91 (overlapped, 4H), 4.30 (t, J = 4.84 Hz, 2H), 7.44 (s, 1H), 7.50 (s, 1H), 8.73 (s, 1H); 13C NMR (400 MHz, D2O, 298 K): 35.28, 51.08, 52.44, 56.53, 59.34, 122.01, 123.18, 135.92. ES-MS: ES+ m/z 127.00 [C2OHMIM]+, 288.87 [C2OHMIM]+?H3O2-?[C2OHMIM]+, 378.80 [C2OHMIM]+?[HOC2SO3]-?[C2OHMIM]+; ES- m/z 124.93 [HOC2SO3]-, 272.87 [HOC2SO3]-?H3O+?[HOC2SO3]-, 376.67 [HOC2SO3]-?[C2OHMIM]+?[HOC2SO3]-. 3-Hydroxypropyl-tri(2-hydroxyethyl) ammonium 2-hydroxyethane sulfonate ([C3OHTEA][HOC2SO3]) 1H NMR (Brueker AV-600, 600 MHz, D2O, 298 K): 1.92-1.93 (m, -OH), 3.06 (t, J = 6.55 Hz, 2H), 3.36 (not resolved, 2H), 3.50-3.51 (m, 2H), 3.58 (not resolved, 6H), 3.86 (not resolved, 6H), 3.96 (not resolved, 4H); 13C NMR (Brueker AV-600, 600 MHz, D2O, 298 K): 24.61, 52.99, 55.06, 55.38, 55.47, 57.10, 58.36, 58.58, 61.25. ES-MS (AB SCIEX Triple TOF 5600 +): ES+ m/z 208.1578 [C3OHTEA]+, 266.2013 Na+?H3O2-?[C3OHTEA]+; ES- m/z 124.9882 [HOC2SO3]-.

The synthetic route of 1562-00-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ou, Guangnan; He, Biyan; Halling, Peter; Biochimica et Biophysica Acta – General Subjects; vol. 1860; 7; (2016); p. 1404 – 1408;,
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Application of 100-37-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Preparation of N,N-diethylaminoethyl 4-[bis(2-chloroethyl)amino] ben- zenebutyrate.HCl; [19] 30.4 g (0.1 mol) of 4-[bis(2-chloroethyl)amino]benzenebutanoic acid was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.7 g of N,N-diethylaminoethanol and 0.2 g of 4-dimethylaminopyridine were added into the reaction mixture. The mixture was stirred overnight at 0C. The solid was removed by filtration. The chloroform solution was washed with water (1 x 100 ml), 5% NaHCO (1 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 4 g of HCl gas in methanol (10 ml) was added into the reaction mixture with stirring. Hexane (200 ml) was added. The solid product was collected by filtration. After drying, it yielded 35 g of the desired product (79.6 %). Hygroscopic product; Solubility in water: 300 mg/ml; Elementary analysis: C H Cl N 2O2; MW: 439.85. Calculated % C: 54.61, H: 7.56, N: 6.37; O: 7.27; Cl: 24.18; Found % C: 54.55; H: 7.58; N: 6.34, O: 7.29; Cl: 24.24. 1H-NMR (400 MHz, D O): delta: 1.56 (t, 6H), 2.01(m, 2H), 2.25 (m, 2H), 2.55 (m, 2H), 3.22 (m, 4H), 3.52 (m, 2H), 3.60-3.65 (m, 8H), 4.50 (m, 2H), 6.55 (m, 2H), 6.95 (m, 2H).

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TECHFIELDS BIOCHEM CO. LTD; YU, Chongxi; XU, Lina; WO2008/41059; (2008); A1;,
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