Tag: M.W=100-200

Related Products of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

59.23 g of 99.5% magnesium ethoxide was added to the obtained n-butyl glycolate, and the alcohol formed by the reaction was simultaneously removed at 60 C. After the reaction, 154.42 g of 99% o-dichlorobenzene was added thereto, and the condensation reaction was carried out at 90 C. After the reaction, the unreacted o-dichlorobenzene was decompressed under reduced pressure, and the condensation liquid was cooled to 35 C for filtration. The filter cake was dried under reduced pressure, and the dried fraction was collected and combined with the filtrate to obtain n-butyl o-chlorophenoxyacetate (243.96 g). The content is 98.4%, and the yield is 98.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Chi Zhilong; Hou Yongsheng; Zhang Liguo; Hu Yishan; (8 pag.)CN108947816; (2018); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2568-33-4, name is 3-Methylbutane-1,3-diol. A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Methylbutane-1,3-diol

Example 19; Synthesis of Chain Transfer Agent; CTA-14.; 17 g (40 mmol) of 3-methyl-1,3-butanediol and 20.0 mL of tetrahydrofuran (THF) were weighed and placed in a 500 mL round bottom flask. The temperature of the system was adjusted to 25 C. and the mixture was stirred. After adding 18.98 g (240 mmol) of pyridine, 36.6 g (240 mmol) of S-acetyl mercaptoacetic acid chloride were added thereto dropwise over 30 minutes. After the addition, the mixture was aged at 25 C. for 5 hours. Subsequently, 20 mL of toluene and 20 mL of pure water were added thereto followed by stirring and the oil phase was concentrated. 35.0 g of the concentrate was weighed and placed in a 500 mL round bottom flask and 100 mL of methanol was added thereto. 200 mL of a saturated sodium bicarbonate solution was then added thereto dropwise over 30 minutes with cooling on an ice bath. Four hours after completion of the addition, 50 mL of pure water and 100 mL of ethyl acetate were added thereto and the mixture was stirred. The oil phase of the reaction solution was concentrated. The concentrate was recrystallized using hexane to give 5.04 g of CTA-1 shown below (yield 50%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Mitsubishi Rayon Co., Ltd.; US2009/198065; (2009); A1;,
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Reference of 18776-12-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 18776-12-0 as follows.

In 250ml three-necked flask was added 3-chlorophenyl propanol 10g,9.29 g of 1-naphthol and 100 ml of DMF,Stirring to dissolve, solution temperature control at about 5 , adding sodium hydroxide 2.34g,The reaction at 0 ~ 5 for 30 minutes, and then slowly warmed to 50 ~ 55 for 8 hours to obtain a reaction solution,The reaction solution was cooled to about 0 C, ice water 100ml, extracted with toluene 60ml * 3, andAnd the organic layer, respectively, the organic layer was washed with water 100ml,1% sodium hydroxide 100ml * 4 washing, 100ml * 4 washed with water and saturated brine 100ml, and then dried, suction filtered, concentrated under reduced pressure at 50 C,To obtain a concentrate, take concentrate 34.6g, 207ml of n-hexane and 17.8ml of ethyl acetate was added to a three-necked flask,The mixture was heated to 25-35 C for 2 hours, then cooled to 0-5 C, stirred for 3 hours and filtered. The cake was washed with a small amount of n-hexane and ethyl acetate and dried at 40 C.19.3 g of 1-phenyl-3- (1-naphthalenyloxy) -1-propanol was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18776-12-0, its application will become more common.

Reference:
Patent; Anhui Jinnan Medical Treatment Technology Co., Ltd.; Hu Huiping; Li Jie; Lu Hai; Tang Zhongyao; (10 pag.)CN106748817; (2017); A;,
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Electric Literature of 100-37-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, molecular weight is 117.1894, as common compound, the synthetic route is as follows.

General procedure: To a solution of phenol (1 equiv), triphenylphosphine (1.3equiv) and 2-(diethylamino)ethanol (1.3 equiv) in THF wasadded diisopropyl azodicarboxylate (DIAD, 1.3 equiv) atambient temperature. After being stirred at ambient temperatureuntil no starting material could be observed byTLC, the reaction mixture was quenched with H2O anddiluted with EtOAc. The organic layer was washed withwater and brine, dried over MgSO4, and concentrated invacuo. Purification of the residue via flash column chromatographyon silica gel afforded the titled compound.

