Tag: M.W=100-200

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4720-29-0, name is 3-(Benzylamino)-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C10H15NO

(a) A solution of 7 g of 3-N-benzylamino-propanol in 40 ml of dimethylformamide is reacted analogously to the process described in Example (1a) with 1.9 g of a sodium hydride suspension (55% strength in paraffin oil), and then with 5.5 g of 6-chloro-nicotinic acid amide. The crude 6-(3-N-benzylamino-propyloxy)-nicotinic acid amide thus obtainable is reacted with 4.9 g of 1,2-epoxy-3-(2-methyl-phenoxy)propane; this gives 1-{N-benzyl-N-[3-(5-carbamoyl-2-pyridyloxy)-propyl]-amino}-3-(2-methyl-phenyloxy)-2-propanol, which is processed further without purification.

With the rapid development of chemical substances, we look forward to future research findings about 4720-29-0.

Reference:
Patent; Ciba-Geigy Corporation; US4027027; (1977); A;,
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Synthetic Route of 111-90-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A. 3-(3-(2-(2-Ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-4-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

According to the analysis of related databases, 111-90-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Muhlhauser; Mark A.; Shannon; Harlan E.; Thor; Karl B.; US5565475; (1996); A;,
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Electric Literature of 3319-15-1, Adding some certain compound to certain chemical reactions, such as: 3319-15-1, name is 1-(4-Methoxyphenyl)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3319-15-1.

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

According to the analysis of related databases, 3319-15-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., Recommanded Product: 15484-46-5

General procedure: Into a round bottom flask charged with a magnetic stirbar was added 1 equiv. MBH adduct, followed by 3 equiv. 33wt % HBr (in HOAc). The solution was vigorously stirred until judged complete by TLC, then was poured into a 1 : 1 (volumetric) mixture of deionized water and CH2Cl2. The organic layer was separated, then the residual product was extracted from the aqueous layer with an additional portion of CH2Cl2. The combined organic layers were washed with deionized water then brine, then were dried with Na2SO4, filtered, concentrated, and purified via column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15484-46-5, Methyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Nicponski, Daniel R.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2075 – 2077;,
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Adding a certain compound to certain chemical reactions, such as: 1875-89-4, 2-(m-Tolyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(m-Tolyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-(m-Tolyl)ethanol

Example 8-2- [2- (3-methylphenyl) ethoxy]-2′, 3′, 5-TRI-O-(TERT- butyldimethylsilyl)-adenosine [54] To a dry 250-mL, 3-neck roundbottom flask was added 2-chloro- 2′, 3′, 5-TRI-O-(TERT-BUTYLDIMETHYLSILYL) adenosine (5 g, 7.8 mmol, Example 1) and 2- (3-methylphenyl) ethanol (15 mL). The mixture was flushed with nitrogen for 5-10 minutes, then heated to 50 ¡ãC. To this mixture was added sodium hydride (1.56 g, 39 mmol, as a 60percent dispersion in mineral oil) at such a rate as to avoid excessive gas evolution. The reaction was maintained at 50 ¡ãC until the predominant component was the product by HPLC (partially deprotected products were also seen). The reaction was then cooled to room temperature, carefully quenched with water (40 mL), and extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were washed with brine (120 mL), dried (MGS04), filtered, and concentrated under reduced pressure to afford a brown oil. This material was purified by passing through a plug of silica gel, eluting with CH2CL2, 5percent methanol in CHSCIS, and 10percent methanol in CH2CL2. Those fractions containing products were combined and evaporated to dryness, to afford a mixture of starting material and monosilyl-protected and disilyl-protected alkylated products in a ratio of 2: 5: 12.This mixture was used without further purification in the next step

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC.; WO2005/33121; (2005); A2;,
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Reference of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 1 L three-necked flask equipped with a stirrer, a dry air inlet tube, a thermometer, a distillation column (inner diameter 25 mm ¡Á height 300 mm, packing tower packed with 6 mm McMahon packing) and a distillation head,100 g of 3-methyl-3-hydroxy-1-butyl alcohol, 240 g of methyl methacrylate,0.24 g of 2,2,6,6-tetramethyl-4-hydroxypiperidine-N-oxide as a polymerization inhibitor was charged,While stirring while blowing a small amount of air,The inside of the system was heated to 100 to 110 C. 8 g of methyl methacrylate was withdrawn from the top portion of the distillation column. After cooling the inside of the system to 40 C., 0.55 g of magnesium diethoxide was charged as a catalyst, and a small amountWhile blowing air while stirring,The inside of the system was heated to 100 to 130 C. Methanol produced as the reaction proceeded was gradually withdrawn from the top of the distillation column by azeotropic distillation with methyl methacrylate to allow the reaction to proceed.The conversion of 3-methyl-3-hydroxy-1-butyl alcohol 7 hours after the start of the reaction was 78.3%. The reaction was further continued, and after 9 hours from the start of the reactionThe conversion of 3-methyl-3-hydroxy-1-butyl alcohol was 94.0%The yield of 3-methyl-3-hydroxy-1-butyl methacrylate based on 3-methyl-3-hydroxy-89.3%,The diester yield based on 3-methyl-3-hydroxy-1-butyl alcohol was 1.7%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Mitsubishi Gas Chemical Company; Kushida, Eriko; Takemoto, Makiko; (16 pag.)JP2018/135285; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Preparation 10: 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(3,3,3-trifluoro-2-hydroxypropyl)-1-naphthamide To a solution of 4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthoic acid (Preparation 7, 1 g, 2.1 mmol) in DMF (25 mL) was added HATU (970 mg, 2.5 mmol) and triethylamine (1.0 mL, 7.0 mmol).The reaction was stirred at room temperature for 15 minutes then treated with 3-amino-1,1,1-trifluoro-2-propanol (275 mg, 2.1 mmol). The reaction was stirred at room temperature for 18 hours. Next, the reaction was diluted with 0.1NNaOH and extracted with EtOAc (2¡Á150 mL). The combined organic phase was dried (Na2SO4) and concentrated under vacuum. The crude material was chromatographed (80 g Redi-Sep column) eluting from 100% heptane to 40:60 EtOAc:heptane to afford the intermediate (1.06 g, 85%) as a solid. 1HNMR (CDCl3) delta ppm: 8.81 (1H), 8.28 (1H), 7.71-7.57 (5H), 7.49 (1H), 6.55 (1H) 4.32-4.25 (3H), 4.08-3.91 (1H), 3.85 (1H), 3.79-3.74 (1H); m/z (Cl) 583 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; US2012/77765; (2012); A1;,
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Application of 23147-58-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23147-58-2, name is Glycerol aldehyde dimer. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of (4-chloro-3-fluorophenyl)methanamine (266 mg, 1.67 mmol, Alfa) in a methanol buffer (3.6 weight % sodium acetate trihydrate and 2.4 weight % acetic acid in methanol, 15mL) was added l,4-dioxane-2,5-diol (100 mg, 0.833 mmol, Aldrich) in one portion followed by sodium cyanoborohydride (105 mg, 1.67 mmol) and trifluoroacetic acid (0.1 mL). After stirring at ambient temperature for 10 minutes, the reaction mixture was concentrated under reduced pressure to less than 5 mL and was filtered through a glass microfiber frit. Then the filtrate was purified by preparative HPLC [YMC TriArt CI 8 Hybrid 5 mupiiota column, 50 x 100 mm, flow rate 140 mL/minute, 5-100% gradient of acetonitrile in buffer (0.025 M aqueous ammonium bicarbonate, adjusted to pH 10 with ammonium hydroxide)] to give the title compound (0.18 g, 0.88 mmol, 53.0 % yield). MS (ESI+) mJz 204 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 23147-58-2, Glycerol aldehyde dimer.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; MURAUSKI, Kathleen; (288 pag.)WO2019/90074; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 149E (20 mg, 0.06 mmol) and 2-(3-fiuorophenyl)ethanol (9.3 mg, 0.066 mmol) were dissolved in 1 mL tetrahydrofuran. To this, PS-triphenylphosphine (58 mg, 0.18 mmol, 3.1 mmol/g) was added followed by di-tert-buty azodicarboxylate (20.9 mg, 0.09 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was filtered, concentrated and purified by flash chromatography (0-50% ethyl acetate in hexane). To the material thus obtained was added 0.5 mL 4 MEtaC1 in dioxane. The reaction was stirred at 50 0C until completion. The mixture was concentrated to give the title compound as the hydrochloride salt. 1H NMR (500 MHz, DMSO-J6) delta ppm 9.44 (br, IH), 9.07 (br, 2H), 7.36 (dd, J = 14.4, 7.9 Hz, IH), 7.18 (t, J = 8.0 Hz, 2H), 7.05 (td, J = 8.8, 2.4 Hz, IH), 6.87 (d, J = 8.6 Hz, IH), 6.70 – 6.54 (m, 2H), 4.26 – 4.08 (m, 2H), 3.59 – 3.47 (m, IH), 3.30 (m, 4H), 3.11 – 2.85 (m, 4H), 2.60 (dd, J = 13.4, 7.0 Hz, IH), 1.97 (d, J = 13.5 Hz, IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
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Electric Literature of 6240-11-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6240-11-5, name is 1-Adamantaneethanol. A new synthetic method of this compound is introduced below.

A. A mixture of 2-(adamant-1-yl)ethanol (2.1 g, 12 mmoles), disuccinimidyl carbonate (3.3 g, 13 mmoles) and pyridine (0.86 ml, 10 mmoles) in acetonitrile (50 ml) was stirred at room temperature for 24 hours, then the solvent was evaporated off in the cold and the residue was dissolved in methylene chloride (100 ml). The solution was washed with water (50 ml), 1N HCl (50 ml) and water again (50 ml). The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated off to give 3 g (9 mmoles) of crude 2-(adamant-1-yl)ethyl-succinimidyl carbonate which was redissolved in THF (30 ml).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6240-11-5, 1-Adamantaneethanol, and friends who are interested can also refer to it.

Reference:
Patent; Italfarmaco S.p.A.; US6034096; (2000); A;,
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