Tag: M.W=0-100

Related Products of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.

Cyclopent-3-en-1-yl 4-methylbenzenesulfonate To a solution of cyclopent-3-ene-1-ol (70.2 g, 835 mmol) in pyridine (150 mL) and DCM (300 ml) cooled at 4 C. under N2 atm was added slowly with stirring 4-toluene-sulfonyl chloride (175 g, 918 mmol). The mixture was then stirred under N2 atm at this temperature for 1 h, then stood in cold room at 4 C. for 48 h. Most of the dichloromethane was evaporated at reduced pressure. The mixture was diluted with EtOAc/Hexane (20%, 600 ml) and washed with water (5*) and brine. The aqueous phases were back extracted with EtOAc/hexanes (20%, 1*400 ml), the organic layers combined, dried over MgSO4, and then filtered through a short plug (3 cm*11 cm) of silica (washed with a further 1000 ml 20% EtOAc/Hexane). The solvent was evaporated at reduced pressure to give a colorless oil. The residual solvent in the crude product was azeotroped with hexanes then twice with toluene. The resulting colorless oil was further dried by azeotroping once with hexanes and then crystallizing by diluting with an equal volume of hexane and heating at 50 C. The resulting biphasic mixture of colorless oil and solids in hexanes was allowed to age at RT overnight. The solid was removed by filtration and washed with cold hexanes and then dried in-vacuum to give the title compound (173 g, 727 mmol, 87%). 1H NMR (CHLOROFORM-d) delta: 7.79 (d, J=7.9 Hz, 2H), 7.34 (d, J=7.9 Hz, 2H), 5.65 (s, 2H), 5.11-5.24 (m, 1H), 2.59-2.67 (m, 2H), 2.48-2.55 (m, 2H), 2.45 (s, 3H).

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Board of Regents, The University of Texas System; LEWIS, Richard T.; HAMILTON, Matthew; JONES, Philip; PETROCCHI, Alessia; REYNA, Naphtali; MCAFOOS, Timothy; CROSS, Jason Bryant; SOTH, Michael J.; US2020/24236; (2020); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of Ethylene Glycol Vinyl Ether

C. General procedure for the Heck arylation ofhydroxyalkyl vinyl ethers (le-f)An oven-dried, two-necked round-bottom flask containing a stir bar was charged with an aryl bromide 2 (1.0 mmol), Pd(OAc)2 (0.025 mmol), DPPP (0.05 mmol), [HNEt3][BF4] (1.5 mmol), and [bmim] [BF4] (2 mL) under nitrogen at room temperature. Following degassing three times, a hydroxyalkyl vinyl ether 1 (2.0 mmol) and HN1Pr2 (1.5 mmol) were injected sequentially. The flask was placed in an oil bath, and the mixture was stirred and heated at 115 0C. After an appropriate reaction time, the flask was removed from the oil bath and cooled to room temperature. A small sample was then taken for NMR analysis. The rest of the mixture was extracted with CH2Cl2 (3 x 20 mL), and the combined organic layer was washed with water until neutral, dried (Na2SO^, filtered, and concentrated in vacuo. The cyclic ketal derived from the arylated olefin was isolated out of the crude product by flash chromatography on silica gel using a mixture of ethyl acetate and hexane (10/90 to 20/80) containing 2% (in volume) triethylamine as eluant. The isolated yields of the products are given in Table 1.

With the rapid development of chemical substances, we look forward to future research findings about 764-48-7.

Reference:
Patent; THE UNIVERSITY OF LIVERPOOL; WO2007/57658; (2007); A1;,
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Related Products of 14320-38-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14320-38-8, name is Cyclopent-3-enol. A new synthetic method of this compound is introduced below.

NaH (60% in mineral oil, 66.4 mg, 1.66 mmol) was added portion-wiseto a cooled (0C) solution of secondary alcohol 8 (116 mg, 1.385 mmol) and p-methoxybenzyl chloride (0.206 mL, 1.52 mmol) in anhydrous DMF (8 mL). The reaction mixture was stirred overnight at rt. The solvent was removed in vacuo and the residue was diluted with H2O (50 mL) followed by extraction with diethyl ether (60 mL) two times. The combined organic layer was washed with brine, dried over anhydrous MgSO4, and concentrated under vacuum. The residue was purified by silica gel column chromatography (EtOAc/hexane, 1:20) to give 9 (189.6 mg, 67%) as a colorless oil: 1HNMR (CDCl3, 300 MHz) delta 7.11 (d, J = 7.8 Hz, 2H), 6.72 (d, J = 7.9 Hz, 2H),5.62 (m, 2H), 4.65 (s, 2H), 3.74 (s, 3H), 3.25 (quint, 1H), 2.57 (m, 2H),2.38 (m, 2H); 13CNMR (CDCl3, 75 MHz) delta 159.7, 137.5, 134.5, 129.9, 115.7,73.5, 72.6, 56.3, 42.5; Anal. Calc. for C13H16O2: C, 76.44; H, 7.90; Found: C,76.52; H, 7.84.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14320-38-8, Cyclopent-3-enol, and friends who are interested can also refer to it.

Reference:
Article; Shen, Guang Huan; Hong, Joon Hee; Nucleosides, nucleotides and nucleic acids; vol. 33; 1; (2014); p. 1 – 17;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below., Product Details of 534-03-2

General procedure: Amine (1 mmol) and Fmoc-Cl (1.1 mmol) were placed in a glass tube under neat conditions and were sonicated for a suitable time (as indicated in Tables 1, 2 and 3). All reactions were performed in a water bath at room temperature. After completion of the reaction (as indicated by TLC), 5 cm3 of diethyl ether was added to the mixture. The N-Fmoc derivatives were crystallized and were obtained in good to excellent yields. Purification of the product was accomplished by recrystallization from diethyl ether.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Mansouri, Rachida; Aouf, Zineb; Lakrout, Salah; Berredjem, Malika; Aouf, Nour-Eddine; Journal of the Brazilian Chemical Society; vol. 27; 3; (2016); p. 546 – 550;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

4-Methoxy-2,6-dimethylbenzenesulfonyl chloride (12 g, 51 mmol) is added to a solution of 2- (methylamino)ethanol (4.6 mL, 61 mmoi), diisopropyl ethyl amine (22 mL, 130 mmol), and CH2Cl2 (130 mL) under N2. The reaction vessel is sealed and left to stir for 21 h. The solution is washed with 1 :1 sat. aq. NH4C.: H2O (2 X 200 mL) and brine (200 mL). The aqueous layers are extracted with CH2Cl2 (200 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to afford the title compound as a pale yellow oil. LC-MS m/? (M + Na~): 296.06 (§).

With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.

Reference:
Patent; NEUROGEN CORPORATION; WO2007/140383; (2007); A2;,
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Electric Literature of 2516-33-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2516-33-8 as follows.

EXAMPLE 3 Cyclopropanecarboxyaldehyde, 2-(1-nonenyl)-,(Z)- A solution of cyclopropanemethanol, 2-(1-nonenyl)-, (21.6 g, 0.11 moles) in methylene chloride (25 ml) is added dropwise to a solution of pyridinium dichromate (79.8 g, 0.208 moles) in methylene chloride (200 ml) at room temperature under nitrogen. The reaction mixture is stirred overnight. The mixture is diluted with ether (500 ml), filtered through celite and then through a short column of silica gel. The solvents are stripped from the filtrate to give the crude product (21.6 g). Distillation at reduced pressure gives the product as a clear colorless oil (14.8 g, 69%), b.p. 81-86 C. (0.06 mm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Patent; Warner-Lambert Company; US4562006; (1985); A;,
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Application of 504-63-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) Put 440kg of 1,3-propanediol, 600kg of hydrochloric acid, and 3kg of benzenesulfonic acid into a 2000L glass-lined kettle with a stirring and reflux condensing device, heat up to 90 C with stirring, and keep the reaction warm;(2) After holding for 3 hours, lower the temperature of the kettle to 50 C, then put 460kg of hydrochloric acid into the kettle, continue to warm to 90 C and keep the reaction for 10 hours. The temperature of the kettle is sampled for GC analysis. When the content reaches 80%, the feed liquid is poured into the distillation kettle, and 150 kg of toluene is poured into the distillation kettle to carry out the reaction of heating and refluxing with water;(3) After the reaction with water is completed, the temperature of the kettle is reduced to room temperature, and sodium bicarbonate is added to neutralize the oil phase in the kettle to neutrality, and the salt formed by the neutralization and excess sodium bicarbonate are filtered;(4) The filtered oil phase is pumped into the rectification kettle, and the solvent toluene is concentrated under normal pressure. After the toluene is collected, the product is rectified by high vacuum. The rectified fraction is put into the reaction kettle to continue the reaction.The content detected by GC gas chromatography was 99.3%, and the product yield was 96%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-63-2, 1,3-Propanediol.

Reference:
Patent; Zouping Mingxing Chemical Co., Ltd.; Chen Qiang; Zhang Peng; Zhang Junling; Cao Xinming; Sun Fantong; Wang Tao; Du Xiaoyang; (6 pag.)CN110668918; (2020); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56-81-5, name is Propane-1,2,3-triol, molecular formula is C3H8O3, molecular weight is 92.0938, as common compound, the synthetic route is as follows.Computed Properties of C3H8O3

A solution of glycerol (11.2 mmol) in 20 mL CH2Cl2 was charged with a freshly prepared porous silicon chip (Example 1). Trifluoroacetic acid (TFA) (3.4 mL, 44.7 mmol) was added to the solution via syringe. The mixture was allowed to stir at ambient temperature (23 C.) for 20 hours. The solvent was then removed under reduced atmospheric pressure. Column chromatography was used to separate the PDO from product impurities. The desired 1,3-propanediol product was isolated in 32-55% yield.All publications, patents, and patent documents are incorporated by reference herein, as though individually incorporated by reference. The invention has been described with reference to various specific and preferred embodiments and techniques. However, it should be understood that many variations and modifications may be made while remaining within the spirit and scope of the invention.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56-81-5, Propane-1,2,3-triol, and friends who are interested can also refer to it.

Reference:
Patent; Iowa State University Research Foundation, Inc.; US7514587; (2009); B1;,
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Related Products of 616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The Schiff base ligand, H2L, N,N0-bis(salicyaldehydene)-1,3-diaminopropan-2-ol was synthesized in a reported literature [19].Salisaldehyde (0.244 g, 2 mmol) was heated under reflux with1,3-diaminopropan-2-ol (0.089 g, 1 mmol) in 30 ml dehydratedalcohol. After 10 h the reaction solution was evaporated underreduced pressure to yield a gummy mass, which was dried undervacuum and stored over CaCl2 for subsequent use. Yield, 0.278 g(82.8%). Anal. Calc. for C17H18N2O3 (H2L): C, 68.48; H, 6.08; N,9.39. Found: C, 68.40; H, 6.02; N, 9.35%. 1H NMR (CDCl3) d = 3.68(dd, J = 12.4, 6.8 Hz, 2H), 3.84 (dd, J = 12.4, 4.0 Hz, 2H), 4.23-4.25(m, 1H), 6.88 (t, J = 7.2 Hz, 2H), 6.96 (d, J = 8.4 Hz, 2H), 7.25 (dd,J = 7.6, 1.6 Hz, 2H), 7.32 (td, J = 8.8, 1.6 Hz, 2H), 8.36 (s, 2H) ppm.13C NMR d, 62.9, 70.2, 117.0, 118.5, 118.6, 131.5, 132.5, 161.1,167.3 ppm. IR (KBr, cm1): 1634, 1611 (vCN), 3412 (vOH), UV-Vis(kmax, nm): 221, 267, 316, 410 nm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 616-29-5, 1,3-Diaminopropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dey, Dhananjay; Kaur, Gurpreet; Patra, Moumita; Choudhury, Angshuman Roy; Kole, Niranjan; Biswas, Bhaskar; Inorganica Chimica Acta; vol. 421; (2014); p. 335 – 341;,
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Related Products of 2867-59-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Part B;Triethylamine (73.5 g, 726 mmol) and the material from Part A were added to a solution of 7-bromo-4-chloro-3-nitroquinoline (34.8 g, 121 mmol, U.S. patent application publication no. US 2004/0147543, Example 1, Parts A through D) in DMF (300 mL), and the reaction mixture was stirred overnight at room temperature. Additional triethylamine (48.97 g, 67.46) and t°t-butyldimethylsilyl chloride (40.1 g, 266 mmol) were then added, and the reaction was stirred for two hours at room temperature and filtered. The filtrate was concentrated under reduced pressure, and the residue was dissolved in chloroform. The solution was washed twice with a 2:1 mixture of saturated aqueous sodium bicarbonate and water and three times with 10% aqueous sodium carbonate and then concentrated under reduced pressure. The resulting oil was passed through a plug of basic alumina to provide (7-bromo-3-nitroquinolin-4-yl)-[3-(tert-butyldimethylsilanyloxy)-l- methy lpropy 1] amine .

According to the analysis of related databases, 2867-59-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2006/74003; (2006); A2;,
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