Category: alcohols-buliding-blocks

Related Products of 124-68-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

A 2 L Morton flask equipped with overhead stirring was charged with dichloromethane (200 ml_), 2-amino-2-methylpropan-1-ol (10.71 ml_, 112 mmol) and a saturated solution of sodium bicarbonate (200 ml_) and the reaction mixture was stirred. Benzyl chloroformate (16.61 ml_, 1 18 mmol) was added rapidly via syringe to the reaction mixture and stirring was continued (1H NMR after 6 hours indicated complete conversion). The mixture was poured into a separatory funnel and the layers were separated. The organic layer was washed with water and saturated sodium chloride, dried over sodium sulfate, and concentrated in vacuo to afford a colorless liquid (23.5 g). This liquid was purified by silica gel chromatography, eluting with ethyl acetate: heptane (1 :9 to 1 :1) to afford benzyl (1-hydroxy-2-methylpropan-2-yl)carbamate (13.61 g, 61.0 mmol, 54.3 % yield) as a colorless syrup. NMR (400 MHz, CD3SOCD3) d 1 .16 (s, 6 H), 3.35 (d, J = 6 Hz, 2 H), 4.69 (t, J = 6 Hz, 1 H), 4.97 (s, 2 H), 6.69 (br s, 1 H), 7.26-7.42 (m, 5 H); LC-MS (LC-ES) M+H = 224.

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CADILLA, Rodolfo; DEATON, David Norman; LARKIN, Andrew L; SCHULTE, Christie; SMALLEY JR, Terrence L.; (237 pag.)WO2020/95215; (2020); A1;,
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Adding a certain compound to certain chemical reactions, such as: 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 117284-59-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: 117284-59-0

At 0C, to a solution of Cr03 (5.70 g, 57.00mmol) in sulfuric acid (8.3 mL) was added water (92 mL). Then a solution of 2-(2,2- difluorocyclopropyl)ethan-1-ol (180 mg, 1.47 mmol) in acetone (30 mL) was added dropwise over 20 mm period. The resulting mixture was stirred for 4 h at room temperature. Whe the reaction was done, the reaction mixture was extracted with ether (50 mL x 4). The organic layers were combined, washed with 2 M sodium hydroxide solution (50 mL x 4) and the aqueous layers were combined. The pH value of the resulting aqueous solution was adJusted to 1 using sulfuric acid and extracted with ether (50 mL x 4). The organic phases were combined, washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure to yield 2-(2,2- difluorocyclopropyl)acetic acid as colorless oil (117 mg, 58%). GCMS: m/z = 136 [Mj.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK PATENT GMBH; SHERER, Brian A.; BRUGGER, Nadia; (546 pag.)WO2017/106607; (2017); A1;,
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Electric Literature of 504-63-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, molecular weight is 76.0944, as common compound, the synthetic route is as follows.

To a dried 250 mL RBF under an atmosphere of argon at room temperature was added 1 00 mL of distilled THF and 2.1 g of sodium hydride (60% dispersion in mineral oil; Aldrich). The mixture was stirred vigorously and 1 ,3-propanediol (4.0 g, 50 mmol; Aldrich) was added over 1 0 minutes via syringe. The reaction was allowed to stir for 45 minutes before tert-butyldimethylsilyl chloride (7.9 g, 52.7 mmol; Aldrich) was added portion wise over 5 minutes. The reaction was then allowed to stir for a further 45 minutes at room temperature before being quenched slowly with 20 mL of 10% aqueous sodium carbonate solution. This mixture was then transferred to a separatory funnel. After being vigorously shaken, the biphasic mixture was separated and the aqueous phase was further extracted with two 50 mL portions of ether. The combined organic phases are then dried with sodium sulfate and filtered through a plug of 1 inch of Celite and 1 inch of flash silica (silica gel 60, EMD) via a 100 mL sinter funnel under vacuum into a 500 mL RBF, with the sodium sulfate residue washed with a further 50 mL of ether. The collected solution was then reduced under vacuum on a Buchi rotary evaporator to give compound L, as a light yellow oil in 99% yield and >95% purity

Statistics shows that 504-63-2 is playing an increasingly important role. we look forward to future research findings about 1,3-Propanediol.

Reference:
Patent; THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION; PREVACUS, INC.; CRAN, John, W.; HAN, Yinglin; ZHANG, Faliang; WO2014/145302; (2014); A2;,
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Application of 2566-44-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2566-44-1 as follows.

Example 14 N-(2-Cyclopropylethyl)-N-(3-ethyl-8-trifluoromethylimidazo[1,2-a]pyridin-2-yl)benzenesulfonamide (Compound 63). To a solution of compound 13-E (0.074 g, 0.2 mmol), compound 14-A (0.021 g, 0.24 mmol), and triphenylphosphine (0.068 g, 0.26 mmol) in THF (2 mL) was added diisopropylazodicarboxylate (0.053 g, 0.26 mmol) and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water and ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium bicarbonate (2*), and dried over sodium sulfate. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography, eluting with a hexanes-EtOAc gradient to give Compound 63 as a white solid (0.036 g, 41%); MS m/z (M+H+) 438.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.

Reference:
Patent; Macielag, Mark J.; Xia, Mingde; McNally, James J.; Matthews, Jay M.; US2012/149699; (2012); A1;,
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Electric Literature of 148043-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 148043-73-6 as follows.

To an aqueous solution of pentafluoropentanol (1M, 1.0 g, 5.61 mmol) was addedtetraethylammonium hydrogen sulfate (10.21mg, 0.045 mmol). The solution was heated to 70 C and an aqueous solution of sodium permanganate monohydrate (1.5M, 1.257 g, 7.86 mmol) was added over 20 minutes. The reaction was stirred at 70 C for an additional 4 hours. The reaction mixture was filtered through Celite (diatomaceous earth). The filter cake was washed with hot water (10 mL). The aqueous solution was acidified to a pH = 1 with concentrated sulfuric acid (200 uL) and extracted with methyl tert-butyl ether (3 10 mL). The organic fractions were combined and dried over magnesium sulfate, filtered and concentrated. NMR (500 MHz, CH3 CN-ds ): delta 2.59 (t, J = 7.5 Hz, 2H); 2.49-2.39 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,148043-73-6, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; RAGHAVAN, Subharekha; STELMACH, John, E.; SMITH, Cameron, J.; LI, Hong; WHITEHEAD, Alan; WADDELL, Sherman, T.; CHEN, Yi-Heng; MIAO, Shouwu; ORNOSKI, Olga, A.; GARFUNKLE, Joie; LIAO, Xibin; CHANG, Jiang; HAN, Xiaoqing; GUO, Jian; GROEPER, Jonathan, A.; BROCKUNIER, Linda, L.; ROSAUER, Keith; PARMEE, Emma, R.; WO2011/149921; (2011); A1;,
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Related Products of 2215-78-3 ,Some common heterocyclic compound, 2215-78-3, molecular formula is C13H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

First, 2-amino-6-methylnicotinic acid (3.04 g) was suspended in m-xylene (20 mL), potassium carbonate (4.15 g) was added thereto, followed by stirring for 30 minutes at 40 C. to obtain Solution 1. On the other hand, (4-phenoxyphenyl)methanol (4.00 g) was dissolved in m-xylene (7 mL), thionyl chloride (1.46 mL) was added dropwise at ice-cold temperature, followed by stirring for 30 minutes while returning to the room temperature. Then, hydrogen chloride, sulfur dioxide and thionyl chloride in the system were evaporated, Solution 1 was added, tetrabutylammonium bromide (194 mg) was added, followed by stirring under heating for 4 hours at 110 C. The reaction solution was cooled to room temperature and about 95% of m-xylene was evaporated under reduced pressure. Ice water was added to the residue, followed by stirring for 30 minutes at room temperature. The precipitated crystal was collected by filtration and dried and 6.39 g (yield of 95.7%, volume efficiency of 25%) of the target substance (compound 2 described in Table 1) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2215-78-3, (4-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGRO-KANESHO CO., LTD.; AIZAWA, Ryo; ARAKI, Koichi; (6 pag.)US2018/362464; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145691-59-4, name is (3,5-Dibromophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 145691-59-4

Step 2: To a mixture of (3,5-dibromophenyl)methanol (1 g, 3.759 mmol, 1 equiv) and PdCI2(dppf).CH2Cl2 complex (0.21 g, 0.263 mmol, 0.07 equiv) in 10 mL of dry THF at -70 ¡ãC was added 1 M diethyl zinc in hexane (15 mL). The resulting mixture was allowed to warm to room temperature, and stirred at 45 ¡ãC for overnight. To drive the reaction to completion, additional 11.3 mL of 1 M diethyl zinc in hexane was added with continued stirring at 45 ¡ãC for overnight. After cooling, the reaction mixture was added to a stirred mixture of dilute HCI and EtOAc. Organic layer was separated, washed with water, dried over Na2S04, filtered, and concentrated in vacuo to afford crude product. The crude product was purified by flash column chromatography with silica gel cartridge using gradient elution of 0 to 10percent EtOAc in Hexane. The collected fractions with pure product were combined and concentrated in vacuo to afford (3,5-diethylphenyl)methanol as colorless liquid (0.2 g, 32percent). LC-MS (ES) m/z = 147.2 [M+H]+. H NMR (400 MHz, DMSO-d6) delta ppm 1.14 (t, J = 7.2 Hz, 6H), 2.50 – 2.56 (m, 4H), 4.41 (d, J = 5.2 Hz, 2H), 5.01 (t, J = 5.6 Hz, 1 H), 6.87 (s, 1 H), 6.93 (s, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145691-59-4, (3,5-Dibromophenyl)methanol.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AXTEN, Jeffrey Michael; FAUCHER, Nicolas Eric; DAUGAN, Alain Claude-Marie; (153 pag.)WO2017/46739; (2017); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 597-31-9, name is 3-Hydroxy-2,2-dimethylpropanal. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Hydroxy-2,2-dimethylpropanal

Hydrogenation; The starting solution used was the mixture described above as hydrogenation feed. From 0 to 7% by weight (based on the hydrogenation feed) of a 15% by weight aqueous solution of trimethylamine (from 2 to 5% by weight (based on the hydrogenation feed), or of a 5% by weight aqueous solution of citric acid in the comparative examples) were added to this mixture in order to establish the particular pH of the hydrogenation effluent specified in Table 1. The hydrogenation feed thus obtained was pumped over the catalyst in a hydrogenation reactor with liquid circulation (circulation:feed=10:1) with a catalyst hourly space velocity of 0.4 kgHPA/Icat¡Áh in trickle mode at 40 bar and 120 C.A comparison of the process according to the invention with comparative examples V1 and V2, in which the pH of the hydrogenation effluent is in each case outside the inventive range, is shown by Table 1.For pH measurement, a Knick model 766 pH meter with a Schott N1041A glass electrode was used.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 597-31-9, 3-Hydroxy-2,2-dimethylpropanal.

Reference:
Patent; BASF SE; US2009/69604; (2009); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., name: Ethyl 2-(hydroxymethyl)acrylate

General procedure: To a solution of the appropriate allylic alcohol 6 (1.00 equiv.) in dichloromethane (0.1 M) was added vinyl acetic acid 7 (1.20 equiv.), dicyclohexylcarbodiimide (1.20 equiv.) and 4-N,N-dimethylaminopyridine (0.15 equiv.) at 0C. The mixture was allowed to warm to ambient temperature and stirred until the product was fully converted (TLC). The solution was filtered and the filter cake was washed three times with dichloromethane. The combined organic layers were washed with aq. HCl (1 M) and then with saturated aq. NaHCO3 solution, dried with Na2SO4, filtered and dry-loaded on silica gel. The pure product was obtained after column chromatography on silica, using hexane/MTBE mixtures of increasing polarity as eluents.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Article; Schmidt, Bernd; Audoersch, Stephan; Kunz, Oliver; Synthesis; vol. 48; 24; (2016); p. 4509 – 4518;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C3H5F3O

Intermediate 31 3f3-trifluoropropoxy)methyl)pyrimidine To a solution of (2-chloro-6-(l-ethoxyvinyl)pyrimidin-4-yl)methyl methanesulfonate (0.452 g, 1.54 mmol) in benzene (7 mL) were added 3,3,3-trifluoropropan-l-ol (0.264 g, 2.32 mmol), sodium hydroxide (5 M, 0.463 mL, 2.32 mmol) and tetrabutylammonium hydrogen sulfate (0.052 g, 0.15 mmol). The mixture was stirred vigourously over night at room temperature. The mixture was filtered through a short silica plug with magnesium sulfate on top. The filter was washed with EtOAc. The mixture was purified by preparative HPLC to give 2-chloro-4-(l- ethoxyvinyl)-6-((3,3,3-trifluoropropoxy)methyl)pyrimidine 0.055 g 11 percent). MS (ES+) m/z 311 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 2240-88-2.

Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MACSARI, Istvan; MALMBORG, Jonas; PAPTCHIKHINE, Alexander; ARVIDSSON, Per; WO2014/195323; (2014); A1;,
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