Tag: M.W=100-200

Related Products of 59365-66-1 , The common heterocyclic compound, 59365-66-1, name is 3-(3,5-Dimethylphenoxy)propane-1,2-diol, molecular formula is C11H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 3-(3,5-dimethylphenoxy)propane-1,2-diol (1.00 g, 5.10 mmol) and urea (0.618 g, 10.29 mmol) was heated at 185-195 C. for about 6 hours. The resulting brown viscous material was cooled to ambient temperature and partitioned between water and chloroform. The organic layer was concentrated in vacuo to provide a crude residue that was purified by Preparative HPLC on a Zodiacsil C18 (250*33 mm, 10mu) column (eluding with acetonitrile/0.1% formic acid (55:45) at a flow rate of 48 mL/min). The title compound eluted at 5.74 min. Following standard extractive workup with ethyl acetate, the solvent was removed in vacuo to yield the title compound as a white solid (0.180 g, 16%). m.p. 121-124 C.; 1H NMR (400 MHz, CDCl3) delta 2.29 (s, 6H), 3.57-3.63 (m, 1H), 3.72-3.79 (m, 1H), 4.07-4.16 (m, 2H), 4.90-4.98 (m, 1H), 5.02 (br, exchangeable with D2O, 1H), 6.54 (s, 2H), 6.64 (s, 1H); IR (KBr) upsilon 3283, 1734, 1600, 1321, 1236 cm-1; MS 222 (M+1).

The synthetic route of 59365-66-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2009/270469; (2009); A1;,
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Synthetic Route of 6149-41-3, Adding some certain compound to certain chemical reactions, such as: 6149-41-3, name is Methyl 3-hydroxypropanoate,molecular formula is C4H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6149-41-3.

EXAMPLE 18 20 grams of Cu(NO3)2.3H2O was dissolved in 40 ml of distilled water, and precipitated at PH=8 with 10% by weight of sodium hydroxide to obtain liquid A. 26.0 grams of Na2SiO3.9H2O and 2.3 ml of ethanol solution containing 30% of TiCl4 were dissolved in 60 ml of distilled water, and then precipitated at PH=8 with 10% by weight of sodium hydroxide to obtain liquid B. The liquid A and liquid B were mixed, aged at 80 C. for 4 hours, filtrated, and washed until the filtrate became neutral, dried at 120 C. for 16 hours, baked at 600 C. for 4 hours, and crushed into fine particles, and screened. The particles with a particle size of 20-40 mesh were selected for future use. 1.0 gram of CuCl was prepared into 20 ml of solution, and the above catalyst particles were immersed into the solution for 8 hours, and baked at 350 C. for 4 hours. The catalysts prepared by the above three methods were charged into fixed reactors each having an inner diameter of 15 mm and a length of 250 mm, respectively. The charging amount of the catalyst was 4 grams. H2 was firstly introduced into the reactor, and then the temperature was increased to 300 C. with a increasing speed of 0.5 C./min. The resultant was reduced in situ for 4 hours, followed by decreasing the temperature to 140 C. A methanol solution containing methyl 3-hydroxyl-propionate was introduced into the reactor to carry out a hydrogenation reaction and the results are shown in table 1. TABLE 1 The selectivity of methyl The selectivity of Catalyst 3-hydroxyl-propionate % 1,3-propylene glycol % Method 1 80.3 79.6 Method 2 90.9 87.1 Method 3 93.9 88.2

According to the analysis of related databases, 6149-41-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chen, Jing; Cui, Fang; Liu, Jianhua; Xia, Chungu; Tong, Jin; US2007/191629; (2007); A1;,
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Reference of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A previously dried round bottom flask fitted with a magnetic stirrer was charged with NaH (19 mg, 0.81 mmol) and then benzyl glycolate (230 muIota, 1 .62 mmol) in anhydrous THF (3 ml) were added in dropwise. Immediately after the addition was complete, a solution of 2-methanesulfonyl-3-(4-trifluoromethoxy-benzyl)-3H-imidazo[4,5-b]pyridine (90 mg, 0.24 mmol) in anhydrous THF (3 ml) was added. Reaction was left stirring under N2 at r.t. over the weekend. The reaction was quenched with water and a white solid crashed out of solution. This solid was filtered off and dried to afford the title compound (76 mg, 69%). [00355] LCMS Method: 1 , RT: 5.51 min, Ml: 458 [M+1] [00356] 1H NMR, Method 1 : (DMSO) 8.17 (dd 1 H), 7.84 (dd 1 H), 7.43 (d 2H), 7.40 – 7.36 (m 1 H), 7.32 (s 4H), 7.27 (d 2H), 7.22 (dd 1 H), 5.34 (s 2H), 5.29 (s 2H), 5.22 (s 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; STOCKLEY, Martin Lee; MACDONALD, Ellen Catherine; PRITOM, Shah; JORDAN, Allan; HITCHIN, James; HAMILTON, Niall; (217 pag.)WO2016/124939; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4442-79-9, name is 2-Cyclohexylethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Cyclohexylethanol

General procedure: The N-substituted phthalimides were prepared according to literature.30 A mixture of phthalimide (2.21 g, 15 mmol), triphenylphosphine (3.93 g, 15 mmol), and appropriate alcohol (15 mmol) in 20 mL of dry THF was cooled to 0 C. Diethyl azodicarboxylate (DEAD) (2.61 g, 15 mmol) in 15 mL of dry THF was slowly added dropwise (1 h). The reaction mixture was then allowed to warm to room temperature and stirred overnight. Solvent was evaporated under reduced pressure and the residue suspended in Et2O. After the precipitate was filtered, the solvent was evaporated and the residue purified by column chromatography [eluent CH2Cl2] to afford appropriate N-substituted phthalimide.

The synthetic route of 4442-79-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wicek, Ma?gorzata; Kottke, Tim; Ligneau, Xavier; Schunack, Walter; Seifert, Roland; Stark, Holger; Handzlik, Jadwiga; Kie?-Kononowicz, Katarzyna; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 2850 – 2858;,
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Application of 629-41-4 ,Some common heterocyclic compound, 629-41-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: DHP (3.46 ml, 37.9 mmol) and a catalytic amount of PPTS were added to a solution of 1,8-octanediol (Compound 7, 5.85 g, 40.0 mmol) in CHCl3 (100 ml) in a stream of argon at room temperature, and the mixture was stirred for 16 hours. The reaction solution was stirred for 5 minutes after addition of H2O. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with a saturated aqueous NaHCO3 solution then with a saturated aqueous NaCl solution, and was dried over Na2SO4. After evaporation of the solvent, the residue was purified by column chromatography on silica gel (Hexane:EtOAc = 3:1 to 2:1) to yield the corresponding THP ether (4.95 g, 54%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,629-41-4, its application will become more common.

Reference:
Patent; aRigen Pharmaceuticals, Inc.; SAIMOTO, Hiroyuki; KITA, Kiyoshi; YABU, Yoshisada; YAMAMOTO, Masaichi; EP2636663; (2013); A1;,
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Related Products of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

DMSO (7.88 mL, 0.11 mol) was added at -78 oC to a solution of oxalyl chloride (7.24 mL, 0.08 mol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the monobenzylated alcohol 19 (10 g, 55.55 mmol) in CH2Cl2 (50 mL), was added drop wise at -78 oC over 30 min. After the solution had been stirred for an additional 30 min, Et3N (46.37 mL, 0.33 mol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4, and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification. To a stirred solution of aldehyde (8.9 g, 50.0 mmol) in C6H6 (100 mL), was added (ethoxycarbonylmethylene)triphenylphosphorane (19.2 g, 55.0 mmol) and the mixture was heated at reflux for 4 h. After completion of the reaction, solvent was removed in vacuo then purified by column chromatography to afford 20 (11.78 g, 85% over two steps) as a light yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Bujaranipalli, Sheshurao; Das, Saibal; Tetrahedron Letters; vol. 57; 25; (2016); p. 2800 – 2802;,
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Synthetic Route of 16700-55-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16700-55-3, name is (2,6-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

iv) Production of 1-(4-chloro-6-methyl-2-pyridinyl)ethanone O-[(2,6-dimethoxyphenyl)methyl] oxime 1.86 g (11.1 mmol) of 2,6-dimethoxybenzyl alcohol was dissolved in 15 ml of benzene, and the resultant solution was cooled to 5 C. The solution was then added with 1.55 g (13.0mmol) of thionyl chloride at the same temperature. The mixture was subjected to temperature elevation up to a room temperature, then stirred for 70 min. to complete a reaction. The reacted solution was condensed under reduced pressure to thereby obtain a crude product of 2,6-dimethoxybenzyl chloride.

According to the analysis of related databases, 16700-55-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Soda Co. Ltd.; US6589967; (2003); B1;,
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Application of 671802-00-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.671802-00-9, name is tert-Butyl 3-(2-hydroxyethoxy)propanoate, molecular formula is C9H18O4, molecular weight is 190.24, as common compound, the synthetic route is as follows.

To a solution of Compound (g-2) (0.20 g, 1.1 mmol) and triethylamine (0.31 g, 3.2 mmol) in THF (15 mL) was added p-toluenesulfonyl chloride (0.30 g, 1.6 mmol) at 0 C. over 10 minutes, and then the reaction mixture was stirred at at room temperature 16 hours. The solvent was removed in vacuo, and the residue was purified by preparative TLC (pentane:ethyl acetate=4:1) to give Compound (h-1) (0.20 g, 55% yield). (1098) 1H-NMR (CDCl3, 400 MHz) delta: 7.71 (d, J=8.2 Hz, 2H), 7.27 (d, J=8.2 Hz, 2H), 4.07-4.05 (m, 2H), 3.55-3.54 (m, 4H), 2.39-2.33 (m, 5H), 1.36 (s, 9H).

Statistics shows that 671802-00-9 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 3-(2-hydroxyethoxy)propanoate.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; WATANABE, Hitoshi; ISOBE, Yoshiaki; KIMURA, Hidenori; FUJIWARA, Yuji; US2019/16711; (2019); A1;,
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Related Products of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

(4-Aminophenyl)methannol 6a (2.00 g, 16 mmol) was dissolved in 6MHCl (16 mL). Sodium nitrate (1.67 g, 24 mmol) was added slowly at 0 C. After stirring at sametemperature for 30 min, sodium azide (4.23 g, 65 mmol) was added slowly at 0 C. The reaction mixturewas stirred at same temperature for 30 min then extracted with Et2O twice. The organic layer was washedwith saturated aq. NaHCO3 and saturated aq. NaCl, dried over MgSO4, filtrated and concentrated. Theresidue was subjected to silica column chromatography (AcOEt : hexane = 1 : 1) to afford yellow oil(2.17 g, 90%). IR (neat, cm-1) 2154. 1H-NMR (CDCl3) delta: 7.24 (2H, d, J = 8.6 Hz), 6.94 (2H, d, J = 8.6Hz), 4.52 (2H, s), 3.27 (1H, s). 13C-NMR (CDCl3) delta: 139.0, 137.4, 128.3, 118.8, 64.1. ESI-TOF-MS:[M+H]+ calculated for C7H7N3O 150.0667, found 150.0663.

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hashimoto, Makoto; Yoshida, Takuma; Tachrim, Zetryana Puteri; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hatanaka, Yasumaru; Kanaoka, Yuichi; Heterocycles; vol. 95; 1; (2017); p. 462 – 473;,
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Synthetic Route of 2979-22-8 , The common heterocyclic compound, 2979-22-8, name is 2-Methoxy-2-phenylethanol, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An aldehyde (30 mmol), Zn(OTf)2 (13 mg, 35 mmol), and (N-Chloroethyl)morpholine HCl 6.5 mg, 35 mmol) were added to a 1dram vial. The dry solvent, acetonitrile (1mL), was added to the vial. Afterwards dipicolylamine (7 muL 35 mmol) was added to the vial and the vial was sonicated. Once the solution was transparent molecular sieves were added to the solution along with the respective alcohol (175 mmol). The assemblies were incubated for 16 h at room temperature in the dark.

The synthetic route of 2979-22-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Minus, Matthew B.; Featherston, Aaron L.; Choi, Sooyun; King, Sam C.; Miller, Scott J.; Anslyn, Eric V.; Chem; vol. 5; 12; (2019); p. 3196 – 3206;,
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