Tag: M.W=100-200

Synthetic Route of 15149-10-7, Adding some certain compound to certain chemical reactions, such as: 15149-10-7, name is 2-(p-Tolyloxy)ethanol,molecular formula is C9H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15149-10-7.

General procedure: A mixture of 3 (46.1 mmol) and NaH (138.2 mmol) inanhydrous THF (100 ml) was stirred under a nitrogen atmosphere at rt. After 1h, epichlorohydrin (230.5 mmol) in the THF (10 ml) was added dropwise into themixture. Then, the mixture was hold at reflux for 10 h. The mixture was pouredinto ice water (300 ml) and extracted with Et2O (2 ¡Á 200 ml). The Et2Oextracts were combined and dried over anhydrous MgSO4. After thesolvent was evaporated, the residue was purified by column chromatography(petroleum ether : ethyl acetate = 8 : 1) to afford 4 in 65% yield. Yield 65%. White solid, mp 87-88 oC.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15149-10-7, 2-(p-Tolyloxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jia, Jian-Min; Liu, Fang; Xu, Xiao-Li; Guo, Xiao-Ke; Jiang, Fen; Cherfaoui, Bahidja; Sun, Hao-Peng; You, Qi-Dong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1557 – 1561;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 107-75-5, 7-Hydroxy-3,7-dimethyloctanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 7-Hydroxy-3,7-dimethyloctanal, blongs to alcohols-buliding-blocks compound. Quality Control of 7-Hydroxy-3,7-dimethyloctanal

General procedure: Amine (0.1 mmol) in MeOH (2 mL) was treated with an equimolaramount of aldehyde in MeOH (1 mL), held at 20C for 12 h, and evaporated. PMR and 13C NMR spectra of imines (+)-12 and(+)-(13) agreed with the literature [21] for (-)-(12) and (-)-(13). The yields of imines (+)- and (-)-(12) were 98 and 97%,respectively; of (+)- and (-)-(13), 96%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,107-75-5, 7-Hydroxy-3,7-dimethyloctanal, and friends who are interested can also refer to it.

Reference:
Article; Zakharenko; Mozhaitsev; Suslov; Korchagina; Volcho; Salakhutdinov; Lavrik; Chemistry of Natural Compounds; vol. 54; 4; (2018); p. 672 – 676; Khim. Prir. Soedin.; 4; (2018); p. 569 – 572,4;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 6006-82-2, 2-(Benzo[d][1,3]dioxol-5-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(Benzo[d][1,3]dioxol-5-yl)ethanol, blongs to alcohols-buliding-blocks compound. name: 2-(Benzo[d][1,3]dioxol-5-yl)ethanol

B. 1-Acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane To a stirred solution of 2-(3,4-methylenedioxy)phenyl-1-ethanol (1.68 g, 10 mmol) in dry pyridine was added acetic anhydride and the resultant reaction mixture was stirred at 80 C. for 1h. The reaction mixture was poured into ice-water and was extracted with ether (2*75 mL). The combined ether extract was washed with water (2*50 ml), 5% Hcl (2*50 mL) and then with 5% NaHCO3 (2*50 mL). The organic layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane as a solid (1.7 g, 81% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6006-82-2, 2-(Benzo[d][1,3]dioxol-5-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Texas Biotechnology Corp.; US6248767; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 2-(2-aminoethoxy)ethanol (99.52 g) and ethyl acetate (200 mL) was added dropwise a mixture of di-tert-butyl dicarbonate (208.57 g) and ethyl acetate (50 mL) under ice-cooling. The reaction solution was stirred at room temperature for 60 hrs, and concentrated under reduced pressure. The residue was dissolved in ethyl acetate (500 mL), and washed with water (200 mL), 1 N hydrochloric acid (200 mL), water (300 mL), and saturated brine (300 mL), followed by drying over anhydrous sodium sulfate. The solution was concentrated under reduced pressure to give tert-butyl [2-(2-hydroxyethoxy)ethyl]carbamate as colorless oil (169.2 g).1 H-NMR (cdcl3) : 1.45 (9H,s), 3.33(2H,q,J=5.1Hz), 3.54-3.59(4H,m), 3.74 (2H, q, J=5. 1Hz), 4.88(2H,bs).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 3068-00-6 ,Some common heterocyclic compound, 3068-00-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 2,2-Dilinoleyl-4-(2-hydroxyethylH1 ,31-dioxolane (II)A mixture of dilinoleyl ketone (I, previously prepared as described in Example 1 , 527 mg, 1.0 mmol), 1 ,3,4-butanetriol (technical grade, ca. 90%, 236 mg, 2 mmol) and pyridinium p-toluenesulfonate (50 mg, 0.2 mmol) in 50 mL of toluene was refluxed under nitrogen overnight with a Dean-Stark tube to remove water. The resulting mixture was cooled to room temperature. The organic phase was washed with water (2 x 30 mL), brine (50 ml_), and dried over anhydrous Na2SO4. Evaporation of the solvent resulted in a yellowish oily residual (0.6 g). The crude product was purified by column chromatography on silica gel (230-400 mesh, 100 mL) with dichloromethane as eluent. This afforded 0.5 g of pure H as colourless o. 1H NMR (400 MHz, CDCI3) delta: 5.25- 5.48 (8H, m, 4 x CH=CH), 4.18-4.22 (1 H, m, OCH), 4.08 (1 H, dd, OCH), 3.82 (2H, t, OCH2), 3.53 (1 H, t, OCH), 2.78 (4H, t, 2 x C=C-CH2-C=C), 2.06 (8H, q, 4 x allylic CH2), 1.77-1.93 (2H, m, CH2), 1.52-1.68 (4H, m, 2 x CH2), 1.22-1.45 (32H, m), 0.86-0.94 (6H, t, 2 x CH3) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3068-00-6, 1,2,4-Butanetriol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TEKMIRA PHARMACEUTICALS CORPORATION; THE UNIVERSITY OF BRITISH COLUMBIA; HOPE, Michael, J.; SEMPLE, Sean, C.; CHEN, Jianxin; MADDEN, Thomas, D.; CULLIS, Pieter, R.; CIUFOLINI, Marco, A.; LAHERTY, Carol, D.; MUI, Barbara; WO2010/42877; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 37585-16-3 , The common heterocyclic compound, 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol, molecular formula is C7H8ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

The synthetic route of 37585-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1467-84-1, Adding some certain compound to certain chemical reactions, such as: 1467-84-1, name is (trans-4-Aminocyclohexyl)methanol,molecular formula is C7H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-84-1.

The reference gathers the precedent 14 of the resulting 1 – (4-chloro-1 – {[ 2 – (trimethyl silicon alkyl) ethoxy] methyl} – 1H-pyrrolo [2,3-b] pyridine-5-yl) prop-2-en-1-one (35.3g, 105mmol) add in order to Japan International disclosed in paragraph 2013/024895 of the recorded reference gathers the precedentb 122 the method obtained (trans-4-amino-cyclohexyl) methanol (16.4g, 126mmol), potassium phosphate (44.7g, 210mmol) and dimethyl sulfoxide (175 ml), in 100-110 C stirring 2 hours 30 minutes. Subsequently, to the cold-discharge 50 C rear, for adding water in the reaction mixture. Filter the resulting solid, after washing with ethyl acetate, dried under reduced pressure, the title compound is obtained as light yellow solid (32.1g, yield 71%).

According to the analysis of related databases, 1467-84-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WATANABE, TSUNEO; TAKAHASHI, KEIJI; HAYASHI, KEISHI; NAKAMURA, TAKANORI; MINAMI, MASATAKA; KURIHARA, KAZUNORI; YAMAMOTO, AKIO; NISHIMURA, TAKUYA; UNI, MIYUKI; KAMIYAMA, TOSHIHIKO; IWAMOTO, SHUNSUKE; (96 pag.)TW2016/7947; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 111-45-5, 2-(Allyloxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111-45-5, blongs to alcohols-buliding-blocks compound. name: 2-(Allyloxy)ethanol

10065] In a one-liter flask equipped with a stirring device, a dimroth condenser, a thermometer and a dropping thnnel, put were 38.25 g (0.375 mol) of ethylene glycol monoallyl ether represented by the following formula (8) and 100 g oftoluene, and heated to 70 degrees C. 0.38 Gram of a solution of a catalyst, complex of alkali-neutralized chloroplatinic acid with vinyl siloxane, in toluene, containing 0.5% of platinum, was added in the flask. Then, 185 g (0.25 mol) of the compound represented by the aforesaid formula (7) was added dropwise in the flask with the dropping funnel over one hout The reaction mixture was held at 100 degrees C. for one hour and, then, analyzed in GC. The peak of the compound representedby the aforesaid formula (7) disappeared, which means that the reaction completed. 100 Grams of ion exchanged water were added to the reaction mixture with stirring to wash it and, then, left standing to cause phase separation. The aqueous phase containing the excessive ethylene glycol monoallyl ether was removed. The organic phase was similarly washed twice with each 100 g of ion exchanged water and, then, the toluene in the organic phase was stripped off under a reduced pressure to obtain 193.7 g (0.23 mol) of a colorless and transparent liquid, silicone compound representedby the following formula (9). The yield was 92%. The ratio of the silicone compound represented by the following formula (9) in the obtained product was 98.1 mass %, as determined in GC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-45-5, its application will become more common.

Reference:
Patent; SHIN-ETSU CHEMICAL CO., LTD.; KUDO, Muneo; ICHINOHE, Shoji; GOTO, Tomoyuki; US2015/266905; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 22436-06-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol. A new synthetic method of this compound is introduced below.

Example 115.1 g (100 mmol) of 2-methyl-3-phenylpropanol were introduced as initial charge in 87 g of dichloromethane. Over the course of 4 hours, 13.4 g (100 mmol) of AlCl3 and 9.3 g (100 mmol) of tert-butyl chloride were added at a temperature of 1-10 C. The mixture was heated to room temperature and worked-up with water and sodium hydroxide solution and the solvent was removed. This gave a mixture with the following composition: 2-methyl-3-(3-tert-butylphenyl)propanol (41%); 2-methyl-3-(4-tert-butylphenyl)propanol (24%); 3-(3,5-di-tert-butylphenyl)-2-methylpropanol (19%); 2-methyl-3-phenylpropanol (15%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; US2012/209030; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7515-29-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7515-29-9, name is 1-Cyclobutylethanol. This compound has unique chemical properties. The synthetic route is as follows.

In a 20 mL reaction vial, 3-(4-bromo-phenyl)-5-methyl-3H-[l,2,3]triazole-4-carboxylic acid (300 mg, 1.06 mmol), 1-cyclobutylethanol (170 mg, 1.70 mmol) and triethylamine (218 mg, 0.3 mL, 2.15 mmol) were combined with toluene (10 mL) to give a yellow solution and to this was added diphenylphosphorylazide (585 mg, 0.458 mL, 2.13 mmol). The vial’s atmosphere was purged with nitrogen, sealed, heated in an oil bath at 65 C for 2.5 h, and cooled to room temperature overnight. The reaction was diluted with EtOAc and washed with water, saturated ammonium chloride, and brine. The aqueous layers were extracted once with EtOAc. The organic layers were combined, dried over MgS04, filtered, concentrated, diluted with DCM, and purified by flash chromatography (silica gel, 0% to 50% EtOAc in hexanes). Appropriate fractions combined, concentrated, and dried from DCM / hexanes yielding [3-(4-Bromo-phenyl)-5-methyl-3H-[l,2,3]triazol-4-yl]-carbamic acid 1-cyclopropyl-ethyl ester (295.2 mg, 73.2%> yield) as a colorless waxy solid. LC/MS calcd. for Ci6Hi9BrN402 (m/e) 378/380, obsd. 379/381 (M+H, ES+).

According to the analysis of related databases, 7515-29-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189865; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts