Tag: M.W=100-200

Related Products of 5339-85-5 ,Some common heterocyclic compound, 5339-85-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 49 2-(2-(2-hydroxyethyl)phenyl)isoindoline-1,3-dione; [0379] A flask containing 2-aminophenethyl alcohol (565 mg, 4.12 mmol), phthalic anhydride (641 mg, 4.32 mmol) and acetic acid (4 mL) was heated at 100 C for 1 h. The reaction mixture was poured into water (30 mL) and the solid was filtered off and the solids were washed with water. The crude was purified by flash column chromatography to afford the desired product as white solid (435 mg, 1.63 mmol, 40%). NMR: 1.79 (br s, 1H), 2.78 (t, 2H, J = 6.4 Hz), 3.81 (t, 2H, J = 6.4 Hz), 7.20 (d, 1 H, J = 8 Hz), 7.36-7.41 (m, 1H), 7.46 (d, 2H, J = 4 Hz), 7.79-7.83 (m, 2H), 7.94-7.97 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5339-85-5, 2-(2-Aminophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEWLINK GENETICS; MAUTINO, Mario, R.; KUMAR, Sanjeev; JAIPURI, Firoz; WALDO, Jesse; KESHARWANI, Tanay; ZHANG, Xiaoxia; WO2011/56652; (2011); A1;,
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Reference of 599-67-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, molecular weight is 198.26, as common compound, the synthetic route is as follows.

General procedure: The procedure is the same for solid and liquid substrates.Alcohol (1 mmol) and iodine (3 mol%) weremixed together in a 5 mL conical reactor and the reactionmixture stirred at 25 C or 55 C for various times (5 minto 192 h), progress was monitored by TLC or by 1H NMRspectroscopy. The crude reaction mixture was dilutedwith tert-butyl methyl ether, washed with an aqueoussolution of Na2S2O3, water, dried over Na2SO4 and the solventevaporated under reduced pressure. The crude reactionmixture was subjected to column chromatography orpreparative TLC using hexane or petroleum ether/tert-butylmethyl ether mixtures and pure product(s) were obtained.Conversions were determined by 1H NMR spectroscopy.The effects of reaction variables on the type oftransformation and conversions are stated in Tables andFigures. In order to obtain the information (role) of thereaction variables and structure of substrate, the data (reactiontimes with lower conversion) are presented in someTables. In the experimental section, the best reaction conditionsare named; 3 mol% of I2 were used, giving thehighest yield.

Statistics shows that 599-67-7 is playing an increasingly important role. we look forward to future research findings about 1,1-Diphenylethanol.

Reference:
Article; Jereb, Marjan; Vra?i?, Dejan; Acta Chimica Slovenica; vol. 64; 4; (2017); p. 747 – 762;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below., Safety of 1-(m-Tolyl)ethanol

General procedure: A 1,2-dichloroethane (2.0 or 5.0 mLmL) solution of alcohol 1 (0.3mmol), enol acetate 2 (0.3mmol), and ReBr(CO)5 (5mol%) was stirred under an atmosphere of nitrogen at 80C for 5h. After the reaction was complete, H2O was added to the reaction mixture and extracted with ethyl acetate. The organic layer was dried with MgSO4. The resulting mixture was filtered, and the filtrate was concentrated. Purification of the residue by silica gel column chromatography afforded carbonyl compounds. Further purification was carried out by recyclable preparative HPLC, if necessary. The structures of the products were assigned by their 1H and 13C NMR, and mass spectra. The product was characterized by comparing its spectral data with those of authentic sample or previous reports 3a [23], 3b [24], 3c [24a], 3e [25], 3f [24a,26], 3h [27], 3i [28], 3j [29], 3k [25], 3l [30], 3m [31], 4b [27], 4d [32], 4g [24a,33], 4h [34], 6a [35], 6g [24a], 6h [36], 8e [37], and 8e? [38]. The structures of the products (3d, 4c, 4e, 4f, 4i, 6b, 6c, 6d, 6e, 6f, 6i, 6j, 6k, 6l, 8a, 8a?, 8b, 8b?, 8c, 8c?, 8d, 8d?, 8f, 8f?, 8g, and 8g?) were assigned by their 1H and 13C NMR, IR, and high resolution mass spectra analysis.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Umeda, Rui; Takahashi, Yuuki; Yamamoto, Takaaki; Iseki, Hideki; Osaka, Issey; Nishiyama, Yutaka; Journal of Organometallic Chemistry; vol. 877; (2018); p. 92 – 101;,
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Synthetic Route of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

REFERENCE EXAMPLE 1 Synthesis of 2-methyleneadamantane One liter flask equipped with a Dean-Stark condenser was charged with 166.3 g (1.0 mol) of 2-methyl-2-adamantanol (supplied by Sigma-Aldrich Co.), 2.0 g (20 mmol) of sulfuric acid and 500 g of toluene. The content was heated to the solvent reflux temperature. While toluene and water produced through the reaction were collected as an azeotrope by the Dean-Stark condenser, the reaction mixture was refluxed for 2 hours. After completion of the reaction, the catalyst was removed by washing the reaction mixture with water and the obtained organic phase was concentrated to dryness to give 152.5 g of white solid 2-methyleneadamantane (purity: 99.0%, yield: 98.0%).

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH CORPORATION; US2003/139613; (2003); A1;,
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Application of 13674-16-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate, molecular formula is C10H12O3, molecular weight is 180.2, as common compound, the synthetic route is as follows.

EXAMPLE 11 2-[4′-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxy]-3-phenyl-propionic acid The title compound was prepared from 4′-(2-benzyl-benzofuran-3-yl)-biphenyl-4-ol, and 3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 164-166 C.; MS m/e 524 (M+); Analysis for: C36H28O4 Calc’d: C, 82.42; H, 5.38 Found: C, 82.14; H, 5.20.

Statistics shows that 13674-16-3 is playing an increasingly important role. we look forward to future research findings about Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Patent; American Home Products Corporation; US6232322; (2001); B1;,
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Related Products of 15852-73-0 ,Some common heterocyclic compound, 15852-73-0, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 50 {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane TBSCl (18.7 g, 124.3 mmol), Et3N (14.08 g, 139.2 mmol) and DMAP (194.3 mg, 8.9 mmol) were dissolved in CH2Cl2 (120 mL) and the solution was cooled to 0-5 C. (3-Bromophenyl)methanol (18.5 g, 99.4 mmol) was added dropwise to the solution. After the addition of the (3-Bromophenyl)methanol, the mixture was warmed to room temperature and stirred for 2 h. 5% HCl was added to the reaction mixture to adjust the pH=4-5. Then the organic phase was separated and the aqueous layer was extracted with CH2Cl2 (50 mL*2). The combined organic phases were washed with water and dried over Na2SO4. After removing the solvent, 28.5 g of {[(3-bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane was obtained (Yield: 95.1%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15852-73-0, (3-Bromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
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Related Products of 4152-92-5, Adding some certain compound to certain chemical reactions, such as: 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4152-92-5.

A solution of 1.7 g of 2-(aminomethyl)benzyl alcohol (12. 4 mmol) and 1.76 mL of triethylamine (12. 4 mmol) was dissolved in 20 mL anhydrous methanol, 1.96 mL of ethyl trifluoroacetate (16.4 mmol) was added dropwise under argon and the reaction was stirred at 25 C for 2 hours. After the reaction, ethyl acetate (30 mL) and water (30 mL) were added to the extract. The ethyl acetate layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate overnight, and the solvent was removed in vacuo to give 2-[(trifluoroacetamido)methyl]benzyl alcohol. The crude product was purified by silica gel column chromatography eluting with ethyl acetate / cyclohexane (1: 2, v / v) to give 2-[(trifluoroacetamido)methyl]benzyl alcohol (2.0 g, 8.6 mmol), 69% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4152-92-5, (2-(Aminomethyl)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Beijing University of Technology; Zhao, Lijiao; Sun, Guohui; Zhong, RuGang; (20 pag.)CN104031048; (2016); B;,
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Reference of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

0.675 mol of isethionic acid sodium salt (100.0 g) and 2.02 mol benzylchloride (233 mL) were mixed in a 750 mL multi-necked flask with KPG-stirrer. The mixture was heated at 70C inside temperature (95C outside temperature) and thenTriethylamine (120 mL) was added drop wise over one hour and the outside temperature was increased to 125C and maintained. Subsequently, outside temperature increased to 140C, and the inside temperature rose to 130C. A solid clustered at the stirrer, but went back into suspension. Hydrochloric acid vapors evolved.30 mL of triethylamine was added drop wise and then reacted for 1 .5 more hours. A viscous yellowish suspension formed. The product was allowed to cool to 50C inside temperature, then 300 mL water was added and vigorously stirred for 20 minutes and the mixture was transferred to a 2L separatory funnel. Then, the flask was rinsed out with 100 mL of water.The combined aqueous phases were washed twice with 280 mL dichloromethane.The aqueous phase was held at 40C, while KCI was added to the solution until saturated (about 130 g KCI). The mixture was filtered through a fluted filter and stored overnight in a refrigerator.The remaining solid was extracted and dried, resulting in 30.85 g, yield of 17.9%. fl: OH band is present, similar to the precursor.The mother liquor was again treated with KCI and stored (at 35-40C) overnight in the refrigerator.Solid from the second precipitation with KCI was filtered off and dried, resulting in 60.0 g = 34.9 % and the fl corresponds to the desired product.Solid 1: Was boiled with 150 mL EtCH and filtered while hot.By repeated precipitating with KCI, boiling and crystallization, 32 g of the product were obtained for a yield of 19 %.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (101 pag.)WO2016/98054; (2016); A1;,
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Related Products of 6850-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6850-39-1, name is 3-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.17, as common compound, the synthetic route is as follows.

To a solution of 5-chloro-3-(5-fluoro-4-(methylsulfonyl)pyrimidin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine, 1a, (1.09 g, 2.34 mmol) and 3-aminocyclohexanol (0.32 g, 2.82 mmol) in THE was added DIEA (0.60 g, 4.69 mmol). The reaction mixture was heated at 130 C. in microwave for 10 min. The solvent was removed under reduced pressure and the resulting residue was purified by silica gel chromatography to afford 550 mg of the desired product, 27a.

The chemical industry reduces the impact on the environment during synthesis 6850-39-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, PAUL S; CLARK, MICHAEL P; BANDARAGE, UPUL K; BETHIEL, RANDY S; COURT, JOHN J; DENG, HONGBO; DAVIES, IOANA; DUFFY, JOHN P; FARMER, LUC J; GAO, HUAI; GU, WENXIN; JACOBS, DYLAN H; KENNEDY, JOSEPH M; LEDEBOER, MARK W; LEDFORD, BRIAN; MALTAIS, FRANCOIS; PEROLA, EMANUELE; WANG, TIAN-SHENG; WANNAMAKER, M WOODS; BYRN, RANDAL; CHOU, II; LIN, CHAO; JIANG, MIN; JONES, STEVEN; GERMANN, URSULA A; SALITURO, FRANCESCO G; KWONG, ANN DAK-YEE; (541 pag.)JP2015/38146; (2015); A;,
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Reference of 3391-86-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3391-86-4 as follows.

General procedure: In a Schlenk tube, 11.5 mg (4 105 mol) Na2CO310H2O wasdissolved in 4.6 mL H2O. After deoxygenation, 9.3 mg (2 105mol) [RuCl2(pta)(g6-p-cymene)] was added and the solution wasstirred for 15 min at 80 C. 310 lL (2.02 mmol) oct-1-en-3-ol wasinjected to the catalyst solution and the reaction mixture was stirredfurther at 80 C. At the end of the desired reaction time themixture was cooled and extracted with hexane under air. Theorganic phase was dried on MgSO4 and analyzed by gas chromatography.Products were identified by comparison of theirretention times to standards and the composition of the productmixture was calculated from peak areas.In recycling experiments, following extraction and phase separation,the aqueous phase was deoxygenated, heated to 80 C, anew batch of the substrate was added and the reaction was initiatedby stirring.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3391-86-4, its application will become more common.

Reference:
Article; Bolyog-Nagy, Evelin; Udvardy, Antal; Barczane-Bertok, Agnes; Joo, Ferenc; Katho, Agnes; Inorganica Chimica Acta; vol. 455; (2017); p. 514 – 520;,
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