Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79418-41-0, name is 3-Amino-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Amino-7-hydroxy-2H-chromen-2-one

General procedure: To a solution of 3-amino 7-hydroxycoumarin (1.0 eq) in dimethylformamide (DMF) (20 mL) was added anhy. K2CO3 (2.5 eq) and stirredat room temperature for 10-15 min. To this mixture, alkyl bromide(1.0 mmol) was added and resulting solution was stirred at room temperature(rt) for 22-24 h. The completion of reaction was checked byTLC. After completion of reaction, the reaction mixture was pouredinto ice-cold water to give solid. The solid was filtered, washed withwater, dried and recrystallized from ethanol to give compound 13 asoffwhite solid. These compounds 14a-lwere directly used for next step.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 79418-41-0, 3-Amino-7-hydroxy-2H-chromen-2-one.

Reference:
Article; Durgapal, Sunil Dutt; Soni, Rina; Soman, Shubhangi S.; Prajapati; Journal of Molecular Liquids; vol. 297; (2020);,
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Adding a certain compound to certain chemical reactions, such as: 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (3,4,5-Trimethoxyphenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (3,4,5-Trimethoxyphenyl)methanol

i 3,4,5-Trimethoxybenzyl chloride In 40 ml of benzene was dissolved 10 g of 3,4,5-trimethoxybenzyl alcohol. To the resulting solution was dropwise added under chilling with ice 10 ml of benzene solution containing 7.6 g of thionyl chloride. After the addition was complete, the mixture was stirred at room temperature for 15 min. The reaction solution was poured into a chilled aqueous potassium carbonate, and a separated benzene portion was collected. The benzene portion was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and placed under reduced pressure to distill off the solvent. The desired compound was obtained as a yellow solid (yield: 11.0 g).

The synthetic route of 3840-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; US5070089; (1991); A;,
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Related Products of 530-91-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, molecular formula is C10H12O, molecular weight is 148.2017, as common compound, the synthetic route is as follows.

EXAMPLE 81 To a mixture of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropanol (318 mg), 2-hydroxytetralin (296 mg), tributylphosphine (405 mg) and tetrahydrofuran (10 ml) was added 1,1′-(azodicarbonyl)dipiperidine (400 mg) at room temperature, and the resulting mixture was stirred for 1 hour. After the reaction mixture was concentrated, the residue was subjected to silica gel column chromatography, and 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(5,6,7,8-tetrahydro-2-naphthoxy)propyl]oxazole was obtained as an oil from an ethyl acetate-hexane (1:1, v/v)-eluted fraction. (358 mg, 80%).

Statistics shows that 530-91-6 is playing an increasingly important role. we look forward to future research findings about 1,2,3,4-Tetrahydronaphthalen-2-ol.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6605629; (2003); B1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.478163-35-8, name is (2-Fluoro-6-methylphenyl)methanol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.Recommanded Product: (2-Fluoro-6-methylphenyl)methanol

After dissolving (2-fluoro-6-methylphenyl)methanol (CAS 478163-35-8) (2.35 g) in toluene (20 ml), thionyl chloride (3.68 ml) was added dropwise while stirring on ice. A catalytic amount of N,N-dimethylformamide was added, and the mixture was stirred at room temperature for 25 hours and 30 minutes. The reaction mixture was concentrated under reduced pressure, a saturated aqueous solution of sodium hydrogencarbonate was added to the residue, and extraction was performed with n-heptane. The organic layer was washed with water and brine in that order and then dried over anhydrous magnesium sulfate. After filtration with NH silica gel, the filtrate was concentrated under reduced pressure. The title compound (2.04 g) was thus obtained.1H-NMR (400 MHz, CDCl3); delta 2.45 (s, 3H), 4.68 (d, J=1.6 Hz, 2H), 6.89-7.01 (m, 2H), 7.17-7.24 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,478163-35-8, (2-Fluoro-6-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2009/270369; (2009); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(3-Fluorophenyl)ethanol

A mixture of 2-(3-fluorophenyl)ethanol (0.052 mL, 0.419 mmol), NaH (0.017 g, 0.419 mmol), and (S)-isopropyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?- difluoro-6-methyl-[3,3?-bipyridinj-5-yl)acetate (0.041 g, 0.084 mmol) in THF was stirred at ambient temperature for 1 h. Then, 5 M NaOH (0.167 mL, 0.837 mmol) was added andthe mixture was heated at 80 C for 2 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (23.4 mg, 49%). ?H NMR (500 MHz, DMSO-d6) 8.14 – 8.03 (m, 1H), 7.93 (d,J= 1.8Hz, 1H),7.70(dd,J 11.0, 1.8Hz, 1H),7.42-7.24(m, 1H),7.21 -6.97(m, 3H), 5.83 (s, 1H), 4.67 (t, J= 6.6 Hz, 2H), 3.18 -3.00 (m, 1H), 1.32 (br s, 3H), 1.14 (s, 1OH), 0.89 – 0.76 (m, 6H) [note: piper/dine protons not all visiblej. LCMS (M+1) =568.3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, molecular weight is 136.6198, as common compound, the synthetic route is as follows.SDS of cas: 2009-83-8

In a 100 mL three-necked flask, 2.73 g (0.01 mol) of Compound 1 was dissolved in 50 mL of dry DMF,2.09 g (0.015 mol) of 6-chlorohexanol was added,3 g (0.022 mol) of anhydrous potassium carbonate and a catalytic amount of a phase transfer catalyst 18-crown-6,The reaction was carried out under the protection of nitrogen at a temperature of 100 C. for 12 hours;The solid in the solution obtained after the reaction was removed by filtration and the DMF was distilled off under reduced pressure. The resulting residue was separated by column chromatography (silica gel of 200 to 300 mesh was used as a stationary phase,The mobile phase consisted of a mixture of petroleum ether and ethyl acetate with a volume ratio of petroleum ether to ethyl acetate of 5: 1 to give 2.76 g of compound 2 (pale yellow solid, 74% yield)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Liu Xinhou; Si Peng; Zhen Zhen; Bo Shuhui; Deng Guowei; Huang Heyan; Peng Chengcheng; Xu Huajun; (23 pag.)CN104974151; (2017); B;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3236-48-4, name is trans-1,4-Cyclohexanedimethanol, molecular formula is C8H16O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C8H16O2

To a 100 mL-flask containing 79 (4.0 g, 27.8 mmol) in DMF (40 mL) was added TBDMSCl (3.56 g, 23.6 mmol) and imidazole (3.79 g, 55.6 mmol). The reaction was allowed to stir at 25 C. for 16 hours after which time saturated aqueous LiBr (50 mL) was added and the reaction extracted with ether (2¡Á50 mL). The ether layers were pooled and extracted again with LiBr (2¡Á35 mL). The ether layer became clear. The ether layer was then concentrated in vacuo and the product purified by flash chromatography, on a silica gel column, eluting with 1:2 ether/petroleum ether to yield 83 (3.80 g, 62%) as a homogenous oil. 1H NMR (CDCl3) delta 3.46 (d, J=6.2 Hz, 2H), 3.39 (d, J=6.2 Hz, 2H), 1.95-1.72 (m, 4H), 1.65 (m, 1H), 1.40 (m, 1H), 1.03-0.89 (m, 4H), 0.88 (s, 9H), 0.04 (s, 6H); 13C NMR (CDCl3) delta 69.2, 69.1, 41.2, 41.1, 29.5, 26.5, 18.9, -4.8; APCI m/z (rel intensity) 259 (MH+, 100).

With the rapid development of chemical substances, we look forward to future research findings about 3236-48-4.

