Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1805-32-9

General procedure: The alcohol (1 mmol) was added to a mixture of TBHP(1 mmol) and VO(ephedrine)2MNPs (50 mg) in PEG(1 mL), and then the mixture was refluxed at 80 C for thetime specified. The progress was monitored by TLC (EtOAc/n-hexane, 1/2). After completion of the reaction, the catalystwas separated from the product by an external magnet(within 5 s), and the mixture was washed with EtOAc(25 mL) and decanted. The decanted mixturewas washedwith 30% NaOH (5 mL) and the organic layer was dried overanhydrous Na2SO4. The evaporation of EtOAc underreduced pressure gave the pure products in 85e98% yields.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1805-32-9, 3,4-Dichlorobenzyl alcohol.

Reference:
Article; Rostami, Amin; Pourshiani, Omid; Darvishi, Neda; Atashkar, Bahareh; Comptes Rendus Chimie; vol. 20; 4; (2017); p. 435 – 439;,
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Electric Literature of 6351-10-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6351-10-6, name is 2,3-Dihydro-1H-inden-1-ol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of alcohol (0.5 mmol) in the case of solids, which had been powedered for 1-2 min and halosilanes (0.55 mmol) was transferred to a 4 mL screw-capped vial, and stirred at rt or heated at 70-75 C for 0.5 h-24 h. The progress of the reaction mixture was monitored by TLC. Upon completion of the reaction, the crude reaction mixture was cooled down to the room temperature and volatile product (TMS)2O was removed by evaporation at 30-35oC under reduced pressure and the remaining was analysed by 1H NMR. Finally, if necessary, the pure final product was obtained after column chromatography on dried silica. Detailed experimental information such as isolated yields, and spectroscopic and other identification data are given in Characterization Data of Isolated Final Products chapter in the SI.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6351-10-6, its application will become more common.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Tetrahedron Letters; vol. 57; 22; (2016); p. 2430 – 2433;,
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Related Products of 14002-80-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 14002-80-3 as follows.

Intermediate 5: Methyl 2,2-dimethyl-3-oxopropanoateTo a solution of methyl 3-hydroxy-2,2-dimethylpropanoate (2 g, 15.13 mmol) and TEMPO (0.236 g, 1.513 mmol) in dichloromethane (15 ml) was added iodobenzene diacetate (5.36 g, 16.65 mmol) and the solution was stirred for 3 hours at ROOM TEMPERATURE. The reaction was quenched with a saturated solution of NaHCtheta3/5%Na2S2theta3 (10ml) and extracted with DCM (20ml). The organic layer was washed with brine and then dried (Na2SO4), filtered and evaporated to afford the title compound (4.8 g, 14.75 mmol) as an -1 :1 mixture with iodobenzene that was used in the following reaction without further purification; 1H NMR (CDCI3) only signals relating to title compound: delta 1.38 (s, 6H), 3.78 (s, 3H), 9.69 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14002-80-3, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; DI FABIO, Romano; GIANOTTI, Massimo; LESLIE, Colin Philip; STASI, Luigi Piero; WO2010/142652; (2010); A1;,
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Related Products of 15258-73-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15258-73-8 as follows.

2,6-Dichlorobenzyl alcohol (1.1 mmol) was dissolved in dry DMF (5 ml) and treated with sodium hydride (60% dispersion in mineral oil, 1.21 mmol). The mixture was stirred at room temperature for 30 mins, then treated with lithium-5-chloro-pyrazine-2- carboxylate (1 mmol) and stirred at reflux overnight. The reaction mixture was partitioned between ethyl acetate and water, then the organic layer was separated, dried [(MGSO4),] filtered, evaporated and the residue purified by column chromatography on silica. Elution with mixtures of petroleum ether and diethyl ether afforded the title product. MS (ES): m/e 300 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15258-73-8, its application will become more common.

Reference:
Patent; ASTEX TECHNOLOGY LIMITED; WO2004/4720; (2004); A1;,
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Electric Literature of 10488-69-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, molecular formula is C6H11ClO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take raw materialsS-4-chloro-3-hydroxybutyric acid ethyl ester 5 g,Add a bottle of bottles,Add 10 ml of methanol,Add 5 g of sodium azide to stir,The reaction was carried out at a temperature of about 50 ° C for 4 hours to stop the reaction to obtain a yellow solution.20 ml of water was added, and the mixture was extracted with 20 ml of ethyl acetate, and the ethyl acetate was concentrated to obtain a yellow oil as an intermediate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10488-69-4, Ethyl 4-chloro-3-hydroxybutanoate.

Reference:
Patent; Chongqing Runze Pharmaceutical Co., Ltd.; Ye Lei; (12 pag.)CN107011235; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. A new synthetic method of this compound is introduced below., Formula: C7H7N3O

To a solution of 3 ,4,6-trimethyl-2-(5 -((1 -methylcyclopropyl)methoxy)-2-azabicyclo[4. 1. Ojheptan-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-bjpyridin-5-one (77 mg, 0.217 mmol) in THF (1 mL) was added LiHMDS (1.083 ml, 1.083 mmol) at -78C. Then the mixture was stirred at -78 C for 30 mm. Then(1H-benzo[dj[1,2,3jtriazol-1-yl)methanol (48.5 mg, 0.325 mmol) in THF (1 mL) was dropwise added to the mixture and the mixture was stirred for another 30 mm. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (10 mLx 2). The combined organic layers were dried over Na2504 and filtered, and the filtrate was concentrated in vacuo to give the residue, which was further purified by prep-TLC (dichloromethane : MeOH = 10:1) to provide the title compound as yellow oil. The title compound was separated by chiral SFC (AD(250mm*3Omm,lOum), 30% MeOH with 0.1%NH3.H20/C02 at 6OmL/min) and Prep-HPLC (TFA) to give four isomers. Example 5 (firstpeak): MS: 386.1 (M+1). ?H NMR (400 MHz, Methanol-d4): oe 4.23-4.25 (1 H, m), 4.11-4.14 (2H, m), 3.97-3.99 (1 H, m), 3.79-3.82 (1 H, m), 3.46-3.49 (1 H, m), 3.33-3.35 (1 H, m), 3.13 (3H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m),1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.45 (2 H, m), 0.30-0.32 (2 H, m).Example 6 (second peak): MS: 386.2 (M+1). ?H NMR (400 MHz, Methanol-d4): oe 4.23-4.25 (1H, m), 4.11-4.14 (2 H, m), 4.01-4.04 (1 H, m), 3.79-3.82 (1 H, m), 3.46-3.49 (1 H, m), 3.32-3.35(1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H,m), 0.58-0.61 (1 H, m), 0.42-0.45 (2 H, m), 0.30-0.32 (2 H, m). Example 7 (third peak): MS: 386.2 (M+1). ?H NMR (400 MHz, Methanol-d4): oe4.23-4.25(1 H, m), 4.11-4.14(2 H, m), 4.01-4.02 (1 H, m), 3.79-3.82 (1 H, m), 3.45-3.47(1 H,m), 3.32-3.35 (1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01(1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.45 (2H, m), 0.3 1-0.32 (2 H, m). Example 8 (fourth peak): MS: 386.1 (M+1).?H NMR (400 MHz,Methanol-d4): oe 4.23-4.26(1 H, m), 4.11-4.14(2 H, m), 3.98-4.01 (1 H, m), 3.79-3.82(1 H, m), 3.45-3.47 (1 H, m), 3.32-3.35 (1 H, m), 3.13 (3 H, s), 2.94-3.01 (2 H, m), 2.60 (3 H, s), 2.36 (3 H, s), 1.95-2.01 (1 H, m), 1.46-1.70 (2 H, m), 1.14 (3 H, s), 0.87-0.92 (1 H, m), 0.58-0.61 (1 H, m), 0.42-0.44 (2 H, m), 0.3 1-0.32 (2 H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CLAUSEN, Dane James; FELLS, James, I.; KOZLOWSKI, Joseph, A.; LIU, Ping; MAZZOLA, Robert, D., Jr.; (94 pag.)WO2018/226545; (2018); A1;,
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Application of 140373-17-7 , The common heterocyclic compound, 140373-17-7, name is 2-Amino-2-(4-fluorophenyl)ethanol, molecular formula is C8H10FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Method E, Step 5Compound E5 will be reacted with E6 and EDCI in DMF to give compound E7 after purification.

The synthetic route of 140373-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2009/61699; (2009); A1;,
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Application of 87327-65-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 87327-65-9, name is 1-(2,6-Difluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 82; 5- [1-(2,6- Difluorophenyl)-ethoxy ]-q uinazoline-2,4-diamine; [00258] Step 1; To a cold (ice water) suspension of sodium hydride (409 mg; 10 mmol) in anhydrous DMF (4 mL) is added a solution of 2,6-difluoro-alpha- methylbenzyl alcohol (1.63 g; 10 mmol) in anhydrous DMF (5 mL) over 10 minutes. After allowing to room temperature over 1 hour, this solution is added to a cold (ice water) stirred solution of 2,6-difluorobenzonitrile (1.53 g; 11 mmol) in anhydrous DMF (6 mL), and allowed to room temperature over 2.5 hours. The reaction mixture is poured into ice water with vigorous stirring and the resulting solid is filtered, washed with water, and dried under vacuum at 40 C overnight to give 1.92 grams of 2-[ 1-(2,6-difluorophenyl)-ethoxy]-6-fluorobenzonitrile.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 87327-65-9, 1-(2,6-Difluorophenyl)ethanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
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Synthetic Route of 495-76-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.

To a solution of the piperonyl alcohol (8) (2.0 g, 13.15 mmol) in anhydrous CH2Cl2 (30 mL), cooled to 0 C and stirred, under an argon atmosphere, freshly distilled PBr3 (3.7 mL, 39.45 mmol), was added dropwise. The resulting solution was kept under stirring at 0 C for a further 20 minutes. After, the ice bath was removed, maintaining the stirring for a further 2 h. The system was cooled again to 0 C and a saturated solution of NaHCO3 (75 mL) was slowly added. Extraction was carried out with ethyl ether (3x 70 mL). The combined organic phases were washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford crude bromide (9). This bromide (used immediately after its preparation) was solubilized with anhydrous acetonitrile (30 mL), treated with triphenylphosphine (3.45 g, 13.15 mmol) and stirred overnight, under reflux. Acetonitrile was removed under reduced pressure and the residue was recrystallized from ethanol to provide (5.21 g) Wittig salt (10) in 83% overall yield. Rf 0.53 (CH2Cl2/MeOH 9:1). mp: 237.2-238.5 C. IR (neat) numax/cm-1: 3018, 1492, 1438, 1246, 1109, 750, 687. 1H NMR (400 MHz, CDCl3) delta 7.80-7.62 (m, 15H), 6.62-6.59 (m, 1H), 6.53 (d, 2H, J=5.5 Hz), 5.87 (s, 2H), 5.28 (d, 2H, J=13.9 Hz). 13C NMR (100 MHz, CDCl3) delta 147.6, 134.9 (d, J=11.5 Hz), 134.2 (d, J=38.6 Hz), 130.0 (d, J=49.7 Hz), 125.3, 119.9 (d, J=36 Hz), 118.0, 117.2, 111.2 (d, J=18.4 Hz), 108.4 (d, J=13.5 Hz), 101.1, 30.4 (d, J=187.4 Hz). HRMS (ESI+) calcd for C26H22BrO2P [M-HBr]+ 397.1352, found 397.1358.

Statistics shows that 495-76-1 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-5-ylmethanol.

Reference:
Article; Diaz-Munoz, Gaspar; Isidorio, Raquel Geralda; Miranda, Izabel Luzia; de Souza Dias, Gabriel Nunes; Diaz, Marisa Alves Nogueira; Tetrahedron Letters; vol. 58; 33; (2017); p. 3311 – 3315;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7589-27-7, name is 2-(4-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.16, as common compound, the synthetic route is as follows.Recommanded Product: 7589-27-7

To a 50 mL round bottom flask equipped with a stir bar was added 6-chloropyridazin-3-ol (250 mg, 1.9 15 mmol), 2-(4-fluorophenyl)ethanol (268 mg, 1.9 15 mmol), triphenylphosphine (603 mg, 2.298 mmol) and THF (10 mL). To the stirred solution was added DIAD (0.447 mL, 2.298 mmol). The solution had a mild exotherm, then cooled within 5 minutes. The solution was stirred at RT for 2 hrs. The reaction solution was concentrated in vacuo and purified via silica gel chromatography (40 gcolumn, 5-40percent EtOAc:Hex) to afford the semi pure product. The material was further purfied via reverse phase C18 chromatography (55 g column, 20-100percent CH3CN:Water with 0.1percent TFA buffer). The desired fractions were isolated, diluted with sat. sodium bicarbonate solution (25 mL) and EtOAc. The organic layer was washed with brine, collected, dried over MgSO4, and volatiles evaporated to afford the pure product 3-chloro-6-(4-fluorophenethoxy)pyridazine (450 mg, 1.781 mmol, 93 percent yield) as a white solid. 1H NMR (400 MHz, CDC13) 7.22 (dd, J=8.3, 5.4 Hz, 2H), 7.18 (d, J=9.8 Hz, 1H), 7.04 – 6.97 (m, 2H), 6.91 (d, J9.5 Hz, 1H), 4.37 -4.30 (m, 2H), 3.13 – 3.06 (m, 2H). LCMS (M+1) = 253.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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