Category: alcohols-buliding-blocks

Application of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2: This example illustrates the preparation of 3,3-dimethyl-1 -pyrrolo[1 ,2-b]pyridazin- 3-yl-4H-isoquinolinea) Preparation of 1 ,3,3-trimethyl-4H-isoquinolineAcetonitrile (1.5 g, 37 mmol) was slowly added to 98% sulfuric acid (50 g, 0.5 mol) at 0 00. Then 2-methyl-i -phenyl-propan-2-ol (5.0 g, 33 mmol) was added to this solution at 0 00 The reaction mixture was allowed to reach room temperature, stirred for 1 h at this temperature and poured on aqueous sodium hydroxide solution of pH 9. The mixture was extracted withethyl acetate, the organic layer washed with water and brine, dried over sodium sulfate and evaporated under reduced pressure to obtain 1 ,3,3-trimethyl-4H-isoquinoline (4.3 g, 25 mmol, 74 %), which was pure enough to be directly used in the next step. 1H-NMR (400 MHz, 0D013): oe (ppm) = 1.20 (s, 6H), 2.37 (s, 3H), 2.69 (s, 2H), 7.14 (d, 1H), 7.27-7.36 (m, 2H), 7.48 (d, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-86-7, 2-Methyl-1-phenyl-2-propanol.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA (CHINA) INVESTMENT CO., LTD.; BOU HAMDAN, Farhan; QUARANTA, Laura; TRAH, Stephan; LAMBERTH, Clemens; LU, Long; LU, Qiang; WO2015/117563; (2015); A1;,
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Application of 28539-02-8 , The common heterocyclic compound, 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

7.4 g of hydroxymethylbenzotriazole was added to a single-necked flask, 25 ml of S0C12 was added dropwise,After the end of the mixing, the mixture was stirred for 30 min and refluxed at 80 C for 3 h. The excess S0C12 was distilled off with a rotary evaporator, To give a white crystal, i. EforChloromethyl benzotriazole

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Henan College of Traditional Chinese Medicine; Wang, Xia; Zhang, Chao; Ceng, Dai; Cheng, Di; Song, Ning; Yang, Huai Xia; (11 pag.)(2016);,
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Synthetic Route of 3068-00-6, Adding some certain compound to certain chemical reactions, such as: 3068-00-6, name is 1,2,4-Butanetriol,molecular formula is C4H10O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3068-00-6.

General procedure: To a solution of CoCl2 (0.6 mmol) in anhyd MeCN (4 mL), the selecteddialkyl acetal (1 mmol), TMSCl (1.1 mmol), and butane-1,2,4-triol (3 mmol) were added, with stirring, at r.t. At the end ofthe reaction, the mixture was extracted with EtOAc and the combinedextracts were washed with 5% NaHCO3. The organic layerwas dried (anhyd Na2SO4) and filtered, and the solvent was evaporatedunder vacuum. The oils obtained were purified by flash chromatographyto give the desired compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3068-00-6, 1,2,4-Butanetriol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Battisti, Umberto Maria; Sorbi, Claudia; Franchini, Silvia; Tait, Annalisa; Brasili, Livio; Synthesis; vol. 46; 7; (2014); p. 943 – 946;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5333-42-6, name is 2-octyldodecan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

2-octyldecanol (2-Octyldecanol) (4.3 g, 14.5 mmol)Anhydrous DMFIt was dissolved in0 In NaH (60% dispersion inparaffin) (0.58 g, 14.5 mmol) to It was added. After stirring 1 hour the reaction solution at 0 With 5,6-difluoro-benzo [c] [1,2,5] – thiadiazole was added (1 g, 5.8 mmol). Then, and after stirring at room temperature for 12 hours to terminate the reaction was added to a saturated NH4Cl solution and extracted with 100 mL of diethyl ether.The extract solution after silica gel column chromatography was concentrated by vacuum distillation (DCM: Hexanes (1: 3)) to give the compound through a 1 (4.0 g, 95% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5333-42-6, 2-octyldodecan-1-ol.

Reference:
Patent; Korea Research Institute of Chemical Technology; Lee, Jong Chul; Mun, Sang Jin; Sin, Won Suk; Lee, Sang Gyu; Song, Chang Uhn; Soh, Won Wook; Woo, Han Young; (18 pag.)KR2016/31958; (2016); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

Example 1A; 5,5′-Bis(octyloxymethyl)-2-phenyl-1 ,3-dioxane (1 a); 1a[00105] Sodium hydride (60% oil dispersion, washed with hexanes, 8.6 g, 0.22 mol, 2.0 5 eq) is added in portions slowly to a stirred solution of mono-O-benzylidenepentaerythritol (II, Scheme 1 , prepared by the method of Issidorides, C. H.; Gulen, R. C. Organic Syntheses Collected Volume IV, Rabjohn, N., Ed.; John Wiley and Sons: New York, 1963; pp 679-681) (24.11 g, 0.1076 mol) in dry DMF (600 ml_) under a nitrogen atmosphere. The stirred reaction mixture is cooled with an ice water bath for one hour,10 then 1-bromooctane (46.76 ml_, 51.90 g, 0.268 mol, 2.5 eq) is added dropwise over 2 h. After the reaction mixture has been stirred 12 h, another addition of sodium hydride (4.5 g, 0.11 mol, 1.0 eq) and 1-bromooctane (20 ml_, 0.11 mol, 1.0 eq) is made. If after the reaction mixture has been stirred a further 12 h, TLC shows that some mono-O-octyl product is present, another identical addition is made. When all of the mono-O-octyl15 derivative has been consumed, the reaction mixture is quenched by the addition of methanol dropwise until foaming ceases. The reaction mixture is filtered under vacuum and the reaction flask and filter are washed with dichloromethane (~150 ml_). The combined filtrate and washings are concentrated and the residue is extracted with hexanes (300 mL, then 200 ml_). The combined extracts are washed with water (10020 mL), dried (MgSO4) and concentrated under reduced pressure to an oily residue that is passed through a short silica gel column using hexanes, then 5% ethyl acetate/95% hexanes as eluents. The title compound (1a) is a colourless oil (44.71 g, 93 %): RF 0.46 (94 : 6, hexanes : ethyl acetate); 1H NMR (500.13 MHz) delta 0.88, 0.89 (2 t, 6H, J = 6.5 Hz, 2 x Me), 1.20-1.35 (br m, 2OH, 10 x CH2), 1.54, 1.57 (2 pentet, 4H, J = 6.8 Hz, 225 OCH2CH2), 3.22 (s, 2H, eq CCH2O), 3.35 (t, 2H, J = 6.5 Hz, eq octyl OCH2), 3.45 (t, 2H, J = 6.6 Hz, ax octyl OCH2), 3.71 (s, 2H, ax OCH2C), 3.88, 4.09 (2d, 4H, J = 11.5 Hz, H- 4,H-4′, H-6.H-6′), 5.42 (s, 1 H, acetal H), 7.31-7.49 (m, 5H, Ph); 13C NMR delta 138.5 (q Ph) , 128.8 (para Ph), 128.3 (2C, mPh), 126.1 (2C, oPh), 101.7 (acetal C), 71.8 (eq OCH2CH2), 71.7 (ax OCH2CH2), 70.8 (eq OCH2C), 70.2 (C-4 and C-6), 69.4 (ax OCH2C),30 38.9 (q C), 2 x 31.89 (CH2CH2CH3), 29.68, 29.54, 29.51 , 29.45, 2 x 29.34 (6 octyl CH2), 26.22, 26.19 (CH2CH2CH2O), 2 x 22.70 (CH2CH3), 14.3 (Me); MS ESI: CaIc for C28H49O4 449.3631 , found 449.2; calc for C28H48O4Na+ 471.35, found 471.3; calc for (C28H68O4)2Ca2+ 468.34, found 468.5; calc for C28H48O4K+ 487.32, found 487.3.

The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ST. FRANCIS XAVIER UNIVERSITY; MARANGONI, D. Gerrard; GRINDLEY, T. Bruce; JAHAN, Nusrat; PETROPOLIS, Christian; TRAN, Thomas; PAUL, Nawal; WO2010/48715; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.Application In Synthesis of 3,3,3-Trifluoropropan-1-ol

To a solution of 3,3,3-trifluoropropan-1-ol (5.0 g, 43.8 mmol) in CH2Cl2 (25 mL) and pyridine (25 mL) was added 4-(dimethylamino)pyridine (0.27 g, 2.2 mmol) followed by p-toluenesulfonyl chloride (8.4 g, 43.8 mmol). The mixture was allowed to stir at ambient temperature for 72 h then was quenched with 5percent aqueous HCl (20 mL). The layers were separated and the aqueous phase was extracted with CH2Cl2 (3.x.7 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 75percent hexanes in EtOAc) afforded the title compound (8.0 g, 29.8 mmol, 68percent yield). MS (DCI/NH3) m/z 286 (M+NH4)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2240-88-2, 3,3,3-Trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; US2010/69348; (2010); A1;,
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Reference of 7218-43-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol. A new synthetic method of this compound is introduced below.

A suspension of Intermediate B (190 mg, 0.297 mmol), 2-(2-(prop-2-yn-1-yloxy)ethoxy) ethanol [King-Underwood et al., WO2011/048111] (257 mg, 0.890 mmol), PdCI2(PPh3)2 (208 mg, 0.297 mmol) and copper(l) iodide (57 mg, 0.30 mmol) in a mixture of Et2NH and DMF (4: 1 v/v, 7.5 ml_) was degassed with N2 and was then heated to 60C for 16 hr. The reaction mixture was cooled to RT and was evaporated in vacuo onto silica gel and purified by flash column chromatography (Si02, 12 g, MeOH in DCM, 0-5%, gradient elution) to afford the title compound, Compound (la), as a pale tan solid (30 mg, 14%); Rt 1.88 min, m/z 704 (M+H)+ (ES+); 1 H NMR delta: 3.36-3.50 (6H, overlapping m), 3.61-3.63 (2H, overlapping m), 4.37 (2H, s), 4.58 (1 H, m), 5.48 (2H, s), 5.76 (2H, s), 6.41 (1 H, d), 6.64 (1 H, m), 6.72 (1 H, d), 6.78 (1 H, s), 7.14 (1 H, t), 7.27 (1 H, t), 7.52 (1 H, d), 7.65-7.71 (2H, overlapping m), 7.82 (1 H, t), 8.13 (1 H, s), 10.19 (1 H, br s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.

Reference:
Patent; RESPIVERT LIMITED; ONIONS, Stuart Thomas; COPMANS, Alex Herman; BROECKX, Rudy Laurent Maria; SMITH, Alun John; TADDEI, David Michel Adrien; WO2014/140597; (2014); A1;,
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Synthetic Route of 756520-66-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

2. To a stirred solution of triphenyl phosphine (8.2 g, 0.03 mol) and DEAD (13.65 mL of a 40% solution in toluene) in THF (200 mL) at 0C was added a solution of 1-(2,6- dichloro-3-fluoro-phenyl)-ethanol (4.55 g, 0.021 mol) and 3-hydroxy-nitropyridine (3.35 g, 0.023 mol) in THF (200 mL). The resulting bright orange solution was stirred under a nitrogen atmosphere at ambient temperature for 4 hours at which point all starting materials had been consumed. The solvent was removed, and the crude material was dry loaded onto silica gel, and eluted with ethyl acetate-hexanes (20:80) to yield 3-(2,6- dichloro-3-fluoro-benzyloxy)-2-nitro-pyridine (6.21 g, 0.02 1 mol, 98%) as a pink solid. 1H NMR (CDCI3, 300 MHz) 61.8-1.85 (d, 3H), 6.0-6.15 (q, 1H), 7.0-7.1 (t, 1H), 7.2-7.21 (d, 1H), 7.25-7.5 (m, 2H), 8.0-8.05 (d, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; PFIZER INC.; CHRISTENSEN, James Gail; ZOU, Yahong; WO2013/17989; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.623-69-8, name is 1,3-Dimethoxypropan-2-ol, molecular formula is C5H12O3, molecular weight is 120.15, as common compound, the synthetic route is as follows.name: 1,3-Dimethoxypropan-2-ol

To a solution of 1, 3-dimethoxy-2-hydroxypropane (3.84g, 0. 032mol) in DCM (70ml) cooled at 5 C was added triethylamine (Sml, 0. 036mol) followed by slow addition of methanesulphonyl chloride (2. 72ml, 0. 035mol). The mixture was then stirred at ambient temperature for 24 hours. The mixture was then absorbed onto silica gel and purified by flash silica chromatography DCM: isohexane (3: 1) to give the title compound (3.74g, 59percent). NMR 3.15 (s, 3H), 3.28 (s, 6H), 3.52 (d, 4H), 4.78 (q, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-69-8, 1,3-Dimethoxypropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/76436; (2003); A1;,
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Related Products of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of(Intermediate 3) 60ml of N, N-dimethylacetamide Intermediate 2 was added 21.1 g(50 mmol), and stirred in an ice bath, was added dropwise so as to keep the following 10 C N- ethyl ethanolamine 8.9 g (100 mmol) . After completion ofthe dropwise addition, stirring under an ice bath for 2 hours, ethyl acetate100ml reaction solution, ion-exchanged water 100ml, and extracted concentratedhydrochloric acid was added to 3 ml. The organic layer was washed with asaturated sodium chloride aqueous solution, dried over anhydrous magnesiumsulfate, and the solvent was evaporated. Then purified by silica gel columnchromatography (hexane / ethyl acetate = 1/1), Intermediate 3 19.0 g: yield(yield: 80%).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM Corporation; Takasaki, Yuta; Ishiwata, Yasuhiro; Morozumi, Kazuma; (58 pag.)JP2015/124376; (2015); A;,
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