Reference:
Patent; Rieger, Jayson M.; Linden, Joel M.; Macdonald, Timothy L.; Sullivan, Gail W.; Murphree, Lauren J.; Figler, Robert Alan; Thompson, Robert Douglas; US2006/40889; (2006); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-(Dimethylamino)butan-1-ol

100 mg of intermediate compound 5 and 86 mg of triphosgene were dissolved in 10 ml of anhydrous dichloromethane, replaced with nitrogen three times, 0.12 ml of triethylamine was added under ice bath, and after 5 minutes, 0.12 ml of N,N-dimethylbutanol was dissolved in 10 ml of anhydrous dichloromethane, and added to the reaction solution, and reacted at room temperature overnight and TLC showed that the substrate completely disappeared. The reaction mixture was quenched and the reaction mixture was cooled to room temperature, the reaction mixture was extracted with ethyl acetate, the organic layer was washed with water three times, dried over anhydrous sodium sulfate, and concentrated, and subjected to column chromatography to obtain of 90 mg of yellow crystals (compound 1-1) (yield 64%).

With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Zuo Jianping; Lu Dong; Tong Xiankun; Zhang Yunzhe; Tang Wei; Ren Wenming; He Peilan; Chen Wuhong; Yang Xiaoqian; Zeng Limin; Yang Li; Liu Jianan; (61 pag.)CN109384727; (2019); A;,
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Related Products of 15258-73-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15258-73-8, name is (2,6-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, molecular weight is 177.03, as common compound, the synthetic route is as follows.

To a solution of (2,6-dichloro-phenyl)-methanol (4.97 mmol) in DMA was added NaH (200 mg, 4.97 mmol) at RT, and the mixture was stirred for 1 h at RT. 2- Chloro-pyrido[3,4-d]pyrimidin-4-ol (150 mg, 0.83 mmol) was added. The mixture was stirred overnight at RT and concentrated. The residue was purified by FC (DCM/MeOH=20/1) to give 140 mg (53%) of the title compound. ?H NMR (400 MHz, DMSO): oe 5.68 (s, 2H), 7.49-7.53 (m, 1H), 7.59-7.6 1 (m, 2H), 7.86 (d, J 4.8 Hz, 1H), 8.53 (d, J= 4.8 Hz, 1H), 8.92 (s, 1H), 12.71 (s, 1H). [M+H] Calc?d for C,4H9C12N302, 322; Found, 322.

Statistics shows that 15258-73-8 is playing an increasingly important role. we look forward to future research findings about (2,6-Dichlorophenyl)methanol.

Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; KANOUNI, Toufike; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/151106; (2014); A1;,
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Reference of 86770-74-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, molecular formula is C8H19NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-mercapto-4-methylpentanoic acid (163 mg, 1.10 mmol) in MeCN (2.0 mL) were added sequentially acetic anhydride (1 14 pL, 1.21 mmol, 1.10 equiv.), Et3N (307 pL, 2.20 mmol, 2.00 equiv.) and DMAP (1.34 mg, 1 1.0 pnnol). The mixture was stirred for 32 minutes, followed by the addition 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (319 mg, 1.65 mmol, 1.50 equiv.). The resulting reaction mixture was stirred for 18 hours at rt and then cone in vacuo. The residue was purified by silica chromatography (1 10% MeOH in DCM). The desired product was obtained as a yellow oil (342 mg, 1.05 mmol, 96%). 1 H NMR (400 MHz, CDC ) d (ppm) 7.22 (bs, 1 H), 3.79-3.71 (m, 4H), 3.71-3.59 (m, 8H), 3.57-3.51 (m, 2H), 3.50-3.41 (m, 2H), 2.43-2.34 (m, 2H), 1.98-1.89 (m, 2H), 1.65 (bs, 1 H), 1.40 (s, 6H). LCMS (ESI+) calculated for CMHSONOSS* (M+H+) 324.18, found 324.36.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; HOOGENBOOM, Jorin; VAN BERKEL, Maria Antonia; VAN DELFT, Floris Louis; (95 pag.)WO2019/110725; (2019); A1;,
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