Category: alcohols-buliding-blocks

Related Products of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

DMSO (7.88 mL, 0.11 mol) was added at -78 oC to a solution of oxalyl chloride (7.24 mL, 0.08 mol) in CH2Cl2 (100 mL), and the resulting solution was stirred for 15 min. A solution of the monobenzylated alcohol 19 (10 g, 55.55 mmol) in CH2Cl2 (50 mL), was added drop wise at -78 oC over 30 min. After the solution had been stirred for an additional 30 min, Et3N (46.37 mL, 0.33 mol) was added and the reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into ice cooled water and extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4, and concentrated under reduced pressure to give crude aldehyde (8.9 g) which was directly used for next step without further purification. To a stirred solution of aldehyde (8.9 g, 50.0 mmol) in C6H6 (100 mL), was added (ethoxycarbonylmethylene)triphenylphosphorane (19.2 g, 55.0 mmol) and the mixture was heated at reflux for 4 h. After completion of the reaction, solvent was removed in vacuo then purified by column chromatography to afford 20 (11.78 g, 85% over two steps) as a light yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Article; Bujaranipalli, Sheshurao; Das, Saibal; Tetrahedron Letters; vol. 57; 25; (2016); p. 2800 – 2802;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Compound 6 (100g, 0.41mol, 1eq), compound 8 (87g, 0.8eq) and Al2O3 (415g, 10eq) was put inside the reactor (connected with Dean-Stock device) containing toluene (3L). The reaction mixture was deoxygenized with the stream of nitrogen gas followed by refluxing the reaction mixture. On completion, the reaction mixture was cooled to room temperature, washed with NaOH solution and removed the toluene on rotary. After that solid product was mixed with ethyl acetate: water and organic layer was separated, removed excess solvent on rotary to afford 9 which was purified by column chromatography using hexane: ethyl acetate: toluene (5:1:1) solvent system. Fine yellow crystals of 9 were collected on mixing it with ethyl acetate [32-38]. 1H NMR (CDCl3, ppm): delta 3.09 (s, 6H), 3.76 (s, 6H), 3.9 (s, 3H), 6.09 (d, 1H), 6.79 (d, 4H), 7.05 (dd, 1H), 7.25 (d, 1H), 7.35 (d, 4H), 7.60 (dd, 2H), 7.95 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 101597-25-5, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Moon-Hwan; Saleem, Muhammad; Seo, Ji-Su; Choi, Chang-Shik; Lee, Ki Hwan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1291 – 1297;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 16700-55-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16700-55-3, name is (2,6-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

iv) Production of 1-(4-chloro-6-methyl-2-pyridinyl)ethanone O-[(2,6-dimethoxyphenyl)methyl] oxime 1.86 g (11.1 mmol) of 2,6-dimethoxybenzyl alcohol was dissolved in 15 ml of benzene, and the resultant solution was cooled to 5 C. The solution was then added with 1.55 g (13.0mmol) of thionyl chloride at the same temperature. The mixture was subjected to temperature elevation up to a room temperature, then stirred for 70 min. to complete a reaction. The reacted solution was condensed under reduced pressure to thereby obtain a crude product of 2,6-dimethoxybenzyl chloride.

According to the analysis of related databases, 16700-55-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Soda Co. Ltd.; US6589967; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 671802-00-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.671802-00-9, name is tert-Butyl 3-(2-hydroxyethoxy)propanoate, molecular formula is C9H18O4, molecular weight is 190.24, as common compound, the synthetic route is as follows.

To a solution of Compound (g-2) (0.20 g, 1.1 mmol) and triethylamine (0.31 g, 3.2 mmol) in THF (15 mL) was added p-toluenesulfonyl chloride (0.30 g, 1.6 mmol) at 0 C. over 10 minutes, and then the reaction mixture was stirred at at room temperature 16 hours. The solvent was removed in vacuo, and the residue was purified by preparative TLC (pentane:ethyl acetate=4:1) to give Compound (h-1) (0.20 g, 55% yield). (1098) 1H-NMR (CDCl3, 400 MHz) delta: 7.71 (d, J=8.2 Hz, 2H), 7.27 (d, J=8.2 Hz, 2H), 4.07-4.05 (m, 2H), 3.55-3.54 (m, 4H), 2.39-2.33 (m, 5H), 1.36 (s, 9H).

Statistics shows that 671802-00-9 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 3-(2-hydroxyethoxy)propanoate.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; WATANABE, Hitoshi; ISOBE, Yoshiaki; KIMURA, Hidenori; FUJIWARA, Yuji; US2019/16711; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

(4-Aminophenyl)methannol 6a (2.00 g, 16 mmol) was dissolved in 6MHCl (16 mL). Sodium nitrate (1.67 g, 24 mmol) was added slowly at 0 C. After stirring at sametemperature for 30 min, sodium azide (4.23 g, 65 mmol) was added slowly at 0 C. The reaction mixturewas stirred at same temperature for 30 min then extracted with Et2O twice. The organic layer was washedwith saturated aq. NaHCO3 and saturated aq. NaCl, dried over MgSO4, filtrated and concentrated. Theresidue was subjected to silica column chromatography (AcOEt : hexane = 1 : 1) to afford yellow oil(2.17 g, 90%). IR (neat, cm-1) 2154. 1H-NMR (CDCl3) delta: 7.24 (2H, d, J = 8.6 Hz), 6.94 (2H, d, J = 8.6Hz), 4.52 (2H, s), 3.27 (1H, s). 13C-NMR (CDCl3) delta: 139.0, 137.4, 128.3, 118.8, 64.1. ESI-TOF-MS:[M+H]+ calculated for C7H7N3O 150.0667, found 150.0663.

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hashimoto, Makoto; Yoshida, Takuma; Tachrim, Zetryana Puteri; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hatanaka, Yasumaru; Kanaoka, Yuichi; Heterocycles; vol. 95; 1; (2017); p. 462 – 473;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2979-22-8 , The common heterocyclic compound, 2979-22-8, name is 2-Methoxy-2-phenylethanol, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An aldehyde (30 mmol), Zn(OTf)2 (13 mg, 35 mmol), and (N-Chloroethyl)morpholine HCl 6.5 mg, 35 mmol) were added to a 1dram vial. The dry solvent, acetonitrile (1mL), was added to the vial. Afterwards dipicolylamine (7 muL 35 mmol) was added to the vial and the vial was sonicated. Once the solution was transparent molecular sieves were added to the solution along with the respective alcohol (175 mmol). The assemblies were incubated for 16 h at room temperature in the dark.

The synthetic route of 2979-22-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Minus, Matthew B.; Featherston, Aaron L.; Choi, Sooyun; King, Sam C.; Miller, Scott J.; Anslyn, Eric V.; Chem; vol. 5; 12; (2019); p. 3196 – 3206;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 59854-12-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59854-12-5, name is tert-Butyl 4-hydroxybutanoate, molecular formula is C8H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Hydroxy-butyric acid t-butyl ester (12.996 g) synthesized according to the reference (J. Org. Chem. 68, 6679-6684(2003)) and imidazole (5.522 g) were dissolved in dry DMF (60 mL). After the solution was cooled with an ice bath, t-butyldimethylsilyl chloride (12.227 g) was added, and the temperature of the mixture was raised gradually to room temperature (25 to 28C). After stirring for 10 hours, hexane (150 mL) was added. The organic layer was washed three times with water (100 mL). The organic layer was washed with a half-saturated aqueous ammonium chloride solution (about 10%) (100 mL), dried over anhydrous sodium sulfate, filtered off, and the filtrate was concentrated to obtain a crude product of Compound 13 as a yellow oil (20.383 g). Out of this amount, 18.232 g was distilled under reduced pressure (bp 93C/1.0 mmHg) to obtain a colorless oil 13 (15.3 g). Physicochemical property of Compound 13 ESI (LC/MS positive mode) (M+H+)275 1H-NMR Chemical shift value delta (in deuterated chloroform): 0.05 (6H, s), 0.89 (9H, s), 1.45 (9H, s), 1.74-1.84 (2H, m), 2.29 (2H, t, J=7Hz), 3.63 (2H, t, J=7Hz)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59854-12-5, tert-Butyl 4-hydroxybutanoate.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1857456; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H11NO

Stage 1: Ethyl-(2-hydroxyethyl)carbamic acid tert-butyl ester: A solution is prepared from 15.2 g of Boc2O and 30 ml of dichloromethane. This solution is added dropwise to a mixture containing 7.36 g of 2-ethylaminoethanol and 30 ml of dichloromethane in the cold state. The reaction medium is allowed to stand for 24 hours at room temperature. After concentrating to dryness, the reaction medium is taken up in an NaCl solution. The medium is extracted three times with ethyl acetate and then washed with a saturated NaCl solution. The organic phase is dried over sodium sulfate and then concentrated to dryness using a vane pump in order to give 12 g of expected product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; sanofi-aventis; US2008/269170; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 23377-40-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, molecular weight is 300.52, as common compound, the synthetic route is as follows.

To a tetrahydrofuran (THF) (1 mL/mmol) solution of l,3-bis(cyclcohexyl) imidazolium tetrafluoroborate (ICyHBF4) salt (0.05 eq.) and molecular sieves (0.5g/mmol), under argon, is added tBuOK (0.9 eq.) and stirred for 10 min. Lipophilic alcohol (1 eq.) and dialkyl H-phosphonate (2 eq.) are added and the reaction stirred at room temperature for 24h. The reaction is quenched with a saturated solution of ammonium chloride (5 mL/mmol) and filtrate on celite. Ethylacetate (AcOEt) (10 mL/mmol) is added to the solution then the organic and aqueous layers are separated. Aqueous phase is then extracted with AcOEt (10 mL/mmol) and the combinated organic layers are evaporated under vaccum. The corresponding alkyl/lipophilic chain H-phosphonate is finally purified by chromatography on silica gel.Example 2 : Synthesis of Bn/HDP H-phosphonateCompound 1 is synthesized according to procedure 1.4. from dibenzylphosphite as reported by the scheme 1. Scheme 11H NMR (400 MHz, CDCl3) delta = 7.74 (s, 0.5H, H-P), 7.41-7.33 (m, 5H, HA1), 5.99 (s, 0.5H, H-P), 5.11 (d, J = 9.5 Hz, 3H, OCH3), 4.20-4.07 (m, 2Eta, P-O-CH2-CH2-CH2-O), 3.46 (t, J = 6.1Hz, 2H, P-O-CH2-CH2-CH2-O), 3.37 (t, J = 6.7 Hz, 2H, 0-CH2-CH2-(CH2)I3-CH3), 1.90 ( p, J = 6.2 Hz, 2H, P-O-CH2-CH2-CH2-O), 1.53 (p, J = 6.9 Hz, 2H, 0-CH2-CH2-(CH2) ?- CH3), 1.35-1.19 (m, 26H, 0-CH2-CH2-(CH2)^-CH3), 0.87 (t, J = 6.4 Hz, 3H, 0-CH2-CH2- 13C NMR (100 MHz, CDCl3) delta = 136.6, 128.7, 128.6, 127.9, 126.9 (CA1), 71.2 (0-CH2-CH2- (CH2)I3-CH3), 67.2 (2C, CH2-Ph), 66.3 (P-O-CH2-CH2-CH2-O), 63.1, 63.0 (P-O-CH2-CH2- CH2-O), 31.9, 30.6 (2C), 29.7, 29.6 (2C), 29.5, 29.3, 26.1, 22.7 (CH2-P, P-O-CH2-CH2-CH2- O, 0-CH2-CH2-(CH2)^-CH3), 14.1 (O-CH2-CH2-(CH2)13-CH3).3 ’11P NMR (162 MHz, CDCl3): delta = 10.05.

The chemical industry reduces the impact on the environment during synthesis 23377-40-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE D’ORLEANS; AGROFOGLIO, Luigi A.; ROY, Vincent; PRADERE, Ugo; WO2010/146127; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3279-95-6, name is 2-(Aminooxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C2H7NO2

33 mg (0.10 mmol) of 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyrazine-3-carboxylic acid from Example 3A were initially charged in a 96-well deep well multititre plate. A solution of 8 mg (0.10 mmol) of 2-(aminooxy)ethanol in 0.4 ml of DMF and a solution of 45.6 mg (0.12 mol) of HATU in 0.4 ml of DMF were added successively. After adding 20.2 mg (0.20 mmol) of 4-methylmorpholine, the mixture was shaken at RT overnight. Then the mixture was filtered and the target compound was isolated from the filtrate by preparative LC-MS (Method 9). The product-containing fractions were concentrated under reduced pressure using a centrifugal dryer. The residue of each product fraction was dissolved in 0.6 ml of DMSO. These were combined and finally freed of the solvent in a centrifugal dryer. 0.4 mg (1% of theory) were obtained. (1378) LC-MS (Method 10): Rt=0.94 min (1379) MS (ESpos): m/z=393 (M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3279-95-6, 2-(Aminooxy)ethanol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; Dietz, Lisa; LI, Volkhart Min-Jian; (85 pag.)US2016/176880; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts