Category: alcohols-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 624-95-3, name is 3,3-Dimethylbutan-1-ol. A new synthetic method of this compound is introduced below., Formula: C6H14O

[00079] 12.2 g of 3,3-Dimethyl-1-butanol of 98% purity (117.3 mmol) and 0.049 g 4-Acetamido-TEMPO (0.223 mmol) are charged in a jacketed glass reaction flask as in Example I. Sodium borate (0.294 g, 0.76 mmol), NaHCO3 (1.472 g, 17.5 mmol) and NaCl (2 g) are dissolved in water (25 cc) and the aqueous solution is added to the stirred organic fraction at 1000 RPM in the reaction flask. The stirred suspension is cooled to 0 C. and the emulsion is re-adjusted to pH 8.6 using 40% solution of NaOH. When the temperature of the reactants reached 0 C., 69.8 g (123.1 mmol) of 13.1% aqueous NaOCl solution are pumped in via a gas-tight syringe over 55 minutes. The reaction mixture is stirred for an additional 15 min at 0 C. and the organic layer is sampled for GC assay. The yield of 3,3-dimethylbutyraldehyde is 88.3% at 2 min of post bleach-addition time and 92.1% at 15 min reaction time

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 624-95-3, 3,3-Dimethylbutan-1-ol.

Reference:
Patent; The NutraSweet Company; US6825384; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4084-38-2, 2,3,5,6-Tetrafluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H4F4O, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H4F4O

Add in a 100mL three-necked flask2,3,5,6-tetrafluorobenzyl alcohol 4.5g (25mmol),Pyridine 3g,Hexane 40mL,Slow dropCis-2,2-dimethyl-3-(E/Z-2-chloropropenyl)cyclopropanecarboxylic acid chloride 6g (30mmol),The reaction was carried out for 4 hours at room temperature.The organic phase is sequentially treated with 20 mL of 5% sodium hydroxide solution.Wash with 5% hydrochloric acid solution and saturated sodium chloride solution, dry,After desolvation, a pale yellow viscous liquid is obtained.After column chromatography (petroleum ether / ethyl acetate = 20/1), 9.2 g of pale yellow liquid was obtained.The yield was 95%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4084-38-2, 2,3,5,6-Tetrafluorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Mt. Huang College; Han Bingbing; Zheng Zubiao; (15 pag.)CN109776327; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 23147-58-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23147-58-2, name is Glycerol aldehyde dimer. This compound has unique chemical properties. The synthetic route is as follows.

Glycol aldehyde dimer (1.0 g) was dissolved in demineralized water (14.5 g) . The solution was loaded into an autoclave along with 5% Ru on carbon catalyst (Sigma Aldrich, 0.20 g). The autoclave was purged 3 times with hydrogen and subsequently pressurized with hydrogen to the respective pressures given in Table 2. The mixture was heated to 80C from room temperature in the course of 15 min and stirred for 3 hours. The autoclave was then cooled to room temperature and the decrease in hydrogen pressure was noted.The product mixture was isolated from the catalyst by filtration and analyzed by HPLC and GC.Results of Examples 9 to 11 are provided in Table 4. The amount of 1, 2-butanediol (1,2-BDO) present in relation to ethylene glycol is provided. It can be seen that an increase in pressure of the reaction results in a reduction of 1,2-butanediol (1,2-BDO) formed, resulting in an increased purity of the ethylene glycol product in milder conditions.Table 4.

According to the analysis of related databases, 23147-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HALDOR TOPSØE A/S; HOLM, Martin Spangsberg; TAARNING, Esben; (22 pag.)WO2016/1169; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 349-75-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, molecular weight is 176.14, as common compound, the synthetic route is as follows.

3-Trifluoromethylbenzyl alcohol (10 g, 56.8 mmol)And pyridine (6.74 g, 85.2 mmol)Was dissolved in 50 ml of DCM at -10 C,The triphosgene was dissolved in 50 ml of DCM,A solution of 3-trifluoromethylbenzyl alcohol and pyridine in DCM was added dropwise to a solution of triphosgene in DCM,The reaction was carried out at -10 C for 2 hours,Room temperature reaction for 42 hours,TLC monitoring,The reaction was terminated, the solvent was decompressed, extracted with EA,Washed three times with water,Combined organic layer,Concentrated in vacuo to give 12.7 g of a colorless oil,Yield 93.7%.

