Category: alcohols-buliding-blocks

Synthetic Route of 599-67-7 ,Some common heterocyclic compound, 599-67-7, molecular formula is C14H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 1 (2 mmol), 2 (4 or 15 mmol) and NaHSO4/SiO2 (2.1 mmol/g, 1.0 or 2.0g) in DCE (10 mL) was stirred at 80 C for 2 h, and then the used supported reagent was removed by filtration. The filtrate was evaporated to leave crude product, which was purified by column chromatography (hexane/chloroform) to obtain substituted chromans 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.

Reference:
Article; Aoyama, Tadashi; Furukawa, Takuya; Hayakawa, Mamiko; Takido, Toshio; Kodomari, Mitsuo; Synlett; vol. 26; 13; (2015); p. 1875 – 1879;,
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Related Products of 558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6-(tert-butylsulfonyl)-4-chloroquinolin-7-ol (250 mg, 0.834 mmol) in DMF (2756 mu) was added K2C03 (576 mg, 4.17 mmol) followed by l-chloro-2- methylpropan-2-ol (209 mu, 2.502 mmol). After 10 min, LCMS showed no product. Heated reaction to 60 ¡ãC. No reaction after 3 hr at this temperature. Added sodium iodide (375 mg, 2.50 mmol) and 2,2-dimethyloxirane (371 mu, 4.17 mmol) and stirred for 2 days at to 60 ¡ãC. The crude sample was purified via Biotage normal phase chromatography (25g SNAP column, 0percent – 80percent, 80percent. hex / EtOAc). The pure product containing-fractions were combined and concentrated leading to the product as an off-white solid: -{{6-{tert- butylsulfonyl)-4-chloroquinolin-7-yl)oxy)-2-methylpropan-2-ol (46 mg, 0.124 mmol, 14.83 percent yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.29 (s, 6 H) 1.33 (s, 9 H) 4.03 (s, 2 H) 4.56 (s, 1 H) 7.72 (s, 1 H) 7.76 (d, J=4.80 Hz, 1 H) 8.64 (s, 1 H) 8.94 (d, J=4.80 Hz, 1 H). MS (m/z) 372.2 (M+H+).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; CASILLAS, Linda, N.; DEMARTINO, Michael, P.; HAILE, Pamela, A.; MEHLMANN, John, F.; RAMANJULU, Joshi, M.; SINGHAUS, Robert, Jr.; WO2014/43437; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.1735, as common compound, the synthetic route is as follows.SDS of cas: 27489-62-9

Preparation of trans-4-(3-(thieno[2,3-b]pyridin-2-yl)imidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To a solution of 6-chloro-3-(thieno[2,3-b]pyridin-2-yl)imidazo[1,2-b]pyridazine (45 mg, 0.157 mmol, 1.0 equiv) in DMSO (2.0 mL) was added p-toluene sulfonic acid monohydrate (22 mg, 0.157 mmol, 1.0 equiv) and trans-4-aminocyclohexanol (0.784 mmol, 5.0 equiv) and heated to 100 C. for 24 h. The reaction mixture was diluted with water and extracted with ethyl acetate. Purification by column chromatography using 5% methanol in dichloromethane elution gave 40 mg of the yellow solid, 70%. Compound 205 was physically characterized by electrospray ionization mass spectrometry. Structures and molecular masses are given below in Table 50.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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Reference of 52244-70-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Protection of phenols can be achieved using PSB-OH (1a) under Mitsunobu conditions (Table 1, entries 1 and 4). Those of skill in the art will recognize that the term “Mitsunobu conditions” is explained in Hughes, D. L.; Org. React. 1992, 42, 335-656; a publication which is incorporated herein by reference in its entirety. Attempts to alkylate potassium, cesium, or sodium salts with 1b were unsuccessful (entries 2 and 6). Arylmethylation of primary alcohols (i.e., 2c) occurs smoothly with PSB-Br (1b) using freshly prepared Ag2O; this afforded the corresponding PSB ether in 80-83percent yield (entry 5). However, secondary alcohols could not be protected efficiently using the same method even after prolonged reaction times (entries 7 and 8). Side products and/or low conversions were observed.

The chemical industry reduces the impact on the environment during synthesis 52244-70-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; The Florida State University Research Foundation, Inc.; US7754909; (2010); B1;,
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Reference of 101597-25-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(c) Methyl 9-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho [1,2-b]pyran-5-carboxylate. A solution of methyl 4-hydroxy-6-methoxy-2-naphthoate (1.0g, 4.3 mmol) and 1,1-di(4-methoxyphenyl)prop-2-yn-1-ol (1.16g, 4.3 mmol) in toluene (45 cm3) containing acidic alumina (Brockmann 1), (4.0g) was refluxed for 45 minutes. The cooled solution was filtered and the alumina was washed well with EtOAc (200 cm3). The organic filtrate was washed with aqueous sodium hydroxide (2M, 2 x 50 cm3) and water (10.0 cm3). Removal of the dried (Na2SO4) EtOAc gave an oil which was flash chromatographed over silica using 25% EtOAc in hexane as the eluent to afford a pale yellow solid. Recrystallisation from EtOAc/hexane gave methyl 9-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran-5-carboxylate (yield = 0.79g, theoretical yield = 2.08g 38%, m.p. = 162.5 – 164.0 C (uncorrected)).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; JAMES ROBINSON LIMITED; EP975619; (2007); B1;,
Alcohol – Wikipedia,
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Synthetic Route of 2919-23-5, Adding some certain compound to certain chemical reactions, such as: 2919-23-5, name is Cyclobutanol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2919-23-5.

General procedure: Solutions of OTMPDMeCN-(X)2 and OTMPDPhCN-(X)2 (10mM, 5mL in CH2Cl2) were prepared from the pre-mixed 1:1 Cu(I)-ligand precursors by addition of excess O2 (1atm) at 193K. Two equiv of substrate per oxidant were used unless otherwise noted. For anaerobic substrate oxidations, excess O2 was removed and the solution was flushed with N2 prior to substrate addition. Similar product distributions were obtained for alcohol oxidation reactions performed under O2 and N2 at 233K. Alcohol oxidations without NEt3 were carried out at 233K, and all other reactions were carried out under N2 at 193K unless otherwise noted. The resulting reaction mixtures were quenched by dropwise addition of aqueous ammonia (30%) until the CH2Cl2 layer turned colorless, and passed through a column of neutral activated alumina (Brockmann I, ?150 mesh, 58A) followed by MeOH (2mL). The copper product is retained, and the organic products elute. The reaction mixture was analyzed by GC/GC-MS. Mass recovery of the products was >90% based on addition of an internal calibrant (benzonitrile for alcohols, acetophenone for amines).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2919-23-5, Cyclobutanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
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Related Products of 3597-91-9 ,Some common heterocyclic compound, 3597-91-9, molecular formula is C13H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Anoven dried 100 mL round bottom was charged with 2.00 g (10.85 mmol) of biphenyl-4-yl-methanol, 30 mlof chloroform, 10.5g of anhydrous magnesiumsulfate and a magnetic stir bar.The solution was then allowed to stir until the solution was homogenous, 4.5 g of pyridinium chlorochromate was then added and the vessel was sealed and allowed to react for 3 hours. Reaction progress was checked by TLC andonce the reaction was complete excess solvent was removed via rotovap. Thes olution was then purified via a silica column. The purification yielded a yellow oil that was thenre-crystallized into a white crystalline solid with hexane and dichloromethane.(1.90 g, 10.43 mmol, 96%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3597-91-9, [1,1′-Biphenyl]-4-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Steiger, Scott A.; Li, Chun; Campana, Charles F.; Natale, Nicholas R.; Tetrahedron Letters; vol. 57; 3; (2016); p. 423 – 425;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 96-35-5, name is Methyl 2-hydroxyacetate, molecular formula is C3H6O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-hydroxyacetate

A certain amount of methacryloyl chloride (0.144 mol) dissolved in anhydrous DCM (60 mL) was added dropwise to methyl glycolate (at a temperature of ?0 C and an argon (Ar) atmosphere) 0.144 mol), TEA (0.288 mol), anhydrous DCM (100 mL), stir overnight, wash and purify, and obtain pure product by column chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 96-35-5.

Reference:
Patent; Southwest University; Xu Zhigang; Shi Xiaoxiao; Ma Xiaoqian; Bai Shuang; Xue Peng; Kang Yuejun; (15 pag.)CN107596383; (2019); B;,
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Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H11NO, blongs to alcohols-buliding-blocks compound. Formula: C4H11NO

THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.08271 mol) were added to the reaction vessel at 20-35¡ã C. The resulting slurry was heated to reflux (75-80¡ã C.) for 16-20 h. The reaction was cooled to 30-40¡ã C. and THF was evaporated at below 45¡ã C. under reduced pressure. The reaction mixture was cooled to 20-35¡ã C., rinsed with ethyl acetate and water, and the ethyl acetate layer was collected. The organic layer was concentrated under vacuum at below 45¡ã C. then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-10 h at 45-50¡ã C. under vacuum to provide 2-methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)-pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol.

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Celgene Corporation; Agios Pharmaceuticals, Inc.; Bhat, Sreenivas S.; Burnside, Scott; Parikh, Darshan; Gu, Chong-Hui; Altaf, Syed; (34 pag.)US2018/64715; (2018); A1;,
Alcohol – Wikipedia,
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Application of 5333-42-6 , The common heterocyclic compound, 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General synthesis of beta-glycosides (amounts based on branched C24 disaccharide glycosides) A solution of 3.4 T beta-peracetate and.2.3 g 2-decyl-tetradecanol in 50 mL anhydrous dichloromethane was treated with 600 muL borontrifluoride dimethyletherate and kept at room temperature for about 5-48 h. The mixture was washed with aqueous sodium bicarbonate and dried over magnesium sulfate. After evaporation of the solvent, the acetylated glycolipid was purified by chromatography (hexane/ethyl acetate). The intermediate product was dissolved in 30-40 mL methanol and treated with a catalytic amount of sodium methoxide. After 30-60 min the catalyst was removed by treatment with amberlite IR 120 (H+) and the solvent was evaporated. Further purification of the anomer by chromatography on ion exchanging resin generally proofed to be unnecessary.

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITI MALAYA; PINTAS PTE LTD; WO2006/98699; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts