Tag: M.W=100-200

Electric Literature of 89-95-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89-95-2, name is 2-Methylbenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The substrate (alcohol, phenol or amine; 1.0 mmol) was treated with Ac2O (2.0 mmol) in the presence of P(4-VPH)ClO4 (50 mg) at room temperature under solvent-free conditions and magnetic stirring. After completion of the reaction as indicated by TLC, the mixture was diluted with Et2O (25 ml) and the catalyst allowed to settle down. The supernatant ethereal solution was decanted off, the catalyst washed with Et2O (2 ml) and the combined ethereal solution concentrated under vacuum to afford the product, identical(mp, IR, 1H and 13C NMR, and GC-MS) to an authentic sample of acetylated product. The recovered catalyst was dried at 50 C under vacuum for 2 h. The recovered catalyst, after drying, was reused for four more consecutive acetylation reactions of benzyl alcohol (1.0 mmol) affording 96, 96, 94, and 94% yields, respectively, in 22, 23, 23, and 25 min (Scheme 2).

According to the analysis of related databases, 89-95-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Khaligh, Nader Ghaffari; Journal of Molecular Catalysis A: Chemical; vol. 363-364; (2012); p. 90 – 100;,
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Application of 179811-63-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.179811-63-3, name is 2-Amino-2-(3-chlorophenyl)ethanol, molecular formula is C8H10ClNO, molecular weight is 171.6241, as common compound, the synthetic route is as follows.

To a stirred solution of 1-(5-chloro-2-(phenylamino)pyridin-4-yl)-1H-imidazole-4-carboxylic acid (0.035 g, 0.11 mmol) in NMP (1.5 mL) was added EDC (0.065 g, 0.33 mmol), HO t (0.005 g, 0.033 mmol), triethylamine (0.02 mL, 0.22 mmol), and 2-amino-2-(3-chlorophenyl)ethanol (0.022 g, 0.13 mmol). The reaction mixture was stirred at RT overnight. The mixture was diluted with water (10 mL) and extracted with ethyl acetate (3×15 mL). The combined organic layers were washed with brine (10 mL), dried over sodium sulfate, and evaporated under reduced pressure. The crude residue was purified by preparative TLC using methanol in DCM as eluent to afford 1-(5-chloro-2-(phenylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-imidazole-4-carboxamide as an off-white solid (19 mg, 36% yield). 1HNMR (400 MHz, DMSO-d6): delta 9.44 (s, 1H), 8.41 (s, 1H), 8.38 (d, J=4.0 Hz, 1H), 8.16 (s, 1H), 8.02 (s, 1H), 7.61 (d, J=7.6 Hz, 2H), 7.44 (s, 1H), 7.33-7.30 (m, 2H), 7.29-7.27 (m, 3H), 6.93 (s, 2H), 5.02-5.01 (m, 2H), 3.72 (t, J=5.6 Hz, 2H). LC-MS calcd exact mass 467.09, found m/z 468.1 [M+H]+; HPLC purity 99.88%.

Statistics shows that 179811-63-3 is playing an increasingly important role. we look forward to future research findings about 2-Amino-2-(3-chlorophenyl)ethanol.

Reference:
Patent; Asana Biosciences, LLC; Venkatesan, Aranapakam M.; Thompson, Scott K.; Smith, Roger A.; Reddy, Sanjeeva P.; (166 pag.)US2016/362407; (2016); A1;,
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Synthetic Route of 112-27-6, Adding some certain compound to certain chemical reactions, such as: 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol,molecular formula is C6H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-27-6.

Ag2O (6.9 g, 30 mmol) was added to a solution of triethylene glycol (3.0 g, 20 mmol) in dry CH2Cl2. BnBr (2.6 mL, 22 mmol) was then added dropwise over 5 min, and the mixture was stirred for 2 h. After this time, the suspension was filtered through a pad of Celite, which was thoroughly washed with CH2Cl2. The combined filtrate was concentrated under reduced pressure, and the residue was purified by column chromatography to yield a yellow oil (4.46 g, 92.9%). 1H NMR (300 MHz, CDCl3): delta 7.26-7.35 (m, 5H, Ph), 4.56 (s, 2H, -CH2Ph), 3.73-3.58 (m, 12H, -OCH2CH2O-), 2.80 (br, 1H, -OH); 13C NMR (75 MHz, CDCl3): delta 138.0, 128.2, 127.6, 127.5, 73.1, 72.4, 70.5, 70.4, 70.2, 69.2, 61.5.

According to the analysis of related databases, 112-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Yang; Xue, Xiao-Chao; Jin, Xiao-Feng; Wang, Li-Jun; Sha, Yin-Lin; Li, Zhong-Jun; Tetrahedron; vol. 68; 35; (2012); p. 7148 – 7154;,
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Electric Literature of 50595-15-8, Adding some certain compound to certain chemical reactions, such as: 50595-15-8, name is tert-Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50595-15-8.

(2) (2R,4S)-2-Ethyl-4-(5-morpholin-4-yl-pyrimidin-2-ylamino)-6-trifluoromethyl-3,4- dihydro-2H-quinoline-l-carboxylic acid tert-butoxycarbonylmethyl ester; Hydroxyacetic acid tert-butyl ester (70 mg) and sodium hydride (60percent; 21 mg) were added to a solution of the compound obtained in Example 21(1) above (200 mg) in tetrahydrofuran (3 ml) and the mixture was stirred at 50°C for an hour. The reaction mixture was cooled to room temperature, a saturated sodium hydrogen carbonate aqueous solution and ethyl acetate were added and the organic layer was separated, washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo. The resulting residue was purified by column chromatography (NH-silica gel; hexane:ethyl acetate = 9: 1–>3 :2) to give the titled compound (183 mg). MS (m/z): 566[MH-H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 50595-15-8, tert-Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2007/116922; (2007); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2612-28-4, name is 2-Propylpropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H14O2

(2-1) In a nitrogen atmosphere, 4-bromo-3-fluorobenzalde- hyde (20.0 g), 2-propyl-1 ,3-propanediol (11.6 g), and p-toluenesulfonic acid monohydrate (0.9 g) were dissolved in toluene (100 mE), and the resulting solution was stirred for four hours under solvent refluxing while removing generated water with a Dean-Stark apparatus. Afier the mixture was left to cool, a saturated aqueous sodium hydrogen carbonate solution (100 mE) was added thereto to conduct separation, and the organic layer was washed with saturated saline (100 mE) and dried by addition of anhydrous sodium sulfate. Afier the solvent was distilled away at a reduced pressure, the residue was purified by silica gel colunm chromatography. As a result, crude 2-(4-bromo-3-fluorophenyl)-5-propyl- 1 ,3-di- oxane (31.0 g) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2612-28-4, 2-Propylpropane-1,3-diol.

Reference:
Patent; DIC CORPORATION; Tojo, Kenta; Kusumoto, Tetsuo; (36 pag.)US2016/159765; (2016); A1;,
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Synthetic Route of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.

In a 500 mL two necked flask, 12.5 g (90 mmol) of K2CO3 and11.8 g (85 mmol) of 4-nitrophenol were measured and dissolvedin 200 mL of DMF. The solution was stirred and heated to 90 C,followed by the drop-wise addition of 100 mL DMF solution containing12.3 g (90 mmol) of 6-chlorohexanol. The temperature ofthe mixture was maintained at 90 C for 4 h. Then, the reactionmixture was allowed to cool to room temperature and subsequentlypoured into 1 L of distilled water in order to obtain a precipitate.The precipitate was filtered, washed with distilled waterand dried under vacuum. The product was recrystallised in 1:3 ratioof ethyl acetate-hexane mixed solvent. The solid product waspale yellow in color.Yield: 74%. Melting point: 66-67 C. IR (KBr, cm1): 3522(AOHstr), 2950 and 2860 (ACH2str), 1596 and 1504 (CCstr aromatic),1463 (ACHben), 1336 (ANO2str), 1260 and 1108 (CAOACstr).1H NMR ppm (CDCl3): d 8.13 (d, 2H), 6.89 (d, 2H), 4.00 (t, 2H), 3.63(t, 2H), 1.90 (bs, AOH), 1.79 (m, 2H), 1.56 (m, 2H), 1.45 (m, 4H). 13CNMR ppm (CDCl3): d 164.30, 141.32, 125.95, 114.47, 68.82, 62.74,32.63, 28.99, 25.81, 25.55. Elemental analysis: calcd. (%) forC12H17NO4: C 60.23, H 7.16, N 5.85; found: C 60.01, H 6.97, N 5.63.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Shanavas; Narasimhaswamy; Rotimi Sadiku; Journal of Molecular Structure; vol. 1054-1055; (2013); p. 18 – 24;,
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Reference of 112-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2, 2?- (ethane-1, 2-diylbis (oxy) ) diethanol (55.0 mL, 410.75 mmol, 3.0 eq. ) in anhydrous THF (200 mL) was added sodium (0.1 g) . The mixture was stirred until Na disappeared and then tert-butyl acrylate (20.0 mL, 137.79 mmol, 1.0 eq. ) was added dropwise. The mixture was stirred overnight and then quenched by HCl solution (20.0 mL, 1N) at 0. THF was removed by rotary evaporation, brine (300 mL) was added and the resulting mixture was extracted with EtOAc (3 × 100 mL) . The organic layers were washed with brine (3 × 300 mL) , dried over anhydrous Na2SO4, filtered and concentrated to afford a colorless oil (30.20 g, 79.0%yield) , which was used without further purification. MS ESI m/z calcd for C13H27O6[M + H]+278.1729, found 278.1730.

According to the analysis of related databases, 112-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HANGZHOU DAC BIOTECH CO. LTD; ZHAO, Robert Yongxin; YANG, Qingliang; HUANG, Yuanyuan; ZHAO, Linyao; GAI, Shun; YE, Hangbo; LEI, Jun; XU, Yifang; CAO, Mingjun; GUO, Huihui; JIA, Junxiang; TONG, Qianqian; LI, Wenjun; ZHOU, Xiaomai; XIE, Hongsheng; BAI, Lu; CAI, Xiang; ZHUO, Xiaotao; ZHANG, Xiuzheng; ZHENG, Jun; (424 pag.)WO2019/127607; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19064-18-7, name is (2,6-Difluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of (2,6-Difluorophenyl)methanol

(b) 13.0 g of 2,6-difluorobenzyl alcohol and 8.4 g of methanesulphonyl chloride are dissolved in 90 ml of methylene chloride, and 17.6 ml of triethylamine in 18 ml of methylene chloride are added dropwise while stirring in an ice bath. The rate at which the triethylamine is added is so regulated that the internal temperature does not exceed 10. The whole is stirred for a further 40 minutes in the ice bath and then 90 ml of ice-water are added and the whole is stirred for a further 60 minutes. The organic phase is separated off and dried over magnesium sulphate, and 21 g of the monosodium salt of imidazole-4,5-dicarboxylic acid diethyl ester (obtainable, for example, by reacting imidazole-4,5-dicarboxylic acid diethyl ester with 2.53 g of sodium dissolved in 60 ml of ethanol) are added. The whole is stirred for 3 hours at room temperature, washed three times with water, dried over magnesium sulphate, concentrated to dryness by evaporation, dissolved in toluene/ethyl acetate (1:1), filtered over silica gel, again concentrated to dryness by evaporation and recrystallized from ether/petroleum ether. 1-(2,6-difluorobenzyl)-imidazole-4,5-dicarboxylic acid diethyl ester having a melting point of 68-70 is obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19064-18-7, (2,6-Difluorophenyl)methanol.

Reference:
Patent; Ciba-Geigy Corporation; US4851424; (1989); A;,
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Related Products of 15484-46-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below.

Briefly, compound la (2.0 g, 17.23 mmol) was dissolved in 20 mL of dry DCM and cooled to 0 C in ice bath. PBr3 (2.332 g, 8.615 mmol) was added slowly to the solution. Then the reaction mixture was stirred at room temperature. The completion of reaction was monitored by TLC. The reaction was then quenched by the addition of ice. The reaction solution was neutralized by sodium bicarbonate solution and then extracted with DCM three times. Organic layers were collected and dried over anhydrous sodium sulfate, then concentrated. Compound lb was obtained by flash chromatography. Yield: 2.52 g, 82%. -NMR (400 MHz, CDCl3): d 6.34 (s, 1H), 5.96 (s, 1H), 4.18 (s, 2H), 3.82(s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERSITY OF MASSACHUSETTS; THAYUMANAVAN, Sankaran; VACHET, Richard, W.; ZHUANG, Jiaming; ZHAO, Bo; (0 pag.)WO2020/6340; (2020); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C2H5NaO4S

Add 0.2mol caprylic acid, 1.0 mol methylamine, 0.10mol sodium isethionate to the reactor, close the reactor, slowly raise the temperature to 150 , keep the reaction for 4 hours,Distill off the unreacted methylamine, add 0.05% hydrochloric acid by weight of the reactant,Adjust the pH at 6.5 ~ 7.5 to obtain light yellow sodium N-octanoyl-N-methyl taurine,The content of N-octanoyl-N-methyl taurine sodium is 95.6%,The caprylic acid content is 0.5%.

With the rapid development of chemical substances, we look forward to future research findings about 1562-00-1.

Reference:
Patent; Zhangjiagang Geruite Chemical Co., Ltd.; Xu Youjiang; Zhu Hongjun; Guo Jingbo; Cui Yibin; Chen Yeli; Zhu Zhiqian; Zang Taotao; (7 pag.)CN111004156; (2020); A;,
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