The chemical industry reduces the impact on the environment during synthesis 349-75-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; North Nationalities University; Hong Wei; Wang Hao; Yang Hao; Ouyang Yifan; Tan Xiaoli; Sun Yutong; Zhu Xuanli; Wang Zhe; (18 pag.)CN106749070; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cooled solution of 53 (2.0 g, 19.20 mmol, 1.0eq) in dichioromethane (40 mE) was added pyridine (3.03 g,38.4 mmol, 2.0 eq) followed by mesyl chloride (2.29 g,20.16 mmol, 1.05 eq) dropwise at 0 C. The reaction mixturewas stirred at room temperature for 1 h. After completion ofreaction, reaction mixture was transferred into ice cold waterand product was extracted with dichloro methane. Organic layer was combined, dried over sodium sulphate and concentrated under reduced pressure to obtain 53.1. (1.5 g, 42.86%), MS(ES): mlz 183.06 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Nimbus Lakshmi, Inc.; Masse, Craig E.; Greenwood, Jeremy Robert; Mondal, Sayan; Cowen, Scott D.; McLean, Thomas H.; (624 pag.)US2019/31664; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 19064-18-7 ,Some common heterocyclic compound, 19064-18-7, molecular formula is C7H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of (2,6-difluorophenyl)methanol (1 mL) and sodium hydride (60%, oil) (34 mg) was stirred at room temperature for 30 min. 3-(4-Chloropyridin-2-yl)quinazoline-2,4(1H,3H)-dione (115 mg) was added, and the obtained mixture was stirred at 150C for 4 hr. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (31 mg). 1H NMR (300 MHz, DMSO-d6) delta 5.24 (2H, s), 7.14-7.31 (6H, m), 7.51-7.65 (1H, m),7.66-7.79 (1H, m), 7.87-8.06 (1H, m), 8.45 (1H, d, J = 5.7 Hz), 11.65 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19064-18-7, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; OGINO, Masaki; IKEDA, Zenichi; FUJIMOTO, Jun; OHBA, Yusuke; ISHII, Naoki; FUJIMOTO, Takuya; ODA, Tsuneo; TAYA, Naohiro; YAMASHITA, Toshiro; MATSUNAGA, Nobuyuki; EP2889291; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

vTn a glass RBF equipped with a Teflon-coated magnetic stirrer was combined 4-fluoro-1,2-dinitrobenzene (1 eq.), 3- amino-3-methylbutan-1-ol (1 eq.) and ethyl diisopropyl amine (1.5 eq.) in DMSO (0.5 M). The resulting mixture was then heated at 100C for 24 h. The reaction mixture was then diluted with water and extracted with EtOAc. The combined organic extracts were washed further with water and brine, dried over MgSO4, filtered and the filtrate concentrated in vacuo. Further purification of the crude product thus obtained by way of column chromatography (Si02, gradient elution, 9:1 (v/v) Hex: EtOAc – EtOAc) furnished the desired product (22% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; LAN, Ruoxi; CHEN, Austin; CLARK, Ryan C.; (268 pag.)WO2017/49068; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5391-88-8, name is 1-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1-(4-Bromophenyl)ethanol

General procedure: Under an N2 atmosphere, a mixture of secondary alcohol (0.5 mmol), primary alcohol (0.6 mmol), 1a (5 mol %), NaOH (0.1 mmol), 4 A molecular sieve (0.6 g), and toluene (1.5 mL) was added into a 25 mL Schlenk tube equipped with a stirring bar. The mixture was heated to 120 C under a slow and steady N2 flow for 24 h. After cooling to ambient temperature, 6 mL water was added and the aqueous solution extracted with ethyl acetate (3 x 5 mL). The combined extracts were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product purified on a short flash chromatography column.

With the rapid development of chemical substances, we look forward to future research findings about 5391-88-8.

Reference:
Article; Zhang, Shi-Qi; Guo, Bin; Xu, Ze; Li, Hong-Xi; Li, Hai-Yan; Lang, Jian-Ping; Tetrahedron; vol. 75; 47; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 7417-18-7, 2-(2-Methoxyphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(2-Methoxyphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(2-Methoxyphenyl)ethanol

b) 4-Bromo-2-(2-hydroxyethyl)-anisole 35.72 g of tetrabutylammonium tribromide am added in portions to a solution of 10.7 g of 2-(2-hydroxyethyl)-anisole in 195 ml of dichloromethane and 130 ml of methanol. The reaction mixture is stirred for 150 minutes at room temperature and is then concentrated by evaporation in a rotary evaporator. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation, and the residue is purified by means of FC (dichloromethane), yielding the title compound: Rf (dichloromethane)=0.26; HPLC Rt =13.04 minutes.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7417-18-7, 2-(2-Methoxyphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Ciba-Geigy Corporation; US5559111; (1996); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 33524-31-1

Example 10; 5-Chloro-1-(2,5-dimethoxybenzyl)-1H-indole-2-carboxylic acid (3-hydroxy-2,2- dimethylpropyDamide EPO A solution of phosphorous tribromide (5.74ml, 60.4mmol) in anhydrous DCM (90ml) was added over 20min to a cooled, stirred solution of 2,5-dimethoxybenzyl alcohol (25.Og, 148.8mmol) in DCM (180ml), maintaining the temperature between -5C and 00C. Following the addition, the reaction was stirred at this temperature for a further 20 min. when water (200ml) was added. After separation of the layers, the organic was washed with water (3x200ml), dried with magnesium sulfate and evaporated to dryness under reduced pressure. The resulting crude product was crystallised from diethyl ether/heptane to afford 2-bromomethyl-1,4-dimethoxy-benzene (24.2g, 72%).The title compound was then prepared in a manner similar to that described in Example 1. 1H NMR (400MHz, CDCI3) deltaH : 0.88(s, 6H), 3.08(d, 2H, J=7.0), 3.25(d, 2H, J=6.8), 3.52(t, 1 H, J=7.0), 3.57(s, 3H), 3.84(s, 3H), 5.75(s, 2H), 6.03(d, 1H, J=2.9), 6.59(br t, 1H, J=6.8), 6.68(dd, 1 H, J=8.8, 2.9), 6.80(d, 1 H, J=8.8), 6.85 (s, 1H), 7.19(dd, J=8.8, 1.9), 7.27(m, 1H), 7.60(d, 1 H, J=1.9); EIMS: m/z = 431.3 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 33524-31-1, (2,5-Dimethoxyphenyl)methanol.

Reference:
Patent; N.V. ORGANON; WO2006/100208; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts