Tag: M.W=200-300

Electric Literature of 20712-12-3, Adding some certain compound to certain chemical reactions, such as: 20712-12-3, name is (2-Amino-5-bromophenyl)methanol,molecular formula is C7H8BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20712-12-3.

(l) To a mixture of lithium aluminum hydride (2.6 g, 69 mmol) in diethyl ether (54 ml) was added dropwise 5-bromoanthranillic acid methyl ester (6.3 g, 27 mmol) in diethyl ether (54 ml) at Ot). The mixture was stirred at O1C for 3 hours. Then water (2.6 ml), 15 wtpercent aqueous solution of sodium hydroxide (2.6 ml) and water (7.8 ml) was addedsequentially at O1C. The mixture was filtrated through a pad of Celite, and concentrated in vacuo. The residue was dissolved into tetrahydrofuran (160 ml), and triethylamine (15 g, 150 mmol) was added. The mixture was cooled to Ot, and trichloromethyl chloroformate (2.9 g, 15 mmol) was added. The mixture was stirred at room temperature for 4 hours. The mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford crude product. This crude product was washed with diethyl ether to afford6-bromo-l,4-dihydro-2H”3,l-benzoxazin-2-one as a colorless solid (4.7g, 21 mmol, 77percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20712-12-3, (2-Amino-5-bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi; WO2011/19090; (2011); A1;,
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Application of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a magnetically-stirred solution of 7-hydroxycoumarin derivatives (2 mmol), aromatic aldehydes (2 mmol) and NEt3 (2 mmol) in THF (8 mL) a mixture of dialkyl acetylenedicarboxylate (2 mmol) in THF (2 mL) was added in 15 min. The reaction mixture was then allowed to stand at room temperature for 0.5-10 h. After completion of the reaction as indicated by thin-layer chromatography (TLC) (n-hexane/EtOAc, 1:1), the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (Merck, 230-400 mesh) using a mixture of n-hexane/EtOAc (1:1) as eluent to afford the pure product as a light yellow powder.

According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Asghari, Sakineh; Baharfar, Robabeh; Darabi, Samaneh Ahangar; Mohammadian, Reza; Journal of the Brazilian Chemical Society; vol. 26; 2; (2015); p. 218 – 223;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C17H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3

General procedure: A solution of the naphthol (1 mol equiv) and the appropriate 1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol (1 mol equiv), in the presence of pyridinium p-toluenesulfonate (PPTS) (5 mole %) and trimethyl orthoformate (2 mol equiv) in 1,2-dichloroethane (150 mL),was heated under reflux for up to 4 h (the reaction time being determined by TLC examination of the reaction mixture). The cooled solvent was removed under vacuum to afford the crude product, which was either purified by flash column chromatography or by crystallisation. The following compounds were obtained in this manner: 4.8.1. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9. 3-Benzoyl-6,6-bis(4-methoxyphenyl)-6H-benzo[h]furo[3,2-f]chromene 9 from 7 and 8 as pale pink microcrystals after crystallisation from EtOAc and hexane, 52.4%, mp 188 – 190C; upsilonmax 2831, 1651, 1606, 1506, 1351, 1236, 1173, 1028, 1017, 876, 836, 726, 706, 683, 663, 646 cm-1; deltaH (CDCl3) 3.76 (6H, s, OMe), 6.13 (1H, d, J9.9 Hz, 5-H), 6.82 e6.85 (4H, m, AreH), 7.44 e7.47 (4H, m, AreH),7.51 e7.65 (6H, m, AreH, 4-H), 7.93 e7.95 (2H, m, Ar eH), 8.02 (1H, s,2-H), 8.19 (1H, d, J 7.8 Hz, Ar eH), 8.45 (1H, d, J 8.1 Hz, AreH); deltaC(CDCl3) 55.22, 82.22, 110.56, 113.38, 117.80, 119.99, 121.17, 122.83,123.08, 123.64, 124.09, 125.90, 127.09, 127.11, 128.28, 128.62, 129.67,132.92, 137.34, 139.29, 145.27, 147.04, 151.68, 158.84, 190.48 (Found M+H+, 539.1844; C36H26O5 requires M+H+, 539.1853).

The synthetic route of 101597-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aiken, Stuart; Allsopp, Ben; Booth, Kathryn; Gabbutt, Christopher D.; Heron, B. Mark; Rice, Craig R.; Tetrahedron; vol. 70; 49; (2014); p. 9352 – 9358;,
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Synthetic Route of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: The reaction mixture was composed by a 3 mL solution of0.048 mmol 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol, 0.096 mmolacyl donor and 60 mg of enzyme (20% w/v) in solvent. The screeningreactions were performed in silicon carbide plates at temperaturesof 60-80 C, under magnetic stirring to obtain 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate (1H NMR (300 MHz, CDCl3)d 7.26 (dd, J = 8.3, 5.6 Hz, 5H), 7.03 (t, J = 8.5 Hz, 3H), 6.39 (q,J = 7.1 Hz, 3H), 2.09 (s, 3H), 1.66 (d, J = 6.9 Hz, 3H). In order toscreen the influence of the different reaction medium?s components,enzymes, solvent, acyl donor and temperature were evaluated.A 20 mL aliquot was transferred to a new vial and 980 mL ofethyl acetate was added and analyzed in the GC-FID.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; de Franca, Alexandre da S.; Silva, Marcus V.M.; Neves, Rebeca V.; de Souza, Stefania P.; Leao, Raquel A.C.; Monteiro, Carlos M.; Rocha, Angelo; Afonso, Carlos A.M.; de Souza, Rodrigo O.M.A.; Bioorganic and Medicinal Chemistry; vol. 26; 7; (2018); p. 1333 – 1337;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 25392-41-0

Sodium hydroxide (1.35 g, 34 mmol) was dissolved in water (8 mL), under ice bath was slowly added 4-(chloromethyl) -7-hydroxy-2H-benzopyran-2-one (2.5 g, 12 mmol) in water (6 mL). The mixture was stirred at room temperature for 1 hour and then reacted at 60 C for 4 hours. Concentrated hydrochloric acid (2.8 mL, 34 mmol) was added at 35 C, maintained at the temperature for 1 hour, then stirred at room temperature for 1 hour. The resulting solid was suction filtered and washed three times with water. The solid was dried to give the product as a white solid (1.2 g, 52% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one.

Reference:
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (37 pag.)CN104250239; (2016); B;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C7H6BrFO

[2-Amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone (?A4?) [0341] 74 mg of (2-bromo-5-fluorophenyl)methanol, 100 mg of potassium carbonate, 1 ml of water and 15 mg of [1,1?-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 150 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 3 ml of ethanol under argon. The mixture is heated at 120° C. for min; the hot mixture is filtered through kieselguhr, and the filtrate is evaporated in vacuo. The residue is purified by reverse-phase column chromatography. [0342] Yield: 8 mg (5percent) of [2-amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone; HPLC retention time: 1.51 min; [0343] 1H NMR (400 MHz, DMSO-d6/TFA-d1) delta [ppm] 8.08-8.02 (m, 2H), 7.81 (d, J=8.7, 1H), 7.42 (d, J=7.2, 1H), 7.39-7.25 (m, 4H), 7.24 (d, J=6.9, 1H), 7.16 (td, J=8.5, 2.8, 1H), 4.99 (s, 2H), 4.82 (s, 2H), 4.36 (s, 2H).

The synthetic route of 202865-66-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; Eggenweiler, Hans-Michael; Sirrenberg, Christian; Buchstaller, Hans-Peter; US2013/178443; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2425-41-4, blongs to alcohols-buliding-blocks compound. Safety of (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

To a solution of (5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)methanol (0.66 g) in DMF (10 mL) was added NaH (0.12 g). The mixture was stirred at RT for 1 hr. To the mixture was added 2-{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-ylmethyl methanesulfonate (0.7 g) prepared in Example 1 (7). The reaction mixture was stirred at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water, and then dried over MgSO4. The solvent was removed under reduced pressure to give the crude title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2425-41-4, its application will become more common.

Reference:
Patent; JAPAN TOBACCO INC.; US2010/331301; (2010); A1;,
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Synthetic Route of 25392-41-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows.

4-Chloromethylcoumarin 12c (2.1g, 10mmol) was dissolved in dry DMF (35mL) and then Cs2CO3 (3.9g, 12mmol) was added followed by 3-chlorobenzyl bromide (1.3mL, 10mmol) after 15min of stirring. The mixture was stirred at room temperature for 24h and then poured onto crushed ice. The resulting solid was filtered, washed several times with hot water and crystallized from CHCl3/n-hexane yielding the desired product. Yield: 87%. Spectroscopic and analytical data are in full agreement with those reported in the literature [39].

According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
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Electric Literature of 19936-14-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 19936-14-2 as follows.

A mixture of 5,5,5′,5′-tetramethyl-2,2′-bi(1,3,2-dioxaborinane) (16.50 g, 48.33 mmol), oven dried potassium acetate (20.03 g, 204.1 mmol), and 1-(4-bromophenyl)cyclobutanol (10.00 g, 44.03 mmol) in 1,4-dioxane (120 mL) was degassed with N2 for 15 min, then treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (2.44 g, 2.99 mmol). The reaction mixture was heated to 110 C. and stirred for 2 hours under N2. The reaction mixture was cooled to room temperature and filtered through celite, eluting with EtOAc. The filtrate was evaporated to give a black oil, which was purified by flash chromatography (0-50% EtOAc/Heptane) three times to afford the title compound (8.68 g, 76%) as a white solid. GC/MS: 259. 1H NMR (400 MHz, CD3Cl) delta 7.83 (d, J=8.05 Hz, 2H), 7.50 (d, J=8.29 Hz, 2H), 3.78 (s, 4H), 2.65-2.52 (m, 2H), 2.38-2.42 (m, 2H), 1.98-2.03 (m, 1H), 1.72-1.80 (m, 1H), 1.03 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19936-14-2, its application will become more common.

Reference:
Patent; PFIZER INC.; Bhattacharya, Samit; Cameron, Kimberly; Dowling, Matthew; Fernando, Dilinie; Ebner, David; Filipski, Kevin; Kung, Daniel; Lee, Esther; Smith, Aaron; Tu, Meihua; US2013/267493; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C12H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 17701-61-0

tert-Butyl phthalate (5.38 g) was dissolved in toluene (50 ml). To this solution were successively added triethylamine (3.7 ml) and diphenylphosphoryl azide (5.7 ml) and the mixture was heated to 130C and stirred for 1 hr. The reaction mixture was allowed to cool to room temperature and 3-hydroxy-2,2-dimethylpropionic acid benzyl ester obtained in Example 1-4 a) (4.95 g) was added. The mixture was stirred at room temperature for 17 hr. The reaction mixture was diluted with ethyl acetate (50 ml), washed successively with water (50 ml) and saturated aqueous sodium chloride solution (5 ml), dried and concentrated under reduced pressure. The obtained oily substance was purified by silica gel column chromatography (n-hexane/ethyl acetate=1:1). The oily substance (3.28 g) after purification was dissolved in dichloromethane (30 ml). This solution was cooled to 0C and trifluoroacetic acid (30 ml) was added. The mixture was heated to room temperature and stirred for 3 hr. The reaction mixture was concentrated under reduced pressure, after which water (50 ml) was added, and the mixture was extracted with ethyl acetate (150 ml). The organic layer was washed successively with water (50 ml×3) and saturated aqueous sodium chloride solution (50 ml), dried and concentrated under reduced pressure. The obtained oily substance was purified by column chromatography to give the title compound (2.54 g, yield 89%) as a colorless oil.1H-NMR(delta, 300MHz, DMSO-d6) 1.22(6H,s),4.20(2H,s), 5.13(2H,s),7.12(1H,m),7.25-7.34 (5H,m),7.60(1H,m), 7.99(1H,dd,J=1.6,7.9Hz),8.23(1H,d,J=7.9Hz),10.72(1H,s),13.63(1 H,brs).

With the rapid development of chemical substances, we look forward to future research findings about 17701-61-0.

Reference:
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
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