Category: alcohols-buliding-blocks

Peng, Jingjing published the artcileDesign, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y₁ receptor antagonists, Application of 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2018), 302-310, database is CAplus and MEDLINE.

A novel series of 2-(phenoxyaryl)-3-urea derivatives I [R¹ = H, Me; R² = n-Bu, 4-F₃COC₆H₄, 5-methoxycarbonyl-2-thienyl, etc.; X = CH, N] were designed, synthesized and biol. evaluated for their anti-thrombotic activity and antiplatelet aggregation study. Most of compounds exhibited good inhibition against P2Y₁ receptor among them, compounds I [R¹ = H, Me; R² = 2-methylcyclohexyl, 2-adamantyl, 4-F₃COC₆H₄; X = N] demonstrated good P2Y₁ receptor antagonistic potency in vitro (IC₅₀ = 0.62 μM, 0.82 μM, and 0.21 μM, resp.). Four compounds I [R¹ = H, Me; R² = 4-methylcyclohexyl, 4-F₃COC₆H₄, 5-ethoxycarbonyl-2-thienyl, 5-benzyloxycarbonyl-2-thienyl, etc.; X = N] showed good antiplatelet activity. The possible binding modes of compounds with P2Y₁ receptor were also explored by mol. docking simulation. The docking studies demonstrated that compound I [R¹ = Me; R² = 4-F₃COC₆H₄; X = N] interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y₁ receptor antagonistic activity.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhuang, Yaping published the artcileSystemic analysis of 150 kinds of tablet, Synthetic Route of 3818-50-6, the publication is Yaoxue Tongbao (1982), 17(6), 332-5, database is CAplus.

Marquis reagent, modified Dragendorff reagent, Folin reagent, ammonium vanadate-H₂SO₄ reagent, Ehrlich’s reagent, Froehde reagent and 8 other test reagents were used in the identification of âˆ?50 different tablets.

Yaoxue Tongbao published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C14H14O5S, Synthetic Route of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Peng, Fang-liang published the artcileClinical observation of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage, Application In Synthesis of 58551-69-2, the publication is Zhongguo Yaofang (2014), 25(32), 3015-3017, database is CAplus.

This paper is to observe clin. efficacy and safety of carboprost tromethamine and oxytocin in the treatment of postpartum hemorrhage. 60 Delivery women with postpartum hemorrhage were randomly divided into control group and observation group. In control group, women undergoing natural labor were given i.m. injection of oxytocin 20 u after delivery of fetus, and women undergoing caesarean section were given intrauterine injection of oxytocin 20 u after delivery of fetus; then all of them received i.v. dripping of oxytocin 20 u added into 5% glucose solution 500 mL, and i.v. injection of oxytocin was given repeatedly and oral dose of misoprostol was given 600 mg if necessary, qd. Observation group was addnl. given intrauterine injection of carboprost tromethamine 0.25 mg on the basis of control group, and repeated injection was given if necessary; total daily dose could not be more than 2.0 mg and medication interval was more than 15 min. The clin. efficacy, the intensity of uterine contraction, hemostatic rates of patients with different amount of bleeding at different time and ADR were observed in 2 groups. The total effective rate, the intensity of uterine contraction hemostatic rates of patients with different amount of bleeding 5, 10 and 15 min after medication in observation group were significantly higher than those in control group, and there were statistical significances(P<0.05); there was no statistical significance in the incidence of ADR between 2 groups(P>0.05). Carboprost tromethamine and oxytocin are more effective and safer than oxytocin alone in the treatment of postpartum hemorrhage.

Zhongguo Yaofang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Kaisu published the artcileEffect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Jianyan Yixue Yu Linchuang (2016), 13(20), 2872-2873, database is CAplus.

Objective: To investigate the effect of hypophysin combined with carboprost tromethamine in treatment of post-partum hemorrhage induced by uterine inertia. Methods: From Mar. 2014 to Aug. 2015, 92 patients with postpartum hemorrhage induced by uterine inertia were randomly divided into control group (46 cases), given combined treatment of hypophysin and oxytocin, and study group (46 cases), further given carboprost Tromethamine on the basis of control group. The postpartum bleeding time, amounts of postpartum blood loss, incidence rate of hysterectomy and fetal mortality rate were compared between the two groups. Results: The amounts of postpartum blood loss at 0.5, 2 and 24 h after delivery, postpartum bleeding time, incidence rate of hysterectomy and fetal mortality rate of study group were significantly lower than those of control group (P < 0.05). Conclusion: Hypophysin combined with carboprost tromethamine might be with significant curative effect in the treatment of post-partum hemorrhage induced by uterine inertia.

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C14H31NO2, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Hongyi published the artcileEfficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, Recommanded Product: 4,5-Difluoro-2-nitrophenol, the publication is RSC Advances (2020), 10(40), 24037-24044, database is CAplus and MEDLINE.

An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examples) were obtained in good to excellent yields and high enantioselectivities with facile operation. Furthermore, four stereoisomers were afforded resp. in high ee values (>97.8%) via using different chiral 2,3-epoxy-4-trityloxybutanol. This methodol. has been applied to the synthesis of key intermediates of drug candidates.

RSC Advances published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C24H29N5O3, Recommanded Product: 4,5-Difluoro-2-nitrophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yahui published the artcileSelective electrocatalytic hydroboration of aryl alkenes, Application In Synthesis of 608534-44-7, the publication is Green Chemistry (2021), 23(4), 1691-1699, database is CAplus.

Organoboron compounds are powerful precursors of value-added organic compounds in synthetic chem., and transition metal-catalyzed borylation has always been dominant. To avoid toxic reagents and costs associated with metal catalysts, simpler, more economical and effective approaches for delivering organoborons are highly desirable. Here, without the use of any metal catalysts, a CH₃CN-involved electrochem. borylation reaction is reported with alkenes and HBpin as substrates. The site-selectivity is realized to achieve mono- or di-functional borylation of an unsaturated bond by regulating the proportion of HBpin. In addition, the success of gram-scale experiments and versatile conversions confirms the potential applications of this strategy in industrial synthesis. The vital auxiliary role of N,N-diisopropylethylamine (DIEA) in the process of acetonitrile electrolysis is disclosed in the mechanism study. The proposed new strategy provides a generic platform for the discovery of addnl. challenging electrochem. systems for hydrogenation reactions.

Green Chemistry published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H14O, Application In Synthesis of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Lan published the artcileClinical observation of uterine suture combining with carboprost tromethamine injection treatment for uterine atony postpartum hemorrhage, HPLC of Formula: 58551-69-2, the publication is Yixue Zongshu (2014), 20(10), 1901-1902, database is CAplus.

The clin. value of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage was investigated. A total of 60 cases of uterine atony postpartum hemorrhage from Jiangyou Second People’s Hospital during Jun. 2012 and Aug. 2013 were randomly divided into two groups, control group (30 cases) received routine uterine suture, observation group (30 cases) received uterine suture combined with carboprost tromethamine treatment. The estradiol, FSH (FSH), hot flashes score, endometrial thickness and proportions of bleeding time (â‰?2 h, > 2 h), bleeding amount (500-1,000 mL, â‰?1,000 mL) of the two groups were observed The level of estradiol of the observation group was higher than the control group, the endometrial thickness bigger than the control group, FSH, hot flash scores were lower than the control group, with statistically significant differences. The proportion of bleeding time â‰?2 h and the bleeding amount of 500-1,000 mL of the observation group was significantly higher than the control group, with statistically significant difference. The use of uterine suture combined with carboprost tromethamine on uterine atony postpartum hemorrhage could effectively improve the clin. symptoms, and reduce the bleeding amount and time, further promotion of the treatment should be done to improve the medical service level.

Yixue Zongshu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C7H6Cl2, HPLC of Formula: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiang-mei published the artcileIdentification of vitamin C precursor 2-keto-L-gulonic acid, Formula: C6H10O7, the publication is Zhongguo Weisheng Jianyan Zazhi (2014), 24(10), 1399-1400, database is CAplus.

The objective of this paper was to establish the method system for identification of 2-keto-L-gulonic acid (2-KLG) in fermentation broth, and to distinguish 2-KLG from its byproducts (5-DKG and 2-DKG). The standard substance and fermentation product samples were analyzed by thin layer chromatog.(TLC), HPLC and m.p. determination, then the results were compared to confirm the consistency of the three methods in identification of 2-KLG. The TLC results indicated that the Rf value, color and size of chromatogram were concordant between fermentation product and the standard substance of 2-KLG. HPLC results showed that the fermentation product exhibited concordant retention time (8 min), m.p.(170 °C or so) and pH value with standard substance of 2-KLG, but different from 2-DKG and 5-DKG. This method system could identify the existence of 2-KLG in unknown fermentation products, with great significance in screening of new strains of 2-KLG from further fermentation of D-glucose.

Zhongguo Weisheng Jianyan Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C5H7NO, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yongju published the artcileTreatment of atonic postpartum hemorrhage with carboprost tromethamine, SDS of cas: 58551-69-2, the publication is Sichuan Yixue (2014), 35(3), 356-358, database is CAplus.

Objective: To observe curative effect of carboprost tromethamine (Hemabate) for controlling atonic postpartum hemorrhage. Methods: A retrospective anal. was undertaken on 87 cases of atonic postpartum hemorrhage which were treated with Hemabate, and 87 cases which didn′t use Hemabate were regarded as controlled group. Results: The hemorrhage was successfully controlled immediately after administration of Hemabate in 69 of 87cases. The total effective rate was 96.5%, four cases failed and two were performed hysterectomy. Conclusion: Hemabate appeared very effective for treatment of severe atonic postpartum hemorrhage. It also has the characters of convenience, safety, quick and high performance. It should be used actively at the early stage of postpartum hemorrhage.

Sichuan Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H5F3N4, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Wen-qu published the artcileComparison of efficacy of hemabate and oxytocin in prevention of high-risk cesarean section postpartum hemorrhage, COA of Formula: C25H47NO8, the publication is Xiandai Zhenduan Yu Zhiliao (2014), 25(19), 4421-4422, database is CAplus.

82 Cases of patients with high-risk cesarean section postpartum hemorrhage were divided into observation group and control group, 41 cases in each group. The observation group received i.m. injection of hemabate, and the control group received i.m. injection of oxytocin after cesarean section. The amount of bleeding 2 h after surgery, amount of bleeding 2 h after surgery and bleeding rate of observation group were 212.6 ± 57.8 mL, 298.6 ± 71.4 mL and 17.1%, and those of control group were 358.7 ± 62.5 mL, 459.7 ± 86.3ml and 41.5%. The incidence of adverse reactions of observation group was 4.88%, and that of control group was 19.51%. The differences of all the data between groups were statistically significant (P < 0.05 or P < 0.01). Compared with traditional drugs, hemabate can effectively control bleeding amount and bleeding rate in preventing high-risk cesarean section postpartum hemorrhage, has high drug safety and is recommended to be used in clinic.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H15NO, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts