Tag: M.W=100-200

Application of 629-41-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 629-41-4 as follows.

In a 2 L three-opening bottle into the 1, 8 – octandiol (250 g, 1.712 muM), toluene (1000 ml), 48% hydrogen bromide (231 ml, 2 . 054 muM, 1.2 eq), heating to 110 C reflux 30 hours. Added 48% hydrogen bromide (84 ml, 0 . 753 muM, 0 . 44 eq), heating reflux for 20 hours, GC detection with a small amount of residues of raw materials. Cooling to the room temperature plus 500 ml petroleum ether dilution, liquid […] bromic acid, organic phase are saturated sodium bicarbonate (400 ml × 2) and saturated brine (400 ml × 2) cleaning, dried with anhydrous sodium sulfate. Turns on lathe does 8 – bromine propyl butyl-carbinol 318 g, yield 83%, direct throws down the step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,629-41-4, its application will become more common.

Reference:
Patent; Changzhou University; He Jiayi; Xia Ran; Wu Linsheng; Hu Xiwen; Jin Xinyu; Chen Ke; Li Yuan; Qiu Lin; Chen Xin; (8 pag.)CN109796336; (2019); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2-Amino-3-chlorophenyl)methanol

EXAMPLE 100 Preparation of 2-benzyloxymethyl-6-chloroaniline This material was prepared from 2-amino-3-chlorobenzyl alcohol and benzyl bromide by the general procedure outlined in Example 98. The product was purified by Kugelrohr distillation to yield an oil, b.p. 118-125 C. (0.1 mm). The product was characterized by IR and 1 H NMR spectroscopy.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61487-25-0, (2-Amino-3-chlorophenyl)methanol.

Reference:
Patent; The Dow Chemical Company; US4818273; (1989); A;,
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Reference of 86770-74-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol. A new synthetic method of this compound is introduced below.

Step A: (9H-fluoren-9-yl)methyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamate (11- 1) To a stirred solution of 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (1.00 g, 5.17 mmol) in DCM (15 mL) was added 9-fluorenylmethyl chloroformate (1.34 g, 5.17 mmol) and triethylamine ( 1.08 mL, 7.76 mmol). The resulting solution was stirred at room temperature for 10 minutes. The reaction was concentrated onto silica gel and flash column separation using a 0-10% isopropanol/ dichloromethane gradient gave 11-1 as an oil (1.43 g, 66%) LRMS (ES) (M+H)+ : observed = 416.1, calculated = 415.4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,86770-74-3, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP; AMBRX, INC; GARBACCIO, Robert, M.; KERN, Jeffrey; BRANDISH, Philip, E.; SHAH, Sanjiv; LIANG, Linda; SUN, Ying; WANG, Jianing; KNUDSEN, Nick; BECK, Andrew; MANIBUSAN, Anthony; GATELY, Dennis; WO2015/153401; (2015); A1;,
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Application of 27129-87-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27129-87-9, name is (3,5-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

The 0.91 g (0.0067 muM) of 3, 5 – dimethyl benzoic alcohol and 0.4 g of the dispersed GO – Ti 10 ml in tetrahydrofuran, and in the oil bath heated to 70 C, 1 . 89 g (0.0167 muM) of 30 wt % aqueous hydrogen peroxide solution in tetrahydrofuran is slowly added, keeping the temperature reaction 5 h, by HPLC detection, 3, 5 – dimethylphenyl methanol conversion rate is 91.3%, 3, 5 – dimethyl formaldehyde selectivity of 98.2%. After filtering to remove the catalyst concentrated filtrate, separation by silica gel column chromatography to obtain 3, 5 – dimethyl benzaldehyde 0.85 g, yield: 94.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.

Reference:
Patent; Shenyang Pharmaceutical University; Wang Qinghe; Cheng Maosheng; Ma Wenxi; Tong Qiaolin; Wang Shicheng; (8 pag.)CN108395369; (2018); A;,
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Related Products of 7287-82-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-82-3, name is 1-(2-Methylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

1-(o-Tolyl)ethanol (513 mg, 3.77 mmol, commercially available from, for example, Alfa Aesar) was dissolved in DCM (5 mL) and stirred at 0 C under N2. PBr3 (0.142 mL, 1.507 mmol) wasadded dropwise and the reaction stirred for 30 mm at 0 C, then allowed to slowly warm to rt. A further portion of PBr3 (0.355 mL, 3.77 mmol) was added dropwise at rt and the reaction stirred for1.5 h. The solution was quenched with sat. aq. sodium bicarbonate (20 mL), the aqueous layer was extracted with DCM (3 x 20 mL) and the combined organic layers were dried over a hydrophobic frit and concentrated to give (+/-)-1-(1-bromoethyl)-2-methylbenzene (670 mg, 2.69 mmol, 71.5 %yield) as a colourless oil.1H NMR (400 MHz, DMSO-d6) O ppm 7.54 – 7.60 (m, 1 H) 7.15 – 7.27 (m, 3 H) 5.62 (q, J=6.8 Hz, 1 H) 2.37 (5, 3 H) 2.03 (d, J=6.8 Hz, 3 H)

According to the analysis of related databases, 7287-82-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
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Synthetic Route of 2009-83-8 , The common heterocyclic compound, 2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A three-necked reactor equipped with a condenser and a thermometer was charged with hydroquinone 104.77 g (0.9515 mol), 100 g (0.7320 mol) of 6-chlorohexanol, 500 g of distilled water and 100 g of o-xylene were added. While stirring the whole volume, 35.15 g (0.8784 mol) of sodium hydroxide was further added in small portions over 20 minutes so that the temperature of the contents did not exceed 40 C. After completion of the addition of sodium hydroxide, the contents were heated and the reaction was further carried out under reflux conditions (96 C.) for 12 hours After completion of the reaction, the temperature of the reaction solution was lowered to 80 C., 200 g of distilled water was added, and then the reaction solution was cooled to 10 C. to precipitate crystals. Precipitated crystals were separated by solid-liquid separation by filtration, and the obtained crystals were washed with 500 g of distilled water and vacuum dried to obtain 123.3 g of brown crystals. Analysis of this brown crystal by high performance liquid chromatography revealed that the content ratio (molar ratio) of the compound contained in the brown crystal is (hydroquinone / intermediate K / by-product K = 1.3 / 90.1 / 8. 1). This mixture was directly used for step 2 without purification.

The synthetic route of 2009-83-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; KIRIKI, SATOSHI; (83 pag.)JP2017/206490; (2017); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol, the common compound, a new synthetic route is introduced below. Safety of (2-(Trifluoromethyl)phenyl)methanol

(2) To a 250 mL four-neck round bottom flask (mechanically stirred,Thermometer, reflux condenser) was added 2-trifluoromethylbenzyl alcohol (88.1 g, 0.5 mol), Then heated to 10 ° C,A solution of thionyl chloride (71.4 g, 0.6 mol)After the dropwise addition, the temperature was raised to 60 ° C, and the reaction was allowed to proceed.Keep T ? 55 ~ 65 /P ? 0.09 MPa The remaining SOCl2 was distilled off under reduced pressure,And then distillation at 75-80 ° C / -0.09 MPa under reduced pressure to give colorless transparent liquid 2-trifluoromethylbenzyl chloride purity> 99percent yield 95percent.

The synthetic route of 346-06-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jin Kai (Liaoning) Chemical Co., Ltd.; Fu, Limin; Wang, Yongcan; Jia, Tiecheng; Yang, Xiaoge; Wang, Xiuying; Wu, Jingrui; (8 pag.)CN106588673; (2017); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, the common compound, a new synthetic route is introduced below. Computed Properties of C8H8Cl2O

(viii) To sodium hydride (144 mmol, 4.32 g, 80% oil dispersion) in anhydrous ethylene glycol dimethyl ether (80 mL) was added a solution of 2,6-dichlorophenethyl alcohol (27.65 g, 144 mmol) in anhydrous ethylene glycol dimethyl ether (80 mL). The resulting mixture was stirred at room temperature under argon atmosphere for 4 hours.(ix) (1R,2R)/(1S,2S)-2-[1,4-Dioxa-7-azaspiro[4,4]non-7-yl]-1-(2,6-dichlorophenethoxy)cyclohexane: The mesylate (vi) in anhydrous ethylene glycol dimethyl ether (80 mL) was added quickly to the alkoxide mixture (viii) and the resulting mixture was readily refluxed for 66 hours. The cooled reaction mixture was poured into water (200 mL) and the organic solvent was evaporated in vacuo. The residual aqueous solution was diluted with more water to a volume of 700 mL, acidified to pH 0.5 with 6M HCI aqueous solution and extracted with diethyl ether (2 x 600 mL). The pH of the aqueous layer was adjusted to pH 5.9 and then the aqueous solution was extracted with diethyl ether (700 mL). The organic extract was dried over sodium sulfate and the solvent was evaporated in vacuo to yield 34.0 g of the title compound (70% yield).

The synthetic route of 30595-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nortran Pharmaceuticals Inc.; EP1087934; (2004); B1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.COA of Formula: C8H7F3O

Complex 2 (8.3 mg, 10 mmol), CsOHH2O (0.84 g, 5 mmol),alcohol (5 mmol) was added to a 25 mL schlenk tube and the solutionwas heated at 150 C (oil bath) for 24 h in an open systemunder argon. After cooling to room temperature, the degassedwater (5 mL)was added and the mixturewas extracted with diethylether (3 10 mL). A sample of ether phasewas subjected to the GCMSanalysis and the residual solution was evaporated, then subjected to the NMR analysis. The aqueous phase was acidifiedwith 6 M HCl and extracted with ethyl acetate (5 20 mL). Thecombined organic phasewaswashed with brine (25 mL), dried overanhydrous Na2SO4, and evaporated under reduced pressure, thepure carboxylic acid was collected and weighed for calculating theyield, which was further characterized by its 1H NMR which isconsist with the standard sample.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Dai, Zengjin; Luo, Qi; Meng, Xianggao; Li, Renjie; Zhang, Jing; Peng, Tianyou; Journal of Organometallic Chemistry; vol. 830; (2017); p. 11 – 18;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7N3O

(2) The hydroxymethyl benzotriazole 7.4g added to a single-necked flask,Dropping 25ml SOCl2,After the dropwise addition and stirring 30min,80 reflux 3h;Excess amount of SOCl2 was distilled off by a rotary evaporator,Get white crystals,Namely chloromethyl benzotriazole;

With the rapid development of chemical substances, we look forward to future research findings about 28539-02-8.

Reference:
Patent; Henan Zhong Medical School; Wang Xia; Song Ning; Yuan Juan; Zhang Chao; Zhang Shuling; Yang Huaixia; (10 pag.)CN106188103; (2016); A;,
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