Tag: M.W=0-100

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H8O

AddN-pyrimidinylpurine 1a (0.2 mmol), RhCl3?3H2O (0.004 mmol), Cu(OAc)2(0.4 mmol) andcyclopent-3-enol 2k (1.0 mmol) to 2.0 mL of DMF. , three times with carbon monoxide in the Young’s replacement tubeafter filling with carbon monoxide (1 atm), the reaction and after 90 deg.] C oil bath for 10 hours, the reaction was stopped until the reaction was cooled to roomtemperature, add ethyl acetate and saturated brine plurality Wash and extract.The organic phase was dried over anhydrous sodium sulfate and filtered.The solvent was evaporated to dryness, and ethyl acetate / petroleum ether (1:10 to 1:1) was purified by chromatography.The product was a whitesolid with a yield of 80%.

With the rapid development of chemical substances, we look forward to future research findings about 14320-38-8.

Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute; Yang Lei; Zhao Kang; Liu Jianhua; Xia Chungu; Du Rongrong; (35 pag.)CN109851608; (2019); A;,
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Electric Literature of 25125-21-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.25125-21-7, name is 1-Hydroxymethyl-3-cyclopentene, molecular formula is C6H10O, molecular weight is 98.143, as common compound, the synthetic route is as follows.

1-a (Cyclopent-3-en-1-yl)methyl toluenesulfonate A mixture of (cyclopent-3-en-1-yl)methanol (1.96 g, 20 mmol) and para-toluenesulfonylchloride (3.81 g, 20 mmol) were stirred at room temperature for 2 hrs in pyridine (30 ml). After the concentration of pyridine, the reaction residues were extracted with dichloromethane, washed 1N HCl, dried with MgSO4, concentrated and separated by the column chromatography to give the desirable product (4.20 g). Yield(%): 83.2 1 H NMR(CDCl3): delta2.11(2H,m), 2.42(3H,s), 2.49(3H,m), 3.82(2H,d), 5.67(2H,s), 7.40(2H,d), 7.65(2H,d).

The chemical industry reduces the impact on the environment during synthesis 25125-21-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Samjin Pharmaceutical Co., Ltd; US5922727; (1999); A;,
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Adding a certain compound to certain chemical reactions, such as: 2516-33-8, Cyclopropylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropylmethanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropylmethanol

To a 2 L flask was charged with cyclopropanemethanol (8A) (18 g, 250 mmol, 1 equiv), TEMPO (78 mg, 0.5 mmol) and CH2Cl2 (250 mL). The solution was cooled to 0 C, and a solution of KBr (2.99 g, 25 mmol, 0.1 equiv), NaHCO3 (52.5 g, 625 mmol, 2.5 equiv), and 10-13% NaOCl (150 mL, 313 mmol, 1.25 equiv) in H2O (80 mL) was then slowly added. After the resulting mixture was had been stirring at 0 C for 45 min, the two layers were separated. The aqueous layer was back extracted with CH2Cl2 (2 x 250 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The resulting residue was purified via shortpath distillation head under N2 (95-100 C) to give the corresponding aldehyde 8B (11. 02 g, 73%) as a colorless liquid.

The synthetic route of 2516-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Trost, Barry M.; Nguyen, Hien M.; Koradin, Christopher; Tetrahedron Letters; vol. 52; 17; (2011); p. 2033 – 2036;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, molecular weight is 89.1362, as common compound, the synthetic route is as follows.HPLC of Formula: C4H11NO

General procedure: Amine (1 mmol) was added to the mixture of (Boc)2O (1 mmol) and DSIMHS (6.5 mg, ~ 0.02 mmol) with constant stirring at room temperature under solvent-free conditions. After completion of the reaction (monitored by TLC), ethyl acetate (3 × 5 mL) was added to the reaction mixture and the catalyst was decanted and washed with ethyl acetate (2 × 5 mL) and dried. The product was purified by column chromatography, using ethyl acetate-petroleum ether (2:8) eluent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Journal of Molecular Liquids; vol. 177; (2013); p. 386 – 393;,
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Adding a certain compound to certain chemical reactions, such as: 96-35-5, Methyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 96-35-5, blongs to alcohols-buliding-blocks compound. Product Details of 96-35-5

4-(3-(3-Fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile 1e (100 mg, 0.24 mmol) was placed in a reaction flask, followed by addition of methyl glycolate (42 mg, 0.47 mmol), triphenylphosphine (93 mg, 0.35 mmol), 5 mL of dichloromethane, and diisopropyl azodicarboxylate (72 mg, 0.35 mmol), successively. The reaction solution was stirred for 1 hour. The reaction solution was concentrated under reduced pressure, and the residue was purified by thin layer chromatography with elution system A to obtain the title compound methyl 2-(4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorophenoxy)acetate 31a (104 mg, yield 89.7%) as a white solid. MS m/z (ESI): 496.2 [M+1]

At the same time, in my other blogs, there are other synthetic methods of this type of compound,96-35-5, Methyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.; Lu, Hejun; Sun, Piaoyang; Fei, Hongbo; Jiang, Hongjian; Wang, Haowei; Dong, Qing; US2015/225381; (2015); A1;,
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Reference of 2919-23-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a) 5-Bromo-6-cyclobutoxy-nicotinic acid 5-Bromo-6-chloronicotinic acid (CAN 29241-62-1; 3 g, 12.7 mmol) was dissolved in DMSO (30 mL); cyclobutanol (1.19 g, 1.29 ml, 16.5 mmol) and potassium hydroxide (powder) (2.14 g, 38.1 mmol) were added and the reaction mixture was stirred at room temperature for 5 h. More cyclobutanol (0.5 mL) and KOH (1 g) was added and the reaction mixture was stirred at room temperature for another 2 days. Water (30 mL) was added and the mixture was acidified (cooling) with 5 mL 37% HCl in water (pH=2). The suspension was filtered and washed with water. The cake was dried in vacuo to obtain the title compound (3.1 g, 88.7%) as white solid; MS (ESI) 270.2 (M-H)-.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2919-23-5, Cyclobutanol.

Reference:
Patent; Grether, Uwe; Hebeisen, Paul; Hoffmann, Torsten; Roever, Stephan; US2012/94993; (2012); A1;,
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Synthetic Route of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.

Add 735ml of ethyl acetate in the flask cooled to 0C under a stream of nitrogen, Sulforhodamine B acid chloride 85g (147mmol) added to the agitation. And serinol 16.1g (177mmol), N, N-dimethylaminopyridine 0.899g (7.37mmol), triethylamine and 38.3g (53ml, 295mmol) was further added the mixture was stirred at room temperature for 15 hours.Then the solid was obtained 70.1.5g compound (yield 69%) of the title mixture of the red solid obtained by concentration under reduced pressure by a rotary evaporator by the formula 6-4 to by washing with ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.

Reference:
Patent; Cheil Industries Co.Ltd; Kim, Won Jung; Kang, Gyung Hee; Park, Chae Won; Sin, Myung Yeop; Jeon, Hwan Sung; Jung, Uii Soo; Hwang, Gi Wook; (40 pag.)KR2015/89702; (2015); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Amino-2-methyl-1-propanol

N-2-Hydroxy-1,1-dimethylethyl carbamic acid tert-butyl ester 2-Amino-2-methylpropan-1-ol (10.0 g, 112 mmol) was dissolved in tetrahydrofuran (100 ml).. A 1N solution of sodium hydroxide in water (112 ml, 112 mmol) was added.. A solution of di-tert-butyl dicarbonate (29.3 g, 134 mmol) in tetrahydrofuran (100 ml) was added over a period of 15 min.. The solution was stirred at 20 C. for 16 h.. water (100 ml) was added.. The phases were separated.. The aqueous phase was extracted with ethyl acetate (3*150 ml) and the combined organic phases were dried (magnesium sulfate).. The solvent was removed in vacuo and the crude product was chromatographed on silica gel (180 g) with ethyl acetate/heptane 1:1 as eluent to give 19.6 g of N-2-hydroxy-1,1-dimethylethyl carbamic acid tert-butyl ester. mp 53 C. 1H-NMR (CDCl3): delta1.22 (s, 6 H); 1.45 (s, 9 H); 3.58 (d, 2 H),; 4.05 (br, 1 H); 4.65 (br, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 124-68-5, 2-Amino-2-methyl-1-propanol.

Reference:
Patent; Novo Nordisk A/S; US6350767; (2002); B1;,
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Related Products of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

Fmoc-beta-alanine (84.5 g, 271 mmol) and N-hydroxysuccinimide (31.2 g, 271 mmol) are dissolved in dichloromethane (850 mL) and DMF (43 mL) with magnetic stirring. N,N-dicyclohexylcarbodiimide (56.0 g, 271 mmol) dissolved in dichloromethane (100 mL) is added in one portion. After stirring 1.5 hours at room temperature, the reaction mixture was filtered, and transferred to a mixture of serinol (24.7 g, 271 mmol) in pyridine (380 mL) and allowed to react 16 hours overnight. The mixture is evaporated to a semi-solid residue, and co-evaporated 3*400 mL toluene to remove the remaining pyridine. The solid residue is refluxed in dichloromethane (3.0 L) and stored at -20 C. for 2 hours. The product was collect by filtration in a sintered glass funnel, and washed 2*1000 mL dichloromethane, and 1*1000 mL diethyl ether. Drying overnight under high vacuum yielded 92.8 g (89%) of 1.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nelson Biotechnologies, Inc.; Glen Research Corporation; US2011/77389; (2011); A1;,
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Synthetic Route of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8Hz), 7.41 (2H, t, J=8Hz), 7.22 (2H, t, J=7Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
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