Category: alcohols-buliding-blocks

Synthetic Route of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: The reaction mixture was composed by a 3 mL solution of0.048 mmol 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol, 0.096 mmolacyl donor and 60 mg of enzyme (20% w/v) in solvent. The screeningreactions were performed in silicon carbide plates at temperaturesof 60-80 C, under magnetic stirring to obtain 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate (1H NMR (300 MHz, CDCl3)d 7.26 (dd, J = 8.3, 5.6 Hz, 5H), 7.03 (t, J = 8.5 Hz, 3H), 6.39 (q,J = 7.1 Hz, 3H), 2.09 (s, 3H), 1.66 (d, J = 6.9 Hz, 3H). In order toscreen the influence of the different reaction medium?s components,enzymes, solvent, acyl donor and temperature were evaluated.A 20 mL aliquot was transferred to a new vial and 980 mL ofethyl acetate was added and analyzed in the GC-FID.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; de Franca, Alexandre da S.; Silva, Marcus V.M.; Neves, Rebeca V.; de Souza, Stefania P.; Leao, Raquel A.C.; Monteiro, Carlos M.; Rocha, Angelo; Afonso, Carlos A.M.; de Souza, Rodrigo O.M.A.; Bioorganic and Medicinal Chemistry; vol. 26; 7; (2018); p. 1333 – 1337;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, molecular weight is 138.9911, as common compound, the synthetic route is as follows.Computed Properties of C3H7BrO

General procedure: Concentrated H2SO4 (1 mL) was added into the fuming HNO3 (0.84 mL) at 0 C and stirred for 10 min. Dichloromethane (DCM,10 mL) and 1-bromo-3-propanol (0.9 mL, 10 mmol) were put in dropwise. The reaction mixture was stirred at room temperaturefor another 3 h, then poured into 10 mL of H2O, and extracted with DCM (10 mL 3). The organic layer was combined, washed with saturated NaCl solution, dried over anhydrous Na2SO4, and concentrated concentrated in vacuo to give the crude product 3a. 3b was obtained according to similar procedures. No further purification was needed for the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,627-18-9, 3-Bromopropan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Zhao, Nan; Tian, Kang-Tao; Cheng, Ke-Guang; Han, Tong; Hu, Xu; Li, Da-Hong; Li, Zhan-Lin; Hua, Hui-Ming; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 2971 – 2978;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 25392-41-0

Sodium hydroxide (1.35 g, 34 mmol) was dissolved in water (8 mL), under ice bath was slowly added 4-(chloromethyl) -7-hydroxy-2H-benzopyran-2-one (2.5 g, 12 mmol) in water (6 mL). The mixture was stirred at room temperature for 1 hour and then reacted at 60 C for 4 hours. Concentrated hydrochloric acid (2.8 mL, 34 mmol) was added at 35 C, maintained at the temperature for 1 hour, then stirred at room temperature for 1 hour. The resulting solid was suction filtered and washed three times with water. The solid was dried to give the product as a white solid (1.2 g, 52% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one.

Reference:
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (37 pag.)CN104250239; (2016); B;,
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Application of 4720-29-0, Adding some certain compound to certain chemical reactions, such as: 4720-29-0, name is 3-(Benzylamino)-1-propanol,molecular formula is C10H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4720-29-0.

Step-1: N-Benzyl-2-chloro-N-(3-hydroxy-propyl)-acetamideTo a solution of 3-benzylamino-propan-1-ol (28 g, 0.17 mol) solution in DCM was added triethylamine (25.9 ml, 0.19 mol) and chloroacetyl chloride (13.4 ml, 0.17 mol) at 0 C. The mixture was stirred for 2 h at room temperature, then concentrated and extracted with ethyl acetate. Concentration of organic layer afforded 41 g (93%) of N-benzyl-2-chloro-N-(3-hydroxy-propyl)-acetamide. LC/MS [M+H]+: 242.3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4720-29-0, 3-(Benzylamino)-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KHAMRAI, Uttam; Ronsheim, Matthew; Karak, Sumit Kumar; US2010/152160; (2010); A1;,
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Reference of 4254-29-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, molecular weight is 134.18, as common compound, the synthetic route is as follows.

General procedure: The alkylation was performed following a published procedure [29] with minor modifications. 1 (1.0 eq.) was dissolved in dry THF under nitrogen in oven-dried round-bottomed flask and alcohol (1.1-2.5 eq.) and PPh3 (1.1-2.5 eq.) was added. The nitrogen flow was temporarily removed when solid alcohols were added. When all of the PPh3 was dissolved, DIAD (1.0-2.5eq.), were added drop wise. The reaction was stirred at room temperature under nitrogen, until TLC indicated full consumption of the starting material, unless otherwise noted. The solvent was removed under reduced pressure and the crude product was purified by flash column chromatography or automated flash column chromatography.

The chemical industry reduces the impact on the environment during synthesis 4254-29-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Pettersson, Mariell; Bliman, David; Jacobsson, Jimmy; Nilsson, Jesper R.; Min, Jaeki; Iconaru, Luigi; Guy, R. Kiplin; Kriwacki, Richard W.; Andreasson, Joakim; Gr°tli, Morten; PLoS ONE; vol. 10; 5; (2015);,
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Adding a certain compound to certain chemical reactions, such as: 623-61-0, Isopropyl glycolate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-61-0, blongs to alcohols-buliding-blocks compound. Recommanded Product: 623-61-0

