Tag: M.W=100-150

Liu, Jiawei; Wang, Chuan published the artcile< Zinc-Catalyzed Hydroxyl-Directed Regioselective Ring Opening of Aziridines in SN2 Reaction Pathway>, Name: (2-Aminophenyl)methanol, the main research area is zinc catalyzed regioselective ring opening aziridinyl alc amine thiophenol.

In this protocol, a zinc-catalyzed catalytic regioselective ring opening of electronically and sterically unbiased 2,3-aziridinyl alcs. has been accomplished. The directing effect of the hydroxyl moiety enables the selective nucleophilic attack to the C-3 position of 2,3-aziridinyl alcs. with various aromatic amines and thiophenols as nucleophiles. This operationally simple reaction provides convenient access to a variety of amino alcs. and hydroxyl sulfides in excellent regiocontrol. Moreover, simple derivatization of the ring opening product establishes a general strategy to approach internal vicinal diamines in regioselective and diastereomerically pure form.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aziridine). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dorosz, Urszula; Barteczko, Natalia; Latos, Piotr; Erfurt, Karol; Pankalla, Ewa; Chrobok, Anna published the artcile< Highly efficient biphasic system for the synthesis of alkyl lactates in the presence of acidic ionic liquids>, Related Products of 104-76-7, the main research area is alkyl lactate preparation green chem; lactic acid alc esterification ionic liquid catalyst.

Alkyl lactates such as 2-ethylhexyl lactate and Et lactate are produced from lactic acid via esterification, and used in the production of plastics, paints, solvents and detergents. In the pursuit of an inexpensive, industry-suitable catalyst for this reaction, the application of protic ionic liquids based on nitrogen base and sulfuric acid is proposed. The ionic liquid was synthesized via a simple reaction of triethylamine and a threefold molar excess of sulfuric acid. Water was added to remove the heat of reaction. Next, the reaction conditions for the model esterification of 2-ethylhexanol with lactic acid without addnl. solvent were optimized. Exceptionally mild conditions, i.e., a twofold molar excess of alc. to lactic acid with the addition of an ionic liquid in a catalytic amount (15 mol%) at 60°C, resulted in high yields of Et and 2-ethylhexyl lactates (96-97%). The driving force of this reaction is the production of a biphasic system with immiscible ester during the reaction. This phenomenon makes it possible to overcome the reaction equilibrium Using an inexpensive ionic liquid, which could be recycled up to five times without diminution in conversion or selectivity, leads to both a greener and a more economically-viable process.

Catalysts published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Related Products of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gvozdev, V. D.; Shavrin, K. N.; Nefedov, O. M. published the artcile< A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols>, Computed Properties of 45434-02-4, the main research area is arylmethylene pyrrolooxazine pyrrolooxazole pyrrolothiazole stereoselective preparation; bicyclic enaminal stereoselective preparation; base mediated cyclocondensation amino alc thiol alkynal.

4-Alkynals RCCCH2CR1R2CHO [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5] underwent base-mediated cyclocondensations with amino alcs. H2NCH2XCH2OH (X = bond, Me2C, 1,1-cyclopropanediyl) or 2-aminoethanethiol hydrochloride with KOH in DMSO to yield arylmethylene pyrrolooxazines, pyrrolooxazoles, and pyrrolothiazoles I [R = Ph, 2-thienyl, 4-F3CC6H4; R1 = R2 = H, Me; R1R2 = (CH2)5; X = bond, Me2C, 1,1-cyclopropanediyl; Y = O, S] (bicyclic enaminals) stereoselectively as the (E)-isomers in 30-82% yields.

Russian Chemical Bulletin published new progress about Alkynals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl). 45434-02-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C5H11NO, Computed Properties of 45434-02-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Chong; Hu, Bowen; Chen, Dafa; Xia, Haiping published the artcile< Manganese(I)-Catalyzed Transfer Hydrogenation and Acceptorless Dehydrogenative Condensation: Promotional Influence of the Uncoordinated N-Heterocycle>, Name: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is manganese pyridylquinoline pyridylnaphthyridine preparation catalyst transfer hydrogenation dehydrogenative condensation; transfer hydrogenation ketone aldehyde catalyzed manganese carbonyl pyridylquinoline pyridylnaphthyridine; dehydrogenative condensation alc ketone catalyzed manganese carbonyl pyridylnaphthyridine; crystal structure manganese carbonyl bipyridinol complex.