The chemical industry reduces the impact on the environment during synthesis 100-37-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Seok-Ho; Han, Young Taek; Archives of Pharmacal Research; vol. 38; 11; (2015); p. 1952 – 1962;,
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Related Products of 6995-79-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6995-79-5, name is trans-Cyclohexane-1,4-diol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of trans-1,4-cyclohexanediol (504.0 mg, 4.34 mmol) in anhydrous DMF (4 mL) was added NaH (139.0 mg, 3.47 mmol, 60percent in mineral oil) at 0° C. and then stirred at 0° C. for 1 h. The compound from step 1 (100.0 mg, 0.29 mmol) was added. The mixture was stirred at 0° C. for 0.5 h and then at r.t. 18 hrs. It was then quenched with MeOH (4 mL) and filtered. The filtrate was purified by prep-HPLC to give the title compound (37.0 mg, 30.0percent) as an off-white solid. 1H NMR (CDCl3, 40 MHz) delta 8.51 (d, J=7.6 Hz, 1H), 7.94 (dd, J1=8.8 Hz, J2=2.4 Hz, 1H), 7.83 (d, J=2.0 Hz, 1H), 7.56 (t, J=6.8 Hz, 1H), 7.51 (t, J=6.8 Hz, 1H), 7.16 (d, J=7.6 Hz, 1H), 7.11 (d, J=8.8 Hz, 1H), 7.05 (s, 1H), 4.43-4.18 (m, 1H), 3.67 (s, 3H), 3.65-3.62 (m, 1H), 3.16 (q, J=7.6 Hz, 2H), 2.00-1.90 (m, 2H), 1.71-1.65 (m, 2H), 1.42-1.30 (m, 7H). LCMS (M+H)+=442.0 (M+1)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6995-79-5, trans-Cyclohexane-1,4-diol.

Reference:
Patent; Bennett, Michael John; Betancort, Juan Manuel; Boloor, Amogh; Kaldor, Stephen W.; Stafford, Jeffrey Alan; Veal, James Marvin; US2015/111885; (2015); A1;,
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Synthetic Route of 621-63-6, Adding some certain compound to certain chemical reactions, such as: 621-63-6, name is 2,2-Diethoxyethanol,molecular formula is C6H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 621-63-6.

(b) 2,2-Diethoxyethyl (S)-(+)-Camphorsulfonate 2,2-Diethoxyethanol (3.82 g), Et3N (3.17 g), dichloromethane (40 mL) and DMAP (4 mg) are combined and the solution is cooled to 4° C. (S)-Camphorsulfonyl chloride (7.5 g) is added at a rate of 1 g /min. The ice-water bath is removed and the reaction is allowed to progress for about 1 hour at room temperature. About 40 mL of water is added slowly to quench the reaction, the phases are separated and the dichloromethane phase is washed with saturated sodium bicarbonate (20 mL) and water (20 mL). The solution is vacuum concentrated to produce 7.9 g of 2,2-diethoxyethyl (S)-(+)-camphorsulfonate.

According to the analysis of related databases, 621-63-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Brantford Chemicals Inc.; US6380388; (2002); B1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-Bromo-1-butanol

2-(4-Bromobutoxy)-tetrahydro-2H-pyran (2): 3,4-Dihydro-2H-pyran (8.5 mL, 90.96 mmol) was added dropwise to the dichloromethane (20 mL) solution of 1 (10.7 g, 69.93 mmol) and p-toluenesulfonic acid monohydrate (26.5 mg, 0.1372 mmol). The mixture was stirred at room temperature over night. After removing the solvent, the residue was purified by flash chromatography on silica gel with 5:1 hexanes/ethyl acetate as the eluent to yield product 2 as a colorless oil (15.3 g, 92 %). 1H NMR (400 MHz, CDCI3): delta 1.48-1.62 (m, 4H), 1.68-1.85 (m, 4H), 1.94-2.02 (m, 2H), 3.40-3.53 (m, 4H), 3.74-3.88 (m, 2H), 4.57-4.59 (m, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 33036-62-3.

Reference:
Patent; DIETRICH, Evelyne; REDDY, Ranga; TANAKA, Kelly; KANG, Ting; LAFONTAINE, Yanick; RAFAI FAR, Adel; TARGANTA THERAPEUTICS CORP.; WO2010/19511; (2010); A2;,
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Adding a certain compound to certain chemical reactions, such as: 929-06-6, 2-(2-Aminoethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 929-06-6, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Aminoethoxy)ethanol

Step 1 2-(2-N-Boc-aminoethoxy)ethanol To a solution of 2-(2-aminoethoxy)ethanol (5.3 g, 50 mmol) and diisopropylethylamine (13 ml, 75 mmol) in DCM (10 ml) at 0 C. was added dropwise a is solution of di-tert-butyl dicarbonate (12 g, 55 mmol) in DCM (20 ml). The reaction was agitated for 4 hours, extracted with DCM and purified by flash chromatography (EtOAc/PE) (75/25) to give the title compound (5.9 g, 60%). 1H NMR (CDCl3) delta 3.65 (dd, J=8.6, 3.8 Hz 2H), 3.47 (m, 5H), 2.23 (dd, J=8.6, 3.8 Hz 2H), 1.35 (s, 9H); 13C NMR (CDCl3) delta 56.1, 79.1, 72.1, 70.1, 61.3, 40.3, 28.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929-06-6, its application will become more common.

Reference:
Patent; Gustavsson, Anna-Lena; Jendeberg, Lena; Roussel, Patrick; Slater, Martin; Thor, Markus; US2003/73862; (2003); A1;,
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Application of 629-41-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 629-41-4, name is 1,8-Octanediol, molecular formula is C8H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound 2-1-1 (octanediol) (1.01 g, 6.91 mmol) was dissolved in 20 ml of toluene, and 40% HBr (aq) (1.12 ml, 7.81 mmol) was added to the reaction system at room temperature, bath reflux.72h after TLC monitoring, there is still the remaining raw materials, add 40% HBr (aq) (0.5ml, 3.49mmol), continue to return 24h.The system was cooled to room temperature, diluted with ether, saturated sodium bicarbonate solution, saturated sodium chloride solution, washed once, sodium sulfate dried about half an hour after the filter, steamed ether.The residue was purified by column chromatography on silica gel, eluting with petroleum ether: ethyl acetate = 6: 1 to give an oily product, 1.21 g, in 84.3% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 629-41-4, 1,8-Octanediol.

Reference:
Patent; PEKING UNIVERSITY; YE, XINSHAN; HOU, JINGFEI; (25 pag.)CN103373955; (2016); B;,
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Related Products of 94022-96-5, Adding some certain compound to certain chemical reactions, such as: 94022-96-5, name is 2-(Trifluoromethyl)phenethyl alcohol,molecular formula is C9H9F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 94022-96-5.

General procedure: A mixture of the substituted phenylethyl alcohol (10 mmol), Chloromethyl methyl ether (15mmol) and N,N-diisopropylethylamine (20 mmol) in dry dichloromethane (25 mL)was stirred under nitrogen atmosphere for 2.5 h at rt. The reaction mixture wasthen washed with water (2×50 mL), dried (NaSO4) and the solvent wasremoved in vacuo. The crude MOM acetal was dissolved in dried CH3CN (25mL) and added to cooled (0 oC) solution of Trimethylsilyltrifluoromethanesulfonate (TMSOTf) (10 mmol). The reaction was carried outunder nitrogen atmosphere for 3 h. Then the mixture was quenched by theaddition of l M NaHCO3 (20 mL ). The orgnic phase was washed withbrine (2×50 mL), dried (NaSO4) and evaporated under reducedpressure. Purification by FC afforded relevant substituted isochromans.

According to the analysis of related databases, 94022-96-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhou, Mei-Yan; Kong, Shan-Shan; Zhang, Ling-Qiong; Zhao, Ming; Duan, Jin-Ao; Ou-Yang, Zhen; Wang, Min; Tetrahedron Letters; vol. 54; 30; (2013); p. 3962 – 3964;,
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