Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 89-95-2, 2-Methylbenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 89-95-2, blongs to alcohols-buliding-blocks compound. SDS of cas: 89-95-2

General procedure: Amine (1 mmol) was added to a mixture of Na+-MMT-[pmim]HSO4 (10 mg, 1 mol %) and formic acid (2 mmol) and the resulting mixture was stirred at 60 C for the appropriate time. After completion of the reaction (monitored by TLC), ethyl acetate (10 mL) was added and the catalyst was separated by filtration. The organic phase was washed with water (2 x 10 mL) and dried over Na2SO4. The solvent was removed under reduced pressure to afford the desired product.

The synthetic route of 89-95-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shirini, Farhad; Mazloumi, Masoumeh; Seddighi, Mohadeseh; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 1759 – 1776;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.Safety of 2-(3,4-Dichlorophenyl)ethanol

[00318] MsCl (2.40 g, 20.92 mmol) was added to a solution of 2-(3,4-dichlorophenyl)ethanol (1.00 g, 5.23 mmol) and TEA (1.59 g, 15.69 mmol, 2.17 mL) in dry DCM (10.00 mL) dropwise under N2 atmosphere for 5 minutes. It was stirred at 0 to 20 C for 0.6 h. The solution was diluted with water and extracted with ethyl acetate. The organic phase was washed with water (100 mL x 2) and brine (100 mL), dried (Na2S04), filtered and concentrated in vacuo to yield the crude product. It was used for the next step directly.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; MAHONEY, Sarah; MOLZ, Lisa; NARAYAN, Sridhar; SAIAH, Eddine; (516 pag.)WO2018/191146; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H14O4

A mixture of 15 g (75.76 mmol) of alcohol 8,7.5 g (113.6 mmol) of 85% potassium hydroxide, and120 mL of DMSO was heated at 110-120 in arotating pressure reactor of 1 liter capacity at acetylenepressure of 1012 atm for 5 h. The mixture was dilutedwith 300 mL of water, the reaction product wasextracted into ethyl acetate (4 × 50 mL). The organic phase was washed with water, dried with Na2SO4, thesolvent was distilled off. To purify the residue it waspassed through a small bed of alkaline alumina (eluentether). Yield 15.45 g (91%), yellowish liquid. 1 NMRspectrum, delta, ppm: 3.73 s (3, OCH3), 3.75 s (6,OCH3), 4.00 d (1, =CH2, 3J 6.8 Hz), 4.22 d (1,=CH2, 3J 14.3 Hz), 4.58 s (2, OCH2), 6.456.52 m (3,=CH, Carom). 13 NMR spectrum, delta, ppm: 55.75(OCH3), 60.05 (OCH3), 69.95 (OCH2), 87.22 (=CH2),106.81 (Carom), 132.32 (Carom), 138.16 (Carom),151.61 (=CH), 153.51 (Carom). Found, %: 64.54; 7.35. C12H16O4. Calculated, %: 64.27; 7.19.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol.

Reference:
Article; Potapov; Panov; Musalov; Zhivet?eva; Musalova; Khabibulina; Amosova; Russian Journal of Organic Chemistry; vol. 52; 11; (2016); p. 1571 – 1575; Zh. Org. Khim.; vol. 52; 11; (2016); p. 1579 – 1583,5;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10488-69-4, blongs to alcohols-buliding-blocks compound. Recommanded Product: Ethyl 4-chloro-3-hydroxybutanoate

S(-)-4-chloro-3-hydroxybutyric acid ethyl ester (100g) andL-2-Aminobutyramide is the starting material (61.3g),With chloroform as solvent,Add acid agent potassium carbonate (81.3g),While stirring at reflux, the reaction was incubated for 4 hours.After confirming that the reaction of raw materials is completed, the reaction solution is washed twice with 150 mL of dichloromethane, and the organic phase is dried.It is reduced to no fractions and purified by column to give product intermediate I, namely (S)-2-((S)-4-hydroxy-2-oxopyrrolidin-1-yl)butyrylAmine, 96.3 g, purity 98.4percent, yield 86.3percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10488-69-4, its application will become more common.

Reference:
Patent; Emeishan Hongsheng Pharmaceutical Co., Ltd.; Lu Chengxian; Tian Jianhong; Tian Yangyang; Che Shangze; Tian Jinyuan; (10 pag.)CN107513032; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 23147-58-2, Glycerol aldehyde dimer, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H8O4, blongs to alcohols-buliding-blocks compound. Formula: C4H8O4

Step 2: (S)-2-Amino-N-[(S)-1-(6-bromo-2-methoxy-naphthalen-1-ylmethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-butyramide was dissolved in MeOH (2 mL) and15 glycolaldehyde dimer (10.9 mg, 90.5 ).IDOl, Eq: 0.55), acetic acid (9.5 )lL, 165 ).IDOl, Eq: 1.0) andsodium cyanoborohydride (15.5 mg, 247 ).IDOl, Eq: 1.5) were successively added. The mixturewas stirred at RT overnight. The mixture was diluted with 1 N HCl, 1 N NaOH added to adjust thepH to ca. 11. The mixture was extracted with EtOAc, the extracts washed with brine, dried overNa2S04, concentrated and the resulting material purified by flash chromatography to afford the20 title compound which was lyophilized from MeCN/H20 (55 mg, 60 %). MS m/z 556.0 (MH+

The synthetic route of 23147-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xiaochun; LOU, Yan; MICHOUD, Christophe; MISCHKE, Steven Gregory; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey; WO2014/9495; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 431-38-9 ,Some common heterocyclic compound, 431-38-9, molecular formula is C3H6F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 150 mg intermediate 6-[4-(difluoromethoxy)phenyl]-2-(3-fluorophenyl)-3-oxo-2,3- dihydropyridazine-4-carboxylic acid, 92.6 mg amino-1 ,1 ,1 -trifluoro-2-propanol, 273 mg HATU, 0.19 mL ethyldiisopropylamine and 2.2 mg 4-dimethylaminopyridine in 3 mL of DMF was stirred at room temperature for 48 hours. Then the reaction mixture was filtered and subjected to RP-HPLC (Instrument: Waters Autopurification MS SingleQuad; Colum: Waters XBrigde C18 5mu 100x30mm; eluent A: water + 0.2 vol % aqueous ammonia (32%), eluent B: acetonitrile; gradient: 0-5.5 min 5-100% B; flow 70 mL/min; temperature: 25 C; DAD scan: 210-400 nm) to yield 62 mg 6-[4-(difluoromethoxy)phenyl]-2-(3-fluorophenyl)-3-oxo-N-(3,3,3- trifluoro-2-hydroxypropyl)-2,3-dihydropyridazine-4-carboxamide. 1H NMR (400 MHz, DMSO-d6) delta ppm = 3.48 (br dd, 1 H), 3.69 – 3.81 (m, 1 H), 4.22 (br s, 1 H), 6.66 (br d, 1 H), 7.27 – 7.43 (m, 4 H), 7.55 (br d, 1 H), 7.58 – 7.66 (m, 2 H), 7.99 – 8.08 (m, 2 H), 8.67 (s, 1 H), 8.62 – 8.74 (m, 1 H), 9.66 (br s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 111-90-0 ,Some common heterocyclic compound, 111-90-0, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Chloroformate solution was made by adding triphosgene (98.9 mg, 0.333 mmol) to a stirred solution of di(ethylene glycol) monoethyl ether (134.2 mg, 1 mmol) and dry triethylamine (101.2 mg, 0.139 mL, 1 mmol) in dry dichloromethane (2 mL) at 0 C. under an argon atmosphere, and stirred for 1 h at 0 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; AllTranz Inc.; US2011/245288; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

EXAMPLE 125 Sulfamic acid 2-[4-[2-[(aminosulfonyl)oxy]ethoxy]phenoxy]ethyl ester A mixture of 19.8 g (0.1 mole) of hydroquinone bis (2-hydroxyethyl)ether (98%, Aldrich) and 41.4 g (0.41 mole) of triethylamine in 350 ml of acetonitrile was added to a cooled (acetone-ice bath, temp?15 C.) solution of 130 ml of sulfamoyl chloride solution (3.14 M solution in acetonitrile) and 100 ml of acetonitrile. The mixture was mechanically stirred at ambient temperature overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 400 ml of water and 800 ml of ethyl acetate. The aqueous layer was extracted with two 400 ml portions of ethyl acetate and the combined ethyl acetate extracts (1.61) were washed with two 400 ml portions of water, dried (magnesium sulfate) and the solvent evaporated under reduced pressure to give a viscous residue which was triturated with 100 ml of methylene chloride and let stand at ambient temperature for two days. The resulting solid was collected by filtration and then washed with water until the filtrate was neutral to pH paper and dried (air). The solid was recrystallized from acetonitrile to yield 9.9 g (29%) of a white solid containing a small amount of acetonitrile, mp 162-164 C. Analysis: Calculated for C10 H16 N2 O8 S2: C, 33.70; H, 4.53; N, 7.86. Found: C, 34.30; H, 4.62, N, 8.03.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; A. H. Robins Co., Inc.; US5025031; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol, blongs to alcohols-buliding-blocks compound. Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol

General procedure: General procedure for preparation of benzyl bromides from benzaldehydes: To a stirring solution of aldehyde (1.0 equiv) in methanol (0.2 M) was added sodium borohydride (2.0 equiv.). The resulting solution was stirred at RT for 30-60 mins, until no precipitate was evident in solution and flask was cool to the touch. Solvent was removed in vacuo and dichloromethane introduced. Organic layer was washed using water, dried over sodium sulfate, filtered and solvent removed in vacuo to yield crudebenzyl alcohol, which was used without further purification. To a stirring solution of benzyl alcohol (1.0 equiv.) in dry dichloromethane (0.1 M) at 0 C was added phosphorus tribromide (1.1 equiv.). The reaction solution was stirred at 0 00 for 30 mins, quenched with water, transferred to a separating funnel and the organic layer washed with water. Combined organic layers were dried over sodium sulfate, filteredand solvent removed in vacuo to yield crude benzyl bromide, which was used without purification in catalytic Wittig reactions. o Br 5-(Bromomethyl)-1,3-benzodioxole was prepared inaccordance with the general procedure. 1,3-Benzodioxol-5-o – ylmethanol was prepared in 88% yield (2.68 g, 17.6 mmol) fromthe reaction of piperonal (3.00 g, 20 mmol, 1 .0 equiv.) and sodium borohydride (1 .51 g,40 mmol, 2.0 equiv.). Upon reaction with phosphorus tribromide (1.82 mL, 19.4 mmol,1.1 equiv.), 5-(bromometh/l)-1,3-benzodioxole was obtained as a white solid in 85%yield (3.54 g, 16.5 mmol). H NMR (400 MHz, CDCI3) 6: 3.84 (s, 3H), 3.87 (s, 6H), 4.47(s, 2H), 6.62 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; DUBLIN CITY UNIVERSITY; O’BRIEN, Christopher; WO2014/140353; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16297-94-2, name is 3-(3-Methyl-3H-diazirin-3-yl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Intermediate 1 was dissolved with 40 mL of dichloromethane, then 3 mL of triethylamine was added.Then, p-toluenesulfonyl chloride (2.86 g, 15 mmol) was slowly added to the reaction solution.The reaction was stirred at room temperature overnight. After the reaction was completed, 1N HCl was added to the reaction solution. The organic phase is separated and the aqueous phase is extracted with dichloromethane. The combined organic phases were washed first with 1 N HCl and then with 1 N NaOH.Dry over anhydrous sodium sulfate and concentrate.The product was purified by silica gel column to give Intermediate 2 (2.2 g, yield 82%).

With the rapid development of chemical substances, we look forward to future research findings about 16297-94-2.

Reference:
Patent; Peking University; Zhou Demin; Si Longlong; Zhang Ziwei; Han Xu; Meng Kun; Zhang Bo; Xiao Sulong; Zhang Lihe; Zhou Xueying; (24 pag.)CN107304221; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts