Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 83647-43-2, (3-Bromo-2-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 83647-43-2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9BrO

: To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of ThalliumTrifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. Analysis by TLC showed no starting material remaining. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 mm to ensure complete removal of TFA. To the residue was then added Palladium(II) Chloride (529 mg, 2.98 mmol), Lithium Chloride (2.53 g,59.7 mmol), Magnesium Oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The solution was filtered through a CELITE pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5 -bromo-4-methyl-2-benzofuran- 1 (311)-one.1H-NMR (500 MHz, CDC13) oe ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J 8.0 Hz, 1H), 5.25 (s,2H), 2.37 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83647-43-2, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; TANG, Haifeng; FRIE, Jessica; FERGUSON, Ronald Dale; GUO, Zhiqiang; SHI, Zhi-Cai; CATO, Brian; FU, Qinghong; WO2015/65866; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 101597-25-5, Adding some certain compound to certain chemical reactions, such as: 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol,molecular formula is C17H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101597-25-5.

To the vial tube, 5-hydroxy-7,7,13,13-tetramethyl-7H, 13H-benzo [g] indeno [3,2-b] fluorene (8) (50 mg, 0.13 mmol)1,1-bis (4-methoxyphenyl) prop-2-yl-1-ol (9) (35 mg, 0.13 mmol)P-Toluenesulfonic acid monohydrate (1.0 mg, 0.0053 mmol) was added,Sealed with a Teflon (registered trademark) septum cap, purged with nitrogen and toluene (1.3 mL) was added,And the mixture was stirred at 0 C. for 12 hours.Progress of the reaction was confirmed by TLC (hexane / ethyl acetate = 9/1)After confirming the completion of the reaction, the reaction was terminated with an aqueous solution of sodium hydrogencarbonate, and extraction was carried out using ethyl acetate. The extracted organic layer was dried over magnesium sulfate, filtered, and concentrated. The obtained crude product was isolated and purified by silica gel column chromatography (hexane / ethyl acetate = 19/1 to 9/1) to give 64 mg (77%)of3,3-di (4-methoxyphenyl) -10, 10, 16,16-tetramethyl-3H, 10H, 16H-benzo [3,4] indeno [2 ‘, 3’: 6,7] fluoreno [1,2-b] pyran(10) as a dark green solid.

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH ORGANIC CHEMICAL COMPANY LIMITED; KITO, FUKASHI; HAGIWARA, HIDEKI; SOGA, SHINICHI; (20 pag.)JP2017/36248; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 17100-58-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

4-Bromo-1-bromomethyl-2-methyl-benzene (Intermediate 138) A solution of (4-bromo-2-methyl-phenyl)-methanol (Intermediate 133, 319.0 mg, 1.58 mmol) and triphenylphosphine (466.0 mg, 1.74 mmol) in 5 mL CH2Cl2 was cooled to 0 C. and N-bromosuccinimide (309.0 mg, 1.74 mmol) was added in 5 portions over 20 minutes. The solution was warmed to 25 C. and stirred for 17 hours. The reaction was quenched by the addition of dilute aqueous NaHCO3. The resulting mixture was extracted with Et2O and the combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (Na2SO4) and concentrated under reduced pressure. The title compound, 350.0 mg (84%), was isolated by column chromatography (2-3% EtOAc-hexanes) as a colorless oil. 1H NMR (CDCl3) delta: 7.32 (1H, d, J=2.0 Hz), 7.29 (1H, dd, J=2.0, 7.9 Hz), 7.15 (1H, d, J=7.9 Hz), 4.43 (2H, s), 2.37 (3H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17100-58-2, (4-Bromo-2-methylphenyl)methanol.

Reference:
Patent; Allergan Sales, Inc.; US6313107; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4654-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.

A solution of methane sulfonyl chloride (12.8 ml, 165.8 mmol, 1.1 eq) in methylisobutylketone (MIBK) (40 ml) was added dropwise to a cooled (5-10C) solution of bromophenethyl alcohol 12 (30.3 g, 150.7 mmol) and triethylamine (23.1 ml, 165.8 mmol, 1.1 eq) in MIBK (300 ml) an argon atmosphere within ca. 1 hour. Then, the reaction mixture was left to slowly heat up to the room temperature for ca. 2 h. After a check of the reaction by means of HPLC the reaction suspension was processed by addition of diluted aqueous HC1 (37 ml of 1M HC1 + 100 ml of H20) and intensively stirred for 15 min to achieve mixing of the phases; after stabilization and separation the aqueous phase was removed and the organic phase was still washed with 5% aqueous NaHC03 (50 ml), H20 ( 100 ml) and brine (100 ml). The crude mesylate solution was then heated up to boil under an argon atmosphere and dried by azeotropic distillation (ca. 50 ml of the H 0-MIBK mixture removed by distillation

The chemical industry reduces the impact on the environment during synthesis 4654-39-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ZENTIVA, K.S; ZEZULA, Josef; HAJICEK, Josef; WO2014/26657; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 862135-61-3, name is 5-Bromoindan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 862135-61-3

To a solution of NaH (60%, 160 mg, 3.99 mmol) in dry THF (5 mL) at 0 C. was added a solution of 5-bromo-2,3-dihydro-1H-inden-2-ol (500 mg, 2.347 mmol) in dry THF (5 mL). The resulting solution was stirred for 30 min at 0 C. Benzyl bromide (0.335 mL, 2.82 mmol) was added and the solution was stirred at 25 C. for 15 h. The mixture was quenched by saturated, aqueous ammonium chloride (10 mL), which was extracted with EtOAc (40 mL¡Á3). The combined organic layers were washed by brine (15 mL¡Á3) and concentrated to give the crude product, which was purified by silica gel chromatography (1:0-10:1 petroleum ether: EtOAc) to afford the title compound. 1H NMR (400 MHz, CDCl3): delta 7.25-7.37 (7H, m), 7.07 (1H, d, J=8.0 Hz), 4.57 (2H, s), 4.38-4.47 (1H, m), 2.95-3.23 (4H, m).

The synthetic route of 862135-61-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 552331-15-4 ,Some common heterocyclic compound, 552331-15-4, molecular formula is C8H8BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Chromium trioxide (2.6 g, 26.0 mmol) was dissolved in water (3.7 ml) and cooled in an ice bath. Concentrated sulfuric acid (2.2 ml) was added over 5 min, and the solution was diluted with water (7.4 ml). The mixture was then added dropwise to a solution of the product from Step A (5.7 g, 26.0 mmol) in acetone (17 ml) at 0-20 C. over 30 min. The resultant solution was allowed to warm to room temperature over 14 h. It was then partitioned between ether (300 ml) and water (300 ml) and the organic phase removed. The aqueous phase was washed with ether (100 ml) and the combined organic phases were dried over sodium sulfate then concentrated, providing the ketone (5.2 g, 92%) as a dark liquid: 1H NMR (300 MHz, CDCl3) delta 8.01-7.98 (dd, J=6.2, 2.3 Hz, 1H), 7.64-7.59 (m, 1H), 7.08-7.02 (t, J=10.0 Hz, 1H), 2.65-2.63 (d, J=4.9 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,552331-15-4, its application will become more common.

Reference:
Patent; Alcon, Inc.; US2006/142307; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. A new synthetic method of this compound is introduced below., Safety of 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol

Example 32 Preparation of 2,2,3,3,4,4,5,5-octafluoropentyl bis(pentafluoroethyl-) phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H Potassium fluoride (0.185 g; 3.2 mmol) is suspended in cooled (0 C.) tris-(pentafluoroethyl)phosphine oxide, (C2F5)3P=O, (9.957 g; 24.6 mmol) in a 100 ml glass flask, and 2,2,3,3,4,4,5,5-octafluoropentan-1-ol (5.491 g; 23.7 mmol) is added dropwise. The reaction suspension is warmed and stirred at room temperature for 46.5 h. After condensation in vacuo (10-3 mbar) at room temperature to 60 C. and double fractional distillation in vacuo (6.10-3 mbar) (b.p.: 31 to 32 C.), 2,2,3,3,4,4,5,5-octafluoropentyl bis-(pentafluoroethyl)phosphinate, (C2F5)2P(O)OCH2CF2CF2CF2CF2H, can be isolated as clear and colourless liquid (1.603 g; 3.1 mmol) in a yield of 13% and a purity of 98%. The isolated product is characterised by means of 1H, 19F and 31P NMR spectra in CD3CN. 1H NMR: delta in ppm: 6.44 t, t (1H), 2JH,F=51.1 Hz, 3JH,F=5.3 Hz; 5.11 t, d (2H), 3JH,F=12.9 Hz, 3JH,P=8.0 Hz. 19F NMR: delta in ppm: -81.3 m (6F); -121.7 m (2F); -123.8 m (4F); -125.5 m (2F); -130.7 m (2F); -139.4 d,m (2F), 2JH,F=51.1 Hz. 31P NMR: delta in ppm: 10.6 quin, m, 2JF,P=92.2 Hz.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Patent; MERCK PATENT GmbH; Ignatyev, Nikolai Mykola; Schulte, Michael; Jablonka, Christoph Alexander; Koppe, Karsten; Frank, Walter; US2015/45572; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 106-28-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of geraniol (1b, 4.45 g, 28.8?mmol) in dichloromethane (15?ml) were added DMAP (175?mg, 1.43?mmol) and acetic anhydride (6.0?ml, 63?mmol) and the mixture was stirred at room temperature under nitrogen for 1 h. After addition of methanol (10?ml), the reaction mixture was further stirred for 1 h, diluted with diethyl ether, washed twice with aq. 4% sodium hydrogen carbonate, distilled water, and brine, and dried over sodium sulfate. The solvents were evaporated and the residue was purified with FCC (hexane:ethyl acetate?=?20:1) to give geranyl acetate (2b, 4.04?g, 20.6?mmol) in 71% yield:

According to the analysis of related databases, 106-28-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tamiaki, Hitoshi; Nomura, Kota; Mizoguchi, Tadashi; Bioorganic and Medicinal Chemistry; vol. 25; 24; (2017); p. 6361 – 6370;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 61439-59-6 ,Some common heterocyclic compound, 61439-59-6, molecular formula is C15H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 3 d2-l-Benzyloxv-4-(2-methoxv-ethyl)-benzene-OH ^- ‘J ^-OCD3[00262] 2-(4-Benzyloxyphenyl)-ethanol (3.94 mmol) was added to a suspension of sodium hydride (11.3 mmol) in 9 mL of dry dimethylformamide at 0 C. d3-Methyl methanesulfonate (5.92 mmol) was added dropwise and the reaction mixture was stirred at ambient temperature overnight, quenched with water, and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, and the solvent was removed under reduce pressure to afford the title compound as an oil. Yield: 90%. 1H- NMR (CDCl3): delta7.35-7.47 (m, 5H); 7.18 (d, J = 8.1 Hz, 2H); 6.94 (d, J= 8.1 Hz, 2H); 5.07 (s, 2H); 3.60 (t, J= 6.6 Hz, 2H); 2.86 (t, J= 6.6 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2007/139923; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2077-19-2, 2-(4-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(4-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(4-Bromophenyl)propan-2-ol

To a 50 mL round-bottom flask were placed 2-(4-bromophenyl) propan-2-ol (5.10 g, 23.71 mmol), 2H-l ,2,3-triazole (3.28 g, 47.4 mmol), acetonitrile (10 mL) and iron (III) trichloride (1.50 g, 9.48 mmol). The reaction mixture was heated at 60C for 16 hours and then quenched by a saturated aqueous ammonium chloride solution (50 mL). The mixture was extracted with ethyl acetate (3 x 80 mL) and the combined organic layers dried over sodium sulfate and filtered. The filtrate was concentrated under vacuum to afford 3.50 g of the crude product mixture as a yellow oil that was then purified by prep-HPLC (ccolumn: X Bridge CI 8, 19 x 150 mm, 5 um; mobile phase A: water/0.05% trifluoroacetic acid, mobile phase B: acetonitrile; flow rate: 20 mL/min; gradient: 30%B to 70%B in 10 min; 220 nm) to give the title compounds: l-(2-(4-Bromophenyl)propan-2-yl)-lH-l ,2,3-triazole, LCMS (ESI) calc’d for CiiHi3BrN3 [M + H]+: 266, 268 (1 : 1), found 266, 268 (1 : 1); 1H NMR (400 MHz, CDC13) delta 7.68 (s, 2H), 7.43 (d, / = 8.8 Hz, 2H), 6.93 (d, / = 8.8 Hz, 2H), 2.10 (s, 6H); 2-(2-(4- Bromophenyl)propan-2-yl)-2H-l ,2,3-triazole, LCMS (ESI) calc’d for CnHi3BrN3 [M + H]+: 266, 268 (1 : 1), found 266, 268 (1 : 1); 1H NMR (400 MHz, DMSO-d6) delta 8.28 (s, 1H), 7.82 (s, 1H),7.54 (d, / = 8.4 Hz, 2H), 6.93 (d, / = 8.4 Hz, 2H), 2.02 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2077-19-2, 2-(4-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DINSMORE, Christopher; FULLER, Peter; GUERIN, David; KATZ, Jason David; THOMPSON, Christopher F.; FALCONE, Danielle; DENG, Wei; TORRES, Luis; ZENG, Hongbo; BAI, Yunfeng; FU, Jianmin; KONG, Norman; LIU, Yumei; ZHENG, Zhixiang; WO2014/146493; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts