Category: alcohols-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20712-12-3, name is (2-Amino-5-bromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H8BrNO

General procedure: A mixture of 2-aminobenzyl alcohol 1 (0.2 mmol), allylic alcohol 2(0.4 mmol), [IrCp*Cl2]2 (0.0020 mmol, 1.0 molpercent), and KOH (0.2 mmol) were dissolved in anhyd toluene (1 mL) in a 25-mL Schlenk tube. The system was flushed with N2 and allowed to react at the specified temperatureand for the specified time. The mixture was allowed to cool to r.t. and filtered through a short silica gel column (washed with EtOAc). Removal of the solvent left an oil that was separated by column chromatography (silica gel, EtOAc?hexane) to give the quinoline.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20712-12-3, (2-Amino-5-bromophenyl)methanol.

Reference:
Article; Chen, Shu-Jie; Lu, Guo-Ping; Cai, Chun; Synthesis; vol. 47; 7; (2015); p. 976 – 984;,
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Related Products of 127-66-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127-66-2, name is 2-Phenylbut-3-yn-2-ol, molecular formula is C10H10O, molecular weight is 146.19, as common compound, the synthetic route is as follows.

(2-Ethoxybut-3-yn-2-yl)benzene (Table 2, entry 1) [39a]:2-phenyl-3-butyn-2-ol (0.106 g, 0.728 mmol) was added to a 5-mLscrew cap vial and dissolved in CH2Cl2(1 mL). Ethanol (0.036 g,0.897 mmol) was added followed by the addition of [Fc]PF6(0.007 g, 0.022 mmol). The vial was then sealed and heated at40C for 3 days. The solvent was removed and the residue waschromatographed on a neutral alumina oxide (Aluminar®) column(2.5 × 30 cm, hexane and then CH2Cl2) to give the product as a yel-low solid (0.085 g, 0.487 mmol, 67percent). NMR (, CDCl3)1H: 7.67?7.29(m, 7H, aromatic), 3.69 (doublet of quintets, 1 H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 3.22 (doublet of quintets, 1H,2JHH= 7.2 Hz,2JHH= 4.2 Hz, OCHH?), 2.74 (s, 1H, C CH), 1.78 (s, 3H, CH3), 1.24 (t,3H,2JHH= 7.2 Hz, OCH2CH3) ppm.13C{1H}: 143.3 (s, aromatic ipso),128.6 (s, aromatic), 128.5 (s, aromatic), 127.9 (s, aromatic), 127.6(s, aromatic*), 126.1 (s, aromatic), 84.7 (s, C CH), 75.9 (s, CC CH),75.2 (s, C CH), 60.6 (s, OCH2), 33.2 (s, CH3), 15.6 (s, OCH2CH3)ppm. IR (ATR, Neat): 3284 (m), 3055 (w), 2973 (m), 2926(w), 1714(s), 1670 (s), 1575 (s), 1491 (s), 1335 (s), 1264 (s), 1057 (s), 997 (s)

The chemical industry reduces the impact on the environment during synthesis 127-66-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Queensen, Matthew J.; Rabus, Jordan M.; Bauer, Eike B.; Journal of Molecular Catalysis A: Chemical; vol. 407; (2015); p. 221 – 229;,
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Synthetic Route of 403-41-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of corresponding alcohol 1a,b,d-al (8 mmol), nitroxide 4a (0.085 g, 0.4 mmol) and compound 6d (0.097 g, 0.8 mmol) in CH2Cl2 (10 mL) was added to a vigorously stirred solution of NaHCO3 (2.016 g, 24 mmol) in water (10 mL) at 20 C. Then I2 (4.06 g, 16 mmol) powder was added in one portion to the formed reaction mixture at vigorous stirring and temperature 20-22 C. The reaction mixture was stirred at 20-22 C for appropriate time (see Table 1 in the article). Then, a saturated solution of sodium thiosulfate was added to the stirred reaction mixture for discoloration. Organic and aqueous phases were separated and the aqueous phase was then extracted with CH2Cl2 (3×5 mL). Organic phase and the extracts were combined and washed subsequently with saturated aqueous solution of NaCl (5 mL), aqueous solutionof HCl (1%) saturated with NaCl (3 mL), and then with water (5 mL). The washed extract was dried with anhydrous Na2SO4 and evaporated to dryness to give crude product, which was then purified by vacuum distillation under argon atmosphere or by recrystallization.

According to the analysis of related databases, 403-41-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kashparova, Vera P.; Klushin, Victor A.; Zhukova, Irina Yu.; Kashparov, Igor S.; Chernysheva, Daria V.; Il’chibaeva, Irina B.; Smirnova, Nina V.; Kagan, Efim Sh.; Chernyshev, Victor M.; Tetrahedron Letters; vol. 58; 36; (2017); p. 3517 – 3521;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C20H40O

Example 75Synthesis of 1-O-(3,7,11,15-tetramethylhexadec-2-enyl)-D-glucoside 3.4 g (8.7 mmol) of 13-D-Glucose pentaacetate and 2.0 g (6.7 mmol) of phytol were dissolved in dry acetonitrile (7 mL). 1.70 mL (13.4 mmol) of boron trifluoride diethyl etherate complex was added to the solution with cooling on ice. The reaction mixture was allowed to warm up slowly to room temperature while being stirred for 18 hours before addition of 2.8 mL (20 mmol) of triethylamine at 0 C. The resulting solution was diluted with ethyl acetate, and washed with water, 1M hydrochloric acid, saturated sodium bicarbonate aqueous solution, and saturated brine, successively, and dried over sodium sulfate. After filtration, the filtrate was concentrated to obtain a crude product of 1-O-(3,7,11,15-tetramethylhexadec-2-enyl)-D-glucopyranoside tetraacetate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol.

Reference:
Patent; Chemgenesis Incorporated; US2012/264923; (2012); A1;,
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Reference of 14426-21-2 ,Some common heterocyclic compound, 14426-21-2, molecular formula is C4H12ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Into a reaction flask equipped with a stirrer, a condenser and a thermometer, 4.84 g (0.01 mol) of intermediate III-2 was added, 30mL dichloromethane to dissolve, add DCC 4. lg, stirring for some time after adding DMAP. After stirring for a period of time, bis (2-hydroxyethyl) amine hydrochloride l.lg (O.Olmol) was added to the reaction system in batches, and the reaction was continued for 2 hours. The filtrate was washed with 3 X 40 mL of water, the dichloromethane layer was separated, dried over anhydrous sodium sulfate, filtered, and evaporated to dryness under reduced pressure. Column chromatography [eluent: nu (petroleum ether) Nu (ethyl acetate) = 90: 10] to give a white solid product of 3.818 (yield 99.8%), yield 66.8%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14426-21-2, its application will become more common.

Reference:
Patent; Tianjin Pharmaceuticals Research Institute Co., Ltd.; Liu, Ying; Liu, DengKe; Jie, xiaoshuai; Qi, haofei; Wang, jingyang; (13 pag.)CN102838652; (2016); B;,
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Reference of 5339-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

From the reaction solution, 0.24 g of the catalyst was recovered. The recovered catalyst was regenerated by supporting 12 mg (5wt%) of K2 CO3. The procedures of Example 1 was repeated except that the so regenerated catalyst was used. The conversion of 2-(o-aminophenyl)ethanol was 100% and the yield of indole was 87.7%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
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Adding a certain compound to certain chemical reactions, such as: 3279-95-6, 2-(Aminooxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3279-95-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3279-95-6

The oxime compound, (E)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyi mino)-methyl]-benzamide obtained in Step B of Example 6 may be easily prepared from 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide obtained in Step F of Example 1 by a reaction with 2-aminooxyethanol in THF at room temperature. Namely, 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide (1.37 g) and aminooxy ethanol (262 mg) were mixed in THF at room temperature for 12 hours, and then the solvent was evaporated to give 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide.

The synthetic route of 3279-95-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP1780197; (2007); A1;,
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Electric Literature of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

11091] To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3- hexafluoropropan-2-ol (2.50 g, 9.64 mmol) (preparation, for example, W. A. Sheppard, J Am. Chem. Soc. 1965, 87, 24 10-2420) in glacial acetic acid (40 ml) was added, at RT, N-chlorosuccinimide (2.71 g, 20.2 mmol). The mixture was stirred at 75° C. for 3 h and then at RT for 14 h. Subsequently, the mixture was added to water and extracted with EtOAc. The organic phase was washed with water and saturated aqueous NaHCO3 solution and dried over magnesium sulphate. Afier solvent had been removed, the residue was taken up in MTI3E and the solids were filtered off. The filtrate was concentrated under reduced pressure and the crude product was purified by means of column chromatography on 5i02 (n-hexane/EtOAc gradient). 2.89 g (91percent) of 2-(4-amino-3,5-dichlorphenyl)- 1,1,1 ,3,3,3-hexafluoropro- pan-2-ol were obtained.11092] HPLCMSa): log P=3.04, mass (m/z)=328 [M+H].11093] ?H NMR (400 MHz, d3-acetonitrile): oe=5.13 (br s, 2H), 6.02 (br s, 1H), 7.51 (s, 2H).

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; HALLENBACH, WERNER; SCHWARZ, HANS-GEORG; ILG, KERSTIN; GOERGENS, ULRICH; KOEBBERLING, JOHANNES; TURGERG, ANDREAS; BOEHNKE, NIELS; MAUE, MICHAEL; VELTEN, ROBERT; HARSCHNECK, TOBIAS; HAHN, JULIA JOHANNA; HORSTMANN, SEBASTIAN; (160 pag.)US2016/278379; (2016); A1;,
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Electric Literature of 19936-14-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 19936-14-2 as follows.

To a solution of 5.66 g of 1-(4-bromophenyl)-cyclobutanol (24.92 mmol, described in example S2-A) in 70 ml DCM were added 4.23 g of (diethylamino)sulfur trifluoride (95%, 24.92 mmol) at 0 C. The reaction mixture was stirred at 0 C. for 35 min, then sat. NaHCO3- solution was added and the resulting mixture was extracted with DCM. The combined organic extracts were washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to give a residue which was purified by flash column chromatography (100% pentane) to give 1-bromo-4-(1-fluoro-cyclobutyl)-benzene (3.66 g, 64%) as a colorless liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19936-14-2, its application will become more common.

Reference:
Patent; Conte, Aurelia; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe; US2007/185058; (2007); A1;,
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Reference of 6966-10-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6966-10-5, name is (3,4-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

Example 39; 3′,4′-Dimethvlphenylmethyl 2-cvanopvrazolidine-1 -carboxylate (39)3′,4′-Dimethylphenylmethyl chloroformate was prepared by dissolving 3,4-dimethylbenzyl alcohol (94.0 mg, 0.69 mmol) was in 3 ml_ dichloromethane followed by diisopropylethylamine (145 uL, 0.83 mmol). 20% Phosgene in toluene (473 uL, 0.83 mmol) was added dropwise and the reaction mixture was allowed to stir at room temperature for 2 hours.4 was prepared according to Example 4. To this was added the 4′-acetylaminophenyl chloroformate in one portion and the reaction mixture was stirred overnight at room temperature. After removal of solvent by rotary evaporation, the title compound was purified by silica gel chromatography (CombiFlash, 20% ethyl acetate in hexanes to 100% ethyl acetate over 10 minutes.) The appropriate fractions were collected, combined and evaporated to dryness to yield 39 (57.0 mg, 31.9%), ESMS 260.4 (M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6966-10-5, (3,4-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/94003; (2006); A1;,
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