Tag: M.W=100-200

Application of 41175-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol. A new synthetic method of this compound is introduced below.

Hydroxyjulolidine (3.7 g, 19.3 mmol) and diphenyl malonate (4.1 g, 15.9 mmol) were added into anhydrous toluene (10 mL). The mixture was heated to reflux for 4 h, and compound 2 was obtained by filtration as a straw yellow solid (3.6 g, 88%): mp 268-270C; NMR (400 MHz, DMSO): delta (ppm) 1 1.73 (s, 1H), 7.15 (s, 1H), 5.21 (s, 1H), 3.24-3.20 (m, 4H), 2.70 (s, 4H), 1.91-1.83 (m, 4H); 13C NMR (100 MHz, DMSO): delta (ppm) 166.5, 162.8, 151.0, 146.0, 119.8, 117.3, 105.3, 103.1, 85.8, 49.2, 48.7, 26.9, 21.0, 20.1, 20.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Reference:
Patent; MICHIGAN TECHNOLOGICAL UNIVERSITY; BI, Lanrong; WO2014/63033; (2014); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 456-47-3, name is 3-Fluorobenzyl alcohol, molecular formula is C7H7FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 456-47-3

General procedure: GeneralProcedure for the preparation of 2-Phenyl-1H-benzoimidazole (3aa): A 25mL over-dried Schlenk tube was charged with 2-nitroaniline (41.4 mg, 0.3 mmol),benzyl alcohol (97.2 mg, 0.90 mmol) and Pd(dppf)Cl2 (12.2 mg, 0.015mmol). The tube was purged with nitrogen three times. Toluene (1 mL) was addedto the sealed reaction vessel by syringe. The reaction mixture was stirred in apreheated oil bath at 160 oC for 24 h. After cooling to roomtemperature, the reaction mixture was then concentrated in vacuo, and theresidue was purified by column chromatography (silica gel, petroleumether/ ethyl acetate = 4:1) to give 3aa as a pale yellow solid (56.5 mg, 97%).

With the rapid development of chemical substances, we look forward to future research findings about 456-47-3.

Reference:
Article; Li, Xiaotong; Hu, Renhe; Tong, Yao; Pan, Qiang; Miao, Dazhuang; Han, Shiqing; Tetrahedron Letters; vol. 57; 41; (2016); p. 4645 – 4649;,
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Synthetic Route of 6329-73-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6329-73-3, name is 1-(Benzo[d][1,3]dioxol-5-yl)ethanol, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of alcohol (1 equiv) in dry DCM (10 to 20 mL), thionyl chloride (1 .7 to 3 equiv) was added slowly at 0 C. The reaction mixture was warmed to rt and was refluxed for 1 h. The reaction mixture was concentrated under vacuum and the resulting residue was diluted with DCM (20 to 50 mL). The DCM layer was washed with water (5 to 10 mL), brine solution (5 to 10 mL), dried over anhydrous Na2SO4 and concentrated under vacuum to give chloro compound.

According to the analysis of related databases, 6329-73-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
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Electric Literature of 455-01-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol. A new synthetic method of this compound is introduced below.

Reference Example 19-1 [3-(Trifluoromethyl)phenyl]acetaldehyde To a solution of 3-(trifluoromethyl)phenethyl alcohol (2.00 g) in chloroform (50.0 mL), Dess-Martin periodinane (4.70 g) was added under cooling with ice. After being brought to room temperature, the reaction mixture was stirred for an hour. Subsequently, a saturated aqueous solution of sodium hydrogencarbonate (25.0 mL) and a saturated aqueous solution of sodium thiosulfate (25.0 mL) were added and the mixture was vigorously stirred for an hour. After phase separation, the organic layer was dried over anhydrous magnesium sulfate, the desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 98:2-85:15) to give the titled compound as a pale yellow oil (1.19 g). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 3.79 (s, 2 H) 7.36 – 7.62 (m, 4 H) 9.77 – 9.81 (m, 1 H). MS ESI/APCI Dual nega: 187[M-H]-.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TAKAYAMA, Tetsuo; SHIBATA, Tsuyoshi; SHIOZAWA, Fumiyasu; KAWABE, Kenichi; SHIMIZU, Yuki; HAMADA, Makoto; HIRATATE, Akira; TAKAHASHI, Masato; USHIYAMA, Fumihito; OI, Takahiro; SHIRASAKI, Yoshihisa; MATSUDA, Daisuke; KOIZUMI, Chie; KATO, Sota; EP2881384; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1562-00-1

Approximately 1.7 g of Compound A was added to a bottle and dissolved in 34 mL of acetone, concentration of 50 mg/mL. 400 pL (20 mg of freebase) of the stock solution was then dispensed into 84 vials and the acetone allowed to evaporate. 1M stock solutions of each counterion were prepared in either THF, ethanol or water, where appropriate as outlined in Table 27. L-aspartic acid was added as neat counterion due to low solubility. 1.05 equivalents of each counterion was added at room temperature and observations made. 2-hydroxy ethanesulfonic acid was supplied as a sodium salt and had 1.05 equivalents of HC1 added after counterion addition. All samples were then temperature cycled using the following procedure: a) Heat to 40 C, hold for 1 hour; b) Cooled to room temperature, hold for 3 hours; c) Heat to 40 C, hold for 1 hour; and d) Samples were held at 5 C overnight.All samples displaying solutions had the lids removed from the vials and were allowed to evaporate at ambient temperature. Samples with solid material had the mother liquor removed and the solids analyzed by XRPD. The mother liquor was transferred to a new sample vial and stored at 5 C to allow for further precipitation. The analyzed solids on the XRPD plate were exposed to 40 C/75 % RH conditions for 6 hours before analysis by XRPD. Table 27. Solvents Used to make Acid Stock Solutions

With the rapid development of chemical substances, we look forward to future research findings about 1562-00-1.

Reference:
Patent; ALDEYRA THERAPEUTICS, INC.; MACHATHA, Stephen, Gitu; LOUGHREY, Jonathan, James; MCLACHLAN, Hannah, Ruth; SNEDDON, Gregor; (194 pag.)WO2020/33344; (2020); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C4H8O3

a solution of methyl (2S)-2-hydroxypropanoate (5 g, 48.03 mmol, 1.00 eq.) and 1H-imidazole (4.9 g, 71.98mmol, 1.50 eq.) in dichloromethane (100 mL) was placed into a 250-mL round-bottom flask. This was followed by the addition of a solution of tert-butyl(chloro)dimethylsilane (8.69 g, 57.66 mmol, 1.20 eq.) in dichloromethane (50 mL) dropwise with stirring at 0C. The resulting solution was stirred for 2 hours at room temperature. The reaction was then quenched by the addition of 80 mL of water/ice and extracted with dichloromethane (3×50 mL). The resultingmixture was washed with brine (2×100 mL), dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 8 g (76%) of methyl (2S)-2-[(tert- butyldimethylsilyl)oxy]propanoate as a colorless liquid.

With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.

Reference:
Patent; BASTOS Cecilia M.; MUNOZ Benito; TAIT Bradley; WO2015/196071; (2015); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 558-42-9

Step 1: Methyl 1H-pyrazole-3-carboxylate (2.52 g, 20 mmol, 1 equiv.) was dissolved in DMF (20 mL). K2CO3 (5.53 g, 40 mmol, 2 equiv.) was added, followed by 1-chloro-2-methyl- 2-propanol (2.67 mL, 26 mmol, 1.3 equiv.). The reaction mixture was heated to 80 °C for 40 hours and cooled to room temperature. The reaction mixture was poured into water, extracted with EtOAc, and the combined organic extracts were washed with water and brine. The organic layer was concentrated, and the crude residue was purified on SiO2 (25 100percent EtOAc/Hexanes) to afford the title compound as a colorless oil that solidified upon standing (2.08 g, 53percent yield).

With the rapid development of chemical substances, we look forward to future research findings about 558-42-9.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; LELETI, Manmohan Reddy; MILES, Dillon Harding; POWERS, Jay Patrick; ROSEN, Brandon Reid; SHARIF, Ehesan Ul; (109 pag.)WO2018/213377; (2018); A1;,
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Related Products of 50919-06-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50919-06-7, name is 2-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 5.1.57.3. Step 3. To a solution of 2-(3-fluorophenyl)ethanol(25.26 g, 180 mmol) in pyridine (180 mL) was added TsCl(36.49 g, 186 mmol) at 0 C with silica gel blue tube. After stirringat rt for 4 h, the reaction was quenched by the addition of 2 N HCl (750 mL) at 0 C. This mixture was extracted with EtOAc (300 mL).The separable organic layer was washed with 2 N HCl (250 mL),H2O (200 mL), brine (100 mL), and dried over MgSO4, filtered, concentratedunder reduced pressure. The residue was purified by columnchromatography (SiO2, n-hexane/EtOAc = 10/1-5/1) to obtain2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate (38.54 g, 73%)as a colorless oil.

According to the analysis of related databases, 50919-06-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imaeda, Toshihiro; Ono, Koji; Nakai, Kazuo; Hori, Yasunobu; Matsukawa, Jun; Takagi, Terufumi; Fujioka, Yasushi; Tarui, Naoki; Kondo, Mitsuyo; Imanishi, Akio; Inatomi, Nobuhiro; Kajino, Masahiro; Itoh, Fumio; Nishida, Haruyuki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3719 – 3735;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (Perfluorophenyl)methanol

Example 11 In a 30 ml two-necked flask were added 0.004 g of LeOH.H2O, 0.40 g of methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.8 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropanecarboxylate was 84% based on the starting ester.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
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Related Products of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetyl chloride (1.816 g, 23.14 mmol) was added slowly to a solution of (±)-4a (1.728 g, 11.50 mmol) and dry pyridine (2.757 g,34.85 mmol) in dry CH2Cl2 (30 mL) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with water (30 mL) at 0 C. The mixture was extracted with Et2O (50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4 and filtered. After removal ofthe solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc 5/1) to afford (±)-5a (2.079 g, 94%) as a colorless oil. 1H NMR data were identical to those reported in the literature [40].

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kato, Daiki; Kawasaki, Masashi; Morita, Yuko; Okada, Takuya; Tanaka, Yasuo; Toyooka, Naoki; Tetrahedron; (2020);,
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