Author: tianli

Related Products of 33893-85-5 , The common heterocyclic compound, 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol, molecular formula is C7H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 42 Synthesis of Compound I-31 To a solution of 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in THF (15 mL) was added triphenylphosphine (0.718 g, 2.74 mmol) and 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0 C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.

The synthetic route of 33893-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2807-30-9, name is 2-Propoxyethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Propoxyethanol

General procedure: A mixture of the corresponding 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-6-aryl-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-7(8H)-one (VI) (0.42 mmol), Cs2C03 (0.54 mmol) and the corresponding alcohol (9 ml) was heated a reflux overnight. The resulting solution was cooled down, water (100 mL) was added and the reaction crude was neutralized with 2M HCI. The solid was collected by filtration and washed with water, and EtOEt to afford the corresponding 4-alkoxy-substituted pyrido[2,3- d]pyrimidine (XXVII). 1H N M R (400 MHz, DMSO-d(6): delta 10.51 (s, 1H), 7.58 – 7.47 (m, 2H), 7.37 (t, J = 8.1 Hz, 1H), 6.42 (s, 2H), 4.63 (dd, J = 12.9, 9.2 Hz, 1H), 4.35 – 4.32 (m, 2H), 3.63 (t, J = 4.9 Hz, 2H), 3.35 (t, J = 6.6 Hz, 2H), 2.93 – 2.79 (m, 2H), 1.46 (hex, J = 7.3 Hz, 2H), 0.80 (t, J = 7.4 Hz, 3H).

The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUT QUIMIC DE SARRIA, CETS FUNDACIO PRIVADA; BORRELL BILBAO, Jose Ignacio; TEIXIDO CLOSA, Jordi; CAMARASA NAVARRO, Marta; PUIG DE LA BELLACASA CAZORLA, Raimon; MARTINEZ DE LA SIERRRA, Miguel Angel; FRANCO CIRERA, Sandra; BADIA CORCOLES, Roger; CLOTET SALA, Bonaventura; ESTE ARAQUE, Jose; WO2015/118110; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: (Perfluorophenyl)methanol

General procedure: To 100 mg compound 2 (0.54 mmol) suspended in 5 mL CH2Cl2 was added 0.5 mL oxalyl chloride (0.27 mmol) slowly. The mixturewas reacted under room temperature for 1 h. Solvent was distilled under reduced pressure, residue dissolved in 2 mL CH2Cl2 and dropwised to a mixture containing 0.6 mmol relevant ROH, 1.8 mmol triethylamine and 5 mL CH2Cl2. The mixture was reacted underroom temperature and monitored by TLC to the end of reaction, solvent distilled, residue recrystallization from ethyl acetate and hexane affords target compounds.

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Reference:
Article; Du, Qing-Shan; Shi, Yan-Xia; Li, Peng-Fei; Zhao, Zhen-Jiang; Zhu, Wei-Ping; Qian, Xu-Hong; Li, Bao-Ju; Xu, Yu-Fang; Chinese Chemical Letters; vol. 24; 11; (2013); p. 967 – 969;,
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Reference of 1072-52-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. A new synthetic method of this compound is introduced below.

Example 10 (Table 1, entry 4 and Scheme 7): Preparation of 2- [(2-iodoethyl)-2,4- dinitro-6-({[2-(tetrahydro-2/£pyran-2-yloxy)ethyl]amino}carbonyl)anih’no]ethyl methanesulfonate (17c); A slurry of 15 (520 mg, 1.4 mmol) in dry 3-methyl-2-butanone (20 mL) and NaI (3.1 g) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added. The reaction was kept at 20 0C overnight, then water (100 mL) was added, and the mixture was extracted with EtOAc (3×50 mL). The combined organic layer was washed with water, dried and concentrated under pressure, then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 2-[(2-hydroxyethyl)(2-iodoethyl)amino]-3,5- dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (16c) (630 mg, 82%) as a yellow foam; 1H NMR (CDCl3) delta 8.63 (d, / = 2.8 Hz, 1 H), 8.56 (dj = 2.8 Hz, 1 H), 8.24 (br, 1 H), 4.54 (m, 1 H), 4.48 (m, 1 H), 3.93 (m, 2 H), 3.84 (m, 1 H), 3.70 (m, 6 H), 3.54 (m, 1 H), 3.30 (m, 2 H), 3.18 (m, 2 H), 1.90-1.40 (m, 6 H); 13C NMR delta 165.7, 146.7, 144.4, 140,9, 134.5, 129.2, 123.5, 101.6, 67.0, 65.4, 58.0, 55.0, 53.7, 40.7, 31.3, 25.1, 21.2, 0.3; HRMS (FAB) calcd for C18H26IN4O8 [MH]+ m/z 553.0795; found 533.0797.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-52-2, 2-(Aziridin-1-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 33524-31-1

Example 10; 5-Chloro-1-(2,5-dimethoxybenzyl)-1H-indole-2-carboxylic acid (3-hydroxy-2,2- dimethylpropyDamide EPO A solution of phosphorous tribromide (5.74ml, 60.4mmol) in anhydrous DCM (90ml) was added over 20min to a cooled, stirred solution of 2,5-dimethoxybenzyl alcohol (25.Og, 148.8mmol) in DCM (180ml), maintaining the temperature between -5C and 00C. Following the addition, the reaction was stirred at this temperature for a further 20 min. when water (200ml) was added. After separation of the layers, the organic was washed with water (3x200ml), dried with magnesium sulfate and evaporated to dryness under reduced pressure. The resulting crude product was crystallised from diethyl ether/heptane to afford 2-bromomethyl-1,4-dimethoxy-benzene (24.2g, 72%).The title compound was then prepared in a manner similar to that described in Example 1. 1H NMR (400MHz, CDCI3) deltaH : 0.88(s, 6H), 3.08(d, 2H, J=7.0), 3.25(d, 2H, J=6.8), 3.52(t, 1 H, J=7.0), 3.57(s, 3H), 3.84(s, 3H), 5.75(s, 2H), 6.03(d, 1H, J=2.9), 6.59(br t, 1H, J=6.8), 6.68(dd, 1 H, J=8.8, 2.9), 6.80(d, 1 H, J=8.8), 6.85 (s, 1H), 7.19(dd, J=8.8, 1.9), 7.27(m, 1H), 7.60(d, 1 H, J=1.9); EIMS: m/z = 431.3 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; N.V. ORGANON; WO2006/100208; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7417-18-7, 2-(2-Methoxyphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(2-Methoxyphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(2-Methoxyphenyl)ethanol

b) 4-Bromo-2-(2-hydroxyethyl)-anisole 35.72 g of tetrabutylammonium tribromide am added in portions to a solution of 10.7 g of 2-(2-hydroxyethyl)-anisole in 195 ml of dichloromethane and 130 ml of methanol. The reaction mixture is stirred for 150 minutes at room temperature and is then concentrated by evaporation in a rotary evaporator. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation, and the residue is purified by means of FC (dichloromethane), yielding the title compound: Rf (dichloromethane)=0.26; HPLC Rt =13.04 minutes.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7417-18-7, 2-(2-Methoxyphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Ciba-Geigy Corporation; US5559111; (1996); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5391-88-8, name is 1-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1-(4-Bromophenyl)ethanol

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

With the rapid development of chemical substances, we look forward to future research findings about 5391-88-8.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

vTn a glass RBF equipped with a Teflon-coated magnetic stirrer was combined 4-fluoro-1,2-dinitrobenzene (1 eq.), 3- amino-3-methylbutan-1-ol (1 eq.) and ethyl diisopropyl amine (1.5 eq.) in DMSO (0.5 M). The resulting mixture was then heated at 100C for 24 h. The reaction mixture was then diluted with water and extracted with EtOAc. The combined organic extracts were washed further with water and brine, dried over MgSO4, filtered and the filtrate concentrated in vacuo. Further purification of the crude product thus obtained by way of column chromatography (Si02, gradient elution, 9:1 (v/v) Hex: EtOAc – EtOAc) furnished the desired product (22% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; LAN, Ruoxi; CHEN, Austin; CLARK, Ryan C.; (268 pag.)WO2017/49068; (2017); A1;,
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Reference of 19064-18-7 ,Some common heterocyclic compound, 19064-18-7, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of (2,6-difluorophenyl)methanol (1 mL) and sodium hydride (60%, oil) (34 mg) was stirred at room temperature for 30 min. 3-(4-Chloropyridin-2-yl)quinazoline-2,4(1H,3H)-dione (115 mg) was added, and the obtained mixture was stirred at 150C for 4 hr. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (31 mg). 1H NMR (300 MHz, DMSO-d6) delta 5.24 (2H, s), 7.14-7.31 (6H, m), 7.51-7.65 (1H, m),7.66-7.79 (1H, m), 7.87-8.06 (1H, m), 8.45 (1H, d, J = 5.7 Hz), 11.65 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19064-18-7, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; IKEDA, Zenichi; FUJIMOTO, Jun; OHBA, Yusuke; ISHII, Naoki; FUJIMOTO, Takuya; ODA, Tsuneo; TAYA, Naohiro; YAMASHITA, Toshiro; MATSUNAGA, Nobuyuki; EP2889291; (2015); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2-Amino-3-chlorophenyl)methanol

EXAMPLE 100 Preparation of 2-benzyloxymethyl-6-chloroaniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 98. The product was purified by Kugelrohr distillation to yield an oil, b.p. 118-125 C. (0.1 mm). The product was characterized by IR and 1 H NMR spectroscopy.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61487-25-0, (2-Amino-3-chlorophenyl)methanol.

Reference:
Patent; The Dow Chemical Company; US4818273; (1989); A;,
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