Category: alcohols-buliding-blocks

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1,2,4-Butanetriol

A mixture of compound 32 (10.6 g, 100 mmol), compound 7 (10.54 g, 20 mmol) and PTSA (0.1 eq) was heatedunder toluene reflux with Soxhlet extractor containing activated 4A molecular sieves for 3 h. Removal of solvent thencolumn purification (silica gel, 0-30% EtOAc in hexanes) gave compound 33 (11 g, 90 %) as a colorless oil. 1H NMR(400 MHz, CDCl3) delta 5.45 – 5.24 (m, 8H), 4.30 – 4.17 (m, 1H), 4.08 (dd, J = 7.8, 6.1, 1H), 3.80 (dd, J = 10.6, 5.0, 3H),3.53 (t, J = 8.0, 1H), 2.77 (t, J = 6.4, 5H), 2.29 – 2.18 (m, 1H), 2.05 (q, J = 6.7, 9H), 1.86 – 1.74 (m, 2H), 1.59 (dd, J =18.3, 9.7, 5H), 1.42 – 1.18 (m, 43H), 0.89 (t, J = 6.8, 6H). 13C NMR (101 MHz, CDCl3) delta 130.39, 130.36, 130.35, 128.14,112.80, 77.54, 77.22, 76.90, 75.74, 70.14, 61.08, 37.97, 37.50, 35.56, 31.74, 30.14, 30.13, 29.88, 29.80, 29.73, 29.57,29.53, 27.45, 27.41, 25.84, 24.20, 24.00, 22.79, 14.30

With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.

Reference:
Patent; Arbutus Biopharma Corporation; Akinc, Akin; Querbes, William; Wong, Frances; Dorkin, Joseph, Robert; Qin, Xiaojun; Cantley, William; Borodovsky, Anna; De, Soma; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil, G.; (109 pag.)EP3243504; (2017); A1;,
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Electric Literature of 558-42-9, Adding some certain compound to certain chemical reactions, such as: 558-42-9, name is 1-Chloro-2-methyl-2-propanol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 558-42-9.

To a stirred solution of 54 (3.4 g, 12.0 mmol) in dry DMF (20 mL), Cs2CO3 (7.7 g, 24.0 mmol) and 1-chloro-2-methylpropan-2-ol 55 (1.6 g, 14.0 mmol) were added and heated at 90°C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with water and extracted with EtOAc. The combined organic layer were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 56. Yield: 1.7 g, 40percent. ?H NIVIR (400 MHz, DMSO-d6) 1.06- 1.11 (m, 4H), 1.21 (s, 6H), 2.13 -2.22 (m, 2H), 2.55 -2.60 (m, 1H), 3.01-3.07 (m, 1H), 3.76 (s, 2H), 4.84-4.94 (m, 2H), 5.00 – 5.19 (m, 1H), 5.53-5.60 (m, 1H), 6.91-6.98 (m, 1H), 7.10- 7.18 (m, 1H), 7.24 -7.31 (m, 1H), 8.26 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 558-42-9, 1-Chloro-2-methyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. A new synthetic method of this compound is introduced below., Safety of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-Pentafluoropentan-1-al (or related compounds) has already been described in the literature [see, for example,iii oriv]. Here, 4,4,5,5,5-pentafluoropentan-1-al was prepared by oxidizing 4,4,5,5,5-pentafluoropentan-1-ol under standard conditions (a dichloromethane solution was prepared by reacting with pyridinium dichromate or else by a TEMPO oxidation [see, for example,v]-the dichloromethane solution of the 4,4,5,5,5-pentafluoropentan-1-al was used directly in the Wittig reaction owing to the low boiling point). A Swern oxidation of pentafluoropentanol is problematic [vi].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; SANDER, Michael; Grossbach, Danja; Dinter, Christian; Hassfeld, Jorma; Voigtlaender, David; US2009/62558; (2009); A1;,
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Electric Literature of 2612-28-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2612-28-4, name is 2-Propylpropane-1,3-diol, molecular formula is C6H14O2, molecular weight is 118.17, as common compound, the synthetic route is as follows.

EXAMPLE 21 According to Scheme II given above 1-(4-chloro-3-fluorophenyl)-2-(4-(5-propyldioxane-2-yl)-phenyl)-ethane is obtained from 1-(4-chloro-3-fluorophenyl)-2-(4-bromophenyl)-ethane and 2-(hydroxymethyl)-pentan-1-ol.

Statistics shows that 2612-28-4 is playing an increasingly important role. we look forward to future research findings about 2-Propylpropane-1,3-diol.

Reference:
Patent; Merck Patent Gesellschaft mit beschrankter Haftung; US5254698; (1993); A;,
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Related Products of 3319-15-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3319-15-1, name is 1-(4-Methoxyphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The catalytic reactions were performed in a 10-mL autoclave reactor with an internal Teflon insert. Typically, 0.5 mmol of secondary alcohols, 0.04 mmol of Cu(OAc)2 and 0.04 mmol of ligand, 1 mmol of base, and 2 mL of solvent were added to the reactor.Then, the reactor was charged with 0.4 MPa O2 and heated to the desired temperature under magnetic stirring. When the reaction reached completion, the reaction mixture was diluted with 4 mL of methanol, and the catalyst was separated via centrifugation.The acid product was esterified with addition of 40 mul of BF3OEt2 at 100 C for 6 h in Ar atmosphere. In reaction condition optimization experiment, the products were identified and quantified using gas chromatography-mass spectrometry (GC-MS) and an Agilent7890A/5975C instrument equipped with an HP-5 MS column (30 m in length, 0.25 mm in diameter). p-Xylene was used as the internal standard. In the substrate scope experiment, the product was isolated and identified by NMR. The procedure for the isolation of the product is as follows: after the reaction completed, the reactor was cooled to room temperature in water and vented the gas.The reaction mixture was acidified with HCl 1.0 M (pH 1-2,15 mL) and then extracted with Et2O (3 x 20 mL). Next, the combined organic layers were washed with HCl 1.0 M (pH 1-2,3 10 mL), dried over anhydrous Na2SO4, and filtered and the Et2O was rotary evaporated. Solid products obtained were vacuum dried for 10 h at 60 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3319-15-1, 1-(4-Methoxyphenyl)ethanol.

Reference:
Article; Wang, Min; Lu, Jianmin; Li, Lihua; Li, Hongji; Liu, Huifang; Wang, Feng; Journal of Catalysis; vol. 348; (2017); p. 160 – 167;,
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Adding a certain compound to certain chemical reactions, such as: 111-45-5, 2-(Allyloxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 111-45-5, blongs to alcohols-buliding-blocks compound. Product Details of 111-45-5

Reactions under ambient pressure: In a glove box, a 4 ml_ vial equipped with a magnetic stirring bar and a screw cap was charged with the substrate (0.1 mmol) and 2 mg of hexamethylbenzene (internal standard). Then a solution of the catalyst (5×10″3 mmol, 5 mol %) dissolved in the right amount of toluene to achieve the final concentration of 1 M in substrate, was added to the vial containing the substrate and the internal standard. The vial was closed and the reaction mixture was stirred at room temperature (22 SC). Samples (about 10 mu_) of the reaction mixture were withdrawn at regular time intervals, and quenched with an excess of ethyl vinyl ether. Determination of conversions, yields, and Z-selectivities were carried out by comparing the integrals of the peaks due to the olefinic protons of substrates and products, identified by comparison with literature data,( 20, 37-41 ) with that of the internal standard.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-45-5, 2-(Allyloxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; BERGEN TEKNOLOGIOVERFØRING AS; JENSEN, Vidar Remi; OCCHIPINTI, Giovanni; (64 pag.)WO2017/9232; (2017); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71176-54-0, name is (5-Amino-1,3-phenylene)dimethanol, the common compound, a new synthetic route is introduced below. Quality Control of (5-Amino-1,3-phenylene)dimethanol

Compound 3d (5.6 g, 18.52 mmol) was dissolved in anhydrous dichloromethane (1 18 mL) and anhydrous methanol (58.8 mL). (5-amino-1 ,3- phenylene)dimethanol (2.70 g, 17.64 mmol) and EEDQ (8.72 g, 35.3 mmol) were then added, and the reaction was stirred at room temperature overnight. The solvent was stripped and ethyl acetate was added. The resulting slurry was filtered, washed with ethyl acetate, and dried under vacuum/N2 to give compound 3e (2.79 g, 36% yield). 1 H NMR (400 MHz, DMSO-d6): delta 9.82 (s, 1 H), 8.05, (d, 1 H, J = 9.2 Hz), 8.01 (d, 1 H, J = 7.2 Hz), 7.46 (s, 2H), 6.95 (3, 1 H), 5.21 -5.12 (m, 2H), 4.47-4.42 (m, 4H), 4.40-4.33 (m, 1 H), 4.33-4.24 (m, 1 H), 3.58 (s, 3H), 2.33-2.26 (m, 2H), 2.16-2.09 (m, 2H), 1 .54-1 .46 (m, 4H), 1 .30 (d, 3H, J = 7.2 Hz), 1 .22 (d, 3H, J = 4.4 Hz).

The synthetic route of 71176-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; IMMUNOGEN, INC.; VEIBY, Ole Peter; CHARI, Ravi, V. J.; LAMBERT, John M.; LAI, Katharine C.; HERBST, Robert W.; HILDERBRAND, Scott A.; (128 pag.)WO2017/136693; (2017); A1;,
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Synthetic Route of 86770-74-3 ,Some common heterocyclic compound, 86770-74-3, molecular formula is C8H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (256 mg, 1.32 mmol) in DCM (30 mL) were added BCN-OSu (351 mg, 1.20 mmol) and Et3N (502 muIota_, 364 mg, 3.60 mmol). The resulting solution was stirred for 30 min and washed with a saturated aqueous solution of NH4CI. After separation, the aqueous phase was extracted with DCM (30 mL). The combined organic phases were dried (Na2S04) and concentrated. The residue was purified with column chromatography (MeOH in DCM 0? 10%). The product was obtained as a colourless oil (397 mg, 1.07 mmol, 90%). H NMR (400 MHz, CDCI3) delta (ppm) 5.93 (bs, 1 H), 4.14 (d, J = 8.1 Hz, 2H), 3.77-3.69 (m, 4H), 3.68-3.59 (m, 8H), 3.58-3.52 (m, 2H), 3.42-3.32 (m, 2H), 2.34-2.16 (m, 6H), 1.66-1.51 (m, 2H), 1 .36 (quintet, J = 8.7 Hz, 1 H), 1.00-0.85 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN GEEL, Remon; VAN DELFT, Floris Louis; VAN BERKEL, Sander Sebastiaan; (117 pag.)WO2017/137456; (2017); A1;,
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Application of 68120-35-4, Adding some certain compound to certain chemical reactions, such as: 68120-35-4, name is (3-Bromo-4-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68120-35-4.

A mixture of (3-Bromo-4-methyl-phenyl)-methanol (8.5 g, 42.2 mmol) and bis(pinacolato)diboron (11.8 g, 46.50 mmol) in 1 ,4-dioxane (50 ml_) was degassed under N2 atmosphere for 10 min. Potassium acetate (8.2 g, 84.55 mmol) was added to the above followed by [1 ,1 – Bis(diphenylphosphino)ferrocene]dichloropalladium(ll).CH2Cl2 (1.54 g, 2.11 mmol) and the reaction mixture was heated at 100 C for 15 h. The solvents were removed under reduced pressure, the residue obtained was diluted with water and extracted with EtOAc (2×150 mL). Combined organic phases were washed with water, brine, dried over anhydrous Na2S04, filtered and concentrated. Purification of this crude by flash chromatography on silica (EtOAc:n-hexane; 70:30) afforded the title compound as a brown liquid (5.0 g, 84%). 1H NMR (400 MHz, DMSO-d6): delta 7.59 (d, J = 1.72 Hz, 1 H), 7.25 (dd, J = 7.76, 1.88 Hz, 1 H), 7.11 (d, J = 7.76 Hz, 1 H), 5.10 (t, J = 5.72 Hz, 1 H), 4.43 (d, J = 5.72 Hz, 2H), 2.42 (s, 3H), 1.29 (s, 12H).

According to the analysis of related databases, 68120-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; KULKARNI, Santosh; CHRISTMANN-FRANCK, Serge; WO2014/121942; (2014); A1;,
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Synthetic Route of 15852-73-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, molecular weight is 187.03, as common compound, the synthetic route is as follows.

Example 53 {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane TBSCl (18.7 g, 124.3 mmol), Et3N (14.08 g, 139.2 mmol) and DMAP (194.3 mg, 8.9 mmol) were dissolved in CH2Cl2 (120 mL), then the solution was cooled to 0-5 C. (3-bromophenyl)methanol (18.5 g, 99.4 mmol) was added dropwise to the solution. After the addition, the mixture was warmed to room temperature, and stirred for 2 h. 5% HCl was added to the reaction mixture to pH=4-5, then the organic phase was separated, and the aqueous layer was extracted with CH2Cl2 (50 mL*2). The combined organic phase was washed with water, and dried over Na2SO4. After removing the solvent, 28.5 g of {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane was obtained (Yield: 95.1%).

Statistics shows that 15852-73-0 is playing an increasingly important role. we look forward to future research findings about (3-Bromophenyl)methanol.

Reference:
Patent; Glaxo Group Limited; US2009/197871; (2009); A1;,
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