Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H9BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H9BrO

(1) 6-Bromoindan-1-ol (3.01 g) and dihydropyrane (1.78 g) are dissolved in dichloromethane (50 ml), and thereto is added pyridinium p-toluenesulfonate (178 mg), and the mixture is stirred at room temperature for 1.5 hour. The reaction solution is washed with a saturated aqueous sodium hydrogen carbonate solution, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate) to give 6-bromo-1-tetrahydropyranyloxyindane (4.10 g). MS (m/z): 296, 298 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tanabe Seiyaku Co., Ltd.; US5830873; (1998); A;,
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Application of 202865-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, molecular weight is 205.02, as common compound, the synthetic route is as follows.

General procedure: 2-Halobenzyl tosylates 1a-e were prepared from the corresponding 2-halobenzyl alcohols according to the procedure of Wallace et al.38 p-TsCl (3.2 mmol) was added to a stirred solution of the 2-halobenzyl alcohol (2.7 mmol) in Et2O (15 mL) at 0 C. After addition of freshly powdered KOH (27 mmol) in small portions, the reaction mixture was stirred for 3 h at room temperature. The ethereal solvent was removed in vacuo and the reaction mixture was poured into water (50 mL). The precipitate formed was collected by filtration and purified by flash chromatography over silica gel.

Statistics shows that 202865-66-5 is playing an increasingly important role. we look forward to future research findings about (2-Bromo-5-fluorophenyl)methanol.

Reference:
Article; Omar, Mohamed A.; Conrad, Juergen; Beifuss, Uwe; Tetrahedron; vol. 70; 35; (2014); p. 5682 – 5695;,
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Application of 4654-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below.

Triethylamine (5.2 mL, 37.3 mmol) was added to a solution of 4-bromophenethyl alcohol (5.0 g, 24.9 mmol) in CH2Cl2 (200 ml), and the resulting solution was cooled to 0 C. with an ice bath. Methanesulfonyl chloride (2.7 ml, 34.8 mmol) was added dropwise to the reaction mixture, and the resulting solution was allowed to warm slowly to room temperature overnight. The solution was washed with 0.1 N HCl and brine, and the combined organic extracts were dried over anhydrous MgSO4(s) and filtered, and the solvent was removed under reduced pressure. The crude yellow solid was purified by flash chromatography (silica gel, 70% v/v hexanes in CH2Cl2) to give mesylate 18 as a white solid in 98% yield. 1H NMR (CDCl3, 400 MHz) delta 7.46 (d, J) 8.5 Hz, 2H), 7.12 (d, J) 8.6 Hz, 2H), 4.39 (t, J) 6.9 Hz, 2H), 3.02 (t, J) 6.7 Hz, 2H), 2.89 (s, 3H) ppm; 13C NMR (CDCl3, 125 MHz) delta 135.55, 132.52, 130.92, 121.70, 69.83, 37.68, 35.31 ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Wisconsin Alumni Research Foundation; Raines, Ronald T.; Tam, Annie; Soellner, Matthew B.; US8410247; (2013); B2;,
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Electric Literature of 172023-97-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 172023-97-1 as follows.

Step 2: 3-bromo-5-(trifluoromethyl)benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate To a stirred solution of (3-bromo-5-(trifluoromethyl)phenyl)methanol (567 mg, 2.223 mmol) in DMF (5 mL) at RT under nitrogen was added CU (360 mg, 2.223 mmol) and the reaction mixture heated at 50 C. for 20 hours. Tert-butyl piperidin-4-yl carbamate (445 mg, 2.223 mmol) was added and the reaction mixture stirred at 50 C. for 3 hours. On cooling to RT the mixture was diluted with DCM and washed with a saturated solution of sodium bicarbonate, a saturated solution of brine, and the organic portion was dried over MgSO4 filtered and concentrated under reduced pressure. Purification was carried out by chromatography on silica using 0-100% EtOAc in Hexanes as eluent to afford the title product; LC-MS: Rt 1.59 mins; MS m/z 427.2 [M-tBu]+; Method 2minLowPHv03

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,172023-97-1, its application will become more common.

Reference:
Patent; Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily; US2014/171403; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1611-56-9, 11-Bromoundecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1611-56-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 1611-56-9

General procedure: Tetrahydropyranylation reactions were carried out in a round bottom flask equipped with a reflux condenser, a CaCl2 tube and a magnetic stirring bar. To a solution of 1.0 × 10-2 mol of compound 1 in 2.5 mL of the solvent (CPME or 2-MeTHF) were added 1.1 × 10-2 mol (0.93 g, 1.0 mL) of 2,3-dihydropyran (2) and the required amount of the catalyst (3.3 × 10-4 or 3.3 × 10-5 mol; see Table 1 and Schemes 1 and 2). The resulting mixtures were vigorously stirred for the reported time at the reported temperature (Table 1 and Schemes 1 and 2). The crude mixtures were filtered, the solvent evaporated and the crude product analyzed by 1H-NMR spectroscopy to determine the conversion of compound 1, then purified and characterized as reported below.

The synthetic route of 1611-56-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Azzena, Ugo; Carraro, Massimo; Modugno, Gloria; Pisano, Luisa; Urtis, Luigi; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1655 – 1659;,
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Related Products of 2215-78-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2215-78-3, name is (4-Phenoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

PRODUCTION EXAMPLE 4 Production of Compound (35) by Production Process E To a solution of 0.46 g of 4-(3,3-dichloro-2-propenyloxy)-2,6-dichlorophenol, 0.32 g of p-phenoxybenzyl alcohol and 0.46 g of triphenylphosphine dissolved in 10 ml of tetrahydrofuran was added dropwise a solution of 0.35 g of diisopropylazodicarboxylate dissolved in 5 ml of tetrahydrofuran, while stirring at room temperature. After stirring at room temperature for 12 hours, the reaction mixture was concentrated, and then mixed with 20 ml of diethyl ether. The precipitate was filtered, and the filtrate was concentrated. The residue was subjected to silica gel chromatography, which afforded 0.51 g of 3,5-dichloro-4-(4-phenoxybenzyl)-1-(3,3-dichloro-2-propenyloxy)benzene (68% yield), nD25.5 1.6084.

According to the analysis of related databases, 2215-78-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sumitomo Chemical Company, Limited; US5872137; (1999); A;,
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Reference of 24034-73-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, molecular formula is C20H34O, molecular weight is 290.4834, as common compound, the synthetic route is as follows.

[0270] The resulting 2E-conjugated ester 8 was reduced to the corresponding 2E-alcohol 9 by means of a lithium aluminum hydride (LAH) treatment, which was then converted into the corresponding 2E,6E, 10E-geranylgeranyl bromide 10 by means of phosphorus tribromide (PBr3) treatment in ethyl ether (EE) or with Ph3P and CBr in acetonitrile (ACN) at 0C. Furthermore, the interaction of carbanion (derived from ethyl acetoacetate 5 and sodium ethoxide) with the bromide 10 at 0C afforded the desired 2E,6E,10E-geranylgeranyl ketoester 11, a precursor needed for 5E,9E,13E-geranylgeranyl acetone 1. The subsequent ester hydrolysis and decarboxylation of ketoester 11 using aq. 5N KOH at 80C yielded the requisite 5E,9E,13E-geranylgeranyl acetone 1. TLC Rf: 0.28 (5% Ethyl Acetate in Hexanes); LC Retention time: 16.68 min; MS (m/e): 313 [M – 18 + H]+, 331 [MH]+, 353 [M + K]. Example 2: S-Z.SE.IBE-Geranylgeranyl Acetone Synthesis Scheme 2

The chemical industry reduces the impact on the environment during synthesis 24034-73-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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Adding a certain compound to certain chemical reactions, such as: 13826-35-2, (3-Phenoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13826-35-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 13826-35-2

General procedure: 4-Phenylphenol 2 (34.0mg, 0.2mmol) and cesium carbonate (97.7mg, 0.3mmol) were weighed to a sealed Schlenk (25mL) under Ar atmosphere. Pentafluorobenzene 1a (50.4mg, 0.3mmol) and DMSO (2.0mL) were added to the sealed Schlenk via syringe at room temperature respectively. The mixture was stirred at room temperature until the completion of the reaction (by TLC). Water (5mL) was added and the mixture was extracted with ethyl acetate (3×10mL). The organic extracts were combined, dried with anhydrous magnesium sulfate and then concentrated in vacuo. The residue was purified on silica gel to afford the product 3o (54.1mg, 85% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13826-35-2, its application will become more common.

Reference:
Article; Liu, Cuibo; Cao, Liming; Yin, Xuguang; Xu, Haolan; Zhang, Bin; Journal of Fluorine Chemistry; vol. 156; (2013); p. 51 – 60;,
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Adding a certain compound to certain chemical reactions, such as: 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 329218-12-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 329218-12-4

Step 2:260 g (crude product of several batches, about 1.05 mol) of (3-bromo-4-chlorophenyl)methanol were dissolved in 2.86 litres of dichloromethane, the mixture was cooled to -5 C. and 127.1 g (44.6 ml, 459.6 mmol) of phosphorus tribromide were added slowly. After the addition had ended, the mixture was stirred at -5 C. for another 1 h and then diluted with dichloromethane and water. The organic phase was separated off, dried over magnesium sulphate and concentrated under reduced pressure. This gave, as a crude product, 280.5 g (about 84% of theory) of 2-bromo-4-(bromomethyl)-1-chlorobenzene.GC-MS (Method 1): Rt=5.36 min; m/z=281/283/285 (M+H)+.1H-NMR (400 MHz, DMSO-d6): delta [ppm]=4.71 (s, 2H), 7.49 (dd, 1H), 7.63 (d, 1H), 7.89 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,329218-12-4, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; US2012/172448; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

Example 1; 1.15 g (2.33 mmol) of a naphthol compound represented by the following formula (15) and 0.92 g (3.43 mmol) of a propargyl alcohol compound represented by the following formula (16) were dissolved in 50 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added, and the obtained mixture was refluxed for 1 hour. After the reaction, the solvent was removed, the obtained product was purified by column chromatography, and crystallization was carried out with methanol (5 ml) to obtain 1.21 g of a white powder (yield rate of 70 %). The elemental analysis values of this product were 75.66 % of C, 6.44 % of H and 3.71 % of N which were almost equal to the calculated values of C47H47F3N2O3 (C: 75.78 %, H: 6.36 %, N: 3.76 %). When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 31H peaks based on an alkyl group and an alkoxy group at delta of around 0.5 to 4.5 ppm and a 16H peak based on an aromatic proton at delta of around 5.0 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm and peaks based on the carbons of an alkyl group and an alkoxy group at delta of around 10 to 80 ppm. It was confirmed from the above results that the isolated product was a compound represented by the following formula (17).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tokuyama Corporation; EP2457915; (2012); A1;,
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