Category: alcohols-buliding-blocks

Related Products of 946122-05-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 946122-05-0, name is (2-Amino-4-bromophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Acetophenone (144 mg, 1.2 mmol),[Cp * Ir (6,6 ‘- (OH) 2bpy) (H2O)] [OTf] 2 (8.3mg, 0.01mmol, 1mol%), potassium hydroxide (56mg, 1.0mmol, 1.0 equiv.),2-Amino-4-bromobenzyl alcohol (201 mg, 1.0 mmol) and water (1 mL) were sequentially added to a 5 mL round bottom flask. After the reaction mixture was refluxed in air for 12 hours,Cool to room temperature. It was extracted with ethyl acetate, the solvent was removed by rotary evaporation and then purified by column chromatography (developing solvent: petroleum ether / acetic acidEthyl ester) to give the pure target compound in a yield of 94%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 946122-05-0, (2-Amino-4-bromophenyl)methanol.

Reference:
Patent; Nanjing University of Science and Technology; Li Feng; Wang Rongzhou; (15 pag.)CN107400084; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 92093-23-7, 1-(4-Bromophenyl)ethane-1,2-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(4-Bromophenyl)ethane-1,2-diol, blongs to alcohols-buliding-blocks compound. Safety of 1-(4-Bromophenyl)ethane-1,2-diol

Alternative preparation of chiral 71rans-Lambda/-[2-(4-bromophenyl)cyclopropyl]-2- propanesulfonamide Enantiomer 1 and Enantiomer 2 EPO enantiomer 2enantiomer 1 Intermediate 7 Intermediate 7 enantiomer 2 Enantiomer 1 Enantiomer 2 trans trans; Intermediate 9, Enantiomer 1: chiral 2-(4-bromophenyl)oxirane Enantiomer 1; A 50OmL round bottom flask, equipped with magnetic stirrer, was charged with 10OmL of 1BuOH, 10OmL of water and of AD-mix-beta(30.6g). Stirring at room temperature produced two clear phases; the lower aqueous one appeared bright yellow. The mixture was cooled to 00C whereupon some of the dissolved salts precipitated. 4-Br-styrene (4g, 21.85mmol) was added at once and the heterogeneous slurry was stirred vigorously at 00C for 3h. While the mixture was stirred at 00C, solid sodium sulfite (32.8g) was added and the mixture was allowed to warm to room temperature and stirred for 1h. 20OmL DCM was added to the reaction mixture and after separation of the layers the aqueous one was further extracted with DCM (3x10OmL). Combined organic extracts were dried over Na2SO4 and evaporated to dryness to get 4.9g of crude material as a colourless thick oil.3.9g of this oil (17.97mmol) were dissolved in dry DCM 5OmL, under nitrogen. To this solution trimethylorthacetate (2.962mL, 23.27mmol) was added and the mixture cooled down to O0C. TMS-CI (2.964mL, 23.36mmol) was added dropwise and the reaction mixture left reacting for 1.5h. The volatiles were evaporated and the residue was dissolved in MeOH, treated with K2CO3 (3.1 g) and stirred vigorously at room temperature for 3h. The suspension was filtered, the solid was washed with DCM and the filtrate was evaporated in a rotary evaporator at room temperature under EPO vacuum to get crude title material (3.9g) that was purified by SiO2 flash chromatography eluting with petroleum ether/Et2O from 95/5 to 90/10. Evaporation of the solvent afforded title material, 2.95g, as a colourless oil that became a waxy solid in the fridge. NMR (CDCI3): 7.49 (d,2H), 7.13 (d, 2H), 3.84 (dd, 1 H), 3.13 (dd, 1 H), 2.77 (dd, 1 H). Chiral HPLC: ee 98.6% Analytical Chiral HPLC conditions: column: CHIRALPAK AS-H (25×0.46 cm) mobile phase: n-Hexane/Ethanol 95/5% v/v flow rate: 1 ml/minUV wavelength range: 200-400 nm Rt Enantiomer 1 : 6.1 min 99.3 a/a% Rt Enantiomer 2: 8.5min 0.7 a/a%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,92093-23-7, 1-(4-Bromophenyl)ethane-1,2-diol, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/87169; (2006); A1;,
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Related Products of 111-46-6 ,Some common heterocyclic compound, 111-46-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Protocole 2 To a solution of diethylene glycol (31.83 g ; 300.0 mmol ; 7.0 eq) in CH2Cl2 (90 mL) was added Et3N (4.77 g ; 47.1 mmol ; 1.1 eq). The mixture was stirred vigorously. A solution of p-toluenesulfonyl chloride (8.17 g ; 42.8 mmol ; 1.0 eq) in CH2Cl2 (108 mL) was added dropwise. Following the addition, the reaction mixture was stirred for 24 h at room temperature. Then a 1.0 M solution of HCl (50 mL), water (50 mL) and saturated solution of brine (60 mL) were added. The resultant aqueous layers were further extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was purified by flash column chromatography on silica gel (99% CH2Cl2/MeOH) to give the desired compound 3b as a colorless oil in 67% yield (7.48 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-46-6, 2,2′-Oxybis(ethan-1-ol), other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ricco, Christophe; Abdmouleh, Fatma; Riccobono, Charlotte; Guenineche, Lena; Martin, Frederique; Goya-Jorge, Elizabeth; Lagarde, Nathalie; Liagre, Bertrand; Ali, Mamdouh Ben; Ferroud, Clotilde; Arbi, Mehdi El; Veitia, Maite Sylla-Iyarreta; Bioorganic Chemistry; vol. 96; (2020);,
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Application of 15852-73-0, Adding some certain compound to certain chemical reactions, such as: 15852-73-0, name is (3-Bromophenyl)methanol,molecular formula is C7H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15852-73-0.

General procedure: 1 mmol of the substrate (alcohol, phenol or amine) wasadded to a mixture of RHA/TiO2(30percent) (20 mg) and aceticanhydride (1.5 mmol per OH/NH2 group) and the resulting mixture was stirred at room temperature. After completionof the reaction (mentioned by TLC), dichloromethane(20 mL) was added and the catalyst was separated byfiltration. The organic phase was washed with 10percent aqueoussolution of sodium bicarbonate (2 20 mL) and dried overNa2SO4. The solvent was removed under reduced pressureto afford the desired product in good to high yields. Thespectral (IR, 1H and 13C NMR) data of new compounds arepresented below:

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Seddighi, Mohadeseh; Shirini, Farhad; Goli-Jolodar, Omid; Comptes Rendus Chimie; vol. 19; 8; (2016); p. 1003 – 1010;,
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Reference of 765-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 765-04-8, name is Undecane-1,11-diol, molecular formula is C11H24O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 250 mL round bottom flask, 1,11-undecanediol (2.62 g, 14 mmol) was suspended in toluene (50 mL). Glacial acetic acid (8.41 g, 140 mmol), water (2.5 mL), and concentrated sulfuric acid (82 mg, 0.84 mmol) were added, and the reaction mixture was heated to reflux temperature. The progress of the reaction was monitored by GC-MS. After 4 hours of reflux, the flask was removed from the heating bath and allowed to cool to room temperature. The contents of the flask were transferred to a separatory funnel and washed with water (25 mL), 10% sodium bicarbonate (2×25 mL), water (25 mL), and brine (25 mL). The organic phase was dried over sodium sulfate, filtered, and the solvent was removed under reduced pressure to yield 3.08 g (96% yield) of a water-clear liquid, which crystallized on standing at room temperature overnight. Analysis of the final product by gas chromatography-flame ionization detector (GC-FID) (Varian 3600) confirmed the product composition as 73% monoacetate, 14% diol, and 13% diacetate.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 765-04-8, Undecane-1,11-diol.

Reference:
Patent; Wicki, Markus A.; Nielsen, Kent E.; US2005/143599; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 50595-15-8, name is tert-Butyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below., Safety of tert-Butyl 2-hydroxyacetate

A 100 mL round bottom flask, equipped with a magnetic stir bar, was charged with tert- butyl 2-hydroxyacetate (1.07 g, 8.10 mrnol) and 4,5-dichloro-2-(2,2,2-trifluoroethyl)pyridazin- 3(2H)-one (FCH Group; CAS: 97137-16-1 ; 2 g, 8.10 mrnol). The flask contents were placed under a dry nitrogen atmosphere and tetrahydrofuran (THF) (16 mL) was introduced via syringe. The resulting solution was stirred at ambient temperature as lithium bis(trimethylsilyl)amide (1.0 M in THF; 8.10 mL, 8.10 mrnol) was added dropwise. The reaction mixture was stirred at ambient temperature for 65 hours. The reaction mixture was diluted with ethyl acetate (30 mL) and washed with dilute aqueous citric acid (2 x 10 mL) and with brine (1 x 10 mL). The organic layer was dried over anhydrous MgSC , filtered and concentrated under reduced pressure to give a crude mixture that was purified via column chromatography (Si(, 10-35percent ethylacetate/heptanes) to give the earlier eluting title compound A (577 mg, 1.7 mrnol, 21percent yield) and the later eluting title compound B (768 mg, 2.2 mrnol, 28percent yield). Title compound A:JH NMR (400 MHz, CDC13) delta ppm 7.77 (s, 1H), 5.21 (s, 2H), 4.71 (q, J = 8.3 Hz, 2H), 1.45 (s, 9H); MS (ESI+) m/z 343 (M+H)+. Title Compound B:JH NMR (400 MHz, CDC13) delta ppm 7.68 (s, 1H), 4.80 (q, 8.3 Hz, 2H), 4.80 (s, 2H), 1.50 (s, 9H); MS (ESI+) m/z 343 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 50595-15-8, tert-Butyl 2-hydroxyacetate.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
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Application of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.

C. ((Cyclopent-3-enyloxy)methyl)benzene To a cooled solution of cyclopent-3-enol (30.40 g, 0.36 mol) in THF (300 mL) at 0 C. was added NaH (18.82 g, 0.47 mol, 60% in mineral oil). After effervescence had ceased, benzyl bromide (80.45 g, 0.47 mol) was added dropwise at 0 C. over a 45 min period. The reaction mixture was allowed to warm to RT over a 6 h period. Excess NaH was quenched with MeOH (120 mL) at a temperature below 5 C. The mixture was warmed to RT, diluted with H2O, and the two layers were separated. The aqueous layer was extracted with EtOAc. The organic layers were combined, concentrated, and purified by column chromatography eluting with petroleum ether and EtOAc (PE/EA=40/1 to 30/1) to give the title compound as an oil (45.28 g, 72%). 1H NMR (400 MHz, CDCl3) delta ppm 2.38-2.41 (m, 2H), 2.49-2.54 (m, 2H), 4.20-4.24 (m, 1H), 4.42 (s, 2H), 5.62 (s, 2H), 7.17-7.28 (m, 5H).

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; US2011/152273; (2011); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-63-1, name is 1-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H9FO

Example 101 1-(3-Fluorophenyl)ethyl N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline (98 mg) was added to toluene/triethylamine = 10/1 (10 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (150 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-fluoro-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (49 mg, yield 31%). 1H-NMR (CDCl3, 400 MHz): 8.78 (1H, s), 8.34 (1H, d, J = 9.3 Hz), 8.13 (1H, s), 7.56 (1H, s), 6.97 – 7.38 (7H, m), 5.88 (1H, q, J = 6.5 Hz), 4.17 (3H, s), 4.17 (3H, s), 4.10 (3H, s), 1.61 (3H, d, J = 6.8 Hz) Mass spectrometry value (ESI-MS, m/z): 499 (M++1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 402-63-1, 1-(3-Fluorophenyl)ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Application of 27871-49-4, Adding some certain compound to certain chemical reactions, such as: 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate,molecular formula is C4H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27871-49-4.

To a solution of Intermediate Gen-14-b (694 g, 6.67 mol, 1 eq.) in DCM (7 L) under stirring and nitrogen, are added 1H-imidazole (500 g, 7.34 mol, 1.1 eq.) and Intermediate Gen-9-b (1055 g, 7.00 mol, 1.05 eq.). The reaction mixture is cooled during the addition, then stirred at room temperature overnight under nitrogen. The reaction mixture is diluted in IPE (5.5 L), the organic layer is washed once with an aqueous 1 M HCl solution (2.8 L), once with a mixture of an aqueous 1 M HCl solution and brine (1/1) (1.4 L/1.4 L) and once with brine (2.8 L), dried over Na2SO4, filtered and evaporated to dryness to give Intermediate Gen-15-b. 1H NMR (300 MHz, CDCl3-d) delta ppm 4.34 (1H, q), 3.73 (3H, s), 1.40 (3H, d), 0.91 (9H, s), 0.90 (6H, d)

According to the analysis of related databases, 27871-49-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BONNATERRE, Florence Marie-Emilie; BEAUMONT, Stephane Nicolas Alain; US2015/80391; (2015); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C4H8O2

A mixture of Int-172-22 (7 g, 26.17 mmol), 23 (14.09 mL, 157 mmol), K2CO3 (4.34 g, 31.4 mmol), DPPP (521 mg, 1.3 mmol) and Pd(OAc)2 (59 mg, 0.26 mmol) in 60 mL H2O/toluene (9:1) was heated at 90oC for 24h. After the mixture was cooled to room temperature, concentrated HCl (15 mL) was slowly added and the mixture was stirred at room temperature for 1h. The product was extracted with EtOAc (3X). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The product was purified by column chromatography using hexanes/EtOAc (0 to 20% EtOAc in hexanes) and obtained as a pale yellow solid (1.3 g) in 27% yield. LCMS: (M+1) m/z = 184.

With the rapid development of chemical substances, we look forward to future research findings about 764-48-7.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; BLACKTHORN THERAPEUTICS, INC.; ROBERTS, Edward; GUERRERO, Miguel A.; URBANO, Mariangela; ROSEN, Hugh; JONES, Rob; LAXAMANA, Candace Mae; ZHAO, Xianrui; TURTLE, Eric Douglas; (331 pag.)WO2018/170492; (2018); A1;,
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