Category: alcohols-buliding-blocks

Application of 395-23-3, Adding some certain compound to certain chemical reactions, such as: 395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol,molecular formula is C14H11F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 395-23-3.

General procedure: Caution. tert-Butyl hydroperoxide is an exceptionally dangerous chemical that is highly reactive, flammable, and toxic. It is corrosive to skin and mucous membranes and causes respiratory distress when inhaled. A solution of secondary alcohol (1 mmol) and 70% TBHP (6 or 10 equiv.) was stirred at 100 C for 24 h. The reaction mixture was quenched with the saturated solution of sodium thiosulfate (5 mL) and extracted with dichloromethane (3 x 10 mL). The combined dichloromethane extracts were dried over anhydrous Na2SO4 and filtered, and then the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with PE or PE/EtOAc as the eluent to obtain the desired products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 395-23-3, Phenyl(4-(trifluoromethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wu, Jianglong; Liu, Yan; Ma, Xiaowei; Liu, Ping; Gu, Chengzhi; Dai, Bin; Synthetic Communications; vol. 46; 21; (2016); p. 1747 – 1758;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 15258-73-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15258-73-8 as follows.

2,6-Dichlorobenzyl alcohol (1.1 mmol) was dissolved in dry DMF (5 ml) and treated with sodium hydride (60% dispersion in mineral oil, 1.21 mmol). The mixture was stirred at room temperature for 30 mins, then treated with lithium-5-chloro-pyrazine-2- carboxylate (1 mmol) and stirred at reflux overnight. The reaction mixture was partitioned between ethyl acetate and water, then the organic layer was separated, dried [(MGSO4),] filtered, evaporated and the residue purified by column chromatography on silica. Elution with mixtures of petroleum ether and diethyl ether afforded the title product. MS (ES): m/e 300 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15258-73-8, its application will become more common.

Reference:
Patent; ASTEX TECHNOLOGY LIMITED; WO2004/4720; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 10488-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take raw materialsS-4-chloro-3-hydroxybutyric acid ethyl ester 5 g,Add a bottle of bottles,Add 10 ml of methanol,Add 5 g of sodium azide to stir,The reaction was carried out at a temperature of about 50 ° C for 4 hours to stop the reaction to obtain a yellow solution.20 ml of water was added, and the mixture was extracted with 20 ml of ethyl acetate, and the ethyl acetate was concentrated to obtain a yellow oil as an intermediate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate.

Reference:
Patent; Chongqing Runze Pharmaceutical Co., Ltd.; Ye Lei; (12 pag.)CN107011235; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 124-68-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 124-68-5

2-Amino-2-methyl-l-propanol (5 g, 56.1 mmol), (Boc)20 (13.46 g, 61.7 mmol) and triethyl amine (6.24 g, 61.7 mmol) were dissolved in 50 mL of dichloromethane. The reaction mixture was stirred for 4 h at 22 to 25 C. Above mixture was washed with water (25 mL x 2), dried over anhydrous sodium sulfate and concentrated under vacuum to get tert-buty] (1- hydroxy-2-methylpropan-2-yl)carbamate (10.3 g, 97% yield).

The synthetic route of 124-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEKTAR THERAPEUTICS (INDIA) PVT.LTD.; NEKTAR THERAPEUTICS (Incorporated under the Laws of Delaware and domiclled in the State of California); DUARTE, FRANCO; ANAND, NEEL; SHARMA, PANKAJ; SINGH, DEVENDRAPRATAP U.; WO2015/79459; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. A new synthetic method of this compound is introduced below., Formula: C7H7N3O

To a solution of 3 ,4,6-trimethyl-2-(5 -((1 -methylcyclopropyl)methoxy)-2-azabicyclo[4. 1. Ojheptan-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-bjpyridin-5-one (77 mg, 0.217 mmol) in THF (1 mL) was added LiHMDS (1.083 ml, 1.083 mmol) at -78C. Then the mixture was stirred at -78 C for 30 mm. Then(1H-benzo[dj[1,2,3jtriazol-1-yl)methanol (48.5 mg, 0.325 mmol) in THF (1 mL) was dropwise added to the mixture and the mixture was stirred for another 30 mm. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (10 mLx 2). The combined organic layers were dried over Na2504 and filtered, and the filtrate was concentrated in vacuo to give the residue, which was further purified by prep-TLC (dichloromethane : MeOH = 10:1) to provide the title compound as yellow oil. The title compound was separated by chiral SFC (AD(250mm*3Omm,lOum), 30% MeOH with 0.1%NH3.H20/C02 at 6OmL/min) and Prep-HPLC (TFA) to give four isomers. Example 5 (firstpeak): MS: 386.1 (M+1). ?H NMR (400 MHz, Methanol-d4): oe 4.23-4.25 (1 H, m), 4.11-4.14 (2H, m), 3.97-3.99 (1 H, m), 3.79-3.82 (1 H, m), 3.46-3.49 (1 H, m), 3.33-3.35 (1 H, m), 3.13 (3H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m),1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.45 (2 H, m), 0.30-0.32 (2 H, m).Example 6 (second peak): MS: 386.2 (M+1). ?H NMR (400 MHz, Methanol-d4): oe 4.23-4.25 (1H, m), 4.11-4.14 (2 H, m), 4.01-4.04 (1 H, m), 3.79-3.82 (1 H, m), 3.46-3.49 (1 H, m), 3.32-3.35(1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H,m), 0.58-0.61 (1 H, m), 0.42-0.45 (2 H, m), 0.30-0.32 (2 H, m). Example 7 (third peak): MS: 386.2 (M+1). ?H NMR (400 MHz, Methanol-d4): oe4.23-4.25(1 H, m), 4.11-4.14(2 H, m), 4.01-4.02 (1 H, m), 3.79-3.82 (1 H, m), 3.45-3.47(1 H,m), 3.32-3.35 (1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01(1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.45 (2H, m), 0.3 1-0.32 (2 H, m). Example 8 (fourth peak): MS: 386.1 (M+1).?H NMR (400 MHz,Methanol-d4): oe 4.23-4.26(1 H, m), 4.11-4.14(2 H, m), 3.98-4.01 (1 H, m), 3.79-3.82(1 H, m), 3.45-3.47 (1 H, m), 3.32-3.35 (1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.44 (2 H, m), 0.3 1-0.32 (2 H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CLAUSEN, Dane James; FELLS, James, I.; KOZLOWSKI, Joseph, A.; LIU, Ping; MAZZOLA, Robert, D., Jr.; (94 pag.)WO2018/226545; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 140373-17-7 , The common heterocyclic compound, 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Method E, Step 5Compound E5 will be reacted with E6 and EDCI in DMF to give compound E7 after purification.

The synthetic route of 140373-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2009/61699; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

Step A N-tritylethanolamine Ethanolamine hydrochloride (9.9 g; 100 mmol) is partially dissolved in CH2 Cl2 /CH3 CN (200 ml/100 ml) and Et3 N (23 ml; 170 mmol) is then added. Tritylchloride (18.9 g; 67.6 mmol) is added portionwise over 30 minutes. After the addition is complete the reaction mixture is allowed to stir an additional 30 minutes, diluted with CH2 Cl2, washed With H2 O 2* and brine, dried (MgSO4), concentrated in vacuo and purified by column chromatography with silica/CH2 Cl2 to give N-tritylethanolamine as an oil which is used directly in Step B.

According to the analysis of related databases, 2002-24-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5455260; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1-(5-Bromo-2-fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(5-Bromo-2-fluorophenyl)ethanol

Step 2 [0202] To a solution of Compound 2 (14.01 g) in ethyl acetate (150 ml) was added 2-iodoxybenzoic acid (35.8 g), and the mixture was refluxed for 7 hours. The reaction solution was cooled in an ice bath and the precipitated solid was removed by filtration. The filtrate was evaporated under reduced pressure to afford Compound 3 (13.66 g) [0203] 1H-NMR (CDCl3) delta: 2.64 (d, J=5.0 Hz, 3H), 7.05 (dd, J=10.2, 8.7 Hz, 1H), 7.58-7.64 (m, 1H), 7.98 (dd, J=6.4, 2.5 Hz, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; SHIONOGI & CO., LTD.; Masui, Moriyasu; Tadano, Genta; US2013/210839; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 162744-59-4 ,Some common heterocyclic compound, 162744-59-4, molecular formula is C7H5BrF2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example A-14; 2-(4-bromo-2,6-difluorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-5-carboxamide; Step a – 4-bromo-2,6-difluorobenzaldehyde; To a solution of 4-bromo-2,6-difluorobenzylalcohol (0.20Og, 0.9mmol) in DCM (4ml) and DMSO (0.440ml) was added triethylamine (1 ml, 0.72mmol) and sulfur trioxide pyridine complex (0.57Og, 3.6mmol) and the resulting solution was stirred at room temperature for 3 hours. The solution was diluted with Et2O and washed with 0.5M aqueous HCI, 1M sodium bicarbonate solution and brine. The organic phase was dried over MgSO4 and the solvent removed in vacuo to afford 4-bromo-2,6-difluorobenzaldehyde (0.166g, 0.75mmol, 84%) as a white solid. 1H NMR (CDCI3) delta 7.22 (2H, d), 10.29 (1 H, br. s). LCMS (2) Rt: 2.74min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAREUM LIMITED; WO2008/139161; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 87327-65-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 82; 5- [1-(2,6- Difluorophenyl)-ethoxy ]-q uinazoline-2,4-diamine; [00258] Step 1; To a cold (ice water) suspension of sodium hydride (409 mg; 10 mmol) in anhydrous DMF (4 mL) is added a solution of 2,6-difluoro-alpha- methylbenzyl alcohol (1.63 g; 10 mmol) in anhydrous DMF (5 mL) over 10 minutes. After allowing to room temperature over 1 hour, this solution is added to a cold (ice water) stirred solution of 2,6-difluorobenzonitrile (1.53 g; 11 mmol) in anhydrous DMF (6 mL), and allowed to room temperature over 2.5 hours. The reaction mixture is poured into ice water with vigorous stirring and the resulting solid is filtered, washed with water, and dried under vacuum at 40 C overnight to give 1.92 grams of 2-[ 1-(2,6-difluorophenyl)-ethoxy]-6-fluorobenzonitrile.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 87327-65-9, 1-(2,6-Difluorophenyl)ethanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts