Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, the common compound, a new synthetic route is introduced below. name: (2,6-Dichlorophenyl)methanol

To an ice cooled solution of (2, 6-dichloro-phenyl)-methanol (5 G, 28. 2 MMOL) in anhydrous tetrahydrofuran (200 mL) was added sodium hydride (1. 13 G, 28. 2 mmol, 60% disp.) slowly under nitrogen atmosphere. After stirring for 30 minutes, 3, 5-dibromo-pyrazin-2-ylamine (7. 08 g, 28. 2 MMOL) in anhydrous tetrahydrofuran (50 mL) was added via an addition funnel. Once the addition was complete the ice bath was removed and the reaction was REFLUXED under nitrogen and monitored by reversed phase HPLC. After 18 hr HPLC showed that the majority of the starting 3, 5-dibromo-pyrazin-2- ylamine had been consumed and the reaction was allowed to cool to room temperature. The reaction mixture was concentrated in vacuum until 50 mL remained. The mixture was diluted with ethyl acetate (200 mL) and extracted with 50% brine (2 X 200 ML). The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuum. The crude product was purified using a silica gel column ELUTING with 1 : 1 ETHYL ACETATE/DICHLOROMETHANE TO YIELD 5-BROMO-3- (2, 6-DICHLORO-BENZYLOXY)- PYRAZIN-2-YLAMINE as a white solid (8. 17 G, 83% yield).

The synthetic route of 15258-73-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUGEN, INC.; WO2004/76412; (2004); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1883-32-5, name is 2,2-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,2-Diphenylethanol

General procedure: Substrates, 1 and 2, were synthesized by the same method of 2-adamantyl chloroformate. The triphosgene treated in toluene at 0-4 C (ice bath) for 20 min. The mixture of 2-phenylethanol or 2,2-diphenylethanol with pyridine was prepared in toluene at room temperature. Then the latter mixture was added to the former solution slowly. After the stirring for 1 h, the organic mixture was washed with water and dried by magnesium sulfate. The solvent was removed by the evaporation, the colorless oil (1) or white solid (2) was obtained as a crude product. The substrate 1 was purified from vacuum distillation (120 C and 18 torr) and the substrate 2 was recrystallized by using ligroin. Solvents were purified as described previously.

With the rapid development of chemical substances, we look forward to future research findings about 1883-32-5.

Reference:
Article; Park, Kyoung-Ho; Yang, Gi-Hoon; Kyong, Jin Burm; Bulletin of the Korean Chemical Society; vol. 35; 8; (2014); p. 2263 – 2270;,
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Reference of 349-75-7 , The common heterocyclic compound, 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of the alcohol (3.839 mmol), K2CO3 (2.0 equiv, 7.678 mmol) and cyanuric acid (0.1 equiv, 0.384 mmol) in 20 mL of ethyl acetate were added TEMPO or AZADO (3 mol%, 0.115 mmol) and 12% NaOCl (1.2 equiv, 4.607 mmol, Wako Pure Chemical Industries, Ltd.) at 0-10C. The mixture was then stirred to complete. The reaction mixture was extracted with ethyl acetate. The organic layer was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to afford the corresponding product.

The synthetic route of 349-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fukuda, Naohiro; Izumi, Minoru; Ikemoto, Tomomi; Tetrahedron Letters; vol. 56; 25; (2015); p. 3905 – 3908;,
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Synthetic Route of 29683-23-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 b Synthesis of 4-(4-Bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran To a stirring solution of 4-bromo-3,5-dimethylphenol (710 mg, 3.53 mM), tetrahydro-2H-thiopyran-4-ol (501 mg, 4.24 mM, compound of Step 1 a) and PPh3 (2316 mg, 8.83 mM) in anhydrous DCM (10 ml), DIAD (1785 mg, 8.83 mM) was added under Ar atmosphere. The reaction was warmed at RT and stirred for 16h to 18h. The reaction mixture was then concentrated under reduced pressure to afford the crude product which was purified by column chromatography to afford the title compound 4-(4-bromo-3,5-dimethylphenoxy)tetrahydro-2H-thiopyran (320 mg), and compound used for next step without purification. Yield: 30.1 %.

According to the analysis of related databases, 29683-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; MAHAJAN, Vishal, Ashok; SAWARGAVE, Sangameshwar, Prabhakar; WO2013/128378; (2013); A1;,
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Electric Literature of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 3,6,11-trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, methyl ester (17) To a stirred solution of 2-(2-aminoethoxyl)ethanol (1.05 g, 10 mmol, 1 equiv) in anhydrous ethanol (15 mL) at 0 C. was added di-tert-butyl dicarbonate (2.2 g, 10 mmol, 1 equiv). The reaction mixture was stirred for 2 hours at room temperature. It was concentrated under reduced pressure, re-dissolved in dichloromethane, and washed with brine. The organic extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to give the crude product as a colorless oil. The product 12 was used in the next step without further purification. 1H NMR (600 MHz, CDCl3) delta 1.44 (s, 9H), 3.33-3.34 (m, 2H), 3.54-3.59 (dt, J=10.4, 5.2 Hz, 2H), 3.73-3.75 (dt, J=4.3, 3.4 Hz, 2H).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOLEDO; Tillekeratne, L. M. Viranga; Almaliti, Jehad; Al-Hamashi, Ayad; Bhansali, Pravin; (74 pag.)US2015/329560; (2015); A1;,
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Application of 42142-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42142-52-9, name is 3-(Methylamino)-1-phenylpropan-1-ol, molecular formula is C10H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of N-methy-3-phenyl-3-hydroxy phenylpropylamine (25 g, 0.15 mole) in hexamethylphosphorous triamide and potassium tertiary butoxide (19 g, 0.17 mole) at 50-60C was charged 2-flourotoluene (50 g, 0.45 mole) and the contents of the reaction were heated to 105-110C. The reaction was maintained for 19-20 hours. After the completion of the reaction (checked by TLC) there were charged water (250 ml) followed by toluene (250 ml) and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with toluene (2×75 ml). Thecombined organic layer was washed with water (3×75 ml) and then subjected to distillation to obtain a thick residue. The residue was dissolved in acetone (150 ml) followed by adding oxalic acid and isopropyl ether (200 ml) and the mixture was stirred for 1-1.5 hours at 0-5C, then the obtained solid was separated by filtration and washing with isopropyl ether (100 ml) resulting in the oxalate of atomoxetine. Yield 62.4% and HPLC purity 95.4%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42142-52-9, 3-(Methylamino)-1-phenylpropan-1-ol.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/9884; (2006); A1;,
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Reference of 3597-91-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Carbon tetrabromide (8.99 g) and triphenylphosphine (7.11 g) were added to a stirred solution of biphenyl-4-yl-methanol (5.00 g) in dichloromethane (100 ml) at room temperature and stirrred the reaction mixture for approximately 2 hours at the same temperature. The solvent was evaporated under reduced pressure and the residue thus obtained was purified by column chromatography using 5% diethylether in hexane as eluant to furnish the title compound (6.37 g) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2006/90235; (2006); A1;,
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Reference of 2240-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 74; methyl 4-(3,3,3-trifluoropropoxy)benzoate; [Show Image] 4-Methyl hydroxybenzoate (1.27 g), 3,3,3-trifluoro-1-propanol (1.14 g) and triphenylphosphine (2.63 g) were dissolved in tetrahydrofuran (35 mL), and the solution was cooled to 5°C. A solution of diisopropyl azodicarboxylate (2.25 g) in THF (5 mL) was added dropwise thereto over 10 min, and the mixture was stirred for 17 hr. The reaction mixture was allowed to warm to room temperature, and concentrated. The residue was purified by silica gel column chromatography [eluent; hexane:ethyl acetate=19:1–>3:1 (volume ratio)] to give the title compound (668 mg, yield 32percent) as a white solid. 1H NMR (300 MHz, CDCl3) delta: 2.65 (2 H, qt, J=10.5, 6.6 Hz), 3.89 (3 H, s), 4.25 (2 H, t, J=6.6 Hz), 6.92 (2 H, d, J=8.9 Hz), 8.00 (2 H, d, J=9.0 Hz).

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2261213; (2010); A1;,
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Reference of 180205-28-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 180205-28-1, name is 1-(Aminomethyl)cyclobutanol. A new synthetic method of this compound is introduced below.

3-Oxo-2-(pyridin-3-yl)-6-[4-(trifluoromethyl)phenyl]-2 ,3-di hydropyridazi ne-4-carboxylic acid(100 mg, 0.28 mmol) was dissolved in anhydrous DMF (2.0 mL). 1-(Aminomethyl)cyclobutanol(59.0 mg, 0.55 mmol), N-ethyl-N-isopropylpropan-2-amine (217 pL, 1.25 mmol), and propanephosphonic acid anhydride (T3P, 243 pL, 50% in DMF, 416 pmol) were successively added. Itwas stirred for 3 h at rt. The reaction mixture was concentrated under vacuum and purified by RP-HPLC (column: X-Bridge 018 5pm lOOx3Omm, mobile phase: (water + 0.2 vol% aqueous ammonia (32%)) acetonitrile, gradient) yielding 81 mg (66%) of the title compound.1H-NMR (400MHz, DMSO-d6): 6 [ppm] = 1.44-1.57 (m, 1H), 1.59-1.68 (m, 1H), 1.92 -2.00 (m, 4H), 3.49 (d, 2H), 5.41 (s, 1H), 7.64 (ddd, 1H), 7.89 (d, 2H), 8.16-8.24 (m, 3H), 8.70 (dd, 1H), 8.76 (s, 1H), 8.92 (d, 1H), 9.49 (t, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,180205-28-1, its application will become more common.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
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Reference of 86770-74-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.86770-74-3, name is 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, molecular formula is C8H19NO4, molecular weight is 193.2408, as common compound, the synthetic route is as follows.

Part A Preparation of 11-Benzyloxycarbonylamino-3,6,9-trioxaundecanol A solution of 11-amino-3,6,9-trioxaundecanol (6.56 g, 0.034 mol) and TEA (5.2 mL, 0.037 mol) in DCM (200 mL) was treated with benzyl chloroformate (5.1 mL, 0.036 mol) in one portion. After 18 h the solution was concentrated to a viscous oil and triturated with ether (3 x 100 mL). The combined triturants were concentrated to give an amber oil (9.4 g). Flash chromatoraphy on silica gel (6% MeOH/EtOAc) gave the title compound as a colorless viscous oil (7.0 g, 63%). 1H NMR (CDCl3): 7.36-7.25 (m, 5H), 6.04 (bs, 1H), 5.08 (s, 2H), 3.72-3.48 (m, 14H), 3.41-3.31 (m, 2H).

The chemical industry reduces the impact on the environment during synthesis 86770-74-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bristol-Myers Squibb Pharma Company; EP1293214; (2003); A2;,
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