The four bidentate Mn(I) complexes [(C5H4N-C5H3N-OH)Mn(CO)3Br] (1), [(C9H6N-C5H3N-OH)Mn(CO)3Br] (2), [(C8H5N2-C5H3N-OH)Mn(CO)3Br] (3), and [(C8H5N2-C5H3N-OCH3)Mn(CO)3Br] (4) were synthesized. These complexes were tested as catalysts for the transfer hydrogenation of ketones, and 3 showed the highest activity. The reactions proceeded well with 0.5 mol % of catalyst loading and 20 mol % of t-BuOK at 85° for 24 h. Also, 3 was also used as a catalyst for the synthesis of primary alcs. via transfer hydrogenation of aldehydes and the synthesis of 1,2-disubstituted benzimidazoles and quinolines via acceptorless dehydrogenative condensations.

Organometallics published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Name: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Lebin; Xie, Shimin; Dong, Jianyu; Liu, Feng; Yin, Shuang-Feng; Zhou, Yongbo published the artcile< Copper-Catalyzed Nitrogen Atom Transfer to Isoquinolines via C-N Triple Bond Cleavage and Three-Component Cyclization>, Name: (4-Ethynylphenyl)methanol, the main research area is bromoaryl ketone alkyne acetonitrile copper catalyst three component cyclization; isoquinoline preparation.

A copper(I)-catalyzed tandem reaction of 2-bromoaryl ketones, terminal alkynes, and CH3CN was developed, which combines N atom transfer and three-component [3 + 2 + 1] cyclization, and efficiently produces densely functionalized isoquinolines in a facile, highly selective, and general manner. In the reaction, the formation of aromatic C-N bonds along with the complete C-N triple bond cleavage was first realized; Cu(III)-acetylide species might serve as the intermediates, which allow highly selective 6-endo-dig cyclization.

Organic Letters published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Name: (4-Ethynylphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arora, Vinay; Narjinari, Himani; Kumar, Akshai published the artcile< Pincer-Nickel Catalyzed Selective Guerbet-Type Reactions>, Application of C8H9FO, the main research area is pincer nickel bis imino pyridine preparation crystal mol structure; Guerbet type reaction pincer iminopyridine nickel catalyzed; alkylation phenyl ethanol benzyl alc nickel iminopyridine catalyzed.

Authors report here the synthesis and characterization of a series of NNN pincer-nickel complexes of the type (R2NNN)NiCl2(CH3CN) (R = iPr, tBu, Cy, Ph, and p-F-C6H4) based on bis(imino)pyridine ligands. In solution, these complexes are equilibrium mixtures containing one and two pincer ligands, resp. While the crystal structure of the former was reported by us recently for R = iPr, they report the crystal structure of the latter in this study for R = p-F-C6H4. The considered NNN pincer-Ni complexes have been successfully employed to accomplish the catalytic β-alkylation of several secondary alcs. with a variety of benzyl alcs. at 140° with high yields and unprecedented turnovers. A maximum of 92% yield of the β-alkylated product at 18 400 TON was obtained in the reaction of benzyl alc. with 1-(4-(trifluoromethyl)phenyl)ethane-1-ol in the presence of 0.005 mol % of (Ph2NNN)NiCl2(CH3CN) and 5 mol % of NaOtBu at 140° after 24 h. The reaction exhibits zero-order dependence of rate on catalyst concentration and first-order dependence on the concentration of base, benzyl alc., and 1-Ph ethanol which points to the base-mediated aldol condensation as the rate-determining step. Most of the intermediates involved in catalysis have been identified by HRMS. To the best of their knowledge, this is the first report on a pincer-Ni catalyzed β-alkylation of alcs. and, hitherto, such unprecedented turnovers have not been reported with a homogeneous mol. nickel-based catalyst.

Organometallics published new progress about Aldol condensation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Huaixiang; Xu, Xiaolin; Chen, Chen; Yu, Haiyan published the artcile< Flavoromics approach to identifying the key aroma compounds in traditional Chinese milk fan>, Synthetic Route of 104-76-7, the main research area is milk propanoic butanoic acid octanal aroma profile flavoromics China; aroma recombination and omission; gas chromatography-mass spectrometry; gas chromatography-olfactometry; key aroma compounds; milk fan.

To determine the key aroma compounds in Chinese milk fan cheese, samples from 6 of the most popular handmade milk fan workshops in Yunnan province of China were analyzed by gas chromatog.-mass spectrometry (GC-MS), gas chromatog.-olfactometry (GC-O), sensory evaluation, aroma recombination and omission experiments Seventy-one aroma compounds were identified by GC-MS, and 31 odor-active compounds were detected by GC-O. The relationships between the 31 odor-active compounds and 10 sensory evaluation properties were explored by partial least squares discriminant anal. The results identified 23 initial key aroma compounds, which were used to simulate the aroma profile of milk fan in aroma recombination experiments Aroma omission experiments identified propanoic acid, butanoic acid, octanoic acid, octanal, nonanal, 2-nonanone, and Et hexanoate as the key aroma compounds Propanoic acid and butanoic acid contributed to cheese and rancid aromas, octanal and nonanal to the fat aroma, octanoic acid and 2-nonanone to the cheese aroma, and Et hexanoate to the fruity aroma of milk fan.

Journal of Dairy Science published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Synthetic Route of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Priyanka; Gangwar, Manoj Kumar; Emayavaramban, Balakumar; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< α-Alkylation of Ketones with Secondary Alcohols Catalyzed by Well-Defined Cp*CoIII-Complexes>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alkyl aryl ketone preparation; ketone secondary alc alkylation cobalt catalyst; alkylation; cobalt; ketones; secondary alcohols; α-alkylation.

Herein a well-defined, high-valence cobalt(III)-catalyst was applied for successful α-alkylation of ketones RC(O)CH3 (R = pentamethylphenyl, Ph, naphthalen-2-yl, etc.) and 1,2,3,4-tetrahydronaphthalen-1-one with secondary alcs. R1OH (R1 = 1-phenylethyl, cyclopentyl, octan-2-yl, etc.). A wide-variety of secondary alcs., which include cyclic, acyclic, sym., and unsym. compounds, was employed as alkylating agents to produce β-alkyl aryl ketones RC(O)CH2R1 and 2-(1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one.

ChemSusChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Zhengqiang; Qiao, Hong; Zeng, Fanlong published the artcile< Design, Synthesis, and Application of NNN Pincer Ligands Possessing a Remote Hydroxyl Group for Ruthenium-Catalyzed Transfer Hydrogenation of Ketones>, COA of Formula: C8H9FO, the main research area is ketone transfer hydrogenation alc preparation ruthenium pincer catalyst; crystal structure ruthenium NNN pincer triphenylphosphine dichloro complex preparation.

A new family of pyridyl-based NNN pincer ligands bearing a remote pendent OH group were developed. Considerable acceleration effects on the activity of Ru-catalyzed transfer hydrogenation of ketones were imparted by the pendent OH group, and importantly, introducing a CH2OH group to the 4′-position of the pyrazolyl moiety is an appropriate choice. The results present a general strategy for exploring bifunctional ligands to construct effective catalysts.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saito, Tatsuya; Takojima, Kaoru; Oyama, Takafumi; Hatanaka, Shintaro; Konno, Takashi; Yamamoto, Takuya; Tajima, Kenji; Isono, Takuya; Satoh, Toshifumi published the artcile< Trimethyl Glycine as an Environmentally Benign and Biocompatible Organocatalyst for Ring-Opening Polymerization of Cyclic Carbonate>, Application of C9H8O, the main research area is trimethyl glycine environmentally benign biocompatible organocatalyst.

Tri-Me glycine (TMG), a natural product found in plants as well as in humans, was demonstrated to be an efficient catalyst for the ring-opening polymerization (ROP) of cyclic carbonate, enabling the environmentally benign synthesis of aliphatic polycarbonate (APC). The ROP of trimethylene carbonate (TMC) using TMG proceeded under the bulk condition at 70 °C to give poly(trimethylene carbonate), possessing controlled mol. weight (∼4000) and low dispersity (∼1.22). The results of a matrix-assisted laser desorption/ionization time-of-flight mass spectral anal. and a chain extension experiment confirmed the controlled/living nature of the present ROP system, where side reactions, such as inter- and intramol. transesterifications, were minimized during the polymerization The screening of TMG analogs as a catalyst for ROP revealed that the combination of the carboxylate and quaternary ammonium moieties in TMG is an essential structural requirement. The Fourier transform IR analyses of TMC and alc. initiator in the presence/absence of TMG confirmed the biactivation property of the TMG. End-functionalized APCs were obtained using alc. initiators bearing clickable functionalities, such as azido and ethynyl groups. Furthermore, we demonstrated the synthesis of APC-diol and -triol, which can be used as prepolymers for APC-based polyurethane.

ACS Sustainable Chemistry & Engineering published new progress about Polycarbonates, aliphatic Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts