Month: July 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-18-9, name is 3-Bromopropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromopropan-1-ol

General procedure: To a solution of DHA (10.0 mmol) and 2-bromoethanol (10.0 mmol) in CH2Cl2 (30 mL), boronfluoride ethyl ether (0.5 mL) was added dropwise at 0 C. The reaction mixture was stirred at 0 Cfor 8 h, then washed with saturated NaHCO3 solution (20 mL x 3). The organic layer was dried overanhydrous Na2SO4 and concentrated under reduced pressure. The crude products were purified bysilica gel column chromatography (PET/EtOAc = 10:1, v/v) to get the target compound 7a.The compounds 7b and 9a were synthesized by the same operation procedure of compound 7a.

With the rapid development of chemical substances, we look forward to future research findings about 627-18-9.

Reference:
Article; Tian, Ye; Liang, Zhen; Xu, Hang; Mou, Yanhua; Guo, Chun; Molecules; vol. 21; 6; (2016);,
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Electric Literature of 426831-32-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.426831-32-5, name is (5-Fluoro-2-methoxyphenyl)methanol, molecular formula is C8H9FO2, molecular weight is 156.1543, as common compound, the synthetic route is as follows.

Neat (5-Fluoro-2-methoxy-phenyl) -methanol (19.587g, 1 equiv. ) was added to neat SOC12 (42.2 mL, 4.6 equiv. ) at-78C under a nitrogen atmosphere and the solution was then allowed to warm to room temperature and stirred until evolution of gas had ceased. An equivalent volume of anhydrous toluene was added to the flask and the solution heated to 60C. On cooling the reaction solution was poured onto ice water. The toluene layer was separated and dried (MgSO4) and the solvent removed under reduced pressure. The crude material was sublimed (60-80C/0. 05 mBarr) to give the title compound as a white solid (13.40 g, 61%).’H NMR (300MHz, CDC13) : S 3.87 (s, 3H), 4.60 (s, 2H), 6.79-7. 20 (m, 3H).;

Statistics shows that 426831-32-5 is playing an increasingly important role. we look forward to future research findings about (5-Fluoro-2-methoxyphenyl)methanol.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/60949; (2005); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: (Z)-3-Methylpent-2-en-4-yn-1-ol

General procedure: To a stirred solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.88 g, 9.2 mmol) in dry THF (20 mL)wascooled to 78 °C under an atmosphere of argon. n-Butyl lithium (7.7 mL, 18.4 mmol, 2.4 Min hexane) was then added slowly, via syringe. The mixture was allowed to stir at 78 °C for 1 h,after which, 6-methoxy-2,2-dimethyl-2,3-dihydronaphthalene-1,4-dione 9b (2 g, 9.2 mmol), dissolvedin dry THF (10 mL) was added. The mixture was stirred for a further 1 h at 78 °C, and then thecold bath was removed. The reaction mixture was stirred at r.t. for a further 16 h. The reactionwas quenched by addition of a saturated aqueous solution of NH4Cl. The mixture was stirred for10 min and extracted with ethyl acetate (3 50 mL), washed with water (2 30 mL) and driedover anhydrous Na2SO4. Evaporation of the solvent yielded the desired alcohol as a yellowishoil. The residue was subjected to silica gel chromatography using PE and EtOAc (4:1) as eluentto afford (Z)-(10-hydroxy-30,30-dimethyl-40-oxo-70-methoxy-tetrahydronaphthalene-one-yl)-3-methylpentyl-2-em-4-yn-1-ol 18b (2.37 g, 82percent) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6153-05-5, (Z)-3-Methylpent-2-en-4-yn-1-ol.

Reference:
Article; Wan, Chuan; Wang, Mingan; Yang, Dongyan; Han, Xiaoqiang; Che, Chuanliang; Ding, Shanshan; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 22; 12; (2017);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31775-67-4, name is trans-2-Aminocyclopentanol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C5H12ClNO

To a solution of 1-(4-bromobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (0.83 g) known from a document (Journal of Medicinal Chemistry, 2007, 50, 5471) in DMF (20 mL) were added (1,2-trans)-2-aminocyclopentanol hydrochloride (0.38 g), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (1.1 g) and triethylamine (0.80 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give the title compound (1.0 g) as a pale-yellow solid. 1H NMR (300MHz, DMSO-d6) delta 1.37-1.94 (5H, m), 2.00-2.17 (1H, m), 3.88-4.10 (2H, m), 5.77 (2H, s), 5.86 (1H, s), 7.13-7.30 (2H, m), 7.44-7.97 (5H, m), 8.29-8.44 (1H, m), 9.08 (1H, s), 10.03 (1H, d, J = 7.4 Hz).

The synthetic route of 31775-67-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
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Related Products of 4704-94-3 , The common heterocyclic compound, 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 2 The allylation reaction was carried out as in Example 1 except using 42.07 g of 1,1,1-tri(methylol)methane, 40.43 g of tetrabutylammonium bromide and 95.79 g of allyl chloride. After the allylation reaction, the product was separated and purified as in Example 1. As a result, 59.80 g of 1,1,1-tri(allyloxymethyl)methane was obtained. The yield was 100% and the purity was 99%.

The synthetic route of 4704-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Matsumura, Yasufumi; Komiyama, Hiromi; US2003/135059; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4720-29-0, name is 3-(Benzylamino)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 3-(Benzylamino)-1-propanol

3-(N-tert-Butoxycarbonyl-N-phenylmethylamino)-propan-1-ol (4f) (R3=H, q=1, x=2, R1=BOC) from 3f (method B). 1H-NMR (CDCl3): 7.37-7.15 (m, 5H, Ar); 4.38 (s, 2H, CH2 -Ar); 3.58-3.50 (m, 2H, CH2OH); 3.40-3.30 (m, 2H, N-CH2); 3.10 (bs, 1H, OH); 1.70-1.55 (m, 2H, CH2-CH2-CH2); 1.40 (s, 9H, t.Bu).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4720-29-0, 3-(Benzylamino)-1-propanol.

Reference:
Patent; Zambon Group S.p.A.; US6214833; (2001); B1;,
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Related Products of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device, 14.6 g (0.1 mol) of adipic acid, 35.1 g (0.3 mol) of N, N-diethylaminoethanol, (0.2mol) of water, filtered to remove the catalyst (direct reuse), the filtrate transferred to another 250ml of three bottles, vacuum distillation (20ml), the reaction mixture was heated to 150 C, After recovery of the solvent, recovery of excess diethylaminoethanol and recovery of the low boiling point matter, 3.0 g of activated clay was added and stirred for 30 minutes to lower the temperature to 80C or lower.And the filtrate afforded 31.10 g of a di-ethylaminoethyl adipate as a yellow oily liquid in a yield of 90.4%.And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed with stirring heated to120 C,The citric acid is melted and then cooled and crystallized with stirring to form a salt, thereby obtaining a white powdery solid product of adipic acid bis diethylaminoethanol citrate. Its melting point: 117 C.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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Related Products of 33893-85-5 , The common heterocyclic compound, 33893-85-5, name is 4-(Hydroxymethyl)cyclohexanol, molecular formula is C7H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 42 Synthesis of Compound I-31 To a solution of 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in THF (15 mL) was added triphenylphosphine (0.718 g, 2.74 mmol) and 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0 C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.

The synthetic route of 33893-85-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2807-30-9, name is 2-Propoxyethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Propoxyethanol

General procedure: A mixture of the corresponding 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-6-aryl-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-7(8H)-one (VI) (0.42 mmol), Cs2C03 (0.54 mmol) and the corresponding alcohol (9 ml) was heated a reflux overnight. The resulting solution was cooled down, water (100 mL) was added and the reaction crude was neutralized with 2M HCI. The solid was collected by filtration and washed with water, and EtOEt to afford the corresponding 4-alkoxy-substituted pyrido[2,3- d]pyrimidine (XXVII). 1H N M R (400 MHz, DMSO-d(6): delta 10.51 (s, 1H), 7.58 – 7.47 (m, 2H), 7.37 (t, J = 8.1 Hz, 1H), 6.42 (s, 2H), 4.63 (dd, J = 12.9, 9.2 Hz, 1H), 4.35 – 4.32 (m, 2H), 3.63 (t, J = 4.9 Hz, 2H), 3.35 (t, J = 6.6 Hz, 2H), 2.93 – 2.79 (m, 2H), 1.46 (hex, J = 7.3 Hz, 2H), 0.80 (t, J = 7.4 Hz, 3H).

The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUT QUIMIC DE SARRIA, CETS FUNDACIO PRIVADA; BORRELL BILBAO, Jose Ignacio; TEIXIDO CLOSA, Jordi; CAMARASA NAVARRO, Marta; PUIG DE LA BELLACASA CAZORLA, Raimon; MARTINEZ DE LA SIERRRA, Miguel Angel; FRANCO CIRERA, Sandra; BADIA CORCOLES, Roger; CLOTET SALA, Bonaventura; ESTE ARAQUE, Jose; WO2015/118110; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: (Perfluorophenyl)methanol

General procedure: To 100 mg compound 2 (0.54 mmol) suspended in 5 mL CH2Cl2 was added 0.5 mL oxalyl chloride (0.27 mmol) slowly. The mixturewas reacted under room temperature for 1 h. Solvent was distilled under reduced pressure, residue dissolved in 2 mL CH2Cl2 and dropwised to a mixture containing 0.6 mmol relevant ROH, 1.8 mmol triethylamine and 5 mL CH2Cl2. The mixture was reacted underroom temperature and monitored by TLC to the end of reaction, solvent distilled, residue recrystallization from ethyl acetate and hexane affords target compounds.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Article; Du, Qing-Shan; Shi, Yan-Xia; Li, Peng-Fei; Zhao, Zhen-Jiang; Zhu, Wei-Ping; Qian, Xu-Hong; Li, Bao-Ju; Xu, Yu-Fang; Chinese Chemical Letters; vol. 24; 11; (2013); p. 967 – 969;,
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