To the obtained isopropyl hydroxyacetate, 85.79 g of 99.5% sodium isopropoxide was added, and the alcohol formed by the reaction was removed at 50 C, and 212.60 g of 99% 1,2,3-trichlorobenzene was added thereto. The condensation reaction is carried out at 110 C,After the reaction, the unreacted 1,2,3-trichlorobenzene was removed under reduced pressure.The condensation liquid is cooled to 45 C for filtration, and the filter cake is dried under reduced pressure.The dried fractions are collected and combined with the filtrate.264.21g of isopropyl 2,3-dichlorophenoxyacetate, the content of 98.5%,The yield was 98.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-61-0, its application will become more common.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Chi Zhilong; Hou Yongsheng; Zhang Liguo; Hu Yishan; (8 pag.)CN108947816; (2018); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C7H6BrFO

[2-Amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone (?A4?) [0341] 74 mg of (2-bromo-5-fluorophenyl)methanol, 100 mg of potassium carbonate, 1 ml of water and 15 mg of [1,1?-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 150 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 3 ml of ethanol under argon. The mixture is heated at 120° C. for min; the hot mixture is filtered through kieselguhr, and the filtrate is evaporated in vacuo. The residue is purified by reverse-phase column chromatography. [0342] Yield: 8 mg (5percent) of [2-amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone; HPLC retention time: 1.51 min; [0343] 1H NMR (400 MHz, DMSO-d6/TFA-d1) delta [ppm] 8.08-8.02 (m, 2H), 7.81 (d, J=8.7, 1H), 7.42 (d, J=7.2, 1H), 7.39-7.25 (m, 4H), 7.24 (d, J=6.9, 1H), 7.16 (td, J=8.5, 2.8, 1H), 4.99 (s, 2H), 4.82 (s, 2H), 4.36 (s, 2H).

The synthetic route of 202865-66-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; Eggenweiler, Hans-Michael; Sirrenberg, Christian; Buchstaller, Hans-Peter; US2013/178443; (2013); A1;,
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Electric Literature of 14593-04-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14593-04-5, name is 3-Amino-3-phenyl-1-propanol, molecular formula is C9H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a 4-Chloro-2-[(3-Hydroxy-1-Phenylpropyl)Amino]-Benzonitrile A mixture of 3-amino-3-phenyl-1-propanol (1 g, 6.6 mmol), 4-chloro-2-fluorobenzonitrile (1 g, 6.4 mmol) and N,N-diisopropylethylamine (1.2 ml, 6.9 mmol) was stirred and heated at 140° C. for 5 h. The crude reaction mixture was cooled and purified on silica gel (ether/isohexane 1:4). The product was isolated as a colourless solid (1.1 g, 58percent), m.p. 88-90° C. MS APCI+vem/z287 ([M+H]+). 1H NMR 300 MHz (d6-DMSO) 7.5-7.2 (6H, m), 7.05 (1H, d), 6.63 (1H, dd), 6.51 (1H, d), 4.9 (1H, t), 4.73 (1H, q), 3.49 (2H, q), 2.1-1.88 (2H, m).

According to the analysis of related databases, 14593-04-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cheshire, David; Connolly, Stephen; Cox, David; Millichip, Ian; US2003/73685; (2003); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, the common compound, a new synthetic route is introduced below. name: 4-(Dimethylamino)butan-1-ol

General procedure: 12 (100 mg, 0.35 mmol) was dissolved in the mixture of 1,4-dioxane (10 mL) and H2O (2.00 mL) and then added with boronicacid (2.80 mmol), Pd(dppf)2Cl2 (28 mg, 0.035 mmol) and Cs2CO3(228 mg, 0.70 mmol). The reaction was heated at 100 C underargon atmosphere. After 12 h, the reaction mixture was cooled toroom temperature and was concentrated in vacuo. Then themixture was diluted with water and extracted with ethyl acetate.The combined organic layer was washed by saturated sodiumchloride solution for three times, dried over anhydrous Na2SO4 andconcentrated under reduced pressure. The residue was purified bysilica gel chromatography to give 13.To a stirred solution of 13 and triphosgene (100 mg, 0.34 mmol)in anhydrous dichloromethane (5 mL) was added triethylamine(104 mg, 1.02 mmol) at 0 C under nitrogen atmosphere. After5 min, a solution of 4-(dimethylamino)butan-1-ol (1.02 mmol) indichloromethane (5.00 mL) was added and then the mixture wasstirred at room temperature for overnight. The reactionwas dilutedwith dichloromethane (15 mL) and washed with water (3 20 mL).The organic phases were dried over anhydrous Na2SO4 andconcentrated in vacuo. The residue was purified by using columnchromatography to afford the corresponding product.

The synthetic route of 13330-96-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lu, Dong; Liu, Jianan; Zhang, Yunzhe; Liu, Feifei; Zeng, Limin; Peng, Runze; Yang, Li; Ying, Huazhou; Tang, Wei; Chen, Wuhong; Zuo, Jianping; Tong, Xiankun; Liu, Tao; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 328 – 337;,
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Electric Literature of 27129-87-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 27129-87-9 as follows.

Step 2: 3,5-Dimethylbenzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate To a stirred solution of (3,5-dimethylphenyl)methanol (1.020 g, 7.49 mmol) in DMF (5 mL) at RT was added CU (1.214 g, 7.49 mmol). The reaction mixture was heated at 50 C. for 20 hrs. Tert-butyl piperidin-4-ylcarbamate (1.5 g, 7.49 mmol) was added and the reaction mixture stirred at 50 C. for 4 hrs. The mixture was diluted with EtOAc and washed with a saturated solution of sodium bicarbonate, brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification was carried out by chromatography on silica using 0-100% EtOAc in hexanes as eluent to afford the title product. LC-M: Rt 1.47 mins; MS m/z 263.3, 264.2; [M-Boc]+; Method 2minLowpHv03

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.

Reference:
Patent; Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily; US2014/171403; (2014); A1;,
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