Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 13826-35-2, (3-Phenoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (3-Phenoxyphenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (3-Phenoxyphenyl)methanol

In 1000ml four-necked flask (equipped with lye absorption device) was added 500g of dichloromethane, stirring was started to continue the addition of 100g m-phenoxybenzyl alcohol and 30g of tetramethylethylenediamine.Cooling to -35 C, began to drop prepared 70g of thionyl chloride and methylene chloride solution. During the dropwise addition temperature was controlled at -45 C. After the addition was completed at -45 heat 4h. After that, the reaction solution was pouredInto 1000ml of water, stirring, phase separation, the organic phase were washed with 600ml of water, phase separation. The organic phase was desolvated to 100 C under atmospheric pressure and the solvent methylene chloride was recovered. Then decompression (vacuum degree 0.097MP) fractionation, intermediates chloroacenesulfonic acid phenoxybenzyl 127g. Purity 99%, yield 90%.

The synthetic route of 13826-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianjin Jinlvbao Pesticide To Make Co., Ltd.; Wang Baojun; Cui Weizhong; Lu Sen; (8 pag.)CN106495994; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, blongs to alcohols-buliding-blocks compound. name: (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol

Example 11. Synthesis of Acetic acid 3,7,11-trimethyl-dodeca-2,6,10-trienyl ester, or Farnesyl acetate To a solution of farnesol (100g, 0.45 mol), potassium carbonate (90 g, 0.65 mol) and 4-dimethylamino pyridine (0.5 g) in EtOAc (300 ml) at 0C, acetic anhydride (66.5 g, 0.65 mol) was added dropwise. The reaction was finished in 2 hrs. All the contents of the reaction flask were transferred to a conical flask containing EtOAc (600 ml) and treated with the dropwise addition of a saturated NaHCO3 solution. After neutralization, the organic layer was separated and washed with water (2 x 80 ml), brine (80 ml), and dried over MgSO4 and then removed under vacuum to yield the farnesyl acetate (108 g, 92%). 1H NMR(400 MHz, CDCl3): 5.34 (t, 1H, J = 6.04 Hz), 5.07 (m, 2H), 4.57 (d, 2H, J = 6.84 Hz), 2.10-2.05 (m, 11H), 1.97-1.95 (m, 2H), 1.68-1.66 (m, 6H), 1.58 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106-28-5, (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mehta, Dilip; Eburon Organic International; Mohan, Priya; Shastri, Mayank; Reid, Ted; EP2868658; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 1113-21-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, molecular formula is C20H34O, molecular weight is 290.48, as common compound, the synthetic route is as follows.

The 5E, 9E, 13E-geranyl geranyl acetone (1) can be prepared by reacting 6E-10E-geranyl linalool (23) with diketene (24) catalyzed by DMAP in ethyl ether to give the ester 25. The ester 25 in the Carroll rearrangement using Al(OiPr)3 at elevated temperature can afford the desired 5E, 9E, 13E-geranyl geranyl acetone (1). In another approach, the GGA (1) can be prepared by treating geranyl linalool (23) with the Meldrum’s acid 26 in the Carroll rearrangement using Al(OiPr)3 at 160 C. Similarly, the use of tert-butyl acetoacetate (27) with geranyl linalool (23) in the Carroll rearrangement can also give the desired 5E,9E,13E-geranyl geranyl acetone (1).

Statistics shows that 1113-21-9 is playing an increasingly important role. we look forward to future research findings about 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol.

Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; Look, Gary C.; US2015/133431; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.Safety of 3-(3-(Trifluoromethyl)phenyl)propan-1-ol

Example 2 Synthesis of 3-[3-(trifluoromethyl)phenyl]-propionaldehyde (II) A solution of compound (V) (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in water/ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20 C. The reaction mixture is then cooled in water/ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while temperature raises to 20 C. After one hour the mixture is treated with 5% HCl, the phases are separated and the organic one is further washed with 5% HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure, to afford 0.99 g of the aldehyde of formula (II) in quantitative yield. 1H NMR (300 MHz, CDCl3), ppm: 9.83 (t, 1H, J 0.9 Hz), 7.48-7.38 (m, 4H), 3.02 (t, 2H, J 7.2 Hz), 2.82 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2215-78-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2215-78-3, name is (4-Phenoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

To a solution of (4-phenoxy-phenyl)-methanol (408 mg, 2.04 mmol) in carbon tetrachloride (8.2 mL) was added triphenylphosphine (642 mg, 2.45 mmol) under nitrogen atmosphere at room temperature, and the reaction solution was stirred under reflux for 7 hours and 40 minutes. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (409 mg, 92%). 1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.76 (2H, s), 6.98-7.05 (4H, m), 7.15-7.19 (1H, m), 7.39-7.46 (4H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2215-78-3, (4-Phenoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 756520-66-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 756520-66-8

To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 145691-59-4 ,Some common heterocyclic compound, 145691-59-4, molecular formula is C7H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring cloudy solution of 2.41 g (9.04 mmol) of (3,5-dibromophenyl)methanol in 40 mL of CH2Cl2 at r.t. was added 1.4 mL of Et3N and 62.7 mg of DMAP. The solution was cooled to 0 0C and 1.0 mL of MsCl was added, and the solution was gradually allowed to warm to r.t. After 24.5 h, the organic layer was washed with water (20 mL) and brine (15 mL), dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (5% EtOAc/hexanes) provided 1.88 g of l,3-dibromo-5- (chloromethyl)benzene as a yellow oil in 73 % yield and 476 mg of the mesylate (35% EtOAc/hexanes) as a pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 145691-59-4, (3,5-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32328-03-3, name is Diethyl 3-hydroxyglutarate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C9H16O5

Diethyl 3-hydroxy glutarate (6, 25g, 122.4 mmol) in TetaF (100 mL) was added dropwise to a IM solution OfLiAlH4 in THF (400 mL) at 0 0C under argon atmosphere with vigorous stirring. After addition, reaction mixture was allowed to reach r. t. (~4 h) and stirred for overnight. The reaction mixture was cooled to -78 0C (acetone/dry ice bath) and quenched by dropwise addition of saturated NH4Cl solution (50 rnL) giving white precipitate. The reaction mixture was diluted with another 500 mL of THF and white precipitate was filtered through Celite. The precipitate was treated with boiling THF (250 mL) and filtered. The combined organic solution was dried over anhydrous MgSO4 and solvent removed by rotoevaporation. The residue was purified on a silica gel flash column chromatography using DCM/EtOAc/methanol (6:3:1) affording triol 7 (11.4 g, 95.5 mmol, 78%) as a colorless oil. %). 1H-NMR (DMSO-d6, 400 MHz): deltal.39-1.54 (m, 4H, -CH2CH(OH)CH2-), 3.47 (t, J= 6.6, 4eta, 1 & 5 -CH2-), 3.61-3.68 (m, 1eta, -CH(HO)-) and 4.23 (bs, 3H, 1,3 & 5-OH).

With the rapid development of chemical substances, we look forward to future research findings about 32328-03-3.

Reference:
Patent; IDERA PHARMACEUTICALS, INC.; WO2008/73959; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2043-47-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. A new synthetic method of this compound is introduced below.

Example 5In a 200-ml, three-necked glass reactor were placed 80 ml of toluene, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 5 g (69 mmol) of acrylic acid, 7 g (61 mmol) of methanesulfonic acid chloride and 0.1 g of a polymerization inhibitor, Sumilizer GM. While the reaction temperature was kept at 40 C. or lower, 15 g (149 mmol) of triethylamine was added dropwise. After the completion of the dropwise addition, stirring was conducted at room temperature for 1 hour. At this point, the conversion was 98% and the selectivity was 99%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol, and friends who are interested can also refer to it.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 149965-40-2, Adding some certain compound to certain chemical reactions, such as: 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol,molecular formula is C7H6BrClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 149965-40-2.

A mixture of 5-bromo-2-chlorobenzyl alcohol (2.22 g), tert-butyldimethylsilyl chloride(2.26 g), imidazole (1.36 g) and DMF (25 ml) was stirred at ambient temperature for 1 hour.The mixture was evaporated and the residue was partitioned between ethyl acetate and water.The organic phase was washed in turn with water and with a saturated brine solution, driedover anhydrous sodium sulphate and evaporated. The residue was purified by columnchromatography on silica using an increasingly polar gradient of from 0% to 40% ethyl acetatein isohexane as eluent. There was thus obtained 3-ter^butyldimethylsilyloxymethyl-4-chlorobromobenzene as an oil (2.78 g) which was used without further purification.

According to the analysis of related databases, 149965-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/5914; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts