Tag: M.W=200-300

Related Products of 722-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: To the solution of substituted aniline (7 or 21, 10.0 mmol) in pyridine (1 M) at room temperature, aryl sulfonyl chloride (10,10.5 mmol) was added. The mixture was allowed to stir at room temperature for overnight. After the complete consumption of thesubstituted aniline (monitored by TLC), the reaction mixture wasquenched with water, and the aqueous layer was extracted with dichloromethane. The combined organic layer was washed withaqueous copper sulfate. The organic layer was then dried over sodiumsulfate, filtered, and concentrated under reduced pressure.The obtained residue was purified by silica gel (100e200) columnchromatography using n-hexane: EtOAc as an eluent to get phenylbenzene sulfonamides 11, 22.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Article; Padala, Anil K.; Wani, Abubakar; Vishwakarma, Ram A.; Kumar, Ajay; Bharate, Sandip B.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 744 – 755;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C11H9BrO

stirring to (6-bromonaphthalen-2-yl)methanol (18.1 g, 76.7 mmol, 1.00 eq.) at 0 CPCC (34.6 g, 92.0 mmol, 1.20 eq.) was added portionwise in DCM (300 mL).The mixture was stirred at room temperature for 16 hours and then filtered.The filtrate was concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether: DCM = 10-70%).6-Bromonaphthalene-2-carbaldehyde (12.8 g, a two-step yield of 68%) was obtained as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 100751-63-1.

Reference:
Patent; Huazhong University of Science and Technology; Zhu Mingqiang; Wang Yalong; Li Chong; Fan Cheng; (28 pag.)CN108530392; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H20O5, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H20O5

Synthesis of 2,5,8,11-tetraoxatridecan-13-ol Tosylate Procedure: (JACS, 2007, 129, 13364) To a solution of 2,5,8,11-tetraoxatridecan-13-ol (7 g, 33.6 mmol) and triethylamine (4.9 ml, 35.3 mmol) in dry CH2Cl2 (100 ml), 4-toluenesulfonyl chloride (6.7 g, 35.3 mmol) and DMAP (120 mg) were added. The mixture was stirred at room temperature for 20 h. The reaction mixture was washed with 80 mL of HCl (1M) and then water. The extract was dried over anhydrous MgSO4, filtrated, and the filtrate was evaporated. The residue was used in the next step without further purification. Yield: 11.0 g (90%) NMR: 1H NMR (400 MHz, CDCl3) delta 7.75-7.64 (m, 2H), 7.31-7.26 (m, 2H), 4.16-4.06 (m, 2H), 3.62 (m 2H), 3.59-3.40 (m, 10H), 3.30 (s, 3H), 2.38 (s, 3H). 13C{1H} NMR (101 MHz, CDCl3) delta 144.75 (s), 132.90 (s), 129.77 (s), 127.8 (s), 71.82 (s), 70.60 (s), 70.48 (s), 70.47 (s), 70.41 (s), 70.39 (s), 69.23 (s), 68.55 (s), 58.90 (s), 21.53 (s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23783-42-8, 2,5,8,11-Tetraoxatridecan-13-ol, and friends who are interested can also refer to it.

Reference:
Patent; Bergmann, Frank; Cysewski, Robert; de Cola, Luisa; Dziadek, Sebastian; Fernandez Hernandez, Jesus Miguel; Josel, Hans-Peter; Seidel, Christoph; US2015/147750; (2015); A1;,
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Application of 149965-40-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(2-Chloro-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl)methanol A suspension of (5-bromo-2-chlorophenyl)methanol (2.08 g, 9.39 mmol), potassium acetate (3.50 g, 35.7 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1 ,3,2-dioxaborolane) (2.77 g, 10.89 mmol) degassed with a stream of nitrogen for ~10 mins after which time bis(triphenylphosphine)palladium(ll) chloride (0.396 g, 0.563 mmol) was added and the mixture was heated to 120 C for 30 minutes in a microwave at high power. After this time, the suspension was cooled and filtered through celite using ethyl acetate to wash the celite. The dark colored solution was washed with water (4x gently), brine (1x), dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give the title compound (2.76g, 68.9%), LC-MS m/z 267.7 (M+H)+, 1 .0 minutes (ret time), 63 % purity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 149965-40-2, (5-Bromo-2-chlorophenyl)methanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; LI, Tindy; YAN, Hongxing; HEIGHTMAN, Thomas Daniel; WOOLFORD, Alison Jo-Anne; GRIFFITHS-JONES, Charlotte Mary; WILLEMS, Hendrika Maria Gerarda; (109 pag.)WO2016/203400; (2016); A1;,
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Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(synthesis of chromene compound) [0128] 1.18 g (2.0 mmol) of the above naphthol compound (15) and 0.81 g (3.0 mmol) of the following propargyl alcohol compound were dissolved in 50 ml of toluene, and 0.02 g of camphorsulfonic acid was added to the resulting solution and stirred under heating and reflux for 1 hour. After a reaction, the solvent was removed, and the obtained reaction product was purified by chromatography on silica gel to obtain 1.17 g of a white powder product. The yield was 70 %. [0129] The elemental analysis values of this product were 84.59 % of C and 5.93 % of H which were almost equal to the calculated values of C59H50O5 (C: 84.46 %, H: 6.01 %). [0130] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 20H peaks based on a methyl proton and a methylene proton at delta of around 1.0 to 4.0 ppm and 30H peaks based on an aromatic proton and an alkene proton at delta of around 5.5 to 9.0 ppm. [0131] Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm, and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0132] It was confirmed from the above results that the isolated product was a compound represented by the following formula (E1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tokuyama Corporation; IZUMI, Shinobu; TERANISHI, Kazuhiro; DAIKOKU, Yusuke; SANDO, Mitsuyoshi; EP2725017; (2014); A1;,
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Application of 65735-71-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65735-71-9, name is (4-Chloro-3-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(4-Chloro-3-(trifluoromethyl)phenyl)methanol (5.1 g, 24.22 mmol) was added in small portions to SOCl2 (20 mL, 275 mmol). The reaction was stirred at 50 0C for 18 h and then under reflux for 23 h. The mixture was concentrated and dried under high vacuum to give the title compound as a colorless liquid (5.41 g). 1H NMR (400 MHz, CDCl3) delta ppm 4.58 (s, 2H), 7.50- 7.51(1-1, 2H), 7.71 (s, IH).

According to the analysis of related databases, 65735-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, Daniel J.; SCHRADER, Thomas O.; KASEM, Michelle; ZHU, Xiuwen; JOHNSON, Benjamin R.; LEHMANN, Juerg; HAN, Sangdon; KAWASAKI, Andrew M.; WO2011/5295; (2011); A1;,
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Application of 2077-19-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.09, as common compound, the synthetic route is as follows.

[0168] A mixture of 2-( 4-bromophenyl)propan-2-ol (2.80g, 13.0 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane)(3.30 g, 13.0 mmol),AcOK (2.60 g, 26.0mmol)and Pd(dppf)Cl2 (476 mg, 0.65 mmol) in dioxane (60 mL)was stirred at 80 C. for2 hrs underN2 .After HPLC and TLC(PE:Et0Ac=3: 1) showed the reaction was complete, the mixturewas concentrated and purified by MPLC to give the titlecompound (2.00 g, yield: 58.8%) as a white solid.

Statistics shows that 2077-19-2 is playing an increasingly important role. we look forward to future research findings about 2-(4-Bromophenyl)propan-2-ol.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Hodous, Brian L.; (150 pag.)US2016/31892; (2016); A1;,
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Reference of 24034-73-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below.

This reaction isanalogous to a published procedure,1 with somemodifications as described below. To a stirred solution of geranylgeraniol2 (8, 651 mg, 2.24mmol) and VO(C5H7O2)2 (6 mg, 0.02 mmol) in 1,2-dichloroethane (3 mL), tert-butylhydroperoxide (70 wt% in H2O, 0.35 mL, 2.45 mmol) was added dropwise. The reaction washeated at reflux for 1.5 hours and then allowed to cool to room temperature. After Na2SO4 wasadded to the reaction mixture, it was filtered, the solid was rinsed with EtOAc, and the filtratewas concentrated in vacuo. Purification by flash chromatography (8% EtOAc in hexanes)afforded epoxide 9 (387 mg, 56%) as a clear oil. The 1H NMR and 13C NMR data wereconsistent with literature data.3 The resonance at 16.0 ppm should be labeled as 2C in theliterature report.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Wills, Veronica S.; Zhou, Xiang; Allen, Cheryl; Holstein, Sarah A.; Wiemer, David F.; Tetrahedron Letters; vol. 57; 12; (2016); p. 1335 – 1337;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5391-88-8, name is 1-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1-(4-Bromophenyl)ethanol

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

With the rapid development of chemical substances, we look forward to future research findings about 5391-88-8.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.64372-62-9, name is 2-Chloro-5-(trifluoromethyl)benzyl alcohol, molecular formula is C8H6ClF3O, molecular weight is 210.58, as common compound, the synthetic route is as follows.Safety of 2-Chloro-5-(trifluoromethyl)benzyl alcohol

Step 1 : Suzuki Coupling Reaction of Boronic Acid 5 and Aryl Chloride 13 to yield 6: A 3 M K2CO3 solution is prepared by adding 4.71 kg of solid K2CO3 to 10.3 L water. Cooling is applied to keep the solution at 20-25 0C. THF (12 L), aryl chloride 13 (2.69 kg), and boronic acid 5 (2.74kg) are added to the K2CO3 followed by a 1 L THF rinse. HPLC analysis is used to confirm the 1.00/1.00 ratio of 5/13. The solution is degassed by sparging with nitrogen gas for 70 min. The catalyst, 1,1 bis(di-tert- butylphosphino)ferrocene palladium dichloride (42g) is added as a solid and is followed by a degassed THF rinse (1.5 L). The organic layer turns dark brown immediately. The biphasic mixture is aged at 36-40C with vigorous stirring. After HPLC reveals complete conversion (15-18 h), the mixture is cooled to rt and the aqueous layer is removed. To the organic layer is added heptane (25.6L) and water (25.6 L) and the layers are cut. The organic layer is washed with water (19L). The organic layer is treated with 680 g Darco KB-B at rt for 60 min and filtered through solka-floc with a 10%THF/Heptane rinse (-15 L). The solvent is switched to heptane (-35 L) at -45-50 0C until <0.5v% of THF is left. More heptane is added to bring the total volume to -45-50 L. The solution is seeded with crystals obtained from earlier runs if no seed bed forms. The slurry is slowly cooled to rt and then to -15 0C. After aging at -15 0C for 1-2 h, after LC of the supernatant shows that there will be ~2g/l loss of the product in the supernatant, the slurry is filtered and the product is washed with cold heptane (-25 L), providing compound 6. At the same time, in my other blogs, there are other synthetic methods of this type of compound,64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol, and friends who are interested can also refer to it. Reference:
Patent; MERCK & CO., INC.; WO2007/5572; (2007); A1;,
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