Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 19064-18-7, (2,6-Difluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,6-Difluorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,6-Difluorophenyl)methanol

3-(4-N,N-dimethylaminomethyl)phenyl-2-chloro-6-bromoquinoline(60 mg, 0.16 mmol) was dissolved in 2 mL of anhydrous tetrahydrofuran,Followed by addition of 2,6-difluorobenzyl alcohol (46 mg, 0.32 mmol),60% sodium hydride (30 mg, 0.78 mmol) was added and the reaction was stirred at room temperature for 8 hours.The organic phases were combined, concentrated to dryness and chromatographed on a column (dichloromethane / methanol 25: 1), dried over MgSO4,To give 63 mg of a pale yellow oil in 81.68% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19064-18-7, (2,6-Difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Institute of Materia Medica,Chinese Academy of Medical Sciences; He, Chunxian; Cui, Huaqing; Yin, Dali; (66 pag.)CN106167464; (2016); A;,
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Reference of 623-69-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.

Section 1 step: the epoxychloropropane and methanol under the action of the NaOH, in order to an excess of methanol as a solvent reflux reaction 6 hours, to obtain 1,3-dimethoxy-2-propanol; The mole ratio is that, epoxychloropropane: NaOH= 1 : 1.05; Methanol consumption per mole of epichlohydrin substrate for adding 0.6L of the methanol. Section 2 step: the resulting 1,3-dimethoxy-2-propanol with 4-n-butyl benzoyl chloride in triethylamine under the action of acid, in tetrahydrofuran solvent reflux reaction for 7 hours, shown in formula III obtained ether acid ester composition (i); The mole ratio is that, 1,3-dimethoxy-2-propanol: 4-n-butyl benzoyl chloride: triethylamine = 1:1: 1.5; Tetrahydrofuran according to the amount of per mole of the 1,3-dimethoxy-2-propanol is added to substrate 1.5L tetrahydrofuran

Statistics shows that 623-69-8 is playing an increasingly important role. we look forward to future research findings about 1,3-Dimethoxypropan-2-ol.

Reference:
Patent; China Petroleum and Chemical Corporation; China Petroleum & Chemical Corporation Beijing Research Institute of Chemical; Hu, Jianjun; Liu, Haitao; Gao, Mingzhi; Ma, Jixing; Cai, Xiaoxia; Zhang, Xiaofan; Chen, Jianhua; Ma, jing; Li, Changxiu; Li, Xianzhong; Wang, Jun; (12 pag.)CN103664615; (2016); B;,
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Application of 629-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 629-30-1, name is 1,7-Heptanediol. A new synthetic method of this compound is introduced below.

Fe(NO3)3¡¤9H2O (40.4 mg, 10 molpercent) and ABNO (7 mg, 5 molpercent) were used in this order.1,7-heptanediol (132 mg, 1 mmol) was added to a 10 ml reaction tube.Then add 2ml of acetonitrile as a solvent and open the reaction at room temperature.The degree of reaction was then checked by GC-MS. Reaction 15h,After the reaction is over,An internal standard, n-dodecane, was added and the product was quantitatively analyzed by GC.1,7-heptanediol conversion rate of 86percent,Product yield 85percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,629-30-1, 1,7-Heptanediol, and friends who are interested can also refer to it.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Wang Lianyue; Chen Bo; Lv Ying; (5 pag.)CN106831675; (2017); A;,
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Synthetic Route of 17849-38-6 , The common heterocyclic compound, 17849-38-6, name is 2-Chlorobenzyl alcohol, molecular formula is C7H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: DBDMH (20 mmol) was added in portion wise to a mixture of 1b (5 mmol) andmethanol (30 ml). The reaction was kept at room temperature. After the mixture wasstirred for 12h, the methanol was vacuum evaporated. The residue was dissolved byMTBE (30 ml), washed with water (330 ml).The organic extracts was dried byanhydrous MgSO4, filtered, and concentrated under reduce pressure. The residue waspurified by column chromatography (silica gel: petroleum ether/ethyl acetate, 30:1) toafford the product as light yellow solid ( 92% yield).

The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Zhongzhou; Zhu, Wei; Bao, Jinlong; Zou, Xinzhuo; Synthetic Communications; vol. 44; 8; (2014); p. 1155 – 1164;,
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Synthetic Route of 599-67-7 ,Some common heterocyclic compound, 599-67-7, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 1 (2 mmol), 2 (4 or 15 mmol) and NaHSO4/SiO2 (2.1 mmol/g, 1.0 or 2.0g) in DCE (10 mL) was stirred at 80 C for 2 h, and then the used supported reagent was removed by filtration. The filtrate was evaporated to leave crude product, which was purified by column chromatography (hexane/chloroform) to obtain substituted chromans 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.

Reference:
Article; Aoyama, Tadashi; Furukawa, Takuya; Hayakawa, Mamiko; Takido, Toshio; Kodomari, Mitsuo; Synlett; vol. 26; 13; (2015); p. 1875 – 1879;,
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Related Products of 558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6-(tert-butylsulfonyl)-4-chloroquinolin-7-ol (250 mg, 0.834 mmol) in DMF (2756 mu) was added K2C03 (576 mg, 4.17 mmol) followed by l-chloro-2- methylpropan-2-ol (209 mu, 2.502 mmol). After 10 min, LCMS showed no product. Heated reaction to 60 ¡ãC. No reaction after 3 hr at this temperature. Added sodium iodide (375 mg, 2.50 mmol) and 2,2-dimethyloxirane (371 mu, 4.17 mmol) and stirred for 2 days at to 60 ¡ãC. The crude sample was purified via Biotage normal phase chromatography (25g SNAP column, 0percent – 80percent, 80percent. hex / EtOAc). The pure product containing-fractions were combined and concentrated leading to the product as an off-white solid: -{{6-{tert- butylsulfonyl)-4-chloroquinolin-7-yl)oxy)-2-methylpropan-2-ol (46 mg, 0.124 mmol, 14.83 percent yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.29 (s, 6 H) 1.33 (s, 9 H) 4.03 (s, 2 H) 4.56 (s, 1 H) 7.72 (s, 1 H) 7.76 (d, J=4.80 Hz, 1 H) 8.64 (s, 1 H) 8.94 (d, J=4.80 Hz, 1 H). MS (m/z) 372.2 (M+H+).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; CASILLAS, Linda, N.; DEMARTINO, Michael, P.; HAILE, Pamela, A.; MEHLMANN, John, F.; RAMANJULU, Joshi, M.; SINGHAUS, Robert, Jr.; WO2014/43437; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.1735, as common compound, the synthetic route is as follows.SDS of cas: 27489-62-9

Preparation of trans-4-(3-(thieno[2,3-b]pyridin-2-yl)imidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To a solution of 6-chloro-3-(thieno[2,3-b]pyridin-2-yl)imidazo[1,2-b]pyridazine (45 mg, 0.157 mmol, 1.0 equiv) in DMSO (2.0 mL) was added p-toluene sulfonic acid monohydrate (22 mg, 0.157 mmol, 1.0 equiv) and trans-4-aminocyclohexanol (0.784 mmol, 5.0 equiv) and heated to 100 C. for 24 h. The reaction mixture was diluted with water and extracted with ethyl acetate. Purification by column chromatography using 5% methanol in dichloromethane elution gave 40 mg of the yellow solid, 70%. Compound 205 was physically characterized by electrospray ionization mass spectrometry. Structures and molecular masses are given below in Table 50.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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Reference of 52244-70-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Protection of phenols can be achieved using PSB-OH (1a) under Mitsunobu conditions (Table 1, entries 1 and 4). Those of skill in the art will recognize that the term “Mitsunobu conditions” is explained in Hughes, D. L.; Org. React. 1992, 42, 335-656; a publication which is incorporated herein by reference in its entirety. Attempts to alkylate potassium, cesium, or sodium salts with 1b were unsuccessful (entries 2 and 6). Arylmethylation of primary alcohols (i.e., 2c) occurs smoothly with PSB-Br (1b) using freshly prepared Ag2O; this afforded the corresponding PSB ether in 80-83percent yield (entry 5). However, secondary alcohols could not be protected efficiently using the same method even after prolonged reaction times (entries 7 and 8). Side products and/or low conversions were observed.

The chemical industry reduces the impact on the environment during synthesis 52244-70-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; The Florida State University Research Foundation, Inc.; US7754909; (2010); B1;,
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Related Products of 3597-91-9 ,Some common heterocyclic compound, 3597-91-9, molecular formula is C13H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Anoven dried 100 mL round bottom was charged with 2.00 g (10.85 mmol) of biphenyl-4-yl-methanol, 30 mlof chloroform, 10.5g of anhydrous magnesiumsulfate and a magnetic stir bar.The solution was then allowed to stir until the solution was homogenous, 4.5 g of pyridinium chlorochromate was then added and the vessel was sealed and allowed to react for 3 hours. Reaction progress was checked by TLC andonce the reaction was complete excess solvent was removed via rotovap. Thes olution was then purified via a silica column. The purification yielded a yellow oil that was thenre-crystallized into a white crystalline solid with hexane and dichloromethane.(1.90 g, 10.43 mmol, 96%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Steiger, Scott A.; Li, Chun; Campana, Charles F.; Natale, Nicholas R.; Tetrahedron Letters; vol. 57; 3; (2016); p. 423 – 425;,
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Synthetic Route of 6240-11-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of Intermediate 15 (1 g, 4.3 mmol) in tetrahydrofuran (6 ml_) and 1- Adamantaneethanol (0.77 g, 4.2 mmol) in tetrahydrofuran (6 ml_) was added a solution of diethyl azodicarboxylate (2.9 mL, 6.4 mmol) and triphenylphosphine (1.6 g, 6.4 mmol) in tetrahydrofuran (4 mL). The reaction mixture was stirred at 8O0C for 48 hours. The solvent was removed under reduced pressure and partitioned between methylen chloride and water. The organic layer was washed with water, sodium hydrogen carbonate (4%) and brine. The solvent was removed under reduced pressure and the crude was purified by column chromatography with silica gel, eluting with hexane/ethyl acetate (30:1). The title compound was obtained as a solid (0.39 g, 22%). MS (M+): 414.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6240-11-5, 1-Adamantaneethanol.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/68177; (2009); A1;,
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