Tag: M.W=100-200

Synthetic Route of 2009-83-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound [MA11-1] (50.00 g, 256 mmol) was added to a 2 L four-necked flask,6-chloro-1-hexanol (36.74 g,268 mmol), potassium carbonate (106.2 g, 768 mmol), potassium iodide (21.3 g, 128 mmol),DMF (500 g) was heated at 85C.Reaction tracing by HPLC,After confirming the end of the reaction,The reaction solution was poured into distilled water (3L).Filtration, washing with distilled water,Crude product was obtained.After that, the resulting crude product is washed with methanol and filtered.After drying under reduced pressure, 61.9 g of compound [MA11-2] was obtained (yield 82%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2009-83-8, 6-Chlorohexan-1-ol.

Reference:
Patent; Richan Chemical Industry Co., Ltd.; Gongli University Faren Bingku Li University; Hou Tenggengping; Shan Zhineiyangyi; Nan Wuzhi; Ming Mudazai; Wan Daichunyan; Lu Zeliangyi; Gen Mulongzhi; Ying Yetingdannierandongni; Sen Neizhengren; Chuan Yeyongtai; Chuan Yuexihong; Jin Tengruisui; (73 pag.)CN107473969; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 1450754-41-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450754-41-2, name is 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol, molecular formula is C7H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-picolinic acid (0.065) with a monocarboxylic acid g, 0.145mmol)Dissolved in 3mL anhydrous tetrahydrofuran solution,Add EDC·HCl (0.04 g, 0.218 mmol),HOBT (0.024g, 0.174mmol)Stir well at 0 C,Then DIPEA (0.094 g, 0.725 mmol) was added dropwise and stirred for 1 h.A linker (0.02 g, 0.145 mmol) containing a photoaffinity group diaziridine and an alkynyl group was added.Stir at room temperature for 24 h, after the reaction is over,The organic solvent was removed by a low pressure, and the mixture was washed with water and saturated aqueous sodium hydrogen carbonate. The organic phase obtained after washing with saturated brine was dried over anhydrous sodium sulfate and evaporated. Separating the crude product by column separation,The title compound was obtained by eluting with petroleum ether / ethyl acetate (V/V = 1/3), weight: 0.12 g, yield 14.7%.A compound represented by the general formula (X) based on the VEGFR-2 inhibitor sorafenib photoaffinity probe was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1450754-41-2, 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Lu Wen; Wang Sicen; Pan Xiaoyan; He Langchong; Sun Ying; Wang Jin; Song Jie; (9 pag.)CN109456261; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate, molecular formula is C5H8O3, molecular weight is 116.12, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

General procedure: Under N2 atmosphere and at 0 C, to a stirred solution of MBHalcohols 1 (0.3 mmol) and PPh3 (0.6 mmol) in EtOAc orCH2Cl2 (2 mL) in a Schlenk tube (25 mL) was slowly addedazodicarboxylates 2 (0.6 mmol) over 5 minutes by the means ofa microsyringe. The resulting reaction mixture was allowed towarm up to room temperature and stirred until the MBH alcohols1 were completely consumed, as monitored by TLC. Thesolvent was removed under reduced pressure and the residuewas purified by column chromatography on silica gel (gradienteluant: petroleum ether/ethyl acetate 9:1-3:1) to afford thehydrazines 3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15484-46-5, Methyl 2-(hydroxymethyl)acrylate, and friends who are interested can also refer to it.

Reference:
Article; Xu, Silong; Shang, Jian; Zhang, Junjie; Tang, Yuhai; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 990 – 995;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2568-33-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

To a solution of 3-methylbutan-1, 3-diol (10.0 g, 96.1 mmol) in DCM (100 mL) was added 4-methylbenzene-1-sulfonyl chloride (20.1 g, 106 mmol) and TEA (24.3 g, 240 mmol) . The reaction mixture was stirred at room temperature for 12 h. Then the mixture was extracted with DCM (150 mL×3) . The combined organic layers were washed with water and brine, dried over MgSO4, and filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography over silica gel (eluting with PE:EA5:1) to give the title compound.

The chemical industry reduces the impact on the environment during synthesis 2568-33-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; BIJU, Purakkatle; COLLETTI, Steven L.; CUI, Mingxiang; HAGMANN, William K.; HU, Bin; JOSIEN, Hubert; KAR, Nam Fung; NAIR, Anilkumar; NARGUND, Ravi; SPERBECK, Donald M.; ZHU, Chen; WO2015/51725; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 ° C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0percent.

The synthetic route of 311-86-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 7287-81-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-81-2, name is 1-(m-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take a reaction tube, add 49 mg of sodium azide, 41 mg of 1-(3-methylphenyl)ethanol, and 400 uL of trifluoroacetic acid.200 uL of methanesulfonic acid and 1.0 mL of n-hexane were stirred at 40 C for 6 hours.After the reaction was quenched with 10mL of sodium hydroxide solution was added, extracted 3 times with ethyl acetate, the organic was washed with brine by adding 5mL, the combined organic phases,The nuclear magnetic yield of m-methylaniline was 53%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Patent; Peking University; Jiao Ning; Liu Jianzhong; (27 pag.)CN109134267; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: trans-4-Aminocyclohexanol

To a solution of di-tert-butyl dicarbonate (4.087 mL, 21.01 mmol) and diisopropylethylamine (2.87 mL, 17.4 mmol) in THF (60 mL) was added (1R,4R)-4-aminocyclohexanol (2.00 g, 17.4 mmol) and was stirred at rt for 4h. The reaction was concentrated to dryness and the residue was dried under reduced pressure to yield the title compound as a white solid (3.49 g, 87.0% yield), which was used without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CAI, Min; ARORA, Nidhi; BACANI, Genesis M.; BARBAY, Joseph Kent; BEMBENEK, Scott D.; CHEN, Wei; DECKHUT, Charlotte Pooley; EDWARDS, James P.; GHOSH, Brahmananda; KREUTTER, Kevin D.; LI, Gang; TICHENOR, Mark S.; VENABLE, Jennifer D.; WEI, Jianmei; WIENER, John J. M.; WU, Yao; XIAO, Kun; ZHANG, Feihuang; ZHU, Yaoping; (524 pag.)WO2018/103060; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 140373-17-7, 2-Amino-2-(4-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 140373-17-7, blongs to alcohols-buliding-blocks compound. Formula: C8H10FNO

Step 1 4-(4-Fluorophenyl)oxazolidin-2-one 600 mg of 2-amino-2-(4-fluorophenyl)ethan-1-ol and 80 mg of potassium carbonate were suspended in 914 mg of diethyl carbonate, and the mixture was stirred at 130 C. for 2.5 hours, and further stirred at 100 C. for 2.5 hours while removing the ethanol that was generated. The reaction solution was diluted with ethyl acetate. The solution was washed in turn with water and brine and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 610 mg of the objective compound as pale yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,140373-17-7, its application will become more common.

Reference:
Patent; NIPPON SHINYAKU CO., LTD.; US2011/288065; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a flask was added 29 B008 (0.4g, 1.07mmol), 102 DMSO (10mL), 103 K2CO3 (0.3g, 2.14mmol), 104 3-chloro-4-fluoroaniline (0.31g, 2.14mmol). The mixture was heated and stirred at 90C for 8h, cooled to rt, poured into ice-water (50mL). The solid was collected by filtration and recrystallized from methanol 4 times to afford a white 105 solid (0.23g, yield 45%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 181 – 197;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 626-18-6, name is 1,3-Benzenedimethanol. A new synthetic method of this compound is introduced below., SDS of cas: 626-18-6

Complex 2 (8.3 mg, 10 mmol), CsOHH2O (0.84 g, 5 mmol),alcohol (5 mmol) was added to a 25 mL schlenk tube and the solutionwas heated at 150 C (oil bath) for 24 h in an open systemunder argon. After cooling to room temperature, the degassedwater (5 mL)was added and the mixturewas extracted with diethylether (3 10 mL). A sample of ether phasewas subjected to the GCMSanalysis and the residual solution was evaporated, then subjected to the NMR analysis. The aqueous phase was acidifiedwith 6 M HCl and extracted with ethyl acetate (5 20 mL). Thecombined organic phasewaswashed with brine (25 mL), dried overanhydrous Na2SO4, and evaporated under reduced pressure, thepure carboxylic acid was collected and weighed for calculating theyield, which was further characterized by its 1H NMR which isconsist with the standard sample.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 626-18-6, 1,3-Benzenedimethanol.

Reference:
Article; Dai, Zengjin; Luo, Qi; Meng, Xianggao; Li, Renjie; Zhang, Jing; Peng, Tianyou; Journal of Organometallic Chemistry; vol. 830; (2017); p. 11 – 18;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts