Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 4845-50-5, 1,4-Dioxane-2,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1,4-Dioxane-2,3-diol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1,4-Dioxane-2,3-diol

4.00 g (19.509 mmol) of the compound from example 89A was dissolved in 100 ml ethanol and 2.42 g (19.509 mmol) of 2,3-dihydroxy-l,4-dioxane was added. The mixture was stirred for 4 h at room temperature and a further 2.42 g (19.509 mmol) of 2,3-dihydroxy-l,4-dioxane was added. After stirring for 24 h at room temperature, the mixture was concentrated in a rotary evaporator and the residue was purified by silica-gel chromatography (eluent: dichloromethane/methanol = 30:1). We obtained 3.60 g (80% of theor.) of the target compound.LC-MS (method 1): R, = 1.79 min; MS (EIpos): m/z = 227 [M+H]+.1H-NMR (400 MHz, DMSO-D5): delta [ppm] = 8.06 (dd, IH), 8.24 (t, IH), 9.05 (d, IH), 9.07 (d, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4845-50-5, 1,4-Dioxane-2,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48258; (2012); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115-20-8, name is Trichloroethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 115-20-8

General procedure: To a stirred solution of tri-O-acetyl-D-galactal (50 mg, 0.185 mmol) in DCM(1 mL) were added the corresponding alcohol (0.204 mmol, 1.1 equiv) andFeCl3·6H2O/C (50 mol%) at ambient temperature. After the reaction was completed(monitored by TLC), the reaction mixture was filtered and the catalystwas washed with dichloromethane. After evaporation of the solvent under vacuum,the crude products were purified by silica gel column chromatography(petroleum ether/EtOAc = 10/1).

The synthetic route of 115-20-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Jiafen; Chen, Heshan; Shan, Junjie; Li, Juan; Yang, Guofang; Chen, Xuan; Xin, Kunyun; Zhang, Jianbo; Tang, Jie; Journal of Carbohydrate Chemistry; vol. 33; 6; (2014); p. 313 – 325;,
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Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H9NO2, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H9NO2

Compound 54 (50 mg, 0.33 mmol) was dissolved in a solution of z-Pr0H/H20 (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 7 (63 mg, 0.35 mmol) and HCIO4 (70%, 30 pL) in 90% i- PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-03-41 (50 mg, 44%) as a dark blue solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, and friends who are interested can also refer to it.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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Adding a certain compound to certain chemical reactions, such as: 84832-00-8, (5-Amino-2-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 84832-00-8, blongs to alcohols-buliding-blocks compound. Quality Control of (5-Amino-2-fluorophenyl)methanol

Example 205 : 1 -(2-Fluoro-5 -morpholinobenzyl)-N-( 1 -methyl- 1 H-pyrazol-4-yl)- 1 H- pyrazo lo [3 ,4-d]pyrimidin-6-amineStep (i) To a solution of 5-Amino-2-fluoro benzyl alcohol (500mg, 3.5mmol) in toluene (12mL) was added DIEA (2eq) and 2-bromoethylether (1.5eq) and the reaction heated to 90C for 18h. The solvent was removed in vacuo and the residue partitioned between EtOAc and H20. The organic phase was dried (Na2S04), filtered and concentrated in vacuo. The resultant residue was purified by column chromatography (petroleum ether: EtOAc) to give 2(2-fluoro-5- morpholinophenyl)methanol (550mg, 74%) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,84832-00-8, its application will become more common.

Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C16H26O

General procedure: To a solution of 11 (400 mg, 1.71 mmol) and triethylamine (2 mL) in CH2Cl2 (10 mL) at 0 C was added methanesulfonyl chloride (0.66 mL, 8.53 mmol). After being stirred at room temperature for 6 h, the reaction mixture was evaporated, diluted with water, and the product was extracted with EtOAc. The extract was washed with brine, dried, and evaporated. To a solution of the reaction mixture (300 mg, 0.96 mmol) in DMF (10 mL) was added sodium azide (187 mg, 2.88 mmol). After the reaction mixture was heated at 80 C for 12 h, saturated aqueous ammonium chloride solution was added, and the mixture was extracted with EtOAc. The reaction mixture 15 (200 mg) was dissolved in EtOAc (10 mL), and 10% Pd/C (20 mg, 10 wt %) was added. After the reaction mixture was hydrogenated at room temperature for 12 h, the catalyst was removed by filtration through a pad of Celite, which was rinsed with EtOAc. Product 17 was obtained, without purification, as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

Reference:
Note; Oh, Yoon Sin; Lee, Taeho; Shin, Sang Mi; Shrestha, Jitendra; Lee, Doohyun; Park, Eun-Young; Baek, Dong Jae; Bulletin of the Korean Chemical Society; vol. 39; 2; (2018); p. 261 – 264;,
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Electric Literature of 506-43-4 , The common heterocyclic compound, 506-43-4, name is (9Z,12Z)-Octadeca-9,12-dien-1-ol, molecular formula is C18H34O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of the alcohol 1 (26.6 g, 100 mmol) in 5 dichloromethane (100 mL), 6 triethylamine (13.13 g, 130 mmol) was added and this solution was cooled in an ice-bath. To this cold solution, a solution of 7 mesyl chloride (12.6 g, 110 mmol) in dichloromethane (60 mL) was added dropwise and after the completion of the addition, the reaction mixture was allowed to warm to ambient temperature and stirred overnight. The TLC of the reaction mixture showed the completion of the reaction. The reaction mixture was diluted with dichloromethane (200 mL), washed with water (200 mL), satd. 8 NaHCO3 (200 mL), brine (100 mL) and dried (NaSO4). The organic layer was concentrated to get the crude product which was purified by column chromatography (silica gel) using 0-10% 9 Et2O in hexanes. The pure product fractions were combined and concentrated to obtain the pure product (10 2) as colorless oil (30.6 g, 89%). 1H NMR (CDCl3, 400 MHz) delta=5.42-5.21 (m, 4H), 4.20 (t, 2H), 3.06 (s, 3H), 2.79 (t, 2H), 2.19-2.00 (m, 4H), 1.90-1.70 (m, 2H), 1.06-1.18 (m, 18H), 0.88 (t, 3H). 13C NMR (CDCl3) delta=130.76, 130.54, 128.6, 128.4, 70.67, 37.9, 32.05, 30.12, 29.87, 29.85, 29.68, 29.65, 29.53, 27.72, 27.71, 26.15, 25.94, 23.09, 14.60. MS. Molecular weight calculated for C19H36O3S, Cal. 344.53, Found 343.52 (M-H-).

The synthetic route of 506-43-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALNYLAM PHARMACEUTICALS, INC.; TAKEDA PHARMACEUTICAL CO. LTD; Manoharan, Muthiah; Rajeev, Kallanthottathil G.; Nair, Jayaprakash K.; Jayaraman, Muthusamy; Matsumoto, Satoru; (92 pag.)US9701623; (2017); B2;,
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Reference of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-ol (20 g,55 mmol) and triphenylphosphine (15.7 g, 60 mmol) were dissolved in 110 ml of anhydrous acetonitrile and deoxygenated with argon. The mixture was heated at 60 C and bromine (9.6 g,60 mmol) was added dropwise. The mixture was stirred for 5 h at this temperature. After cooling down to room temperature, the reaction mixture was extracted with diethyl ether and the ether layers were washed with brine. After drying with Na2SO4, the ether was evaporated and the crude product was dissolved in 100 ml of dichloromethane. This solution was stirred with 50 g of silica gel for 2 h and then filtered and evaporated. The crude product was distilled at reduced pressure.

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Luka?, Milo?; Garajova, Maria; Mrva, Martin; Devinsky, Ferdinand; Ondriska, Franti?ek; Kubincova, Janka; Journal of Fluorine Chemistry; vol. 164; (2014); p. 10 – 17;,
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Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.

A solution of 150 mg intermediate 33, 107 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 317 mg HATU, 2.5 mg 4-dimethylaminopyridine and 0.22 mL ethyldiisopropylamine in 3.1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was filtered and the solution was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.2 Vol% ammonia 32%)-gradient)) to yield 1 14 mg 6-[4- (difluoromethyl)phenyl]-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypdihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-d6): delta = 3.43-3.52 (m, 1 H); 3.72-3.80 (m, 1 H); 4.19-4.27 (m, 1 H); 6.67 (s, 1 H); 7.13 (t, 1 H); 7.40 (ddt, 1 H); 7.54-7.67 (m, 3H); 7.72 (d, 2H); 8.12 (d, 2H); 8.71 (s, 1 H); 9.64 (t, 1 Eta).

Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol, molecular formula is C8H7BrO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol

General procedure: In an oven dried round bottomed flask fitted with a rubber septum, were added alcohol 1 (100 mg, 0.30-0.46 mmol), NaH (1.20-1.84 mmol) and DMF (3 mL) followed by addition of allylbromide (0.60-0.92 mmol) at room temperature under a nitrogen atmosphere. The suspension was allowed to stir at the same temperature for 1 h. Progress of the allylation was monitored by TLC till the reaction is completed.GP-3was followed to the alcohol 1f (100 mg, 0.43 mmol) with allyl bromide (104.8 mg, 0.86 mmol) and NaH (42 mg, 1.73 mmol) in DMF (3 mL) at room temperature under a nitrogen atmosphere. Then, the reaction mixture was stirred at the same temperature for 1 h.

With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.

Reference:
Article; Gopi Krishna Reddy; Krishna; Satyanarayana; Tetrahedron Letters; vol. 53; 42; (2012); p. 5635 – 5640;,
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