Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 33524-31-1, (2,5-Dimethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H12O3, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H12O3

General procedure: The benzyl alcohol derivatives (1 mmol), catalyst 1 or 3 (2 mol%),base (5 mol%) and toluene or p-xylene (20 mmol) were added to aSchlenk tube under argon or nitrogen atmosphere. The mixture wasstirred magnetically at reflux temperature. The yields of the prod-ucts were analyzed by GC chromatography using chlorobenzene asan internal standard.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Thangavel, Saravanan; Boopathi, Subramaniam; Mahadevaiah; Kolandaivel, Ponmalai; Pansuriya, Pramod B.; Friedrich, Holger B.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 160 – 171;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5653-67-8, name is (2,3-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2,3-Dimethoxyphenyl)methanol

A. 2,3-Dimethoxybenzyl chloride Thionyl chloride (288 g) is added over 1.5 hour to a stirred solution of 2,3-dimethoxybenzyl alcohol (400 g) and 2,6-lutidine in methylene chloride (2 l). The reaction mixture is then stirred for 30 minutes after which it is washed with 2 N hydrochloric acid (7*1 l) and then with water. The organic layer is separated, dried (MgSO4) and evaporated to give a residue, which upon distillation yields 3,4-dimethoxybenzyl chloride (375 g), b.p. 145-150 C. at 20-25 nm (waterpump vacuum). The material solidifies on standing.

With the rapid development of chemical substances, we look forward to future research findings about 5653-67-8.

Reference:
Patent; Merrell-Toraude et Cie; US4342780; (1982); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 932-01-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, molecular weight is 128.21, as common compound, the synthetic route is as follows.

To a solution of 7-nitroisoquinolin-l(2H)-one (100 mg, 0.52 mmol) and 4,4- dimethylcyclohexanol (100 mg, 0.79 mmol) in THF (2 mL) were added PPh3 (342 mg, 1.30 mmol) and diisopropylazodicarboxylate (263 mg, 1.30 mmol) and the reaction mixture was heated at reflux for 6 h. Then the reaction mixture was quenched with water and was extracted with EtOAc. The organic layer was washed with brine, separated, dried, filtered and concentrated. The residue was purified by column chromatography to afford 100 mg of the title product. MS (m/z): 301 (M+H)+.

Statistics shows that 932-01-4 is playing an increasingly important role. we look forward to future research findings about 4,4-Dimethylcyclohexanol.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2014/167444; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 112-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

250mL single-neck flask was added triethylene glycol (19.69g, 131.13mmol), solution of p-toluenesulfonyl chloride (5.00g triethylamine (7.96g, 78.68mmol) and dichloromethane (50mL), ice-cooled, 26.23 mmol) was dissolved in dichloromethane (50 mL) of. After completion of the dropwise addition, the reaction system was transferred to room temperature overnight. The solvent was removed by rotary evaporation, the residue was added methylene chloride (a 500 mL) was dissolved, washed with water (a 500 mL) and saturated brine (300mL), dried over anhydrous sodium sulfate. Filtered and the solvent was removed by rotary evaporation to give a colorless oil 6.70g, yield 83.94%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Wang, Xiaojun; Yang, Xinye; Zhou, Pingjian; Yang, Chuanwen; Lin, Jihua; Xiong, Shaohui; Zhang, Yingjun; Xiao, Ying; Wang, Hui; Cao, Shengtian; Wu, Fangyuan; Ouyang, Luo; (74 pag.)CN105524053; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 35364-79-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

a. 2-(3,4-Dichlorophenyl)ethyl methansulfonate Using the method of Example 1a, but substituting 3,4-dichlorophenethyl alcohol for 3-methoxyphenethyl alcohol, the title product was obtained as a yellow oil in 88% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,35364-79-5, 2-(3,4-Dichlorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; McNeilab, Inc.; US4729994; (1988); A;; ; Patent; McNeilab, Inc.; EP256888; (1991); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 16308-92-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16308-92-2 as follows.

(2,4-dimethylphenyl)methanol (1.72 g, 12.7 mmol) and triethyl amine (5.1 mL, 38.1 mmol) were dissolved in dichloromethane (50 mL) and the solution was cooled to 0C. A solution of methanesulfonyl chloride (1.18 mL, 15.2 mmol) in dichloromethane (20 mL)was added dropwise for a period of 20 minutes. The reaction mixture was thereafter allowed to reach room temperature, and was stirred at that temperature for 2 hours. The excess of methanesulfonyl chloride wasquenched by addition of methanol (5.0 mL) and stirring for an additional 10 minutes. The reaction mixture was extracted with dilute HC1 (5%, 100 mL), and thereafter washed with sodium bicarbonate (5% solution, 2×50 mL) and with brine (2×100 mL). The dichloromethane phased was dried over anhydrous sodium sulfate and evaporated to dryness,yielding 2.57 g of the title product, which was used without further purification in the subsequent step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16308-92-2, its application will become more common.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 346-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred mixture of Ph2PCl (6.0mmol), NaI (6.0 mmol) and anhydrous CH3CN (5 mL) was added alcohol 2 (1.0 mmol) at room temperature under argon atmosphere. The reaction mixture was stirred at 80 ¡ãC in oil bath for 12 h. When the reaction temperature was cooled to room temperature, aqueous Na2S2O3 (2.0 mL) was added to the reaction mixture, and stirred for another 10 minutes. The organic layer was extracted with dichloromethane, washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel to obtain the corresponding phosphine sulfoxide.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 346-06-5, (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Article; Ma, Yutao; Chen, Feng; Bao, Jifeng; Wei, Hao; Shi, Min; Wang, Feijun; Tetrahedron Letters; vol. 57; 23; (2016); p. 2465 – 2467;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 3597-91-9, Adding some certain compound to certain chemical reactions, such as: 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol,molecular formula is C13H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3597-91-9.

Reference Example 50 4-Phenylbenzyl Bromide To a solution of 4-phenylbenzyl alcohol (1.00 g, 5.43 mmol) in a mixture of diisopropyl ether (10 mL) and chloroform (20 mL) was added phosphorus tribromide (0.98 g, 3.62 mmol) with ice-cooling and the mixture was stirred at room temperature for 1 hour. This reaction mixture was diluted with water and extracted with diisopropyl ether. The organic layer was washed with water and saturated aqueous sodium hydrogen carbonate solution, dried over MgSO4, and filtered. The filtrate was concentrated under reduced pressure and the residue was recrystallized from ethanol-hexane to provide 1.00 g of the title compound. Yield 75%. m.p. 86-88 C. 1H-NMR (CDCl3) delta: 4.55 (2H, s), 7.32-7.67 (9H, m).

According to the analysis of related databases, 3597-91-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6248766; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 67853-03-6 ,Some common heterocyclic compound, 67853-03-6, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 163 (23.0 g, 138 mmol) in THF (300 mL) was added NaH (8.3 g, 207 mmol) at 0 C. Then the mixture was stirred at 25 C. for 30 min. Then CH3I (72.5 g, 511 mmol) was added dropwise and the mixture was stirred at 25 C. for 3 h. The mixture was quenched with HCl (1M) (240 mL) at 0 C. The reaction mixture was combined with a second reaction and extracted with EA (3¡Á400 mL). The organic phase was washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under vacuum to the residue. The residue was purified by column (PE:EA=10:1 to 5:1) to afford 164 as yellow oil (12.0 g, 53% yield, 88% purity). [M+H]+ calcd for C10H12O3 181.09 found 181.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67853-03-6, Methyl 3-(hydroxymethyl)benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Kulyk, Svitlana; Owens, Christina; Sullivan, Steven D.E.; Kozak, Jennifer; Hughes, Adam D.; (248 pag.)US2020/188370; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5187-23-5, Adding some certain compound to certain chemical reactions, such as: 5187-23-5, name is (5-Ethyl-1,3-dioxan-5-yl)methanol,molecular formula is C7H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5187-23-5.

Example 24: Synthesis of Penta(cyclohexylamino)-mono(5-ethyl-1,3-dioxane-5- methyloxy)-decafluoro-phthalocyaninatozinc(II) [00164] FL6ZNPC (10 mg) was dissolved in 1-2 ml of cyclohexylamine and heated to 100C for 1 hour. The product was purified by silica gel chromatography using ethyl acetate as the eluent, and then added to a mixture of 1 ml 5-ethyl-1, 3-dioxane-5-methanol and 0.1 ml nBuLi, which had been stirred at room temperature for 15 minutes before. The whole reaction mixture was heated to 100-120C for 1 hour. The product was purified by silica gel chromatography using a mixture of hexanes : ethyl acetate = 1: 1 as the eluting solvent. A brown fraction was collected. The MALDI-MS shows the following substitution pattern: Cyclohexylamine 5-Ethyl-l, 3-dioxane-5-methanol nnlz 3 0 1100 4 0 1182 5 0 1261 4 1 1307 6 0 1338 5 1 1387 4 2 1432 5 2 1513 [00165] The reaction scheme for the synthesis of this product is provided in Figure 19.

According to the analysis of related databases, 5187-23-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YORK UNIVERSITY; WO2005/33110; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts