Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 612-16-8, name is (2-Methoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 612-16-8

The reactants used were o-methoxybenzyl alcohol (i.e., R1 in the formula (I) was ortho OCH3) 1.0 mmol(138.2 mg), experimental procedure and procedure with Example 1, aqueous ammonia (1.7 mol / L) 5.0 mL,The amount of catalyst used in cuprous chloride was 8 mol% (7.9 mg)TEMPO is used in an amount of 8 mol% (12.5 mg)The reaction temperature was 120 and the reaction time was 24h. The crude product was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give the target product as 123.9 mgYield 93%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 612-16-8, (2-Methoxyphenyl)methanol.

Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2009-83-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2009-83-8, name is 6-Chlorohexan-1-ol. A new synthetic method of this compound is introduced below.

2.2 Preparation of 6-hydroxyhexyl 3,5-dinitrobenzoate 357.70 g (1.686 MoI) of 3,5-dinitrobenzoic acid are suspended in 750 ml of 1-methyl-2- pyrrolidone. The suspension is stirred up to 500C. 386.36 g (4.599 MoI) of sodium hydrogen carbonate are added and the mixture was heated up to 900C. 22.50 g (0.150 MoI) of sodium iodide and 204.0 ml (1.533 MoI) of 6-chlorohexanol are added to the reaction mixture which is heated to 1000C for 1 h. After 1 h of reaction, the reaction is complete and the orange suspension is thrown on 2 I of ice and1 I of water. The product is filtrated, washed water and dried at 5O0C under vacuum for 24 h to give 425.0 g (91%) of 6-hydroxyhexyl 3,5-dinitrobenzoate as a rose powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ROLIC AG; WO2008/145225; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1475-13-4, name is 1-(2,4-Dichlorophenyl)ethanol. A new synthetic method of this compound is introduced below., Computed Properties of C8H8Cl2O

General procedure: A mixture of 2 mmol of substrate, and 4 mL ethylene glycol was stirred for 5 min, and then 2.4 mmol of DBDMH or 4.6 mmol of NBS was added by 5 times in one hour, and the mixture was stirred 24 h at room temperature. Afterward, the mixture was extracted with ether (10 mL × 3). The combined organic layer was washed twice by water (20 mL), and dried over anhydrous Na2SO4. After filtration, the solvent was removed under reduced pressure, and the residual was treated with alumina chromatography (Petroleum ether/AcOEt=20/1,V/V) to generate the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1475-13-4, 1-(2,4-Dichlorophenyl)ethanol.

Reference:
Article; Han, Bingbing; Zheng, Zubiao; Wu, Fang; Wang, Aidong; Synthetic Communications; vol. 47; 24; (2017); p. 2387 – 2394;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol. A new synthetic method of this compound is introduced below., Safety of 4-(4-Methoxyphenyl)-1-butanol

To a stirred solution of 4-(4-methoxyphenyl)butanoi (1 equiv.) in dry dichloromethane at – 100C under an argon atmosphere was added boron tribromide (2.7 equiv., using a 1 M solution of boron tribromide in CH2Cl2)- Stirring was continued at that temperature until completion of the reaction (4 hours). Unreacted boron tribromide was destroyed by addition of aqueous saturated NaHCO3 solution at 00C. The resulting mixture diluted with CH2Cl2 and water, the organic phase was separated, washed with brine, dried (MgSO4) and evaporated. Purification by flash column chromatography on silica gel (30percent diethyl ether-hexane) afforded the title compound in 42percent yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52244-70-9, 4-(4-Methoxyphenyl)-1-butanol.

Reference:
Patent; UNIVERSITY OF CONNECTICUT; WO2008/13963; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H14O4

Polyethylene glycol (9 g, 60 mmol) was dissolved in 70 mL of toluene,Then, 10.2 mL of 48% HBr aqueous solution was added, heated to reflux,With sodium bicarbonate to absorb the release of gas,The reaction temperature was controlled at 115 C and the reaction was stirred for 3 days.After cooling, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate and then solvent was removed. 30 mL of water was added and extracted with CH 2 Cl 2 (3 × 60 mL).The combined organic phases were dried over anhydrous sodium sulfate, and the organic solvent was stripped to give 5.2 g of compound 15 in 41% yield.

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Yang Qinglai; Tan Lianjiang; Li Xinhui; Shao Zhifeng; Gong Bing; Li Xiaowei; Liu Yazhi; Zhang Zhen; (35 pag.)CN104725453; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 42142-52-9 ,Some common heterocyclic compound, 42142-52-9, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

250 milliliters of N,N-dimethylacetamide was taken into round bottom flask to which 115.3 grams of potassium tertiary butoxide, 100 grams of N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine and 100 grams of 2-fluorotoulene were added,followed by heating to 120 to 130C for about 12 to 14 hours. Solvent was distilled from the above reaction mass under vacuum below 118 to 122C, followed by the addition of 500 milliliters of methanol and 300 milliliters of a 45-50 percent by weight sodium hydroxide solution. The reaction mass was transferred into an autoclave and then heated to a temperature of 105 to 110C for about 6 to 7 hours. The solvent was totally distilled off under vacuum at a temperature below 80C, then 1 liter of demineralised water and 1 liter of toluene were added, followed by cooling to 0 to 5C and adjusting the pH to a value between 8 and 9 with dilute hydrochloric acid. The above reaction mass was stirred for about 15 to 30 minutes to separate the organic and aqueous layers and the aqueous layer was extracted with 400 milliliters of toluene followed by stirring for about 5 to 10 minutes. Organic and aqueous layers were separated and the combined organic layers were washed with 400 milliliters of dimineralised water. The organic layer was taken into a round bottom flask followed by complete distillation under vacuum below 80C and then cooled to 25 to 35C. 1.3 liters of acetone and 64.2 grams of oxalic acid were added to the round bottom flask followed by stirring for about 45 to 60 minutes. The solid mass that was obtained was filtered and washed with 520 milliliters of acetone, and then slurried in 700 milliliters of acetonitrile in a round bottom flask and stirred for about 30 to 45 minutes. The solid mass was isolated by filtration and washed with 200 milliliters of acetonitrile, followed by drying at 50 to 60C for 4 to 5 hours under vacuum to afford atomoxetine oxalate.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42142-52-9, 3-(Methylamino)-1-phenylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/9884; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 5299-60-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5299-60-5, name is Ethyl 6-hydroxyhexanoate, molecular formula is C8H16O3, molecular weight is 160.21, as common compound, the synthetic route is as follows.

The PCC (16.20g, 75 . 50mmol) dissolved in dichloromethane (140 ml) in, lowering the temperature to 0 C, dropping 6 – hydroxy hexanoic acid ester (10.30g, 64 . 30mmol) of dichloromethane (20 ml) solution. Heating the reaction to room temperature, stirring the reaction 2 hours, adding ethyl acetate (100 ml), filtered, the filtrate is concentrated. The residue by silica gel column chromatography (petroleum ether/ethyl acetate (v/v)=10/1) to obtain the title compound as white solid (9.28g, 45.0%).

Statistics shows that 5299-60-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 6-hydroxyhexanoate.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Gao Jinheng; Zhang Yingjun; (37 pag.)CN106279153; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 52273-77-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52273-77-5, name is 2-(3-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step B: 2-[3-({5-Chloro-4-[(3-methoxybenzyl)amino]pyrimidin-2-yl}amino)phenyl]ethanol Into a reaction flask were added 2,5-dichloro-N-(3-methoxybenzyl)pyrimidin-4-amine (0.33 g, 1.2 mmol) (prepared according to Example 1, step A), 1,4-dioxane (20 mL), 2-(3-aminophenyl)ethanol (0.22 g, 1.6 mmol), and p-toluenesulfonic acid monohydrate (0.080 g, 0.42 mmol). The mixture was heated at 105 C. for 3 hours and then an aqueous solution of NaHCO3 (saturated) was added. The organic solvent was removed under vacuum followed by the addition of water and EtOAc. The aqueous layer was extracted with EtOAc twice. The organic layers were combined, dried over Na2SO4, and concentrated under vacuum. The crude was purified by silica gel column chromatography to provide the desired product as a white solid (0.33 g, 74% yield). LCMS for C20H22ClN4O2 (M+H)+: m/z=385.1.

According to the analysis of related databases, 52273-77-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INCYTE CORPORATION; US2010/190804; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.928-51-8, name is 4-Chlorobutan-1-ol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.name: 4-Chlorobutan-1-ol

To a suspension of 4-ethynyl-1H-pyrazole (920 mg, 10 mmol) and4-chlorobutan- 1-ol (216 mg, 20 mmol) in acetonitrile (25 mL) was added K2C03 (4.1 g,30 mmol, 3 eq) and KI (166 mg, 1 mmol, 0.1 eq). The mixture was stirred for 6 hours at85 C under N2 protection. The readion mixture was quenched with water and extractedwith EtOAc. The residue was purified by chromatography (DCM:MeOH 10:1) to afford to afford 1.3 g of 4-(4-ethynyl-1H-pyrazol-1-yl)butan-1-ol with 80% yield. ESI-MS mlz 165.02 [M+Hjt

At the same time, in my other blogs, there are other synthetic methods of this type of compound,928-51-8, 4-Chlorobutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; HU, Yang; QIN, Chong; XU, Fuming; HU, Jiantao; XIANG, Weiguo; ZHOU, Bing; (233 pag.)WO2018/52949; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 495-76-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol. A new synthetic method of this compound is introduced below.

To a round-bottomed flask were added piperonyl alcohol (4) (2 mmol, 304 mg) and dichloromethane (20 mL). The mixture was cooled to 0 oC under stirring and anhydrous conditions. Then, a solution of phosphorus tribromide (10 mmol, 2.71 g, 0.9 mL) in dichloromethane (9.1 mL) was added dropwise using syringe and needle. The reaction was maintained under stirring and anhydrous conditions at room temperature for 3 h. Afterwards, distilled water (50 mL) was added to the mixture, which was extracted with CH2Cl2 (3 x 50 mL). The organic phase was dried over MgSO4. After filtration, the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using hexane/ethyl acetate (10:1) as eluent to afford the desired product 3. Yield: 371 mg (86%); off-white solid; m.p. 40-41 oC (m.p. lit.11 39 oC); Rf = 0.44 (eluent: hexane/ethyl acetate (10:1)); 1H NMR (300 MHz, CDCl3): delta 6.85 (d, J = 8.7 Hz, 2H), 6.74 (d, J = 7.9 Hz, 2H), 5.96 (s, 2H), 4.45 (s, 2H); 13C NMR (75 MHz, CDCl3): delta 147.9, 147.8, 131.5, 122.7, 109.4, 108.3, 101.3, 34.2; IR (KBr, cm-1) 3448.7, 2900.9, 1500.6, 1485.2, 1251.8; GC/MS (m/z, %): 214 (10.0), 215 (9.9), 135 (100.0), 77 (23.8), 51 (16.3), 105 (7.0).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Correa, Bianca K.; Silva, Tamiris R.C.; Raminelli, Cristiano; Tetrahedron Letters; vol. 59; 39; (2018); p. 3583 – 3585;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts