Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71176-54-0, name is (5-Amino-1,3-phenylene)dimethanol, the common compound, a new synthetic route is introduced below. Quality Control of (5-Amino-1,3-phenylene)dimethanol

Compound 3d (5.6 g, 18.52 mmol) was dissolved in anhydrous dichloromethane (1 18 mL) and anhydrous methanol (58.8 mL). (5-amino-1 ,3- phenylene)dimethanol (2.70 g, 17.64 mmol) and EEDQ (8.72 g, 35.3 mmol) were then added, and the reaction was stirred at room temperature overnight. The solvent was stripped and ethyl acetate was added. The resulting slurry was filtered, washed with ethyl acetate, and dried under vacuum/N2 to give compound 3e (2.79 g, 36% yield). 1 H NMR (400 MHz, DMSO-d6): delta 9.82 (s, 1 H), 8.05, (d, 1 H, J = 9.2 Hz), 8.01 (d, 1 H, J = 7.2 Hz), 7.46 (s, 2H), 6.95 (3, 1 H), 5.21 -5.12 (m, 2H), 4.47-4.42 (m, 4H), 4.40-4.33 (m, 1 H), 4.33-4.24 (m, 1 H), 3.58 (s, 3H), 2.33-2.26 (m, 2H), 2.16-2.09 (m, 2H), 1 .54-1 .46 (m, 4H), 1 .30 (d, 3H, J = 7.2 Hz), 1 .22 (d, 3H, J = 4.4 Hz).

The synthetic route of 71176-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; IMMUNOGEN, INC.; VEIBY, Ole Peter; CHARI, Ravi, V. J.; LAMBERT, John M.; LAI, Katharine C.; HERBST, Robert W.; HILDERBRAND, Scott A.; (128 pag.)WO2017/136693; (2017); A1;,
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Synthetic Route of 86770-74-3 ,Some common heterocyclic compound, 86770-74-3, molecular formula is C8H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol (256 mg, 1.32 mmol) in DCM (30 mL) were added BCN-OSu (351 mg, 1.20 mmol) and Et3N (502 muIota_, 364 mg, 3.60 mmol). The resulting solution was stirred for 30 min and washed with a saturated aqueous solution of NH4CI. After separation, the aqueous phase was extracted with DCM (30 mL). The combined organic phases were dried (Na2S04) and concentrated. The residue was purified with column chromatography (MeOH in DCM 0? 10%). The product was obtained as a colourless oil (397 mg, 1.07 mmol, 90%). H NMR (400 MHz, CDCI3) delta (ppm) 5.93 (bs, 1 H), 4.14 (d, J = 8.1 Hz, 2H), 3.77-3.69 (m, 4H), 3.68-3.59 (m, 8H), 3.58-3.52 (m, 2H), 3.42-3.32 (m, 2H), 2.34-2.16 (m, 6H), 1.66-1.51 (m, 2H), 1 .36 (quintet, J = 8.7 Hz, 1 H), 1.00-0.85 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN GEEL, Remon; VAN DELFT, Floris Louis; VAN BERKEL, Sander Sebastiaan; (117 pag.)WO2017/137456; (2017); A1;,
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Synthetic Route of 15852-73-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, molecular weight is 187.03, as common compound, the synthetic route is as follows.

Example 53 {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane TBSCl (18.7 g, 124.3 mmol), Et3N (14.08 g, 139.2 mmol) and DMAP (194.3 mg, 8.9 mmol) were dissolved in CH2Cl2 (120 mL), then the solution was cooled to 0-5 C. (3-bromophenyl)methanol (18.5 g, 99.4 mmol) was added dropwise to the solution. After the addition, the mixture was warmed to room temperature, and stirred for 2 h. 5% HCl was added to the reaction mixture to pH=4-5, then the organic phase was separated, and the aqueous layer was extracted with CH2Cl2 (50 mL*2). The combined organic phase was washed with water, and dried over Na2SO4. After removing the solvent, 28.5 g of {[(3-Bromophenyl)methyl]oxy}(1,1-dimethylethyl)dimethylsilane was obtained (Yield: 95.1%).

Statistics shows that 15852-73-0 is playing an increasingly important role. we look forward to future research findings about (3-Bromophenyl)methanol.

Reference:
Patent; Glaxo Group Limited; US2009/197871; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4845-50-5, 1,4-Dioxane-2,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1,4-Dioxane-2,3-diol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1,4-Dioxane-2,3-diol

4.00 g (19.509 mmol) of the compound from example 89A was dissolved in 100 ml ethanol and 2.42 g (19.509 mmol) of 2,3-dihydroxy-l,4-dioxane was added. The mixture was stirred for 4 h at room temperature and a further 2.42 g (19.509 mmol) of 2,3-dihydroxy-l,4-dioxane was added. After stirring for 24 h at room temperature, the mixture was concentrated in a rotary evaporator and the residue was purified by silica-gel chromatography (eluent: dichloromethane/methanol = 30:1). We obtained 3.60 g (80% of theor.) of the target compound.LC-MS (method 1): R, = 1.79 min; MS (EIpos): m/z = 227 [M+H]+.1H-NMR (400 MHz, DMSO-D5): delta [ppm] = 8.06 (dd, IH), 8.24 (t, IH), 9.05 (d, IH), 9.07 (d, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4845-50-5, 1,4-Dioxane-2,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan; WO2010/20363; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115-20-8, name is Trichloroethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 115-20-8

General procedure: To a stirred solution of tri-O-acetyl-D-galactal (50 mg, 0.185 mmol) in DCM(1 mL) were added the corresponding alcohol (0.204 mmol, 1.1 equiv) andFeCl3·6H2O/C (50 mol%) at ambient temperature. After the reaction was completed(monitored by TLC), the reaction mixture was filtered and the catalystwas washed with dichloromethane. After evaporation of the solvent under vacuum,the crude products were purified by silica gel column chromatography(petroleum ether/EtOAc = 10/1).

The synthetic route of 115-20-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhou, Jiafen; Chen, Heshan; Shan, Junjie; Li, Juan; Yang, Guofang; Chen, Xuan; Xin, Kunyun; Zhang, Jianbo; Tang, Jie; Journal of Carbohydrate Chemistry; vol. 33; 6; (2014); p. 313 – 325;,
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Adding a certain compound to certain chemical reactions, such as: 26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H9NO2, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H9NO2

Compound 54 (50 mg, 0.33 mmol) was dissolved in a solution of z-Pr0H/H20 (9/1, 1 mL) at 80 C for 30 min. A suspended solution of 7 (63 mg, 0.35 mmol) and HCIO4 (70%, 30 pL) in 90% i- PrOH (2 mL) was added in 4 portions over 1 h. The resulting solution was stirred overnight. After which, the dark blue solution was evaporated under reduced pressure, and the residue was purified on a Biotage Isolera Flash System using SNAP Ultra cartridge with a mobile phase of CHCh and MeOH containing 0.5% formic acid (gradient, 2-15% of MeOH in CHCh). The fractions containing product were pooled and evaporated, affording LGW-03-41 (50 mg, 44%) as a dark blue solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,26021-57-8, 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol, and friends who are interested can also refer to it.

Reference:
Patent; OREGON HEALTH & SCIENCE UNIVERSITY; GIBBS, Summer L.; WANG, Lei G.; BARTH, Connor W.; (159 pag.)WO2020/23911; (2020); A2;,
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Adding a certain compound to certain chemical reactions, such as: 84832-00-8, (5-Amino-2-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 84832-00-8, blongs to alcohols-buliding-blocks compound. Quality Control of (5-Amino-2-fluorophenyl)methanol

Example 205 : 1 -(2-Fluoro-5 -morpholinobenzyl)-N-( 1 -methyl- 1 H-pyrazol-4-yl)- 1 H- pyrazo lo [3 ,4-d]pyrimidin-6-amineStep (i) To a solution of 5-Amino-2-fluoro benzyl alcohol (500mg, 3.5mmol) in toluene (12mL) was added DIEA (2eq) and 2-bromoethylether (1.5eq) and the reaction heated to 90C for 18h. The solvent was removed in vacuo and the residue partitioned between EtOAc and H20. The organic phase was dried (Na2S04), filtered and concentrated in vacuo. The resultant residue was purified by column chromatography (petroleum ether: EtOAc) to give 2(2-fluoro-5- morpholinophenyl)methanol (550mg, 74%) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,84832-00-8, its application will become more common.

Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
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Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.

A solution of 150 mg intermediate 33, 107 mg 3-amino-1 ,1 ,1 -trifluoropropan-2-ol, 317 mg HATU, 2.5 mg 4-dimethylaminopyridine and 0.22 mL ethyldiisopropylamine in 3.1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction was filtered and the solution was subjected to RP-HPLC ((column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: acetonitrile / water (0.2 Vol% ammonia 32%)-gradient)) to yield 1 14 mg 6-[4- (difluoromethyl)phenyl]-2-(3-fluorophenyl)-3-oxo-/V-(3,3,3-trifluoro-2-hydroxypdihydropyridazine-4-carboxamide. 1H-NMR (400 MHz, DMSO-d6): delta = 3.43-3.52 (m, 1 H); 3.72-3.80 (m, 1 H); 4.19-4.27 (m, 1 H); 6.67 (s, 1 H); 7.13 (t, 1 H); 7.40 (ddt, 1 H); 7.54-7.67 (m, 3H); 7.72 (d, 2H); 8.12 (d, 2H); 8.71 (s, 1 H); 9.64 (t, 1 Eta).

Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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Reference of 15484-46-5 ,Some common heterocyclic compound, 15484-46-5, molecular formula is C5H8O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound la (3.48 g, 30 mmol) was dissolved in 50 mL of dry THF with imidazole (2.250 g, 33 mmol). TBDPSCI (9.070 g, 33 mmol) was added to the solution dropwise at 0 C. The reaction was stirred overnight at room temperature. Then, precipitate was removed by filtration to achieve clear solution which was further extracted with saturated sodium bicarbonate solution, water and brine. The organic layers were combined and dried over anhydrous sodium sulfate. (0396) The solution was collected, concentrated and subjected to flash chromatography to afford compound 8a. Yield, 6.99 g, 66%. -NMR (400 MHz, CDCl3): 5(ppm) 7.64-7.69 (m, 4H), 7.34-7.47 (m, 6H), 6.33(q, J= 1.9 Hz, 1H), 6.1 l(q, J=l.9 Hz, 1H), 4.42 (t, J=2. l Hz, 2H), 3.70 (s, 3H), 1.08 (s, 9H). 13C-NMR (100 MHz, CDCb): 5(ppm) 166.25, 139.33, 135.46, 133.24, 129.78, 127.77, 124.09, 62.21, 51.63, 26.82, 19.30. MS (m/z): [M]+ calcd. for C2, H2(,(LSI. 354.17; found, 377.1 for [M+Na]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 15484-46-5, Methyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF MASSACHUSETTS; THAYUMANAVAN, Sankaran; VACHET, Richard, W.; ZHUANG, Jiaming; ZHAO, Bo; (0 pag.)WO2020/6340; (2020); A1;,
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Application of 4704-94-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Production Example 10-15-Hydroxymethyl-1,3-dioxane To a dichloromethane (4.9 mL) suspension of 2-hydroxymethyl-1,3-propanediol (1.00 g, 9.41 mmol), were added formaldehyde dimethyl acetal (2.94 mL, 33.3 mmol), lithium bromide (159 mg, 1.84 mmol) and p-toluenesulfonic acid monohydrate (160 mg, 0.843 mmol), and the mixture was stirred at room temperature for three days. To the mixture, was added triethylamine (1.0 mL), the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography to obtain the title compound (380 mg, 3.22 mmol) from fraction of n-heptane:ethyl acetate (4:1).1H-NMR (400 MHz, CDCl3) delta: 1.55 (br.s, 1H), 1.92-2.00 (m, 1H), 3.75 (dd, J=4.8, 6.8 Hz, 2H), 3.79 (dd, J=6.0, 11.6 Hz, 2H), 4.01 (dd, J=4.0, 11.6 Hz, 2H), 4.80 (d, J=6.4 Hz, 1H), 4.86 (d, J=6.4 Hz, 1H).

According to the analysis of related databases, 4704-94-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2011/86882; (2011); A1;,
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