Tag: M.W=100-200

Related Products of 67853-03-6, Adding some certain compound to certain chemical reactions, such as: 67853-03-6, name is Methyl 3-(hydroxymethyl)benzoate,molecular formula is C9H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67853-03-6.

To a cooled (0 C) solution of 3 (4.6 g, 27.5 mmol) in anhydrous DCM (75 ml) was slowly added PBr3 solution (11.2 g, 41.3 mmol) under nitrogen atmosphere. The reaction mixture was allowed to gradually reached room temperature and stirred for 2 hours. The reaction vessel was cooled in ice bath and the contents were quenched by slowly adding saturated NaHCO3 solution till slightly basic pH (7 – 8). The organic layer was washed with brine, water, dried with sodium sulphate and evaporated to yield 4 as white crystals (4.4 g, 69%). The product was used in the next step without further purification.

According to the analysis of related databases, 67853-03-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Veron, Jean-Baptiste; Joshi, Advait; Wallinder, Charlotta; Larhed, Mats; Odell, Luke R.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 476 – 479;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5020-41-7, name is 2-(3-Methoxyphenyl)ethanol, the common compound, a new synthetic route is introduced below. COA of Formula: C9H12O2

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

The synthetic route of 5020-41-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 230295-16-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 230295-16-6 as follows.

To a solution of 3-fluoro-4-(trifluoromethyl)benzyl alcohol (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under reflux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%). IR nu maxKBrcm-1: 1634, 1589, 1512, 1435.1H-NMR (CDCl3) delta: 4.58 (2H, s), 7.20-7.32 (2H, m), 7.60 (1H, t, J = 7.6 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,230295-16-6, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1362846; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 500 mL round bottomed flask equipped with a magnetic stir bar containing DCM (200 mL) was placed 87 (5 g, 34 mmol, 1 equiv). To this solution was added mesyl chloride (4.3 g, 38 mmol, 1.1 equiv), Et3N (5 g, 51 mmol, 1.5 equiv) and the reaction was allowed to stir at room temperature for 3 h. The reaction was then poured into water (100 mL) and extracted into DCM (3 x 100 mL). The combined organic extracts were washed with brine (100 mL), NaHCO3 solution (100 mL), dried (Na2SO4) and concentrated in vacuo. The residue was purified over silica gel. Product eluted out in 50percent EtOAc:Hexanes mixture in a gradient elution on a Combiflash purification system. Isolated 87 (7 g, 91percent) as a colorless solid. MS: [M+H]+: 225.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; SIEMENS MEDICAL SOLUTIONS USA, INC.; WO2008/124703; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 112-27-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 112-27-6 as follows.

Under the protection of nitrogen, to a 1000ml three-necked flask were added 200 mL pyridine, 120 g BP103a00(1.0eq), stirred and cooled down to 0C. 151.8g TsCl (1.0eq) was added in batches, stirred for 1h, then slowly warmed up to room temperature, and kept stirring for 3-4h. After the completion of the reaction, the reaction liquid was poured into ice-cold dilute hydrochloric acid solution, extracted with ethyl acetate. The ethyl acetate layer was washed once with dilute hydrochloric acid, washed with saturated sodium bicarbonate, washed with saturated brine, and dried over anhydrous Na2SO4. The solvents were evaporated off at reduced pressure, and chromatographed in a silica gel column to give 55g pure BP103a01.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.

Reference:
Patent; Bright Gene Bio-Medical Technology Co., Ltd.; YUAN, Jiandong; HUANG, Yangqing; SONG, Yunsong; YUAN, Fang; (69 pag.)EP3321279; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 3068-00-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, molecular weight is 106.1204, as common compound, the synthetic route is as follows.

[00181] Step 1 : To neat butane- 1 ,2,4-triol (300 g, 2.83 mol) was added 4-methylbenzenesulfonic acid (10 g, 58 mmol). The reaction mixture was heated to 180C. After 2 hours, the reaction mixture was cooled to ambient temperature and tetrahydrofuran-3-ol was afforded by distillation of the mixture under reduced pressure (10 mm Hg; the product fraction was collected at 46C).

Statistics shows that 3068-00-6 is playing an increasingly important role. we look forward to future research findings about 1,2,4-Butanetriol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; CHILDERS, Kaleen Konrad; DONOFRIO, Anthony; ELLIS, John Michael; KNOWLES, Sandra Lee; NORTHRUP, Alan, B.; WO2013/52393; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 28539-02-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(100 mg, 0.49 mmol), benzotriazolemethanol (72 mg,0.49 mmol) and p-toluenesulfonic acid (10 mg, 0.05 mmol) were stirred for 6 h at the reflux in 10 mL toluene. The crude product was washed with an aqueous KOH solution (10%, 5 mL), dried under MgSO4 and, then, cooled overnight. Filtration and the consecutive solvent evaporation led to 146 mg of the yellow desired product (89% yield). 1H NMR (CDCl3) d: 8.05-7.35 (m, 4H), 6.11 (d, J = 6.9 Hz, 2H), 3.53-3.42 (m, 1H), 3.18-3.01 (m, 2H), 2.43-2.31 (m, 1H), 2.25 (t, J = 7.4 Hz, 2H), 1.87-1.30 m, 7H. 13C NMR (CDCl3) d: 173.39, 128.20, 124.56, 119.69, 111.07, 56.35, 50.90, 40.26, 38.60, 36.09, 34.62, 28.76, 24.96.. Anal. Calcd for C15H20N4OS2: C, 53.54; H, 5.99; N, 16.65; S, 19.06. Found: C, 53.66; H, 6.10; N, 16.16; S, 19.39; ESI-MS: m/z = 337.1 (M+H+); m/z = 359.1 (M+Na+); m/z = 695.3 (2M+Na+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Article; De La Reberdiere, Arnaud; Lachaud, Fabien; Chuburu, Francoise; Cadiou, Cyril; Lemercier, Gilles; Tetrahedron Letters; vol. 53; 45; (2012); p. 6115 – 6118,4;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1883-32-5, name is 2,2-Diphenylethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,2-Diphenylethanol

(3) Preparation of 2,2-diphenylethyl methanesulfonate In a 500 mL three-opening flask, 2,2-diphenyl ethanol (17 g, 86 mmol) was dissolved in 170 mL dichloromethane. To the flask was added triethylamine (13.03 g, 129 mmol). The resulting mixture was stirred at 0 C. for half an hour. To the resulting mixture was slowly added MsCl (11.92 g, 104 mmol) dropwisely. The reaction was conducted at 25 C. After the completion of reaction monitored by TLC, the reaction solution was washed with water thrice. The organic phase was dried over anhydrous sodium sulfate and evaporated to remove the solvent to produce 2,2-diphenylethyl methanesulfonate (23 g) in a yield of 96.78%.

With the rapid development of chemical substances, we look forward to future research findings about 1883-32-5.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Zhang, Hui; Fan, Mingwei; Sun, Liang; US2014/45896; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2807-30-9, name is 2-Propoxyethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Propoxyethanol

10 g of the remaining bottoms of the distillation and 100 g of 2-n-propoxyethanol, 0.05 g of 4-pyrrolidinopyridine was charged into a reaction vessel equipped with a reflux condenser, Example 3 was carried out Distillation yielded 10 g of the preceding distillation and 123.8 g of thionyl chloride (Content 98.8%, sulfuryl chloride content 0.4%) were mixed,The stirring was started, and the mixture was slowly added dropwise to the reaction vessel. The procedure was as in Example 2. After completion of the dropping, heating was started, and the temperature was gradually raised to 98 C according to the reaction gas evolution rate.Until no gas release, continue to heat 4h get crude; The crude product was directly purified by distillation to obtain 116.41g of chloroethyl n-propyl ether. The product chromatogram was 99.2% and the water content was 0.15%. The yield was 98.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Shandong Kaisheng New Materials Co.,Ltd.; Zhang, Taiming; Wang, Ronghai; Zhang, Qingxin; Zhang, Shanmin; Sun, Fengchun; Bi, Yixia; (6 pag.)CN105384612; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 57772-50-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57772-50-6, name is (2-Amino-3-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

Statistics shows that 57772-50-6 is playing an increasingly important role. we look forward to future research findings about (2-Amino-3-methylphenyl)methanol.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts