Month: September 2021

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1777-82-8, name is (2,4-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, molecular weight is 177.03, as common compound, the synthetic route is as follows.Formula: C7H6Cl2O

General procedure: A mixture of alcohol or phenol (1 mmol), DHP (1.2-1.4 mmol), and MNPs-PSA (5 mg, 0.95 mol%) was stirred at room temperature in dry CH2Cl2 (2 mL), and the progress of the reaction was monitored by TLC. After completion of the reaction, catalyst was separated by an external magnet and washed with CH2Cl2. Then, the pure product was isolated by passing of the reaction mixture through a short column using n-hexane and ethyl acetate (9:1) as eluent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1777-82-8, (2,4-Dichlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Rostami, Amin; Tahmasbi, Bahman; Abedi, Fatemeh; Research on Chemical Intermediates; vol. 42; 4; (2016); p. 3689 – 3701;,
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Adding a certain compound to certain chemical reactions, such as: 2566-44-1, 2-Cyclopropylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2566-44-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 2566-44-1

Reference Example 11-1 4-(2-Cyclopropylethoxy)benzaldehyde To a mixture of 4-hydroxybenzaldehyde (2.84 g), 2-cyclopropylethanol (2.00 g), triphenylphosphine (6.09 g) and tetrahydrofuran (100 mL), diethyl azodicarboxylate (2.2 mol/L, solution in toluene, 10.5 mL) was added and the mixture was stirred at room temperature for 4 days. After concentrating the reaction mixture under reduced pressure, ethyl acetate (7.50 mL) and n-hexane (143 mL) were added and the mixture was stirred at room temperature for 15 minutes. The precipitate was removed by filtration through Celite (registered trademark). The filtrate was concentrated under reduced pressure and, thereafter, the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 95:5-50:50) to give the titled compound as a yellow oil (3.34 g). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 0.10 – 0.18 (m, 2 H) 0.46 – 0.55 (m, 2 H) 0.78 – 0.95 (m, 1 H) 1.67 – 1.76 (m, 2 H) 4.12 (t, J=6.6 Hz, 2 H) 6.97 – 7.05 (m, 2 H) 7.80-7.87 (m, 2 H) 9.88 (s, 1 H). MS ESI posi: 191[M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TAKAYAMA, Tetsuo; SHIBATA, Tsuyoshi; SHIOZAWA, Fumiyasu; KAWABE, Kenichi; SHIMIZU, Yuki; HAMADA, Makoto; HIRATATE, Akira; TAKAHASHI, Masato; USHIYAMA, Fumihito; OI, Takahiro; SHIRASAKI, Yoshihisa; MATSUDA, Daisuke; KOIZUMI, Chie; KATO, Sota; EP2881384; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9FO

General procedure: To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (Intermediate IV, 50 mg, 0.19 mmol) and (3-fluorophenyl)methanol (187 mg, 1.48 mmol) was added potassium tert-butoxide (1M in THF, 1.85 mL, 1.85 mmol) and the mixture was stirred for 30 min. The mixture was transferred to a silica gel samplet and purified by column chromatography (SiO2, hexane/ethyl acetate). Combined fractions containing the product were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5 mL) and water (10 mL), frozen and lyophilized to yield 3-(3-((6-((3-fluorobenzyl)oxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (45 mg, 0.12 mmol, 65%) as a white solid.

The synthetic route of 52059-53-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Trzoss, Michael; Covel, Jonathan A.; Kapoor, Mili; Moloney, Molly K.; Soltow, Quinlyn A.; Webb, Peter J.; Shaw, Karen Joy; Bioorganic and Medicinal Chemistry Letters; vol. 29; 23; (2019);,
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Electric Literature of 134575-13-6, Adding some certain compound to certain chemical reactions, such as: 134575-13-6, name is exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol,molecular formula is C6H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 134575-13-6.

Step A (1alpha,5alpha,6alpha)-3-(tert-Butoxycarbonyl)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane A solution of di-tert-butyl dicarbonate (967 mg, 4.42 mmol) in CH2Cl2 (3.0 mL) was added to a stirred solution of (1alpha,5alpha,6alpha)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane (456 mg, 4.02 mmol, for preparation see K. E. Brighty and M. J. Castaldi, Synlett, 1996, 1097-1099) in CH2Cl2 (7.0 mL) at RT. After 15 h, the solution was partitioned between 2 N aq. HCl (50 mL) and EtOAc (50 mL). The organic layer was washed with saturated aq. NaHCO3 (50 mL) and saturated aq. NaCl (50 mL). The aqueous layers were extracted in succession with EtOAc (2*50 mL). The organic layers were dried (Na2SO4), decanted, and evaporated. The crude product was purified by flash column chromatography on silica gel, eluding with 80:20 v/v to 0:100 hexane/EtOAc to give the title compound as a colorless syrup. For the title compound: 1H NMR (500 MHz, CDCl3) delta 3.60 (d, J=11, 2H), 3.53 (d, J=6, 2H), 3.36 (d, J=11, 2H), 1.44 (s, 11H), 0.96 (tt, J=6, 3, 1H); ESI-MS 158.1 (M+H-56); HPLC A: 2.09 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 134575-13-6, exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hale, Jeffrey J.; Lynch, Christopher L.; Caldwell, Charles G.; Willoughby, Christopher A.; Kim, Dooseop; Shen, Dong-Ming; Mills, Sander G.; Chapman, Kevin T.; Chen, Liya; Gentry, Amy; MacCoss, Malcolm; Konteatis, Zenon D.; US2002/94989; (2002); A1;,
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Adding a certain compound to certain chemical reactions, such as: 870-72-4, Hydroxymethanesulfonic Acid Sodium Salt, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Hydroxymethanesulfonic Acid Sodium Salt, blongs to alcohols-buliding-blocks compound. Safety of Hydroxymethanesulfonic Acid Sodium Salt

Intermediate M 18 (10 g, 67.9 mmol) was dissolved in tetrahydrofuran:Water = 1: 1 solution (20 ml)Sodium hydroxymethanesulfonate (9.56 g, 71.3 mmol)And the mixture was heated under reflux at 70 C. for 4 hours. After the reaction solution was cooled to room temperature, it was filtered to obtain Intermediate M19(16.2 g, yield 91%) was obtained.

The synthetic route of 870-72-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAIKIN INDUSTRIES LIMITED; KARUBE, DAISUKE; KISHIMOTO, MASAYUKI; CHAKI, TAKEHIRO; KOMATSU, YUZO; (34 pag.)JP2017/82096; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 1074-16-4, 2-(2-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1074-16-4, blongs to alcohols-buliding-blocks compound. Product Details of 1074-16-4

Benzyl bromide (7 ml, 0.05 mol) was added drop wise to a stirred solution 2 bromo phenethyl alcohol (10 g, 0.0496 mol) and anhydrous NaH (2.28 g, 0.05 mol) in 100 ml of dry THF at 40-50 C. The reaction mixture was stirred for 10 h at 50 C., progress of the reaction was monitored using TLC, cooled to RT and evaporated to remove the solvent. An equal volume of distilled water was added to the residue and the mixture was stirred for one hour at ambient. The organic layer was separated, dried and evaporated. To the resulting liquid 100 ml of 5% ethanolic solution of NaOH was added and refluxed for 3 hr. The resulting solution was evaporated and extracted with ether to give the benzyl protected phenethyl alcohol as a clear liquid at 80% yield.1H-NMR (CDCl3, 400 Mhz): 7.5 (d, 1H), 7.3 (m, 7H), 7.08 (d, 1H), 4.53 (s, 2H), 3.7 (t, 2H), 3.07 (t, 2H) ppm. 13C-NMR (CDCl3, 100 Mhz): 138.43, 132.96, 131.37, 129.01, 128.58, 128.20, 127.78, 127.76, 127.57, 124.87, 73.12, 69.56, 36.71 ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-16-4, 2-(2-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NDSU-Research Foundation; US2011/28721; (2011); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol, the common compound, a new synthetic route is introduced below. Product Details of 2043-47-2

1H,1H,2H,2H-nonafluoro-1-hexanol (52.8 g) as fluoro alcohol and triethylamine (50 g) were dissolved in 500 ml of tetrahydrofuran. A solution of 18.1 g of acryloyl chloride as acid chloride in 100 ml of tetrahydrofuran was dropped in this solution over 2 hours while the mixture was being cooled in ice and stirred. After the completion of the dropping, the resulting white precipitate was filtrated and tetrahydrofuran and triethylamine were removed from the filtrate using a rotary evaporator. NMR measurement revealed that the resulting compound was 1H,1H,2H,2H-nonafluorohexyl acrylate.

The synthetic route of 2043-47-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; POLA CHEMICAL INDUSTRIES, INC.; EP1452161; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101-32-6, name is 2,2-(Benzylimino)diethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2,2-(Benzylimino)diethanol

2-[Benzyl-(2-hydroxyethyl)amino]ethanol (XIX); 16.9 ml (142 mmol) of benzyl bromide were added to a stirred solution of 15.0 g (142 mmol) of diethanolamine and 39.4 g (285 mmol) of potassium carbonate in 200 ml of acetone, and the solution was then heated under reflux for 3 h. The cooled reaction mixture was filtered and concentrated in vacuo. 100 ml of water were added, and the aqueous mixture was extracted with chloroform (3×60). The combined organic phases were washed with water and saturated NaCI solution and dried over magnesium sulfate, and the solvent was removed in vacuo. Yield: 26.9 g (96%) of colorless oil The reaction product was converted into the hydrochloride by dissolving the residue in 70 ml of 5N ethereal HCI and removing the solvent in vacuo. The residue was then coevaporated with toluene twice. Yield: 31.7 g (99%) of colorless oil 1H-NMR (DMSOd6): 2.51-2.59 (m, 2H), 3.41-3.48 (m, 4H), 3.65 (s, 2H), 4.34 (bs, 2H), 7.16-7.36 (m, 5H). MS (API-ES,pos) m/z = 196 [M+H]+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101-32-6, 2,2-(Benzylimino)diethanol.

Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/25736; (2008); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4277-34-3, name is Cyclooct-4-enol, molecular formula is C8H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Cyclooct-4-enol

Synthesis of Cer-TCO (FIG. 7) (0139) Cis-1,5-cyclooctadiene 1 was converted to cyclooctene monoepoxide 2 with m-CPBA (Clark, et al., 2010, J. Am. Chem. Soc. 132:3405-3412). The monoepoxide was reduced with LiAlH4 to the alcohol 3 (Clark, et al., 2010, J. Am. Chem. Soc. 132:3405-3412). Cis-cyclooctenol 3 was isomerized to trans-cyclooctenol 4 according to Royzen, et al., 2008, J. Am. Chem. Soc. 130:3760-3761. From TCO 4 the corresponding p-nitrophenol carbonate 5 was prepared (Liu, et al., 2012, J. Am. Chem. Soc. 134:792-795).

With the rapid development of chemical substances, we look forward to future research findings about 4277-34-3.

Reference:
Patent; Yale University; ERDMANN, Roman; SHRADER, Alanna Schepartz; TOOMRE, Derek; (34 pag.)US2016/115180; (2016); A1;,
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Application of 480449-99-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.480449-99-8, name is Benzyl 3-hydroxycyclobutanecarboxylate, molecular formula is C12H14O3, molecular weight is 206.24, as common compound, the synthetic route is as follows.

To a solution of the compound obtained in Referential Example 151 (317 mg) in N,N-dimethylformamide (3.0 mL) were added methyl iodide (194 muL) and silver oxide (237 mg), followed by stirring at 45C for 1 hour. To the reaction mixture were added additional methyl iodide (194 muL) and silver oxide (226 mg), followed by stirring at 45C for 16 hours. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate : hexane = 1:10), to thereby give the title compound (152 mg).1H-NMR(CDCl3) delta:2.14-2.24(2H, m), 2.44-2.54(2H, m), 2.59-2.72(1H, m), 3.21(3H, s), 3.73-3.81(1H, m), 5.11(2H, s), 7.22-7.39(5H, m). MS(ESI)m/z:221(M+H+).

Statistics shows that 480449-99-8 is playing an increasingly important role. we look forward to future research findings about Benzyl 3-hydroxycyclobutanecarboxylate.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1577301; (2005); A1;,
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